증례 : 기종성 담낭염 1 예

김원천 ( Won Tsen Kim ),김진민 ( Jin Min Kim ),권상옥 ( Sang Ok Kwon ),유승익 ( Seung Ik Yu ),백일기 ( Ill Ki Baek ),김명순 ( Myung Soon Kim ) 대한내과학회 1985 대한내과학회지 Vol.29 No.5

A New Method for Color Feature Representation of Color Image in Content-Based Image Retrieval Projection Maps

김원일,Kim, Won-Ill Korea Institute of Information and Telecommunicati 2010 정보통신설비학회논문지 Vol.9 No.2

The most popular technique for image retrieval in a heterogeneous collection of color images is the comparison of images based on their color histogram. The color histogram describes the distribution of colors in the color space of a color image. In the most image retrieval systems, the color histogram is used to compute similarities between the query image and all the images in a database. But, small changes in the resolution, scaling, and illumination may cause important modifications of the color histogram, and so two color images may be considered to be very different from each other even though they have completely related semantics. A new method of color feature representation based on the 3-dimensional RGB color map is proposed to improve the defects of the color histogram. The proposed method is based on the three 2-dimensional projection map evaluated by projecting the RGB color space on the RG, GB, and BR surfaces. The experimental results reveal that the proposed is less sensitive to small changes in the scene and that achieve higher retrieval performances than the traditional color histogram.

초오의 항알레르기 염증반응 및 기전탐색에 관한 연구

김원일(Won-ill Kim) 한국한의학연구원 2010 한국한의학연구원논문집 Vol.16 No.3

Objetives : The purpose of this study was to examine the pathway of anti-allergic effects of Aconiti Ciliare Tuber (ACT). Methods : We examined cell viability, β-hexosaminidase release, pro-inflammatory cytokines secretion and mRNA expressions, nuclear factor-kappa B (NF-κB) (p65) activation, inhibitor kappa B-alpha (IκB-α) degradation, and MAPKs activation from RBL-2H3 cells pre-treatment by ACT of 1.0 ㎎/㎖, 2.0 ㎎/㎖ separately. Results : We observed that ACT reduced the secretion of β-hexosaminidase, TNF-α, IL-4 and the expression of COX-2 mRNA in RBL-2H3 cells. Futhermore, ACT inhibited the levels of activation of NF-κB (p65) protein, ERK MAPK, and degradation of IκB-α in RBL-2H3 cells. Conclusions : These results show that ACT has an anti-histamine effect and inhibitory effect of NF-κB (p65) through regulation of IκB-α degradation. This improves that ACT could be used as an anti-allergic medicine.

원발성 두통에 대한 별갑약침의 임상적 효과 3례 보고

황윤경,김원일,김광록,Hwang, Yun-kyeong,Kim, Won-ill,Kim, Koang-lok 대한한방내과학회 2017 大韓韓方內科學會誌 Vol.38 No.5

Objectives: To report the clinical application and effects of ByeolGab (Trionycis Carapax) pharmacopuncture in patients with primary headache. Method: Three patients who suffered from primary headache were treated with ByeolGab pharmacopuncture and acupuncture for 2 weeks. We used the Henry Ford Headache Disability Inventory (HDI), a six point scale, and a visual analogue scale (VAS) three times and analyzed the results. Result: After treatment with ByeolGab pharmacopuncture, the VAS, HDI, and six point scale scores were improved in all three patients. The symptoms of headache and other symptoms were also improved. Conclusion: ByeolGab pharmacopuncture is an effective treatment for patients complaining of primary headache.

뇌졸중 환자의 요로감염에 대한 방기복령탕 치험 1례

황윤경,김원일,Hwang, Yun-Kyeong,Kim, Won-Ill 대한한의학방제학회 2015 大韓韓醫學方劑學會誌 Vol.23 No.1

Objectives : This study is to report the effects of Bangkibokryeong-tang(Fanjifuling-tang(BBT)) on stroke patient with Urinary tract infection.(UTI) Methods : A stroke patient diagnosed as UTI was treated with BBT (防己茯笭湯) at one-month intervals. We observed body temperature, amount of urine and recorded photographs of any changes during the treatment period. Treatment efficacy was assessed using urinary analysis. Results : After the treatment, there was improvement in urine analysis. And the symptoms of UTI and her conditions got better. Conclusion : The report suggests that BBT is effective in controlling various symptoms related to UTI with antibiotic resistance on stroke patient.

