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      • 녹농균의 추출물 및 Serine Protease와 Aprotinin이 가토 각막에 미치는 영향에 관한 실험적 연구

        문연성,김재찬,신경환,송계용 중앙대학교 의과대학 의과학연구소 1991 中央醫大誌 Vol.16 No.4

        In this experimental study we had injected Pseudomonas extract, Serine protease and Aprotinin(protease inhibitor) into the corneal stroma of rabbit. For this study we used 44 albino rabbits and divided them into 6 groups according to the injection materials as below: A : Extract of Pseudomonas B : Extract with Aprotinin 2000 u ̄ C : Serine protease D : Serine protease with Aprotinin 500 u ̄ E : Serine protease with Aprotinin 2000u ̄ F : Balanced salt solution(Control) After the injection of each sample we examined the degree of corneal opacity, presence of descemetocele and corneal perforation and the degree of anterior chamber reactions as cells and flares with time interval(1 hour to 1 week) using the slit-lamp biomicroscope. The corneal endothelial thickness and endothelial cell density was also checked with the specular microscope. Fot the histopathologic examination we enucleated every samples with time interval and made specimens for light and electron microscope. The results were as follows: 1. The degree of anterior chamber reaction(cell & flares) was more marked in the serine protease group with peak reaction from 10 hours to 24 hours(p<0.05). 2. The corneal opacity in the Extract group was more marked (+2.1) than combined Aprotinin 2000u ̄ injection group (+0.9)(p<0.01). 3. The descemetocele formation was observed in Extract group and serine protease group, and the occurrence rate was 62.5%, 50.% respectively after 48 hours. The corneal perforation was developed 3 eyes in Extract group within 10 hours after injection(18.8%). 4. Under the specular microscopic examination the increment of corneal thickness secondary to stromal edema and marked endothelial cell loss were observed in Extract group and serine protease group compared with control group (p<0.01). 5. The histopathological changes exhibits loosening of stromal collagen fibers, diffuse intracelluar edema, endothelial degeneration associated with fibrinoid membrane formation in Extract group and serine protease group. 6. Electron-lucent area with loss of web-like pattern of the stromal proteoglycan groud substance was more marked in Extract group and serine protease group. Thus we could make a conclusion that combined injected of Aprotinin with Pseudomonas extract or serine protease was more effective preventing the early period of Pseudomonas infection from corneal damage compared with a single injection of Extract or serine protease.

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        노인의 안질환 분포에 대한 임상 고찰

        문연성(Yeon Sung Moon) 대한안과학회 1986 대한안과학회지 Vol.27 No.4

        '스콜라' 이용 시 소속기관이 구독 중이 아닌 경우, 오후 4시부터 익일 오전 9시까지 원문보기가 가능합니다.

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        Valganciclovir를 이용한 거대세포바이러스망막염의 치료

        김나래,문연성,진희승,윤준호.Na Rae Kim. M.D.. Yeon Sung Moon. M.D.. Hee Seung Chin. M.D.. Jun Ho Yoon. M.D. 대한안과학회 2008 대한안과학회지 Vol.49 No.3

        '스콜라' 이용 시 소속기관이 구독 중이 아닌 경우, 오후 4시부터 익일 오전 9시까지 원문보기가 가능합니다.

        `Purpose: To report a case of a patient with cytomegalovirus (CMV) retinitis who was treated with oral valganciclovir. Case summary: A 34-year-old man who had undergone anti-cancer chemotherapy for Non-Hodgkin lymphoma was referred to the ophthalmologic oncology clinic because of decreased vision in both eyes. Fundus examination showed white, opaque, and granular retinal lesions in both eyes, and a serologic test showed a positive response to CMV antibody IgG and a negative response to CMV antibody IgM. The patient received induction therapy with intravenous ganciclovir and maintenance therapy with oral valganciclovir 900 mg once daily. CMV retinitis reactivated 4 weeks after maintenance therapy was discontinued. At that point, the patient received induction therapy with oral valganciclovir 900 mg twice daily for 3 weeks and maintenance therapy with 900 mg once daily for 5 weeks. The retinal lesion disappeared and did not recur after oral administration of valganciclovir. The patient discontinued valganciclovir after 5 weeks of maintenance therapy, and CMV retinitis did not reactivate during 6 months of follow-up. Conclusion: Oral valganciclovir was clinically effective in the treatment of CMV retinitis in a patient who was treated with anti-cancer chemotherapy for non-Hodgkin lymphoma.`

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        당뇨 환자와 정상인의 스펙트럼 영역 빛간섭단층촬영을 통한 신경절세포-내망상층 두께 차이

        박상준,문연성,김나래.Sang Jun Park. MD. Yeon Sung Moon. MD. PhD. Na Rae Kim. MD. PhD 대한안과학회 2014 대한안과학회지 Vol.55 No.10

        '스콜라' 이용 시 소속기관이 구독 중이 아닌 경우, 오후 4시부터 익일 오전 9시까지 원문보기가 가능합니다.

