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류지용,김근해,김숙영 대한안과학회 2006 대한안과학회지 Vol.47 No.3
Purpose: Most hydatid cysts affecting humans grow in the liver and the lung, but orbital involvement is very rare. To our knowledge, this is the first report of a hydatid cyst of the orbit in Korea. Methods: A 33-year-old woman came to the hospital with a 2-month history of slowly progressive proptosis and ocular pain of the right eye. The right eye showed proptosis, visual impairment and mild limitation of abduction. Orbital CT and MRI revealed a 32×20×24-mm well-defined unilocular cyst in the retrobulbar, intraconal area of the right orbit. Results: The cyst was surgically removed with lateral orbitotomy and it ruptured just prior to the end of the operation. Complete aspiration of the cystic fluid and in situ irrigation with gentamicin-normal saline mixture were performed. Histopathological examination revealed a hydatid cyst. After surgery, the visual acuity and primary position of the right eye were recovered, but its abduction was mildly limited.
류지용,김재우,Ji-Yong Ryu,Jae Woo Kim,Ph,D 대한안과학회 2008 대한안과학회지 Vol.49 No.12
Purpose: To investigate the role of L-ascorbic acid (LAA) on the survival and its association with nitric oxide (NO) production against hydrogen peroxide-induced oxidative stress in trabecular meshwork (TM) cells. Methods: Primarily cultured human TM cells were exposed to hydrogen peroxide; 10, 100 µM for 2 days, or 1 mM single exposure with or without co-exposure of LAA. Cellular survival and nitrite production were assessed with MTT and Griess assays, respectively. Flow cytometry using annexin/PI double staining was performed to evaluate apoptosis. Results: Hydrogen peroxide decreased cellular survival significantly in a dose-dependent manner accompanied with decreased NO production. However cellular survival and NO production were increased significantly with co-exposure of LAA. Cellular survival and NO were highly correlated. Flow cytometric analysis revealed that LAA inhibited hydrogen peroxide-induced apoptosis. Conclusions: LAA demonstrated a cytoprotective effect against the hydrogen peroxide-induced oxidative stress accompanied with increased NO production. The cytoprotective effect of LAA may be mediated by preserving NO in TM cells.
중등도의 어려움을 가진 하부 열공성 망막박리 환자의 수술결과 비교
류지용,김윤영,Ji Yong Ryou,Yun Young Kim 대한안과학회 2010 대한안과학회지 Vol.51 No.9
Purpose: To compare the surgical results between scleral buckling (SB) and pars plana vitrectomy (PPV) for patients with inferior rhegmatogenous retinal detachment (RRD) of medium severity. Methods: Two different types of surgery was performed on patients with inferior RRD of medium severity and divided into group 1 (PPV) and group 2 (SB). The preoperative clinical features, anatomical success rate, and changes of visual acuity (VA) were retrospectively evaluated. Results: Preoperative phakic status in group 2 was statistically significantly high, as compared to the group 1 (p=0.02), but other preoperative clinical features were not different between the 2 groups. The primary surgical success rates were 88% and 92% in group 1 and 2, respectively. The final success rate was 100% in both groups. No statistically significant correlation between surgical method and recurrence was found. The preoperative logMAR VA was 0.96 in group 1 and 0.71 in group 2 and improved postoperatively to 0.42 and 0.40, respectively; these were statistically significant changes. However, the final VA between the 2 groups showed no statistically significant difference. Conclusions: No statistically significant differences of primary and final success rate between SB and PPV groups were found for inferior RRD associated with medium severity. However, preoperative phakic status could influence the selection of the surgical method for RRD. J Korean Ophthalmol Soc 2010;51(9):1224-1230
류지용 고려대학교 한국학연구소 2002 한국학연구 Vol.16 No.-
The three short stories covered in this study - Kim Dong-in's "Potato", Chun Young-tak's 'Hwasuboon", and Hyun Jin-kun's "Lucky Day"-are representative of 1920's literature which covered the correlation of poverty and death. These three stories discuss the reality of the poverty which occurred as a direct result of the seizure of farmlands and farm produce under Japanese Imperialism. The main topic of this study is to reveal the assumption that due to the influences of that period, poverty and death were inevitable. The following discussion will cover two main topics. The first topic is that the aesthetic contemplation of death is directly perinent to the inherent nature of these stories. The other topic is that it is characterstic of the plot of these short stories to investigate the influence of poverty and death. To further study the second topic, the following studies were conducted: "Potato" contemplates the relationship between the reality of poverty and sexual morality. "Hwasuboon" contemplates the relationship between the reality of poverty the love of family. "Lucky Day" contemplates the relationship between the reality of poverty and daily labors. A third topic reinvestigates the rhetorical side of poverty and death discussed in the second topic. This topic reinvestigates the aesthetic plot as a supplement to the formal side of the contents. As a final topic, we investigate the creation of literature and its influence on social conditions. All three stories share the same point of view that the reality of poverty was related to the main problems of contemporary life. However, historians hold the point of view that life and death, wealth and poverty, and other bright and dark points constantly coexist in human society. As the problems between humanity and society, and society versus the individual exist throughout all periods of time, the deaths covered in these stories do not give special attention to those factors since they could occur in any society and age, not just specifically the 1920's.
生脈散이 대동맥 평활근 세포에서 NO 생성에 미치는 영향
허윤,나영훈,한상혁,장호연,임준모,이인,전희준,류지용,문병순 대한동의병리학회 2001 동의생리병리학회지 Vol.15 No.5
Nitric oxide(NO) play an important role in normal and pathophysiologcal cells including as a messenger molecule, neurotransmitter, microbiocidal agent, or dilator of blood vessels and arteriosclerosis, respectively. To understand the mechanism of NO production and effect of Saengmaeg-san extract on NO production in cultured vascular smooth muscle cells(VSMC), firstly, VSMC was isolated from aorta and cultured. Cultured primary cells was identified as VSMC with anti- α smooth muscle actin antibody. High amounts of NO was produced in cultured VSMC treated with IFN-γ and TNF-α as time- and dose-dependent manner. TNF-α was a more efficient stimulator than IFN-γ on the respect to NO production in cultured VSMC. iNOS protein was detected within 3 hr and the detected iNOS was increased up to 12 hr as time-dependent manner. However, accumulated NO in activated VSMC was not detected within 3 hr. NO production in activated VSMC showed the dose- and time-dependent manner, and was increased up to 72 hr. The activated VSMC produced high amounts of NO (about 70 uM) and showed cytotoxicity. The cytotoxicity was apparently responsible to high amounts of NO produced in activated VSMC. Saengmaeg-san extract decreased the accumulation of NO in IFN-γ plus TNF-α or TNF-α treated aortic VSMC. Saengmaeg-san extract suppressed the effect of TNF-α on NO production. TNF-α functions signal molecules for apoptosis in some cells. As NO deeply involved in the development of arteriosclerosis and dilation of blood vessels and NO induced apoptosis in cultured VSMC, one have thought that drugs or chemicals modulating the NO production in VSMC could be used for preventing and treating the arteriosderosis. Therefor, The results strongly suggested that Saengmaeg-san have a potential capacity for preventing and treating the disease of cardiovascular system including arteriosclerosis.