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- 저자 : Yoonji Kim (검색결과 135 건)
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순환 주파수 추정을 통한 직접 시퀀스 대역 확산 신호 탐지 알고리즘 복잡도 저감
김윤지(Yoonji Kim),김근배(Geunbae Kim),강현진(Hyunjin Kang),김재윤(Jaeyun Kim),윤동원(Dongweon Yoon) 한국정보기술학회 2022 한국정보기술학회논문지 Vol.20 No.1
For a non-cooperative context, it is difficult to detect the direct sequence spread spectrum (DSSS) signal at the receiver when the spreading code is unknown due to its low probability of intercept characteristic. To detect the DSSS signal, the detection algorithm exploiting the cyclostationarity of the DSSS signal was proposed, which shows good detection performance in a channel with low signal-to-noise ratio. However, this algorithm requires a long time to detect signals because of its high computational complexity. In this paper, we propose an improved algorithm that can reduce the complexity by first estimating the cyclic frequencies of the incoming signal. Through computer simulations, we verify that the proposed algorithm can show the same detection performance as in conventional algorithms with lower computational complexity.
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Irisin, a Novel Myokine, Regulates Glucose Uptake in Skeletal Muscle Cells via AMPK
Lee, Hye Jeong,Lee, Jung Ok,Kim, Nami,Kim, Joong Kwan,Kim, Hyung Ip,Lee, Yong Woo,Kim, Su Jin,Choi, Jong-Il,Oh, Yoonji,Kim, Jeong Hyun,Hwang, Suyeon-,Park, Sun Hwa,Kim, Hyeon Soo Endocrine Society 2015 Molecular endocrinology Vol.29 No.6
<P>Irisin is a novel myokine produced by skeletal muscle. However, its metabolic role is poorly understood. In the present study, irisin induced glucose uptake in differentiated skeletal muscle cells. It increased AMP-activated protein kinase (AMPK) phosphorylation and the inhibition of AMPK blocked glucose uptake. It also increased reactive oxygen species (ROS) generation. N-acetyl cysteine, a ROS scavenger, blocked irisin-induced AMPK phosphorylation. Moreover, irisin activated p38 MAPK in an AMPK-dependent manner. The inhibition and knockdown of p38 MAPK blocked irisin-induced glucose uptake. A colorimetric absorbance assay showed that irisin stimulated the translocation of glucose transporter type 4 to the plasma membrane and that this effect was suppressed in cells pretreated with a p38 MAPK inhibitor or p38 MAPK small interfering RNA. In primary cultured myoblast cells, irisin increased the concentration of intracellular calcium. STO-609, a calcium/calmodulin-dependent protein kinase kinase inhibitor, blocked irisin-induced AMPK phosphorylation, implying that calcium is involved in irisin-mediated signaling. Our results suggest that irisin plays an important role in glucose metabolism via the ROS-mediated AMPK pathway in skeletal muscle cells.</P>
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Kim, Yoonji,Ju, Huiyeong,Jung, Jong Hwa,Lee, Jai Young,Lee, Shim Sung Elsevier 2019 Inorganic chemistry communications Vol.100 No.-
<P><B>Abstract</B></P> <P>Five soft metal complexes (<B>1</B>–<B>5</B>) of a 16-membered O<SUB>2</SUB>S<SUB>3</SUB>-macrocycle (<B>L</B>) with different topologies and coordination modes, including discrete to infinite forms, and <I>endo</I>-, <I>exo</I>-, and endo/exo-coordination, were prepared and structurally characterized. Both mercury(II) complexes, [Hg(<B>L</B>)(NO<SUB>3</SUB>)<SUB>2</SUB>] (<B>1</B>) and [Hg(<B>L</B>)(DMF)<SUB>2</SUB>](ClO<SUB>4</SUB>)<SUB>2</SUB>·DMF (<B>2</B>), with nitrate and perchlorate anions, respectively, show a typical endocyclic structure. Two nitrate ions in <B>1</B> occupy the coordination sites, while two DMF molecules participate to the coordination sphere in <B>2</B> remaining two perchlorate ions uncoordinated. It is found that the anion-exchange of <B>2</B> in the solid state induced the conversion to <B>1</B> which involves the rearrangement of the coordination sphere. In silver(I) complexations, nitrate afforded a cyclic dimer complex [Ag<SUB>2</SUB>(<B>L</B>)<SUB>2</SUB>(NO<SUB>3</SUB>)<SUB>2</SUB>] (<B>3</B>). While hexafluorophosphate gave a 1-D zigzag coordination polymer {[Ag(<B>L</B>)]PF<SUB>6</SUB>}<SUB> <I>n</I> </SUB> (<B>4</B>). Interestingly, triflate led to the isolation of a tetranuclear bis(macrocycle) complex, {[<SUP> <I>endo</I> </SUP>Ag(<B>L</B>)(CF<SUB>3</SUB>SO<SUB>3</SUB>)]<SUB>2</SUB>[<I>μ</I>-<SUP> <I>exo</I> </SUP>Ag<SUB>2</SUB>(CF<SUB>3</SUB>SO<SUB>3</SUB>)<SUB>2</SUB>]} (<B>5</B>), which are dominated by the coordination modes (<SUP> <I>endo</I> </SUP>Ag and <SUP> <I>exo</I> </SUP>Ag) of <B>L</B> toward two types of silver(I) centers. For instance, two endocyclic complex units, <SUP> <I>endo</I> </SUP>Ag<SUB>2</SUB>(<B>L</B>)<SUB>2</SUB>(CF<SUB>3</SUB>SO<SUB>3</SUB>)<SUB>2</SUB>, are linked by exocyclic metallacycle, [<I>μ</I>-<SUP> <I>exo</I> </SUP>Ag<SUB>2</SUB>(CF<SUB>3</SUB>SO<SUB>3</SUB>)<SUB>2</SUB>], to give a 4:2 (metal-to-ligand) stoichiometry. From the results, it is obviously clear that the role of anions mostly is responsible to such structural diversity based on the <I>exo</I>-coordination mode.