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      • KCI등재
      • KCI등재

        반복 점진적 방법에 의한 2차원 단백질 분리 영상의 반점 정합

        김정자,김동욱,김남균,원용관,Kim, Jung-Ja,Hoang, Minh T.,Kim, Dong-Wook,Kim, Nam-Gyun,Won, Yong-Gwan 대한의용생체공학회 2007 의공학회지 Vol.28 No.5

        2 Dimensional Gel Electrophoresis(2DGE) is an essentialmethodology for analysis on the expression of various proteins. For example, information for the location, mass, expression, size and shape of the proteins obtained by 2DGE can be used for diagnosis, prognosis and biological progress by comparison of patients with the normal persons. Protein spot matching for this purpose is comparative analysis of protein expression pattern for the 2DGE images generated under different conditions. However, visual analysis of protein spots which are more than several hundreds included in a 2DGE image requires long time and heavy effort. Furthermore, geometrical distortion makes the spot matching for the same protein harder. In this paper, an iterative algorithm is introduced for more efficient spot matching. Proposed method is first performing global matching step, which reduces the geometrical difference between the landmarks and the spot to be matched. Thus, movement for a spot is defined by a weighted sum of the movement of the landmark spots. Weight for the summation is defined by the inverse of the distance from the spots to the landmarks. This movement is iteratively performed until the total sum of the difference between the corresponding landmarks is larger than a pre-selected value. Due to local distortion generally occurred in 2DGE images, there are many regions in whichmany spot pairs are miss-matched. In the second stage, the same spot matching algorithm is applied to such local regions with the additional landmarks for those regions. In other words, the same method is applied with the expanded landmark set to which additional landmarks are added. Our proposed algorithm for spot matching empirically proved reliable analysis of protein separation image by producing higher accuracy.

      • KCI등재후보

        신경근전기자극치료가 뇌졸중 환자의 연하장애에 미치는 효과

        김정자,이종원,Kim, Jeong Ja,Lee, Jong Won 대한물리치료과학회 2019 대한물리치료과학회지 Vol.26 No.2

        Background: The purpose of this study was to provide the basis for the treatment intervention by identifying the treatment effect when rehabilitation intervention is applied to patients with dysphagia due to stroke and by comparing the results of the treatment mediation according to the differences of the treatment methods and frequency. Design: Randomized Controlled Trial. Methods: 30 people diagnosed with dysphagia due to stroke were divided in accordance with the differences in treatment mediation techniques and treatment frequency- traditional swallowing rehabilitation coupled with neuromuscular electrical stimulation group and only neuromuscular electrical stimulation group/ 5 times per week group and 2 times per week group, and ten weeks of treatment intervention was performed. Paired t test was employed to show the efficacy of treatment intervention, Independent sample t test was used to compare the results according to difference and number of treatment intervention techniques. Results: There was a significant positive effect of treatment on traditional swallowing rehabilitation coupled with neuromuscular electrical stimulation group, only neuromuscular electrical stimulation group, 5 times per week group and 2 times per week group (p<0.05). There was no statistically significant difference in treatment effect between traditional swallowing rehabilitation coupled with neuromuscular electrical stimulation group and only neuromuscular electrical stimulation group (p<0.05). There was no statistically significant difference in treatment effect between 5 times per week group and 2 times per week group (p<0.05). Conclusion: There was no significant difference according to the technique or number of treatments of swallowing rehabilitation treatment interventions, but it was confirmed that rehabilitation intervention for dysphagia showed positive treatment effect.

      • KCI등재
      • KCI등재후보

        경직형 뇌성마비아의 장악력에 파지기능 훈련이 미치는 영향(4례 증례보고)

        김정자,오명화,김은정,Kim, Jeong-Ja,Oh, Myung-Hwa,Kim, Eun-Jung 대한물리치료학회 2008 대한물리치료학회지 Vol.20 No.2

        Purpose: The purpose of this study is to find the effect of grip strength of the grasping reflex skill training of 4 case children with spastic cerebral palsy. Smedley hand dynamometer(JAMAR, USA) was used for measuring grip strength. Methods: Smedley hand dynamometer(JAMAR, USA) was used for measuring grip strength. Cases were chosen mild, moderate and severe spastic cerebral palsy with sitting balance and perception. To achieve that purpose, this training program was carried out 5 times a week for 4 weeks with 4 children. The performance of grasping reflex skill training and grip strength was evaluated each other. Results: Both hands were investigated with grasping reflex skill test and grip strength in two week intervals. In the dominant or nondominant hand, the more improvement of grasping reflex skill test is high, the more that of grip strength is high. Conclusion: The result were as follows that. The grasping reflex skill training was effective in grip strength.

      • 복부비만 여성의 슬링을 결합한 플랭크 운동 효과

        김정자,강다현,양종화,장인선,조부연,홍창완,Kim, Jeong-Ja,Kang, Da-Hyeon,Yang, Jong-Hwa,Jang, In-Seon,Cho, Bu-Yeon,Hong, Chang-Wan 한국임상보건과학회 2019 한국임상보건과학회지 Vol.7 No.2

        Purpose. The study was conducted to find out the effects that women in their 20s with abdominal obesity can get from sling-based flanks. Methods. The study used In-Body to determine the weight and body fat rate of women in their 20s who were overweight at H University and used a tape measure to measure the circumference of the abdomen. Plank exercise using slings to reduce weight, body fat and abdominal circumference led to muscle stabilization and abdominal obesity reduction. The collected data were analyzed using the SPSS ver. 23.0 statistics program. Results. The results of the study showed statistically significant differences in the weight, body fat rate and abdominal circumference of the subjects before and after intervention. Conclusions. Steady abdominal muscles exercise help stabilize the abdomen, reduce abdominal body fat rate, and are effective in managing obesity.

