각종 악성종양에서 (惡性腫瘍) Levamisole 이 혈청 (血淸) Ferritin 및 임파구 (淋巴球) 로제트 형성율에 (形成率) 미치는 영향

유종선 ( Jong Sun Rew ),윤종만 ( Chong Mann Yoon ),박세원 ( Sei Won Park ) 대한소화기학회 1983 대한소화기학회지 Vol.15 No.2

N/A The effect of short-term levamisole therapy on serum ferritin and E-rosette forming lymphocytes was studied in 29 patients with various malignant tumors. And 8 normal person. In patients with malignant tumors, active form of T-lymphocytes were more decreased than total form of T-lymphocytes and serum ferritin was significantly increased. Levamisole had a moderate enhancing effect on E-rosette formation in patients with malignant tumors. These effect was more prominent in total form of T-lymphocytes than active form of T-lymphocytes, which suggested that active form of T-lymphocytes were more seriously affected than total form of T-lymphocytes and former may be more important in cellmediated immunity of the malignant patients. Serum ferritin was decreased in average 22% after levamisole therapy, but none of cases reduced to normal range in patients with significantly elevated serum ferritin level. There was close correlation(r=0.51) between decrease in serum ferritin and enhancing effect on E-rosette formation in malignant tumors after short-term levamisole therapy. These results indicate that levamisole as a role of immunotherapy may be beneficial in patients with malignant tumors.

원발성 담관암 49예에 대한 임상적 고찰

윤종만(Chong Mann Yoon),유종선(Jong Sun Rew),최성규(Sung Kyu Choi),양대현(Dae Hyun Yang),이숭(Soong Lee),구철(Chull Koo) 대한소화기학회 1989 대한소화기학회지 Vol.21 No.4

N/A Bile duct carcinoma is relatively rare malignancy with an extremely grave prognosis. The case records of 49 patients with primary carcinoma of the bile ducts seen at the Chonnam University Hospital from 1981 to 1988 were reviewed and analyzed. The results were as fo]lows 1) The peak age distribution was in seventh decade and the average age being 61.4 years. The sex ratio of male to female was 1.9:l. 2) In 43 of the 49 patients, anatomic location was extrahepatic bile duct. The most frequently involved site among the extrahepatic bile ducts was common bile duct (38.8%). 3) The most common symptom and sign were RUQ abdominal pain (75.5%), jaundice (89.7%), respectively. 4) Serum alkaline phosphatase and r-GTP were more increased in extrahepatic bile duct carcinoma than intrahepatic bile duct carcinoma. 5) Associated disease were clonorchiasis (12.2%), choledocholithiasis (10.2%), and gall stone (4.0%). 6) The most useful diagnostic modality was percutaneous transhepatic cholangiography and focal stenotic lesions (66.6%) were rnost common. 7) Operability and resectability were 26.5%, 16.3%, respectively. 8) Tubular adenocarcinoma was the most frequent histo]ogic type.

각종 악성종양에서 혈청 Ferritin 치에 관한 연구

윤종만 ( Chong Mann Yoon ),조남중 ( Namm Joong Joh ),유종선 ( Jong Sun Rew ),강형구 ( Hyeong Koo Kahng ),장건성 ( Keon Sung Chang ) 대한내과학회 1982 대한내과학회지 Vol.25 No.7

Allantoin 에 의한 소화성궤양의 (消化性潰瘍) 국소요법

최진,유종선,김양순,조국현,윤종만 ( Jin Choi,Jong Sun Rew,Yang Soon Kim,Kook Hyun Cho,Chong Mann Yoon ) 대한소화기학회 1981 대한소화기학회지 Vol.13 No.1

In a recent three years period, therapeutic effect of topical therapy with Allantoin was studied on 16 cases of benign peptic ulcer who have no improvement after 3 months of med- ical therapy, recurrent ulcer or poor condition for operation. Comparative study was perfor- med in control group, 10 cases with conventional medical therapy. The results were as follows; In topical therapy group, marked subjective improvement was observed after lweek. Also definite healing by endoscopic examination was noted in 8 cases(50%) at 4 weeks, in 1I cases (69%) at 6 weeks, in 13 cases(81po) at 8 weeks and in 16 cases(100%) at 12 weeks. While in medical therapy group, healing was observed only in 21% at 4 weeks, in 44po at 8 weeks and 54% at 12 weeks. 2. During and after performing topical therapy, any complication or side effects were not observed. Also recurrence was not found for 4month to 2 years.

