만성치주염 환자에 대한 저용량 독시싸이클린의 임상적 효과

김윤식,백정원,김창성,최성호,김종관,Kim, Yoon-Sik,Paik, Jeong-Won,Kim, Chang-Sung,Choi, Seong-Ho,Kim, Chong-Kwan 대한치주과학회 2002 Journal of Periodontal & Implant Science Vol.32 No.2

Periodontal disease is a complex infectious disease caused by bacteria in the oral mucosa, which results in gingival inflammation, breakdown of periodontal tissues, bone resorption, and finally tooth loss. Mechanical plaque control methods-scaling and root planing are effective methods to stop the progression of such periodontal disease. It was reported that subantimicrobial dose of doxycycline(SDD) regimen could improve clinical conditions of periodontal tissues without causing the overgrowth of opportunistic organisms that was a typical antibiotic side effect. Therefore pharmacological therapy, used in conjunction with mechanical therapy could be considered a useful treatment modality in the treatment of chronic periodontal disease. In this study, 30 patients diagnosed as moderate to advanced chronic periodontitis were divided into 2 groups. In this double-blind, placebo-controlled study, the patients were administered 20mg doxycycline capsule or placebo capsule b.i.d. for 4months, after scaling and root planing. Clinical parameters-bleeding on probing, pocket depth and clinical attachment level were compared and evaluated between these groups at periods of first visit, 1 month, 2 months, 3 months, 4 months. The results were as follows ; 1. In case of moderate periodontitis, pocket depth showed significant reduction after treatment in both the control & experiment groups, when compared with the baseline values(p<0.01), but in case of advanced periodontitis, only the experiment group showed significant reduction after treatment when compared with the baseline values(p<0.05). Statistically significant reduction in pocket depth was observed in the experiment group compared to the control group(p<0.05). 2. In case of moderate periodontitis, clinical attachment level showed significant reduction after treatment in both the control & experiment groups, when compared with the baseline values(p<0.01), but in case of advanced periodontitis, only the experiment group showed significant reduction after treatment when compared with the baseline values(p<0.05). Statistically significant reduction in clinical attachment level was observed in the experiment group compared to the control group(p<0.05). 3. Bleeding on probing improved after treatment in both the groups. In case of moderate periodontitis, the experiment group showed statistically significant reduction of bleeding on probing when compared with the control group at 1 and 4 months after treatment(p<0.05). In case of advanced periodontitis, treatment resulted in statistically significant reduction of bleeding on probing in both the groups(p<0.05). These results indicate that the use of subantimicrobial dose of doxycycline is a useful supplement to mechanical treatment for periodontal patients in ameliorating the clinical parameters such as periodontal pocket, attachment level, and bleeding on probing.

곤충산업의 법적 지위에 대한 연구

김윤식,박정규,김태영,최종우,Kim, Yun-Shik,Park, Chung Gyoo,Kim, Taeyoung,Choi, Jong Woo 한국응용곤충학회 2018 한국응용곤충학회지 Vol.57 No.4

한국의 곤충 산업은 2010 년부터 "곤충 산업 육성 및 지원에 관한 법률"에 의해 지원을 받았다. 이 법에 의거해 곤충을 사육하는 사람도 '농업인'으로 자격이 있다. 그러나 곤충 산업은 '농업' 및 '농업인', '농산물'과 같은 모든 개념을 정의하는 "농업 농촌 및 식품산업 기본법"에 포함되지 않는다. 법적으로 엄격하게 말하면, 곤충 산업이 농업에 포함되지 않는다는 논쟁이 제기 될 때마다 곤충 산업을 지지할 방법이 없기 때문에 곤충을 사육하는 사람들은 모든 농업 지원과 정부의 보조금을 받을 법적 근거가 부족하다. 따라서 관련 법규를 개정하여 곤충 산업의 법적 지위를 명확히 할 필요가 있다. The insect industry in Korea has been supported by the Act of Fostering and Supporting Insect Industry since 2010. Based on the Act, insect breeders are entitled as farmers. However, the insect industry is not included in the Fundamental Act of Agriculture, Rural Community and Food Industry which defines all concepts, such as agriculture, farmers, and agricultural products. Legally and strictly speaking, there is no method to defense the insect industry when an argument is raised that insect industry is not included into agriculture, so persons who breed insects are not eligible for all agricultural supports and subsidies of the government. Thus, it is necessary to clear the legal status of insect industry by revising the related laws and regulations.

