병렬형 하이브리드 제어를 위한 적응형 Online ECMS

이병관(Byung-Kwan Lee),남경재(Kyung-Jae Nam),김정우(Jeongwoo Kim),임성준(Sungjun Lim),김경수(Kyung-Soo Kim) 대한기계학회 2019 대한기계학회 춘추학술대회 Vol.2019 No.11

In this paper, we propose an adaptive Online ECMS(Equivalent Consumption Minimization Strategy) model using a technique that minimizes the instantaneous cost function at each step of the driving cycle, and satisfies the SOC constraint in real time. While the existing ECMS optimizes the equivalent coefficient for the entire driving cycle, the proposed ECMS satisfies the SOC constraints in real time and makes the equivalent coefficient adapt to the instantaneous power demand of each step of the driving cycle. Therefore, the proposed ECMS effectively reduces the computational load because it uses the technique of minimizing the instantaneous cost function at each step in driving cycle. In addition, since the instantaneous power demand is divided into engine power and motor power by the optimized equivalent coefficient in real time, it is possible to estimate the optimal operating point of the engine and the motor. Finally, to verify the performance of the adaptive online ECMS in this paper, we compare it with the existing ECMS method by performance of SOC constraint and that of fuel consumption.

항공기 랜딩기어용 MR 댐퍼의 설계 및 해석

김보규(Bo-Gyu Kim),한철희(Chulhee Han),남경재(Kyung-Jae Nam),타우시프(Tausif Mulla),최승복(Seung-Bok Choi),탁준모(Jun-Mo Tak),황재혁(Jai-Hyuk Hwang) 한국소음진동공학회 2017 한국소음진동공학회 학술대회논문집 Vol.2017 No.10

통풍의 임상적 고찰

정태기(Tae Gi Chung),김형곤(Hyung Gon Kim),송영수(Young Soo Song),한성훈(Seong Hoon Han),김정수(Jeong Soo Kim),김현대(Hyeon Dae Kim),남경재(Kyung Jae Nam),정성광(Sung Kwang Chung),이윤우(Yun Woo Lee) 대한내과학회 1997 대한내과학회지 Vol.53 No.1

N/A Objectives: The clinical manifestations of gout in Korea would be changed lately according to the rapid economical development and the development of diagnostic methods. This study was done to reveal the late clinical features of gout in Korea. Methods: A retrospective study was done for the 90 gout patients who had been treated in Seoul Paik Hospital from March 1974 to August 1994. Age of onset, sex, duration of disease, serum uric acid level, uric acid concentration of 24 hour urine, joint of first attack, recurrently involved joints, X-ray of involved joint, frequency of tophi, renal ultrasonography, and associated diseases were analyzed. The uric acid levels of the 808 civilians who visited our hospital for the periodic health examination were used as a control value. Results: 1) The serum uric acid level in Korean adults was 5.2±1.1mg/dL in male, 3.8±0.7mg/dL in female, and 4.7mg/dL in general. The serum uric acid concentration of the gout patients was 8.6±2.2mg/dL in male, 6.1±2.1mg/dL in female, and 8.5±2.3mg/dL in general. The age of onset was 46.4±12.9 years old and male to female ratio was 44: 1 2) The renal excretion of uric acid was 470±173 mg/day in gout patients. 3) The sites of first attack were first MTP joint(76%), tarsal joint(13%), knee(5%), and other MTP joints(5%) 4) The involved joints during the repeated attacks were first MTP joint(84%), tarsal joint(23%), and fingers(23%), The duration of disease was significantly longer and the serum uric acid concentration was higher in the patients with tophi than they are in the patients without. 5) The 4l% of patients showed hone change in X-ray. 6) The renal ultrasound examinations were abnormal in 42% of the patients and the serum uric acid concentrations were significantly higher. 7) Obesity was found in 68% of patients, hypertension in 39%, hyperlipidemia in 16%, and chronic renal disease in 12%. Conclusion: The clinical features of gout in our study were similar to those of others done in and out of Korea, except that the frequency of hypertringlyceridemia was much lower than that of the foreign countries.

수산염(oxalate) 섭취에 의한 급성 신부전 1례

경쾌수,송영수,김현대,남경재,노승현,고행일 인제대학교 1994 仁濟醫學 Vol.15 No.4

수산염에 의한 신장애는 신장에서 수산칼슘 형태의 결정체가 세뇨관에 침착되어 신장애 및 대사성 산증 등을 드물게 일으킨다. 저자들은 우연히 수산염을 성취하여 질소혈증 및 단백뇨를 보여 신조직 검사상 옥살산증을 보인 예를 경험하여 보고한다. Acute renal failure caused by oxalate ingestion is very rare. The authors experienced a case of a 17 year old male patient who ingested oxalate incidently and developed acute renal failure. Crystalline deposition of oxalate within tubule and necrosis of tubular epithelium were seen on kidney biopsy. The insult was recovered uneventfully with conservative managent for renal failure.

