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홍창완(Chang-Wan Hong),박도순(Do-Soon Park) 한국정보과학회 1992 한국정보과학회 학술발표논문집 Vol.19 No.2
정지영상(Continuous Tone Still Image) 압축의 국제표준인 JPEG(Joint Photographic Experts Group)을 구현하고 이의 평가 및 개선에 대해 기술한다. JPEG은 CCITT와 ISO에 의해 정의된 정지영상 압축에 대한 규약으로, 표준으로서의 상호 호환성과 응용에 대한 융통성을 갖추고 있다. 압축률은 입력 영상에 따라 달라지게 되는데, 이는 영상마다 서로다른 공간주파수를 가지고 있기 때문이다. 본 논문에서는 영상의 공간 주파수들이 압축률에 어떠한 영향을 미치는 가에 대해 알아보고, 불필요한 고주파성분들을 미리 제거함으로써 압축률을 높일 수 있음을 보였다. 또한 이때 사용될 수 있는 필터링 방법들을 알아보고 필요한 파라메터들을 구하였다. JPEG을 이용한 정지영상 압축 기술은 MPEG(Moving Picture Experts Group)과 같은 동영상 압축의 기초가 되고, 멀티미디어, 이미지 화일링, 화상통신 고품위 텔리비젼 등에 직접 적용되는 기술이다.
洪暢完,朴道淳 弘益大學校 科學技術硏究所 1992 科學技術硏究論文集 Vol.2 No.-
We study JPEG(Joint Photographic Experts Group) which is standardized by CCITT and ISO. The JPEG can compress a continuous tone still image. In this paper, we implement the JPEG, and evaluate improvement of it. Compression ratio can be varied by input image chracteristics, because each image has diffrent spatial frequency. It is showed that filtering previously the high frequency raised the compression ratio.
Anti-tumor immunostimulatory effect of heat-killed tumor cells
윤택준,홍창완,Hyunji Lee,이창권,이광호,홍석만,박세호,Ji Yeon Kim,Hyojeong Kim 생화학분자생물학회 2008 Experimental and molecular medicine Vol.40 No.1
As a part of our ongoing search for a safe and efficient anti-tumor vaccine, we attempted to determine whether the molecular nature of certain tumor antigens would influence immune responses against tumor cells. As compared with freeze-thawed or formaldehyde- fixed tumor antigens, heat-denatured tumor antigens elicited profound anti-tumor immune responses and greatly inhibited the growth of live tumor cells. The heat-denatured tumor antigens induced a substantial increase in the anti-tumor CTL response in the absence of any adjuvant material. This response appears to be initiated by strong activation of the antigen- presenting cells, which may recognize heat-denatured protein antigens. Upon recognition of the heat-denatured tumor antigens, macrophages and dendritic cells were found to acutely upregulate the expression of co-stimulatory molecules such as B7.2, as well as the secretion of inflammatory cytokines such as IL-12 and TNF-α . The results of this study indicate that heat-denatured tumor extracts might elicit protective anti-tumor adaptive immune responses and also raise the possibility that a safe and efficient adjuvant- free tumor vaccine might be developed in conjunction with a dendritic cell-based tumor vaccine.
The role of soluble common gamma chain in autoimmune disease
Byunghyuk Lee,홍창완 대한해부학회 2015 Anatomy & Cell Biology Vol.48 No.1
The common gamma chain (γc) is the central signaling unit for a number of cytokine receptors collectively known as the γc cytokine receptor family. γc is critical for ligand binding and signaling by γc cytokines. γc cytokine signaling had been thought to be mainly regulated by cytokine-specific receptor α chain expression levels with little or no effect by γc surface levels because γc expression was presumed to remain unchanged during T-cell activation and development. The extent of γc cytokine responses is thought to be regulated by cytokine specific receptor subunits and not by the γc receptor. In contrast to this prevailing view, we have recently reported that γc itself actively regulates γc cytokine responses. Interestingly, γc exerted its regulatory effects not only as a conventional membrane receptor protein but also as a secreted protein whose expression was upregulated upon T-cell stimulation. Here we will review how a soluble form of γc, which is generated by alternative splicing, regulates γc cytokine signaling and plays a role in controlling immune activation related to autoimmune disease.