한국인 위암조직의 에스트로겐 수용체에 관한 연구

윤종만(Chong Mann Yoon),유종선(Jong Sun Rew),박일종(Il Jong park),서순팔(Soon Pal Suh),유주용(Joo Yong Yoo) 대한소화기학회 1989 대한소화기학회지 Vol.21 No.3

N/A The biological characteristics and the genesis of gastric carcinoma, the most common malignancy in Korean adult male, have not been established so far. Estrogen receptors (ER) have been idnetified in many hormone-dependent cancer such as breast cancer, prostate cancer and ovarian cancer and utilized clinically to provide hormonal therapeutic manipulation. In order to find any hormonal relation in gastric cancer, the presence of ER was examined in 38 patients with primary gastric carcinoma, six with benign stomach lesions and 17 normal gastric tissues, using monoclonal antibody by enzyme immunoassay in cystosol. The results obtained were as follows; 1) ER concetration (Mean+SD) in cytosol from noraml gastric tissue, benign gastric lesion and gastric cancer tissue were 5.6+4.6, 14.617.7 and 20.1+41.7 fmol/mg protein, respectively. Positivities of ER in normal gastric tissue, benign gastric lesion and gastric cancer tissue were 0, 16.7 and 21.1%, respectively. Concentration and positivity of ER were higher in gastric cancer tissue, especially in female gastric cancer tissue, than noraml gastric tissue and benign gastric lesion. 2) Highest value of ER concentration and ER posiitvity according to the macroscopic classification of the gastric carcinoma was observed in Borrmann type II. There was an increasing tendency in ER positivity as the size of the cancer increase. 3) ER concentration and positivity according to the histologic pattern were higher in poorly and well differentiated tubular adenocarcinoma than mucinous adenocarcinomas, signet ring cell carcinoma and moderately differentiated tubular adenocarcinomas. 4) Concentration and postitivity of ER from cancerous tissue of the postmenopausal patients were more higher than that of the premenopausal patients. These results suggested that there was close reation between the presence of ER and the evolution of gastric carcinoma, but not with the degree of histologic malignancy.

만성 췌장염에서 Camostat Mesilate ( FOIPAN(R) ) 의 임상 효과

김영진 ( Young Jin Kim ),유종선 ( Jong Sun Rew ),윤종만 ( Chong Mann Yoon ),양대현 ( Dai Hyun Yang ) 대한소화기학회 1993 대한소화기학회지 Vol.25 No.1

N/A A potent oral protease inhibitor, Camostat Mesilate (FOIPAN), was developed for the therapeutic agent in chronic pancreatitis. The clinical effects were evaluated in 25 patiented with chronic pancreatitis. 200 mg of FOIPAN' was given t.i.d. orally for 4 weeks. FOIPAN was very effective in the alleviation of the suhjective symptoms such as abdomilial pain, nausea and vomiting, indigestion and abdominal full#oess#. The global utility rate of the FOIPAN in the chronic pancreatitis was 76.0%. It was most effective in the patients with elevated serum amylase level. There were no significant side effects during the clinical trial. It could be said that FOIPAN was a safe and effective drug in the treatment of chronic pancreatitis.

출혈을 동반한 만성 췌장염 4예

김세종(Sei Jong Kim),윤종만(Chong Mann Yoon),유종선(Jong Sun Rew),최성규(Sung Kyu Choi),김현종(Hyun Jong Kim),김영진(Young Jin Kim),김현수(Hyun Soo Kim),백강우(Kang Woo Paik),구철(Cheol Koo),박창환(Chang Hwan Park) 대한소화기학회 1997 대한소화기학회지 Vol.29 No.2

Hemorrhage is an uncommon but serious cornplicaticm of pancreatic pseudocysts. When gastrointestinal bleeding or intra-abdominal hemorrhage is associated with a pancreatic pseudocyst and the usual sources of bleeding are not detected by endoscopy, the rupture of a pseudoaneurysm inside the pseudocyst should be suspeeted. We report four cases presenting with major bleeding. Bleeding was massive in two patients and intermittent in two. It resulted from erosion of the gastroduodenal artery in two patients, bleeding into the pancreatic duct in one patient, erosion of the duodenum by a bleeding pseudocyst in one and involvement of the spleen by a bleeding pseudocyst in one. Of the four patients with bleeding pseudocysts, two underwent primary pancreatic reseetion and the other two underwent transcatheter embolization with embolus coiL Bleeding was successfully controlled by the transcatheter arterial embolization in one out of the two patient and pancreatic resection was performed in the rest of three patients. (Korean J Gastroenterol 1997; 29:266-273)

대장 종양 발생과정에서 c - erbB - 2 암유전자 , / p53 유전자 , PCNA 에 대한 면역조직화학적 연구

안영주(Young Joo An),지미선(Mi Seon Ji),최성규(Sung Kyu Choi),유종선(Jong Sun Rew),윤종만(Chong Mann Yoon),이민철(Min Cheol Lee) 대한내과학회 1996 대한내과학회지 Vol.50 No.6

