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위점막에서 Helicobacter pylori 분포의 내시경적 진단
주영은(Young Eun Joo),김신묵(Sin Mook Kim),김태두(Tae Du Kim),신동현(Dong Hyun Sin),성종호(Jong Ho Seong),안영주(Young Joo Ahn),정용환(Yong Hwan Jeong),양대현(Dae Hyun Yang),유종선(Chong Sun Rew),윤종만(Chong Mann Yoon) 대한내과학회 1994 대한내과학회지 Vol.46 No.1
N/A Background: Since the successful isolation of Helicobacter pylori from the human gastric mucosa by Warren and Mashall, biosy studies have shown that this organism is closely related to chronic gastritis and peptic ulcer. However the distribution of this organism has been proved to be uneven and patchy on the gastric mucosa. The aim of this paper is to assess the distribution of this organism on human gastric mucosa in vivo by endoscopy. Method: To control the gastric pH around 4.0 to 6.0, premedication by the intravenous injection of ranitidine 50mg one hour before the endoscopy, was performed. And thereafter, 0.1% phenol red solution containing 0.5M urea was sprayed onto the mucosal surface of the stomach through the endoscope. A red color change was observed in a few seconds after spraying the phenol red solution. The red color change pattern was classified into three types: diffuse, regional and patchy type. Two biopsies were taken from the red color changed area and the unstained area for hitological and bacteriological study. Results: l) In 26 out of 33patients with chronic gastritis, the red color change was observed after spraying the phenol red solution. The diffuse, regional and patchy type in chronic gastritis patients were observed in 17, 5, 4 patients respectively. In peptic ulcer group, the diffuse type was observed in 6 and the regional and patchy type were observed in 3, 1 patients. 2) The bacteriological and histological identification of Helicobacter pylori was observed in 17 of 26patients (65.4%) With Chronic gastritis and 7 Of 10patiCIltS (70%) with peptic ulcer in the biopsy materials taken from the gastric mucosa showing a red color change with phenol red solution. But the organism was not found in the unchanged and unstained mucosa except for one case of chronic gastritis. Conclusion: These results suggest that this endoscopic spraying technique may be useful to determining the distribution of Helicobacter pylori in human gastric mucosa.
위암종에서 Glutathione S - Transferase π 에 대한 면역 조직화학적 연구
지미선(Mi Seon Jee),류도현(Do Hyun Rhew),백강우(Kang Woo Baek),문범(Beom Moon),주영은(Young Eun Joo),김태두(Tae Du Kim),유종선(Jong Sun Rew),윤종만(Chong Mann Yoon),박창수(Chang Soo Park) 대한내과학회 1995 대한내과학회지 Vol.48 No.6
N/A Objectives: Glutsthione S-Transferases (GSTs) are a family of isoenzymes which catalyse the conjugation of glutathione to a variety of electrophilic compounds which include carcinogens and cytotoxic drugs. These enzymes probably form part of an inherent, protective mechanism against the development of tumors. There is also evidence to suggest s role for GST in drug resistance in cancer chemotherapy. Three classes of cytosolic GST isoenzymes exist in man. These are identified as basic(a), neutral(μ), acidic(π) GST. GSTπ has been studied recently because of its high level in biliary or colon carcinoma. To assess the relation of the expression of GSTπ with malignant index on human gastric carcinoma, this study was designed. Methods: Immunohistochemical study for GSTπ was performed in paraffin sections of 85 primary gastric carcinomas. Results: 1) Strong positive reaction for GST was observed mainly in the nuclei and cytoplasms of tumor cells and normal mucosal epithelium around cancer nest revealed weak positive reaction. 2) The positivity of GSTπ in gastric carcinoma was 94.1%. By the histological differentiation, the positivity was 84.2% in well-differentiated adenocarcinoma, 100% in moderately-differentiated adenocarcinoma, 100% in poorly-differentiated adenocarcinoma, 93.89o in mucinous adenocarcinoma, 90% in signet-ring cell carcinoma. Moderately-differentiated adenocarcinoma and poorly-differentiated adenocarcinoma revealed the most high positivity ratio. 3) Positivity of GSTπ in cancer nest had a increased trend in poorly-differentiated than well-differentiated adenocarcinoma. Conclusion: The results suggest that GSTπ may be a useful tumor marker of human gastric carcinoma.
양대현,한상우,주영은,김신묵,김세종,윤종만,김태두,류도현,지미선,유종선 대한소화기내시경학회 1994 Clinical Endoscopy Vol.14 No.1
Leiomyosarcoma of the duodenum is an uncommon tumor and have not specific symptoms and signs, almost all cases of tumor were diagnosed in operating room. This tumor is generally firm, relatively well encapsulated, lobulated and often soft if they undergo hemorrhagic necrosis. Most authors emphasized the relative number of mitosis as the most reliable findings of leiomyosarcoma. Recently, we experienced a case of leiomyosarcoma of duodenum which was confirmed by operative and pathological diagnosis.