Mitoxantrone as a Single Agent for the Salvage Treatment of Refractory or Recurrent Acute Myeloblastic Leukemia

Nam, Kyung Jae,Kim, Chul Soo,Kim, Re Hwe 인제대학교 1996 仁濟醫學 Vol.17 No.4

배경: 급성골수성 백혈병은 궁극적으로 완치가 어려운 병이며 그 가장 큰 원인은 약제에 의한 내성으로 간주되고 있다. 따라서 더 나은 결과를 위한 새로운 약제 개발의 필요성이 요구되고 있다. 방법: Cytosine arabinoside 와 Daunorubicin을 포함한 항암화학요법으로 표준관해유도에 도달한 18명의 초기내성 또는 재발된 급성골수성 백혈병 환자(남:여=5:13, 연령 16-65세, 평균연령 32세)에게 하루에 Mitoxantrone 20mg을 5일 동안 정맥주사하였다. 결과: 3명(18%)의 환자가 골수회복전 초기에 사망하였다. 백혈구감소 최저치까지 도달일수는 10-20일(평균16일)이었고 이때 호중구수는 중앙치는 0이었다. 한명을 제외한 모든 환자에서 백혈구 감소와 동반된 발열이 있었다. 재발한 8명중 6명(75%)와 초기 불응환자 10명중 2명(20%)을 포함한 8명(44%)에서 완전관해가 유도되었다. 완전관해 도달까지의 기간은 2-40일(평균 32일)이었다. 생존기간은 완전관해유도군에서는 4-50주였고 모든 환자에서는 2-50주였다(평균 10주). 결론: Mitoxantrone이 불응성 또는 재발성 급성골수성 벅혈병환자의 생존에 의미있는 영향을 주는 것 같지는 않지만 이들 예후가 나쁜 군에서의 항암반응율은 표준위험군에서의 다제병합화학요법에서 시도되어야 할 가치가 있다고 여겨진다. Background: Only a small fraction of acute myeloblastic leukemia (AML) patients can be cured wish current chemotherapy because of drug resistance in the majority. Newer drugs are needed for better therapeutic outcome. Methods: Daily dose of mitoxantrone 20 mg was given IV bolus for 5 days regardless of body surface to 18 primary refractory or relapsed AML patients (male:female=5:13, ages 16-65 wish a median of 32) who had been exposed to standard remission induction chemotherapy consisting of cytosine arabinoside and daunorubicin. Results: Three (18%) patients died earlier of bone marrow aplasia. The days to leukopenic nadir ranged 10-20 (median 16) with a median absolute neutrophil count of o/uL. All patients except one had neutropenic fever. Eight (44%) patients achieved complete remission (CR) including 6 of 8 (75%) relapsed patients and 2 of 10 (20%) primary refractory patients. The days to CR ranged 27-40 (median 32). The duration of CH was short ranging 4-26 weeks (median 10). The overall survival duration ranged 4-50 weeks (median 12) in patients who achieved CR and 2-50 weeks (median 10) in all patients. Conclusion: Although mitoxantrone did not seemed to give meaningful impact on survival duration of refractory or relapsed AML patients, the activity in this poor prognosis group warrants further studies including incorporation into combination chemotherapies in standard risk group.

갑상선 기능항진증을 동반한 임신오조에 수반된 Wernicke`s Encephalopathy

임경호,이승진,남경재 대한내분비학회 1998 Endocrinology and metabolism Vol.13 No.3

Wernickes encephalopathy is an illness characterized by mental disturbance, paralysis of eye movements and ataxia of gait. The specific factor for most, if not all, of these symptoms is a deficiency of thiamine. Wemicke's encephalopathy mostly occurs in developing countries when the patient is in a state such as nutritionally deprived state, anorexia nervosa, stomach cancer, long duration of parenteral nutrition. Wernickes encephalopathy was recognized as a complication of hyperemesis of pregnancy in 1914. Unfortunately, cases continue to occur. We present here a case of Wernickes encephalopathy in a 36-year-old pregnant woman. We discuss the clinical picture, histopathology, radiology, therapeutic management and prognosis with review of the literature(J Kor Soc Endocrinol 13:489-494, 1998).

