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      • KCI등재후보

        全羅道 泰仁의 寬谷 崔瑞林과 龍溪書院

        김철배 ( Chul Bae Kim ) 전북대학교 인문학연구소 2012 건지인문학 Vol.8 No.-

        This paper aims to study Choi Seorim (Gwan-gok), who lived in Taein, Jeongeup in the 17th century, and Yonggye Seowon (alecture hall or a memorial hall for Confucianist services to honor distinguished scholars) where Choi Seorim is enshrined. Choi Seorim (1632~1698) is the central figure of Yonggye Seowon. His family originated from Jinju, Gyeongsangnam-do, his pen name is Gwangok, and his second names are Yeobal and Gyeomtoi. The Manchu war of 1636 broke out when he was five years old, so he had to flee for refuge from Seoul to Younggwang and Muan, Jeollanam-do, and moved to Gohyeonnae in Taein, Jeongeup Jeollabuk-do after the war. His family settled down in Gohyeonnae because his aunt was married to Kim Yeobaek from Dogang Kim family, which was very influential in the town. Furthermore, as his academic career was closely related to the school of Kim Jip (Sindokjae), it was quite natural that his family moved to Taein from the south area like Naju, Muan, Hampyeong, and Haenam of Jeollanam-do where the school of Dongin was more influential. Choi Seorim passed the civil service examination in 1661 (the 2nd reign of King Hyeonjong), but refused to go into government service and stayed in Taein only to study and teach students. Lee Ik (Seongho) introduced Choi Seorim in his book Seonghosaseol that as he taught well, there were lots of students who adored and followed him. In the student list called ``Munsaenglok``, there are 178 literary men listed. Among them, 15 students passed minor civil examinations and three students passed higher level ones. Choi Seorim followed the disciplinary flow of Honam whose representatives were Jeong Geugin and four gentlemen from Taein (Song Serim, Jeong Eonchung, Kim Yakmuk, and Kim Gwan), and he became the second origin that was followed by Eun Jeonghwa and Hwang Jeon. Choi Seorim`s learning is said to be a part of Honam school in that Hwang Yunseok (Yijae), one of the greatest Confucianists of the 18th century, is the son of Hwang Jeon who was the student of Eun Jeonghwa. Yonggye Seowon was built at the place where Choi Seorim had given lectures to his students in 1701 (the 27th year of King Sukjong`s reign) which was two years after he passed away, and he and his five students are enshrined in Yonggye Seowon.

      • KCI등재후보

        가상세포를 활용한 항염증 효능 응용모델 연구

        김철,예상준,김진현,김상균,장현철,김안나,남기엽,송미영,Kim, Chul,Yea, Sang-Jun,Kim, Jin-Hyun,Kim, Sang-Kyun,Jang, Hyun-Chul,Kim, An-Na,Nam, Ky-Youb,Song, Mi-Young 대한한의학방제학회 2010 大韓韓醫學方劑學會誌 Vol.18 No.2

        Objective : The purpose of this study was to develop the simulator which can analyze the anti-inflammatory effects of herbs based on e-cell, or the virtual cell. Method : We have ensured the medical herbs and its active compounds by investigating the oriental medicine records and NBCI(Biomedicine database). Also we have developed the web-based search system for confirming database related to anti-inflammation. We have researched the cell signal pathway related with inflammatory response control and established the mathematical model of herb interaction on selected signal pathway in e-cell. Finally we have developed the prototype which can confirm the result of this model visibly. Results : We constructed the database of 62 cases of anti-inflammatory active compounds in 61 cases of medical herbs which have been known anti-inflammation effects in the paper, 16 cases of inflammatory factors, 10 cases of signal pathways related with inflammatory response and 6,834 cases of URL(Uniform Resource Locator) of referenced papers. And we embodied the web-based research system, which can research this database. User can search basic and detailed information of medical plants related with anti-inflammatory by using information system. And user can acquire information on an active compounds, a signal pathway and a link URL of related paper. Among investigated ten pathways, we selected NF-${\kappa}B$, which plays important role in activation of immune system, and we searched the mechanisms of actions of proteins which could be components of this pathway. We reduced total network into IKK-$I{\kappa}B$ - NF-${\kappa}B$, and completed mathematic modeling by using ordinary differential equations and response variables of $I{\kappa}B-NF-{\kappa}B$ signaling model network which is suggested by Baltimore Group. We designed OED(Ordinary Differential Equation) for response of IKK, $I{\kappa}B$, $NF-{\kappa}B$ in e-cell's cytoplasm and nucleus, and measured whether an active compound of medicinal plants which is inputted by an user would have a anti-inflammation effects in obedience to change in concentration over time. The proposed model was verified by using experimental results of the papers which are listed on NCBI.