가리봉 ( 강원 ) 의 식물상 및 보존대책

김윤식,정규영,강명숙,전의식 ( Yun Shik Kim,Gyu Young Chung,Myoung Suk Kang,Eui Shik Jeon ) 한국환경생물학회 1994 환경생물 : 환경생물학회지 Vol.12 No.2

The flora of Kari-bong (1518.5m) was investigated to compare the flora of Mt. Sorak National Park, located close by this area. The vascular plants, collected from May, 1989 to October, 1992, were consisted of a total 652 taxa; 96 families, 348 genera, 569 species, 2 subspecies, 76 varieties and 5 forms. Among them, 554 taxa (85% of total taxa) were distributed in Mt. Sorak National Park. The Korean endemic plants of this area were 37 taxa, the rare and endangered plants were 27 taxa, the special wild plants designating by Environmental Agency were 12 taxa and the alpine plants were 34 taxa. Because many plants, being necessary to conserve, are distributed, Kari-bong should be include into Mt. Sorak National Park, but if development is indespensable, destruction of natrural ecosystem must be minimized.

비상조치선언의 언저리에서-정상화의 진통을 겪으며

김윤식,Kim, Yun-Sik 한국과학기술단체총연합회 1972 과학과 기술 Vol.5 No.7

한우 혈통등록의 확대 필요

김윤식,Kim, Yun-Sik 한국종축개량협회 2006 種畜改良 Vol.11 No.8

High - index 대수 미분방정식으로 모델링된 비선형 화학 공정의 구조적 제어성 평가

김윤식,윤인섭 ( Yoon Sik Kim,En Sup Yoon ) 한국화학공학회 1996 화학공학의이론과응용 Vol.2 No.2

병렬 컨버터에 의한 스위치모드 승압 정류기의 효율 개선

김윤식,김성환,오세진,이성근,전내석,Kim Yoon Sik,Kim Seong Hwan,Oh Sae Gin,Lee Sung Geun,Jeon Nae Sock 한국마린엔지니어링학회 2005 한국마린엔지니어링학회지 Vol.29 No.2

A new technique for improving the efficiency of single-Phase high-frequency switch-mode boost rectifiers is proposed. This rectifier includes an additional boost converter that parallels the main high-frequency switching device. The additional converter. which is controlled at lower frequencies. bypasses most of the current in the main switch and the high frequency switching loss is greatly reduced accordingly. The rectifier works cooperatively in high efficiency and as if it were a conventional rectifier with one switching device. The proposed scheme is verified by computer simulation using software PSIM.

H. pylori 감염 진단 시 ¹⁴C-요소호기검사의 임상적 유용성

김윤식,Kim, Yoon-Sik 대한임상검사과학회 2007 대한임상검사과학회지(KJCLS) Vol.39 No.3

Helicobacter pylori (H. pylori) infection is common in korea and high incidence at gastric ulcer and duodenal ulcer. $^{14}C-urea$ breath test ($^{14}C-UBT$) is regarded as a highly reliable and non-invasive method for the diagnosis of H. pylori infection. The purpose of this study was to evaluate the diagnositc performance of a new and rapid $^{14}C-UBT$, which was equipped with Geiger-Muller counter and compared the results with those obtained by gastroduodenoscopic biopsies (GBx). One hundred sixty-eight patients (M : F = 118 : 50) underwent $^{14}C-UBT$, rapid urease test (CLO test), and GBx. The results of $^{14}C-UBT$ were classified as positive (>50 cpm), borderline (25<p<50 cpm), or negative (<25 cpm) and CLO tests were classified as positive or negative according to color change. The results of GBx on giemsa stain were distribution of H. pylori by the Wyatt method. We compared $^{14}C-UBT$ or CLO test results with GBx as a glod standard. In the assessment of the presence of H. pylori infection, the $^{14}C-UBT$ global performance yielded positive predictive value, negative predictive value and accuracy of 93.3% and 83.3%, respectively. However, the CLO test had performance yielded positive predictive value, negative predictive value and accuracy of 76.9%, 50.0%, respectively. In this study $^{14}C-UBT$ is a highly accurate, simple and non-invasive method or the diagnosis of follow up H. pylori infection.

