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한국형 자궁경부 촬영진 ( New Cervicography ) , 세포검사 그리고 HPV-DNA 검사를 이용한 새로운 자궁경부암 검진 모델 ( Model ) 개발
김승조(SJ Kim),박찬규(CK Park),이효표(HP Lee),남궁성은(SE Namkoong),강순범(SB Kang),서호석(HS Saw),이재관(JK Lee),김수녕(SN Kim),김재원(JW Kim),배석년(SN Bae),김찬주(CJ Kim),이근호(KH Lee),이선영(SY Lee),김인호(IH Kim),이찬(C Lee),이정노(JN Lee) 대한산부인과학회 2001 Obstetrics & Gynecology Science Vol.44 No.5
N/A Objective : The false negative rate of conventional cytology is reported to range from 18 to 45%. It is necessary to develop more effective screening strategies that would ideally be more accurate than conventional cytology. This study is designed to investigate the potential of conventional cytology, cervicography, HPV-DNA testing and their combinations as primary screening techniques for cervical neoplasia. The purpose of this project is to develop the models and guidelines for screening tools of cervical cancer of the uterus by evaluating sensitivity, specificity and cost-effectiveness of all the screening methods. Study design : We conducted a screening of random sample of women who visited the department of OB-Gyn. of five different major university hospitals such as Catholic University Hospital, Korea University Hospital, Seoul National University Hospital, Yeonsei University Hospital and Pochon CHA University Bundang CHA Hospital, from May 1, 1996 to April 30, 1999. In a cohort women with an age range of 20 to 70 who underwent routine cytologic screening at Catholic University, Hospital Bundang CHA General Hospital and local clinics from April 1, 1996 to Decomber 31, 2000. cervicography (n=417,125) and testing for HPV-DNA (n=1,347) by the hybrid capture assay were studied for the ability of the cervical cancer screeuing. A new cervicography system with Kim's classification which was developed by Prof. Kim Seung Jo as an adjunctive method for the cervical cancer screening was applied in this cohort study. And then, accuracy, effectivencess, cost-effectiveness of the single or combined screening method were analysed. Result : Sensitivity and specificity of Pap smear were ranged from 55.6% to 83.1% and 72.8% to 88.3% respectively. The combination of Pap smear and cervicography had sensitivity from 89.7% to 98.6%, specificity from 68.2% to 93.2%. With combination of Pap smear, HPV DNA test and cervicography, sensitivity became also highest accuracy among all screening methods from 92.8% to 98.8%. Considering medical charges for diagnosis and social cost occurred by false positive and false negative results, the most cost-effective diagnostic modality was thought to be the combination of Pap smear and cervicography(91,433 won). In patients who were diagnosed as LSIL, colposcopic examination confirmed progression to high grade intraepithelial lesion(HSIL) in 10.7% patients, persistence of LSIL in 55% patients during the 3 year follow-up period. Accuracy of the screening for cervical cancer and CIN can significantly be improved by cytology with new cervicography rather than cytology alone. We concluded that cervicography can be important adjunctive tests for cervical cytology, improving the effectiveness of cervical screening by allowing a more sensitive detection of cervical neoplasia.
Combelen 처리가 축우의 유혈중 혈액상 , 혈액화학치 및 혈청 cortisol 농도에 미치는 영향
고기환(K . W . Ko),손제영(J . Y . Son),김찬주(C . J . Kim) 한국축산학회 1990 한국축산학회지 Vol.32 No.8
Two experiments were performed to investigate the changes in blood pictures, blood chemical values and serum cortisol concentration according to Combelen administration(Exp. 1, 2). Sixteen Holstein male calves of 5∼10 month-old(weighing 150 to 380 kg) were used. Each experiment was composed of four calves for experimental groups and control groups. In Exp. 1 and Exp. 2, each animal of experimental group was injected Combelen(N-(3`-dimethyl-aminop-ropyl) 3-propionyl phenothiazine l% solution) with intramusculary as level of 3ml/100kg or 2ml/100kg live body weight, respectively. The animals in control group of Exp. 1 and Exp. 2 were given saline administration instead of Combelen. The blood samples were collected just before and 2, 6 and 24 hours after treatment. The results obtained were summarized as follows; 1. There were no changes in erythrocytic blood values except the PCV according to quantity of Combelen and age of calves in Combelen administration. The PCV decreased(p $lt;.05) at 2∼6 hours after administration of Combelen. 2. The total leukocytes and differential leukocyte showed no noticeable change compared with control group. 3. The serum total protein showed a tendency to decrease at 2 hours after administration of Combelen, but A/G ratio was not changed. The blood glucose level had a tendency to increase at 2-6 hours after administration of Combelen, but BUN value showed a tendency to decrease at the same hours. 4. The serum cortisol concentration was not significantly changed after administration of Combelen, but there was slightly increased at 6 hours after injection compared with control group.
이지영(J Y Lee),권용일(Y I Kwon),박태철(T C Park),이은정(E J Lee),권동진(D J Kwon),김찬주(C J Kim),이근호(K H Lee),서상용(S Y Seo),조형권(H G Cho),류진희(J H Ryu),나순숙(S S Na),이진우(J W Lee),김수평(S P Kim) 대한산부인과학회 1999 Obstetrics & Gynecology Science Vol.42 No.10
A case of rapidly grown, huge ovarian cyst in an 18-year old woman is presented with a brief review of literature. This tumor was measured 30x40x45 cm in size, and weighed 13kg. The pathologic diagnosis was mucinous cystadenoma, left ovary.