        Purpose: To analyze the difference of the ganglion cell-inner plexiform layer (GCIPL) thickness in diabetic and normal eyes of patients using spectral domain optical coherence tomography (OCT) (Carl Zeiss Meditec, Dublin, CA, USA). Methods: The authors compared and analyzed the difference of the GCIPL thickness measured with spectral domain optical coherence tomography (OCT) in 42 diabetic and 92 normal subjects. Results: The study subjects were divided into 3 groups: 92 normal subjects, 22 diabetic patients without diabetic retinopathy, and 26 diabetic patients with diabetic retinopathy. Presence of diabetes mellitus (DM) or diabetic retinopathy did not influence the retinal nerve fiber layer (RNFL) thickness. The GCIPL thickness tended to be thinner especially in the superior sector GCIPL. The GCIPL thickness of normal subjects, diabetes patients without diabetic retinopathy, and diabetic retinopathy patients was 82.24 ± 7.21 μm, 81.86 ± 9.53 μm, and 76.77 ± 14.13 μm, respectively, especially in the superior sector GCIPL (<EM>p</EM> = 0.029). Conclusions: Retinal ganglion cell layer thinning was induced by diabetes and diabetic retinopathy, and originated specifically from the superior part of the retina. J Korean Ophthalmol Soc 2014;55(10):1476-1480

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        한국인 나이관련황반변성 환자의 우울 및 불안에 대한 조사 및 그 영향에 대한 고찰

        정지원,문연성,Ji Won Jung,Yeon Sung Moon 대한안과학회 2012 대한안과학회지 Vol.53 No.6

        '스콜라' 이용 시 소속기관이 구독 중이 아닌 경우, 오후 4시부터 익일 오전 9시까지 원문보기가 가능합니다.

        Purpose: To examine the degree of depression and anxiety in Korean patients with age-related macular degeneration (AMD) and to evaluate the influence of mood disturbance on patient’s treatment satisfaction and compliance. Methods: Forty-four patients with AMD and thirty-three controls comprised the study populations. Patients and controls rated themselves on the Korean Beck Depression Inventory (BDI) and Beck Anxiety Inventory (BAI). The effect of mood disturbance on the patient’s satisfaction and compliance was evaluated. Results: The depression and anxiety scores were significantly higher in patients with AMD. The mood disturbance was negatively correlated with the patient’s satisfaction and compliance. 14 patients (31.8%) were lost to follow-up 1 year later. The depression and anxiety scores of these patients were higher than those of remaining thirty patients. Conclusions: Depression and anxiety of patients with AMD affect on patient’s satisfaction and compliance. So recognition and management of mood disturbance may help improving visual function and maintaining quality of life in patients. J Korean Ophthalmol Soc 2012;53(6):792-800

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        망막분지정맥폐쇄 황반부종에서의 유리체강내 트리암시놀론 주입술 후 시력호전의 예후인자

        김숙진,문연성,Suk Jin Kim,Yeon Sung Moon 대한안과학회 2012 대한안과학회지 Vol.53 No.1

        '스콜라' 이용 시 소속기관이 구독 중이 아닌 경우, 오후 4시부터 익일 오전 9시까지 원문보기가 가능합니다.

        Purpose: To evaluate prognostic factors for improvement of visual acuity after intravitreal triamcinolone acetonide injection (IVTA) for treatment of macular edema (ME) secondary to branch retinal vein occlusion (BRVO). Methods: Sixty-eight eyes of 68 consecutive patients treated with IVTA for ME due to BRVO were retrospectively reviewed. Patients were categorized into 2 groups according to the final visual acuity. The ‘gainer group’ consisted of eyes with a gain of 2 or more Snellen chart lines and the ‘non-gainer group’ consisted of eyes with less than 2 lines improvement or which had worsened at the last follow-up visit. Comparative clinical characteristics and ophthalmoscopic examinations were analyzed between the 2 groups. Results: Out of the 68 eyes, 38 (56%) showed improved vision and were categorized as the gainer group; 30 eyes (44%) were categorized as the non-gainer group. The duration of symptoms in the non-gainer group was longer than the gainer group. Additionally, patients with a better baseline vision were expected to show greater improvement. The number of early visual acuity gainers who showed visual improvement at 1 month after IVTA was significantly higher in the gainer group. The number of eyes with angiographically documented macular ischemia was significantly higher in the non-gainer group. Existence of subretinal fluid has been identified as a positive factor for visual improvement. Conclusions: The cases with early treatment, good baseline visual acuity, case of favorable response to the initial IVTA, absence of macular ischemia, and baseline subretinal fluid are favorable prognostic factors for the outcome of visual acuity after IVTA for ME due to BRVO. J Korean Ophthalmol Soc 2012;53(1):49-58

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