교통류 모형을 이용한 도로 점용공사 구간의 지체비용 산정방안

김윤식,이민재,Kim, Yunsik,Lee, Minjae 한국건설관리학회 2016 건설관리 : 한국건설관리학회 학회지 Vol.17 No.5

이용자 비용은 SOC 시설물의 효율적 자산관리를 위한 LCCA에서 시설물의 생애주기, 관리자 비용 그리고 할인율과 함께 반드시 고려되어야 하는 주요한 분석 항목이다. 특히, 도로분야에서는 청소 및 유지보수 등의 공사구간(Work zone)으로 인해 이용자들에게 막대한 지체비용이 발생되는 경우가 많으며, 이와 같은 경우 관리자는 보다 합리적인 의사결정을 위해 관리자비용 뿐만아니라 이용자비용까지도 고려해야만 한다. 그러나 최근까지도 대부분의 의사결정 단계에서 이용자 비용은 고려되지 않고 있으며, 이에 관한 연구들도 활발하지 못한 실정이다. 본 연구에서는 교통류 모형과 교통시설 투자 평가 지침의 직접편익 산정 모델을 이용하여 의사결정 단계에서 필요한 이용자 비용 및 지체비용을 산정 하는 방법론을 제안한다. 그리고 2014년 실제 유지보수가 시행되었던 국도 4개구간에 대해 VISSIM을 이용하여 교통류 모형을 추정하고 제안된 방법론을 토대로 이용자 비용 및 지체비용을 산정하였다. 분석결과, AADT 약 3만대의 A구간은 공사구간 발생 전 평균 17,569천원/$km{\times}day$의 이용자 비용이 발생하는 것으로 분석되었으며, 유지보수로 인해 1차로를 차단 할 경우 추가적으로 평균 10,193천원/$km{\times}day$(158%)의 지체비용이 발생하는 것으로 분석 되었다. AADT 약 2만대의 B구간과 D구간에서는 각각 1,507천원/$km{\times}day$(115%), 1,985천원/$km{\times}day$(119%)의 지체비용이 발생되는 것으로 분석되었으며, AADT 약 1만대의 C구간에서는 262천원/$km{\times}day$(105%)의 지체 비용이 발생하는 것으로 나타났다. 본 연구의 결과는 교통류 모형을 시뮬레이션 기반으로 추정함으로서 실제 적용에는 한계가 있다. 향후 실제 관측 자료를 이용한 적정성 높은 모형의 개발과 시뮬레이션 검증을 통해 적용 가능성을 높이는 연구가 필요할 것으로 판단된다. The user cost is an important analysis item which should be considered together with life-cycle of facility, administrator cost and discount rate in LCCA for efficient asset management of SOC facilities. Especially, a significant delay cost occurs often for users in the road field due to a work zone for cleaning and maintenance, and in such case, the administrator should consider the administrator cost as well as the user cost for more rational decision making. However, the user cost has not been considered in most decision making steps until recently and relevant studies also have not been carried out actively. In this study, the methodology to estimate the user cost and delay cost required in the decision making step using the traffic flow model and the direct benefit estimation model in the traffic facility investment evaluation guideline is suggested. And, the traffic flow model was estimated on 4 national highway sections where maintenance was actually carried out in 2014 using VISSIM and, the user cost and the delay cost were estimated based on the suggested methodology. The analysis result showed that the average user cost of $17,569,000KRW/km{\times}day$ occurred on Section A with approximately 30,000 AADT before a work zone occurred, and in case the first lane was blocked for maintenance, the delay cost of $10,193,000KRW/km{\times}day$ (158%) on average occurred additionally. The delay cost of $1,507,000KRW/km{\times}day$ (115%) and $1,985,000KRW/km{\times}day$ (119%) occurred on Sections B and D with approximately 20,000 AADT respectively and the delay cost of $262,000KRW/km{\times}day$ (105%) occurred on Section C with approximately 10,000 AADT. This result of this study was estimated based on the simulation of traffic flow model so that there is a limitation in its actual application. A study ot develop a highly appropriate model using actual observation data and improve the possibility to apply it through the verification using the simulation will be necessary in future.

OFDM 시스템에서 기억성을 갖는 비선형 왜곡의 보상을 위한 참조 테이블 기반의 사전왜곡기

김윤식,신요안,임성빈,문용,Kim, Young-Sik,Shin, Yoan,Im, Sungbin,Moon, Yong 한국통신학회 2001 韓國通信學會論文誌 Vol.26 No.6

본 논문에서는 OFDM 시스템의 송신기에서 사용되는 선형 필터와 고출력 증폭기의 결합에 의한 \"기억성을 갖는 비선형 왜곡\"을 실제 하드웨어 구현에 적합하게 적은 계산량으로 보상할 수 있는 참조 테이블(look up table; LUT) 기반의 사전왜곡기를 제안한다. LUT를 이용하는 사전왜곡기들은 이미 많이 연구되었으나, 본 논문에서는 다중 입력/단일 출력 형태의 기억성을 갖는 비선형 왜곡을 작은 크기의 LUT를 이용하여 효율적으로 보상한다는 점에서 큰 차이가 있다. 제안 방법에서는 먼저 기억성이 없는 고출력 증폭기만이 존재할 때의 사전왜곡기를 우리가 이미 제안한 고정점 반복 사전왜곡기 알고리즘에 기반하여 LUT로 구현하고, 여기에 선형 역 시스템을 결합하여 기억성을 갖는 비선형 왜곡을 보상한다. 실제 구현 가능성 검토를 위해 제안된 사전왜곡기와 16-QAM, 256-IFFT/FFT OFDM 시스템 기저대역 모뎀을 TMS320C30 DSP를 이용하여 구현하였으며, 실험 결과 작은 크기의 LUT를 이용하여도 원래의 고정점 반복 사전왜곡기에 비해 매우 적은 계산량을 요구하면서 동일한 성능을 얻을 수 있음을 확인하였다.있음을 확인하였다.