      • 고려인삼이 흰쥐의 장기조직 핵산 함유량에 미치는 영향

        김철,최현,김정진,김종규,김명석,허만경,Kim, Chul,Choi, Hyun,Kim, Chung-Chin,Kim, Jong-Kyu,Kim, Myung-Suk,Huh, Man-Kyung 대한생리학회 1971 대한생리학회지 Vol.5 No.1

        I. Chemical analysis A study was planned to see if administration of ginseng extract has any influence upon the adrenal, the hepatic, the splenic, and the pancreatic nucleic acid contents of rats, and to estimate the effect of ACTH administration as a substitute for stress reaction upon these nucleic acid contents of rats previously primed with ginseng. Ninety male rats$(body\;weight:\;150{\sim}200gm)$ were divided into the ginseng, the saline, and the normal control groups, which received for 5 days 0.5ml/100 gm body weight of ginseng extract solution (4 mg of ginseng alcohol extract in 1 ml of saline), same amount of saline, or no medication, respectively. On the 5th experimental day, each of the 3 groups was further divided into 2 subgroups yielding the ginseng, the ginseng-ACTIT, the saline, the saline-ACTH, the normal control, and the normal-ACTH subgroups. The ginseng, the saline, and the normal control subgroups were sacrificed 3 hours after the last medication, while the ginseng-ACTH, the saline·ACTH, and the normal-ACTH subgroups received ACTH(0.1 unit/subject) 1 hour after the last medication and were sacrificed after 1 more hour. The adrenal gland, the liver, the spleen and the pancreas of each rat were measured for RNA and DNA contents using the chemical method of Schmidt-Thannhauser-Schneider. Following results were obtained: 1. Adrenal RNA and DNA contents and RNA/DNA ratio were all significantly higher in the ginseng group compared with the values obtained from the normal control and the saline groups. Generally administration of ACTH reduced nucleic acid contents of the viscera examined. However, in the ginseng group the rate of decrease [(value of ginseng-ACTH subgroup-value of ginseng subgroup) x100/value of ginseng subgroup)] in adrenal RNA and DNA contents and in RNA/DNA ratio were more conspicuous than they were in the normal control and the saline groups. 2. Hepatic RNA and DNA contents and RNA/DNA ratio were all significantly less in the ginseng group than in the normal control and the saline groups. After ACTH, the rate of decrease in hepatic RNA, DNA, and RNA/DNA ratio of the ginseng· group was less conspicuous than those of the other 2 groups. 3. With regard to the splenic nucleic acid contents, the RNA and the RNA/DNA values of the ginseng group were higher than those of the normal control group but lower than those of the saline group, while the DNA value of the ginseng group was lower than that of the normal control group but higher than that of the saline group. Following administration of ACTH, the rate of decrease in RNA and DNA contents and in RNA/DNA ratio of the ginseng group was more conspicuous than that of the normal control group but less remarkable than that of the saline group. 