윈도우 환경에서의 GUI 기반 블랙박스 테스트 자동화 프로그램 도구
정범진,이정우,홍창완,안병구 한국인터넷방송통신학회 2018 한국인터넷방송통신학회 논문지 Vol.18 No.2
In this paper, we propose and develop a test automation program tool that automates GUI based testing using black box testing technique in Windows environment. The main features of the proposed test automation program tool are as follows. First, an error condition is designated as an image, a screen is captured for each test step, and an error message is detected through comparison of image similarity. Second, the proposed system supports various setting options such as event waiting time during execution and coordinate increment value between each test step. Such black box test automation research was common in environments such as Android and Web, but not in Windows environment. The results of performance evaluation show that the proposed system performs GUI test automation as an image comparison module and confirms that the test is performed normally by confirming process status and error image detection. 본 논문에서는 윈도우 환경에서 블랙박스 테스트 기법을 사용하여 GUI 기반 테스트를 자동화하는 테스트 자동화 프로그램 도구를 제안 및 개발한다. 제안된 테스트 자동화 프로그램 도구의 주요한 특징은 다음과 같다. 첫째, 에러 상태를 이미지로써 지정하고, 테스트 스텝마다 화면을 캡처하여 이미지 유사도 비교를 통해 에러 메시지 검출 여부를 확인한다. 둘째, 실행 중 이벤트 대기시간이나 각 테스트 스텝 간 좌표 증가 값 등 여러 옵션 설정을 지원한다. 이러한 블랙박스 테스트 자동화 연구는 안드로이드나 웹 등의 환경에서는 많았지만 윈도우 환경에서는 그렇지 않았다. 제안된 시스템의 성능평가 결과 제안된 시스템은 이미지 비교 모듈로써 GUI 테스트 자동화를 수행하고, 프로세스 상태확인과 에러 이미지 검출 여부를 확인함으로써 테스트를 정상적으로 수행함을 확인하였다.
A New Reporter Vector System Based on Flow-Cytometry to Detect Promoter Activity
정선도,최지혜,홍창완,이현지,박윤경,신정훈,박재원,박세호 대한면역학회 2009 Immune Network Vol.9 No.6
In this study, we report the development of a new dual reporter vector system for the analysis of promoter activity. This system employs green fluorescence emitting protein, EGFP, as a reporter, and uses red fluorescence emitting protein, DsRed, as a transfection control in a single vector. The expression of those two proteins can be readily detected via flow cytometry in a single analysis, with no need for any further manipulation after transfection. As this system allows for the simultaneous detection of both the control and reporter proteins in the same cells, only transfected cells which express the control protein, DsRed, can be subjected to promoter activity analysis, via the gating out of all un-transfected cells. This results in a dramatic increase in the promoter activity detection sensitivity. This novel reporter vector system should prove to be a simple and efficient method for the analysis of promoter activity. In this study, we report the development of a new dual reporter vector system for the analysis of promoter activity. This system employs green fluorescence emitting protein, EGFP, as a reporter, and uses red fluorescence emitting protein, DsRed, as a transfection control in a single vector. The expression of those two proteins can be readily detected via flow cytometry in a single analysis, with no need for any further manipulation after transfection. As this system allows for the simultaneous detection of both the control and reporter proteins in the same cells, only transfected cells which express the control protein, DsRed, can be subjected to promoter activity analysis, via the gating out of all un-transfected cells. This results in a dramatic increase in the promoter activity detection sensitivity. This novel reporter vector system should prove to be a simple and efficient method for the analysis of promoter activity.