N/A Objectives Colon tumors appear to occur as a result of the mutational activation oncogenes coupled with the inactivation of tumor suppressor genes. Cell proliferation is a great importance in gastrointestinal tumorigenesis. Overexpression of c-erbB-2 oncogene and mutated p53 gene have been demonstrated in a number of adenocarcinomas, PCNA has been shown to be available as a single histologic marker of proliferative activity, Methods: To investigate the role of c-erbB-2 oncogene, p53 gene and cell proliferation in colon tumorigenesis, expression of c-erbB-2, p53 and PCNA was evaluated immunohistochemically in paraffinembedded sections of 80 colon carcinomas, 10 adenomas and 10hyperplastic polyps. Results: 1) The positivity for c-erbB-2 oncogene was 77.3% (61 of 80) in carcinoms, 60.0% (6 of 10) in adenomas and 10.0% (1 of 10) in hyperplastic polyps. The difference of reactivity for c-erbB-2 oncogene was statistically significant(p=0,001). 2) p53 expression was detected in 45 of 80(56.3%) cases of colon carcinomas, but all in adenomas and hyperplastic polyps was negative. 3) PCNA index was 12.8±4.9% in hyperplastic polyps, 20.3±8.2% in adenomas and 35.9±19.8% in carcinomas. PCNA index of adenomas and carcinomas was higher than that of hyperplastic polyps (p<0.05, p<0.001). 4) Coexpression of c-erbB-2 oncogene and p53 occurred together in 30 of 80colon carcinomas. Thirty-one carcinomas expressed only c-erbB-2 oncogene, 15expressed only p53 and 4expressed neither. Conclusion: These results suggest that cell proliferation is important in tumorigenesis of the colon and c-erbB-2 oncogene may be associated with early stages of colon tumorigenesis. Expression of p53 may occur as late events in colon tumorigenesis.

위암종에서 Epidermal Growth Factor Receptor 의 발현에 관한 연구 - 면역조직화학적 염색 및 in situ Hybridization -

조정곤(Jung Kon Cho),류도현(Do Hyun Rheu),최성규(Sung Kyu Choi),유종선(Jong Sun Rew),윤종만(Chong Mann Yoon),박창수(Chang Soo Park) 대한내과학회 1996 대한내과학회지 Vol.51 No.1

N/A Objectives: Gastric carcinoma is the leading cause of death among cancer patients in Korea. The etiologic factors of gastric carcinoma were suggested to chronic gastritis, genetic defect, food and environmental factor. Recently, the studies for oncogene and tumor marker have been actively performed to investigate the causes of gastric carcinoma. Epidermal growth factor receptor(EGFR) has homology in amino acids with c-erb B2 oncogene product. EGFR was identified in the placenta, chorionic villi and gastrointestinal mucosa. But it was more expressed in tumor cells, and it may be usedas a tumor marker. Methods: To investigate the correlation between EGFR and malignant potentiality in gastric carcinoma, we performed in situ hybridization of EGFR mRNA and immunohistochemistry of c-erb B2 and EGFR in 127 cases of formalin fixed paraffin embedded tissue sections of gastric carcinoma. Results: The positive reaction for c-erb B2, EGFR protein and EGFR mRNA was identified in the cytoplasm of tumor cells. The positive ratio was 44.196 in c-erb B2, 63.8% in EGFR, and EGFR mRNA was expressed in 72.4% of cases. The expression of c-erb B2 was not related with differentiation of cells, tumor size, invasiveness and metastasis. However the expression of EGFR and EGFR mRNA was related to the invasion of primary tumor and lymph node metastasis (p<.0.05). And expression of EGFR mRNA was increased in the advances of clinical stage. Conclusion: These above results suggest that the expression of EGFR mRNA is related with malignant potentiality of gastric carcinoma. EGFR mRNA might be used as tumor marker and prognostic factor of gastric carcinoma.

위암종에서 p53 , Rb 및 PCNA 발현의 비교연구

이숭(Soong Lee),문범(Beum Moon),최성규(Sung Kyu Choi),유종선(Chong Sun Rew),윤종만(Chong Man Yoon),박창수(Chang Soo Park) 대한내과학회 1997 대한내과학회지 Vol.52 No.6

N/A Objectives: Recently, the studies for oncogene and tumor marker have been actively performed to investigate the carcinogenesis of gastric carcinoma, but it is not clearly understood. We investigated the expression of tumor suppressor gene and proliferation activity in gastric carcinoma. Methods: Immunohistochemistry for p53 protein (wild and mutant type), retinoblastoma protein(wild type), and PCNA was performed in 131 cases of formalin fixed paraffin embedded tissue sections of gastric carcinoma. We compared that expression with tissue invasiveness, lymph node metastasis, staging and, Lauren classification, and that expression with each other. Results: 1) The positive ratio of p53 protein, Rb protein, also PCNA in gastric carcinoma was 64.9%, 98.5%, 99.2%, 2) The expression of p53 protein was related to invasiveness, lymph node metastasis, staging, and Lauren classification(p<0.05). 3) The positive reaction for Rb gene was identified in tumor cells as well as proliferating cells. 4) There was a close relationship between Rb gene expression and PCNA in gastric carcinoma (p<0.05). Colclusion: Theses results suggested that the expression of p53 gene is related to invasiveness, lymph node metastasis, staging and Lauren classification in gastric carcinoma. Expression of retinoblastoma gene is a closely related to proliferating activity.