4. Pancreatic RNA and DNA contents were notably lower in the ginseng group than in the normal control and the saline groups. However, the RNA/DNA ratio of the ginseng group was higher than that of the normal control and the saline groups.'After ACTH, the rate of decrease in pancreatic RNA and RNA/DNA ratio of the ginseng group was less than that of the normal. control group but more than that of the saline group, while the DNA content was actually increased in the ginseng group though it decreased in the normal control and the saline groups. Although the results are not clear enough for an accurate interpretation, they seem to indicate that ginseng exerts notable influence upon the RNA and DNA contents and the RNA/DNA ratio of the viscera stodied. On the whole the drug tends to increase the RNA and DNA contents and RNA/DNA ratio of the adrenal gland but seems to diminish the values of the other 3 viscera. In the early period following ACTH, ginseng facilitates the fall in RNA and DNA contents and RNA/DNA ratio of the adrenal gland, while it tends to reduce the fall in the values of the other viscera studied. II. Autoradiographic and histochemical analysis It was planned autoradiographically and his 1. 인삼주정추출물이 흰쥐의 부신, 간, 비장 및 췌장의 핵산 함유량에 어떤 영향을 미치며, 인삼 투여를 받고 있는 동물이 스트레스(ACTH의 투여로 대신)를 받을 경우에 이들 장기 핵산 함유량에 어떠한 변동이 오는지를 알기 위하여 90마리의 흰쥐($150{\sim}200gm$) 수컷을 인삼군과 식염수군 및 정상군으로 나누고 이것을 각각 다시 둘로 쪼개어 인삼군, 인삼-ACTH군, 식염수군, 식염수-ACTH군, 정상군 및 정상-ACTH군의 여섯 작은 무리로 나누어 다음과 같은 실험을 하였다. 인삼군과 인삼-ACTH군에서는 몸무게 100gm에 대하여 인삼주정추출액(생리적 식염수 1ml속에 4mg의 인삼주정추출물이 포함된 용액)을 0.5ml의 비율로 매일 등뒤 피하에 5일동안 주사하였으며, 식염수군과 식염수-ACTH군에는 생리적 식염수를 몸무게 100gm에 대하여 0.5ml의 비율로 인삼군과 동일한 방법으로 주사하였다. 실험시작 제 5일째에 정상군과 식염수군 및 인삼군은 각각 전처치 없이 또는 인삼 혹은 식염수 주사후 2시간 만에 도살하고, 정상-ACTH군, 인삼-ACTH군 및 식염수-ACTH군은 각각 직접 또는 인삼이나 식염수를 투여한 다음 1시간 만에 ACTH를 주사하고, 그 시각부터 1시간후에 도살하여 부신, 간, 비장 및 췌장 조직의 핵산 함유량을 측정하였다. 이들 측정치를 지표로하여 인삼이 장기 핵산에 미치는 영향을 관찰한바 다음과 같은 결과를 얻었다. 1) 부신조직 RNA, DNA 및 RNA/DNA는 인삼군의 값이 정상군 및 식염수군의 그것보다 현저하게 많다. 인삼군의 값에 대한 인삼-ACTH군 값의 감소율은 정상군 및 식염수군에 대한 정상-ACTH군 및 식염수-ACTH군의 그것보다 현저하게 크다. 2) 간 조직의 RNA, DNA 및 RNA/DNA는 인삼군의 값이 정상군 및 식염수군의 값보다 현저하게 감소되었다. 인삼군 값에 대한 인삼-ACTH군 값의 감소율은 정상군 및 식염수군에 대한 정상-ACTH군 및 식염수-ACTH군의 그것 보다 적다. 3) 비장 조직의 RNA와 RNA/DNA는 인삼군의 값이 정상군의 그것 보다 현저하게 증가되며, 식염수군 보다는 감소된다. 인삼군의 DNA는 정상군에서 보다 감소되며, 식염수군의 그것 보다 증가된다. 인삼군 값에 대한 인삼-ACTH군 값의 감소율은 정상군에 대한 정상-ACTH군의 그것 보다 크며, 식염수군에 대한 식염수-ACTH군의 그것 보다는 작다. 4) 췌장 조직의 RNA와 DNA는 인삼군의 값이 정상군 및 식염수군의 그것 보다 현저하게 감소된다. 인삼군의 RNA/DNA는 정상군 및 식염수군의 그것 보다 증가된다. 인삼군에 대한 인삼-ACTH군의 RNA와 RNA/DNA 감소율은 정상군에 대한 정상-ACTH군의 그것 보다 적으나 식염수군에 대한 실염수-ACTH군의 그것 보다는 현저하게 크다. 인삼-ACTH군의 DNA는 인삼군의 그것 보다 증가되었으나, 정상-ACTH군 및 식염수-ACTH군의 DNA는 정상군 및 식염수군의 그것보다 감소되었다. 이상의 실험성적만으로 명확한 해석을 내리기는 어려우나 인삼은 장기의 RNA, DNA 및 RNA/DNA 비율에 현저한 영향을 미치는 것으로 보인다. 대체로 인삼은 부신의 RNA와 DNA 함유량 및 RNA/DNA 비율을 모두 증가시키나 다른 장기에서는 이들 값을 감소시키는 경향이 있다. 한편 인삼의 투여를 받은 동물에서는 ACTH투여후 조기에 부신 조직의 RNA, DNA 및 RNA/DNA의 감소율이 커지며, 간, 비장 및 췌장 조직의 RNA, DNA 및 RNA/DNA의 감소율은 적어지는 경향이 있다. 2. 인삼 및 ACTH의 투여에 의하여 부신, 췌장, 간 및 비장의 DNA와 RNA 함유량이 변동하는 모습을 화학적 방법으로 추적하여 얻은 전편의 성적