      • Atropine의 가토혈압하강작용(家兎血壓下降作用)에 관하여

        김정자,Kim, Jeong-Ja 대한약리학회 1975 대한약리학잡지 Vol.11 No.1

        Atropinesterase를 가친 가토(家兎)를 선택(選擇)하여 urethane 마취하(麻醉下)에서 atropine에 대한 혈압반응(血壓反應)을 조사(調査)하여 다음과 같은 성적(成績)을 얻었다. 1) 10, $50{\mu}g/kg$의 atropine은 거의 혈압하강(血壓下降)을 일으키지 않았으나, $250{\mu}g/kg$는 미약(微弱)한 혈압하강(血壓下降)을, $1,250{\mu}g/kg$는 현저(顯著)한 혈압하강(血壓下降)을 일으켰다. 2) Hexamethonium 주입하(注入下) 10, $50{\mu}g/kg$의 atropine도 혈압하강(血壓下降)을 일으키고, $^-250$, $1,250{\mu}g/kg$에 대한 하강반응(下降反應)은 더욱 현저(顯著)하였다. 3) Hexamethonium 또는 hexamethonium+angio-tensin주입하(注入下)에서 나타나는 atropine (10, 50, $250{\mu}g/kg$)에 대한 혈압하강(血壓下降) 반응(反應)은 propaneline, phonoxybenzamine, bretylium 존재하(存在下)에서는 현저(顯著)하게 억제(抑制)되었다. 4) 척수이단(脊髓離斷) 가토(家兎)에서는 hexamethonium+angiotensin주입하(注入下)에서도 atropine (10, 50, $250{\mu}g/kg$)은 거의 혈압하강(血壓下降)을 일으키지 않았다. 상기(上記) 성적(成績)에 의거(依據)하여 atropine은 혈관계(血管系)에 분포(分布)되여 있는 교감신경계(交感神經系)의 신경절(神經節)에 있어서의 충격부달(衝擊傅達)을 억제(抑制)함으로써 혈압하강(血壓下降)을 일으키는 것으로 추측(推測)하였다. 1. Atropine has recently been known to possess a sympathetic ganglion blocking effect. If atropine blocks the sympathetic ganglia innervating the blood vessels, the drug should cause depressor responses. The author attempted to verify this assumption in urethane-anesthetized rabbits having atropinesterase. 2. Ten and $50{\mu}g/kg$ of atropine produced little variation of the blood pressure; $250{\mu}g/kg$ slight depressor responses; $1,250{\mu}g/kg$ distinct ones. Under hexamethonium-infusion, 10 and $50{\mu}g/kg$ produced observable depressor responses; 250 and $1,250{\mu}g/kg$ produced more pronounced ones. 3. In experiments examining influence of phenoxybenzamine and bretylium on the atropine responses, the lowered blood pressure by these agents was raised by simultaneous infusion of angiotensin with hexamethonium. The depressor responses to atropine (10, 50 and $250{\mu}g/kg$) were slight after the administration of phenoxybenzamine and bretylium. 4. Propranolol did not affect the depressor responses to atropine. 5. In spinalized rabbits the lowered blood pressure was raised by the angiotensin-infusion. In these animals receiving the simultaneous hexamethonium-infusion, atropine (10, 50 and $250{\mu}g/kg$) produced little depressor responses. 6. From these results it is inferred that atropine produced the depressor responses by blocking the sympathetic ganglia innervating the blood vessels.

      • KCI등재후보

        IT 시대 장애아동 아버지의 양육 스트레스에 관한 연구

        김정자,정복희,오명화,Kim, Jeong-Ja,Chong, Bok-Hee,Oh, Myung-Hwa 한국전자통신학회 2013 한국전자통신학회 논문지 Vol.8 No.2

        본 연구는 장애아 아버지의 양육스트레스를 알아보기 위해 실시되었다. 연구의 대상은 G광역시에서 재활치료를 받고 있는 13세 미만의 장애아들 둔 아버지 50명을 대상으로 설문조사를 하여 응답이 불충분한 자료를 제외한 38부를 활용하였다. 설문지의 구성은 장애아동과 아버지의 일반적 특성, 그리고 부모의 양육스트레스(K-PSI-SF)로 하였으며 그 결과는 다음과 같다. 첫째, 장애아 아버지의 양육스트레스는 K-PSI-SF 하위 항목 가운데 부모의 고통이 가장 높았고 다음은 까다로운 아동, 그리고 역기능적 상호작용 순이었다. 둘째, 아동의 특성에 따른 아버지의 스트레스는 진단명과 마비부위에 따라 유의한 차이를 보였다. 셋째, 아버지의 특성에 따른 스트레스는 아버지의 교육수준과 연령에 따라서 유의한 차이를 보였다. The purpose of this study is to investigate the parental distress of disabled children's fathers. The survey was conducted targeting 50 fathers with disabled children who are under 13 years old and undergoing rehabilitation treatment in G city And 38 questionnaires excluding data with inadequate answer were adopted. The questionnaire was composed of general peculiarities of disabled children and their fathers, and K-PSI-SF of parents. The results are as followings. First of all, among the parenting stress of disabled children's fathers, parental distress got the highest score and difficult child and dysfunctional interaction are next in sequence in the sub items of K-PSI-SF. Secondly, fathers' stress upon the children's general characteristics showed the significant difference depending on diagnostic categories and paralysis area. Thirdly, fathers' stress upon fathers' general characteristics showed the significant difference depending on their education level and age.

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