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Silver(I) and mercury(II) complexes of O<SUB>2</SUB>S<SUB>3</SUB>-macrocycle were prepared. </LI> <LI> Mercury(II) perchlorate complex was converted to nitrate form via anion-exchange. </LI> <LI> A tetranuclear bis(macrocycle) silver(I) triflate complex was isolated. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
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Study on the perception of orthodontic treatment according to age
Yoonji Kim 대한치과교정학회 2017 대한치과교정학회지 Vol.47 No.4
Objective: This questionnaire study aimed to estimate the overall frequencies of positive perception towards orthodontic treatment among adults categorized according to age, sex, and area of living, and to identify barriers or negative perceptions preventing them from receiving orthodontic treatment. Methods: The participants included 598 adults aged over 20 years (230 men and 368 women) who visited the Dental Hospital of Seoul St. Mary’s Hospital. The participants’ opinions regarding their consideration of receiving orthodontic treatment were recorded using a specially designed questionnaire. Results: The overall rate of positive perception towards orthodontic treatment was 48.5%. Compared to adults in their 20s (63.2%), those in their 40s and 50s had a lower percentage of interest in orthodontic treatment (46.2% and 45.1%, respectively; p < 0.05). Overall, women (52.2%) had a higher rate of interest than did men (42.6%; p < 0.05). The area of living had no effect on the percentage of interest. The order of priority of chief complaints differed according to age: protrusion for those in the 20s and 30s, and spacing for those in the 40s to 60s. Overall, the main reason for not seeking treatment was the treatment fee. Respondents aged over 40 considered themselves “too old” for orthodontic treatment. Conclusions: The middle-aged had a relatively high percentage of interest (above 45%) in orthodontic treatment. However, demographic characteristics were not significantly associated with the positive interest. These results highlight the need for educating the middle-aged about the limitations and possibilities of orthodontic treatment to increase its acceptance.
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Association of the Anxiety/Depression with Nutrition Intake in Stroke Patients
( Yoonji Kim ),( Myung-chul Kim ),( Hang-Sik Park ),( Il-Hoon Cho ),( Jean Kyung Paik ) 한국임상영양학회 2018 Clinical Nutrition Research Vol.7 No.1
Stroke patients often experience a walking dysfunction caused by decreased mobility, weakened muscular strength, abnormal posture control, and cognitive dysfunction. Anxiety/depression is the most important and prevalent neuropsychiatric complication of stroke survivors. Brain injury and the presence of malnutrition after stroke contribute to metabolic status and clinical outcome of patients. We examined the level of nutrition intake in stroke patients according to their degree of anxiety/depression. The data were obtained from 2013 to 2015 through the Korea National Health and Nutrition Examination Survey (KNHANES). Study subjects were categorized to either a group having no problem of anxiety/depression (n = 274) or a group having a problem of anxiety or depression (n = 104). The EuroQoL-5 Dimensions Health Questionnaire (EQ-5D) index score was derived from the first description of an individual health status based on the EQ-5D classification system, including mobility, self-care, usual daily activities, pain/discomfort, and anxiety/depression. The mean age was 67.4 years in the normal group and 68.0 years in the anxiety or depression group. In the anxiety or depression group, 39.4% were men vs. 53.3% in the normal group. The total energy intake (p = 0.013), riboflavin (p = 0.041), and niacin (p = 0.038) was significantly higher in stroke patients with no anxiety/depression than those in stroke patients with having an anxiety/depression. The group having no problem of anxiety/depression had significantly higher EQ-5D index compared to the group having a problem of anxiety/depression group (p < 0.001) had. The results suggest the association between nutrition intake, usual activities and pain/discomfort status in the stroke patients with having an anxiety/depression.