      • KCI등재

        SnO/Sn 혼합 타겟으로 스퍼터 증착된 SnO 박막의 열처리 효과

        김철,조승범,김성동,김사라은경,Kim, Cheol,Cho, Seungbum,Kim, Sungdong,Kim, Sarah Eunkyung 한국마이크로전자및패키징학회 2017 마이크로전자 및 패키징학회지 Vol.24 No.2

        SnO:Sn(80:20 mol%) 혼합 타겟을 이용한 RF 반응성 스퍼터링으로 투명하고 전도성이 있는 $Sn_xO_y$ 박막을 증착하였다. 혼합 타겟은 화학적으로 안정한 조성과 높은 투과도를 주는 세라믹 타겟과 Sn과 산소의 반응성 증착으로 박막내 구조적 결함 조절이 용이한 금속 타겟의 장점을 고루 택하고 있다. 산소 분압 0%~12% 구간에서 박막을 증착하였으며, 증착 후 $300^{\circ}C$에서 1시간 동안 진공 열처리를 진행하였다. Sn 함량이 많은 $P_{O2}=0%$의 경우를 제외하고 모든 시편들은 열 처리 전후에 80~90% 이상의 투과도를 보였으며, 안정된 p형 $Sn_xO_y$ 박막은 $P_{O2}=12%$에서 확인하였고, $P_{O2}=12%$에서 열 처리 후 캐리어 농도와 이동도는 각각 $6.36{\times}10^{18}cm^{-3}$와 $1.02cm^2V^{-1}s^{-1}$ 이었다. Conductive $Sn_xO_y$ thin films were fabricated via RF reactive sputtering using SnO:Sn (80:20 mol%) composite target. The composite target was used to produce a chemically stable composition of $Sn_xO_y$ thin film while controlling structural defects by chemical reaction between tin and oxygen. During sputtering pressure, RF power, and substrate temperature were fixed, and oxygen partial pressure was varied from 0% to 12%. Annealing process was carried out at $300^{\circ}C$ for 1 hour in vacuum. Except $P_{O2}=0%$ sample, all samples showed the transmittance of 80~90% and amorphous phase before and after annealing. Electrically stable p-type $Sn_xO_y$ thin film with high transmittance was only obtained from the oxygen partial pressure at 12%. The carrier concentration and mobility for the $P_{O2}=12%$ were $6.36{\times}10^{18}cm^{-3}$ and $1.02cm^2V^{-1}s^{-1}$ respectively after annealing.

      • KCI등재

        물이용부담금 제도의 평가와 기능 재조정 방향

        김철회(Kim Cheol Hoi)(金哲會),박경순(Park Kyoung Soon)(朴慶淳),이병철(Lee Byoung Chul)(李炳哲),정석원(Jang Seok Won)(張碩元) 한국지방공기업학회 2016 한국지방공기업학회보 Vol.12 No.2

        본 연구는 통합물관리(IWRM)의 주요 구성요소인 경제적 효율성, 사회적 형평성, 생태적 지속가능성, 민주적 거버넌스 측면에서 현행 물이용부담금 제도를 분석·평가해보고, 향후 통합물관리 위해 필요한 물이용부담금제도의 기능 재조정 방향을 도출하여 제시하였다. 통합물관리 관점에서 현행 물이용부담금제도를 분석한 결과, 경제적 효율성 관점에서 시장유인성이 낮고, 환경기초시설 설치 및 운영, 토지매수, 주민지원사업 등 주요사업에서 비효율성이 크고, 사회적 형평성 관점에서 비용부담의 형평성이 낮고 편익향유의 공평성이 미흡하며, 생태적 지속가능성 측면에서 지속적 수질개선을 위해 필요한 환경유량를 확보하지 못하고 있는 것으로 평가되었다. 또한 민주적 거버넌스 측면에서 수계관리위원회의 거버넌스가 환경부 중심으로 구성되어 있어, 지자체, 시민 등 다양한 이해관계자의 참여와 활동이 보장되고 있지 못한 것으로 평가되었다. 향후 통합물관리의 실현을 위한 재원으로서 물이용부담금제도는 지출구조 측면에서 기존의 비효율적 사업기능을 축소하고, 새로운 수요가 있는 신규사업 기능을 추가하고, 수입구조 측면에서 부과대상을 확대하고, 저소득계층에 대한 감면제도를 도입할 필요가 있다. 또한 민주적 거버넌스를 실현하기 위해 수계관리위원회 의사결정구조에 다양한 이해관계자를 실질적으로 참여시킬 필요가 있다. This study analyzed present water use charges in the light of main components of integrated water resource management such as economic efficiency, social equity, and ecological sustainability, and proposed direction of functional readjustment of them. Firstly, water use charges do not work for market incentives, and specific programs of them such as basic environmental treatment facilities, land purchase, residents support are inefficient in economic perspectives. Secondly, they are lack of fairness in the light of burden of expenses and share of benefits. Thirdly, they do not secure enough water supply for water quality improvement. Lastly, in the light of democratic governance, they have no appropriate governance because they do not allow various interest groups such as local governments, citizens. For realizing of integrated water resource management, water use charge institutions have to reduce the inefficient program, and increase the new program in need, such as ecological flow in the light of expenditure restructuring, and expand target of charge, and impose reduction system for low-income group in the light of revenue restructuring. In addition, they should adopt participation systems in decision making structure, which admit various interest groups, for improving democratic governance.

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