폐경기 여성에서의 골밀도와 체지방과의 상관관계

한성훈,남경재,김정수,하태완,임경호 인제대학교 1996 仁濟醫學 Vol.17 No.3

골량은 30대에 최고치를 보이고 이후 노년기까지 지속적으로 감소하나, 여성에서는 특히 폐경 직후 감소의 속도가 급격히 증가하여 골절, 골다공증 등의 골질환을 유발한다. 에스트로겐 결핍이 폐경기 이후의 골소실을 촉진하기는 하지만, 연령 증가에 따른 지방의 증가도 골소실과 관계하며 골절 등을 유발시킨다. 비만한 사람은 고혈압, 당뇨병, 동맥경화성 심혈관 질환 등의 성인병을 갖게 되며 최근의 보고는 체지방 분포상태가 질병발생과 관계된다고 알려져 있으므로 이미 알려진 지방과 골밀도와의 관련성 뿐 아니라 지방분포와 골밀도와의 관계를 알아보기 위하여 폐경기 이후 여성환자 67명을 대상으로 DEXA(dual energy X-ray absorptiometry)를 이용하여 전신골밀도, 지방량을 측정하여 상관관계를 조사하였다. We studied the relation of whole body bone mineral density to body fat. To accomplish this, we examined the total bone mineral density, fat distribution, body mass index and body weight with dens-itometry(Dual Energy X-ray Absorptiometry) in 67 postmenopausal women who had been followed up between 1992 and 1995. The results are summarized as follows : 1) The whole body bone mineral density increases with age(r = 0.54). 2) There is a good relation between the whole body bone mineral density and body weight(r= 0.54, p<0.001). 3) There is a relation between the whole body bone mineral density and body mass index(r = 0.28, p<0.01). 4) There is a poor relation between the whole body bone mineral density and total body fat(r =0.24, p<0.01). 5) The trunkal fat shows stronger correlations with the whole body bone mineral density than either the extremity fat or the whole body fat(r = 0.339, p<0.001).

Monoclonal Gammopathy of Undetermined Significance 를 동반한 베체트 병(Behcet`s Disease) 1 예

정성광,남경재,전영빈,이윤우,한성훈,김정수,김현대 대한내과학회 1996 대한내과학회지 Vol.51 No.4

The term $quot;monoclonal gammopathy of undetermined significance (MGUS)$quot; denotes the presence of a M-protein in patients without multiple myeloma, macroglobulinemia, amyloidosis, or other related disease. MGUS is characterized by a serum M-protein concentration $lt;3.0g/dL, $lt;5% plasma cells in the bone marrow, either a small amount of M-protein or none at all in the urine, absence of lytic bone lesion, anemia, hypercalcemia, and renal insufficiency, and, most importantly, stability of the M-protein and failure of development of additional abnormalities. Recently we experienced one ease of MGUS associated with Behcet's disease confirmed by electrophoresis, immunoelectrophoresis and bone marrow biopsy. A 37-year-old woman was admitted to our hospital in 1991 because of migratory joint pain for 2 years. On physical examination oral and genital ulcers were found, and erythematous palpable tender subcutaneous nodules were found also in the forearms and legs. The level of IgG K fraction in the serum was 0.52g/dl and the bone marrow biopsy was normal. Initially she had been treated with ibuprofen, prednisolone, colchicine and azathioprine under the diagnosis of Behcet's disease with MSUS. The concentration of serum M-protein after treatment of four years was 2.69g/dL and she complained only migratory pain in back and extremity, and easy fatigability. Lately she has been managed with the combination of colchicine and azathioprine.

반대측 비기능성 부신 선종을 동반한 기능성 흑색 부신 선종에 의한 쿠싱 증후군 1예

조보연,박경수,박도준,오승근,윤여규,김성연,이홍규,남경재 대한내분비학회 1999 Endocrinology and metabolism Vol.14 No.2

We report herein the case of a 38-year-old woman with Cushings syndrome caused by bilateral adrenocortical adenomas. The adrenal tumor on the left side hypersecreted cortisol and no findings of cortisol hypersecretion from the adrenal tumor on the right side were observed on bilateral adrenal vein samplings. Both adrenal tumors were resected and histologically without any findings of nodular hyperplasia. The left adrenal tumor was histologically diagnosed as a so-called black adenoma. These data imply that the adrenal adenomas developed primarily from the adrenal gland itself, and that one of the tumors was well differentiated and secreted excess hormones, while the other remained in cell proliferation without hypersecretion. (J Kor Soc Endocrinol 14:410-417, 1999)

고콜레스테롤혈증 환자에 대한 Simvastatin 의 지질개선효과 및 안전성에 관한 검토

김형우,하태완,진성림,유원상,류호준,최석구,남경재 한국지질학회 1998 韓國脂質學會誌 Vol.8 No.1

Background: To investigate the lipid-lowering efficacy and safety of simvastatin, HMG-CoA reductase inhibitor, we observed the changes of clinical features and lipid proftles after the administration of simvastatin in patients with hypercholesterolemia. Methods and results: Simvastatin 10㎎ was given once a day for 12 weeks to 45 patients (61±2 years ; 15 male, 30 female) with hypercholesterolemia. Simvastatin significantly decreased total cholesterol(TC) from 270±4㎎/dL to 203±5㎎/dL(24%), low density lipoprotein cholesterol(LDL-C) from 175±5㎎/dL to 116±4㎎/dL(33%), and triglyceride(TG) from 208±13mg/dL to 179±11㎎/dL(10%) in 12 weeks after the drug administration. High density lipoprotein cholesterol(HDL-C) was not changed significantly from 54±2㎎/dL to 51±3㎎/dL after the trial of simvastatin for 12 weeks. One patient complained of myalgia without significant elevation of creatine kinase and two had skin rashes. Serum alanine aminotransferase was slightly increased transiently during the trial in one patient. All data were average±SE mean. Conclusions: Simvastatin is an efficacious and well tolerable lipid-lowering agent in patients with hypercholesterolemia.