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Kim, Yoonji,Bu, Jiyoon,Cho, Young-Ho,Son, Il Tae,Kang, Sung-Bum IOP 2017 Journal of micromechanics and microengineering Vol.27 No.2
<P>Circulating tumor cells (CTCs) contain prognostic information of the tumor, since they shed from the primary tumor and invade into the bloodstream. Therefore, the viable isolation is necessary for a consequent analysis of CTCs. Here, we present a device for the viable isolation and efficient retrieval of CTCs using slanted slot filters, formed by a reversibly deformable membrane barrier. Conventional filters have difficulties in retrieving captured cells, since they easily clog the slots. Moreover, large stress concentration at the sharp edges of squared slots, causes cell lysis. In contrast, the present device shows over 94% of high retrieval efficiency, since the slots can be opened simply by relieving the pressure. Furthermore, the inflated membrane barrier naturally forms the slanted slots, thus reducing the cell damage. By using cancer cell lines, we verified that the present device successfully isolate targeted cells, even at an extremely low concentrations (~10 cells/0.1 ml). In the clinical study, 85.7% of patients initially showed CTC positive while the numbers generally decreased after the surgery. We have also proved that the number of CTCs were highly correlated with tumour invasiveness. Therefore, the present device has potential for use in cancer diagnosis, surgical validation, and invasiveness analysis.</P>
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Kim, Hyoun Oak,Lee, Won,Kook, Yoon-Ah,Kim, Yoonji The Korean Association Of Orthodontists 2013 대한치과교정학회지 Vol.43 No.5
Objective: This study investigated whether temporomandibular joint (TMJ) condyle-fossa relationships are bilaterally symmetric in class III malocclusion patients with and without asymmetry and compared to those with normal occlusion. The hypothesis was a difference in condyle-fossa relationships exists in asymmetric patients. Methods: Group 1 comprised 40 Korean normal occlusion subjects. Groups 2 and 3 comprised patients diagnosed with skeletal class III malocclusion, who were grouped according to the presence of mandibular asymmetry: Group 2 included symmetric mandibles, while group 3 included asymmetric mandibles. Pretreatment three-dimensional cone-beam computed tomography (3D CBCT) images were obtained. Right- and left-sided TMJ spaces in groups 1 and 2 or deviated and non-deviated sides in group 3 were evaluated, and the axial condylar angle was compared. Results: The TMJ spaces demonstrated no significant bilateral differences in any group. Only group 3 had slightly narrower superior spaces (p < 0.001). The axial condylar angles between group 1 and 2 were not significant. However, group 3 showed a statistically significant bilateral difference (p < 0.001); toward the deviated side, the axial condylar angle was steeper. Conclusions: Even in the asymmetric group, the TMJ spaces were similar between deviated and non-deviated sides, indicating a bilateral condyle-fossa relationship in patients with asymmetry that may be as symmetrical as that in patients with symmetry. However, the axial condylar angle had bilateral differences only in asymmetric groups. The mean TMJ space value and the bilateral difference may be used for evaluating condyle-fossa relationships with CBCT.
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Estimation of Dynamic Systems for Gene Regulatory Networks from Dependent Time-Course Data
Kim, Yoonji,Kim, Jaejik Mary Ann Liebert 2018 Journal of computational biology Vol.25 No.9
<P>Dynamic system consisting of ordinary differential equations (ODEs) is a well-known tool for describing dynamic nature of gene regulatory networks (GRNs), and the dynamic features of GRNs are usually captured through time-course gene expression data. Owing to high-throughput technologies, time-course gene expression data have complex structures such as heteroscedasticity, correlations between genes, and time dependence. Since gene experiments typically yield highly noisy data with small sample size, for a more accurate prediction of the dynamics, the complex structures should be taken into account in ODE models. Hence, this study proposes an ODE model considering such data structures and a fast and stable estimation method for the ODE parameters based on the generalized profiling approach with data smoothing techniques. The proposed method also provides statistical inference for the ODE estimator and it is applied to a zebrafish retina cell network.</P>
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