두근거림에 대한 가미온담탕의 치험 14례

공원호,김원일,Kong, Won-ho,Kim, Won-ill 대한한방내과학회 2021 大韓韓方內科學會誌 Vol.42 No.5

Objectives: This study examined cases of patients with palpitations treated with Gami-ondam-tang. Methods: The patients were treated with Gami-ondam-tang and changes in their symptoms were assessed using a self-reported numeral rating scale (NRS) score. Results: Following treatment, the patients' palpitations and accompanying symptoms (e.g., insomnia, hot flushes, dyspepsia, and depression) improved. The study investigated 14 first occurrences and 10 subsequent recurrences. In the subsequent recurrent cases, compared to the first occurrence cases, the symptoms according to the NRS score were not severe, and the treatment period was shorter. Conclusions: The results showed that Gami-ondam-tang is effective for treating palpitations and accompanying symptoms.

삼음교(三陰交) 자극이 초산부(初産婦)의 분만(分娩) 소요시간과 실혈량(失血量)에 미치는 효과(效果)

김우환,김원일,이경희,윤현민,Kim, Woo-hwan,Kim, Won-ill,Lee, Kyung-hee,Youn, Hyoun-min 대한침구의학회 2003 대한침구의학회지 Vol.20 No.5

Objective: To appreciate the effect of San-Yin-Jiao(SP-6) pressure on duratof delivery time and quantity of blood loss in order to verify the possibility of application to clinic of San-Yin-Jiao pressure. Methods: The design of this study is nonequivalent control group non- synchronized design. The subjects are 39 persons who are made up of SP-6 pressure applied(experimental) group 20 persons and to control group 19 persons. Collected data were analyzed as frequency, percentage, t-test, $x^2-test$ using SPSS 10.0 WIN Program. Conclusions: San-Yin-Jiao(SP-6) pressure not only make short duration of delivery time, but also decline quantity of blood loss in effect. 1. It could be necessary that the study of the effects of San-Yin-Jio(SP-6) pressure on duration of delivery time and quantity of blood loss for primipara be done repeatedly. 2. It could be necessary to increase this sort of study through free random experimental design in order to generalize this experimental result.

Effect of Baegieum(BGU) on Oxidant induced cell death in human intestinal epithelial cells

김우환,김원일,Kim, Woo-Hwan,Kim, Won-Ill The Society of Internal Korean Medicine 2000 大韓韓方內科學會誌 Vol.21 No.1

목적 : 본(本) 연구(硏究)는 배기음(排氣飮)이 인간(人間)의 장관내(腸管內)에서 산화물(酸化物)에 의해 유발(誘發)된 세포(細胞)의 사망(死亡) 및 DNA의 손상(損傷)을 방지할수 있는지를 검증(檢證)하기 위한 실험(實驗)이다. 방법 : 배양(培養)된 인체장관(人體腸管) 세포계열(細胞系列)인 Caco-2 세포(細胞)에서 세포(細胞)의 사망(死亡)은 trypan bile의 소실정도에 의해서 평가했으며, DNA의 손상(損傷)은 double stranded DNA의 파괴정도를 측정하여 평가하였다. $H_2O_2$는 표본(標本) 산화제(酸化劑)로 사용되었다. 결과 : $H_2O_2$에 노출된 세포들의 세포사망(細胞死亡) 정도는 노출시간과 용량에 비례하여 증가하는 양상을 보였다. 배기음(排氣飮)은 $H_2O_2$에 의해 유발(誘發)되는 세포방지를 방지하였고, 0.05-1%의 농도범위에 걸쳐서는 그 효과가 용량에 비례하여 증가하는 양상을 보였다. $H_2O_2$에 의해 유발(誘發)된 세포손상(細胞損傷)은 catalase(hydrogen peroxide scavenger enzyme)와 deferoxamine(iron chelator)에 의해 억제되었다. 그러나 강력한 항산화제(抗酸化劑)인 DPPD는 $H_2O_2$에 의해 유발(誘發)되는 세포손상(細胞損傷)에는 영향을 주지 못했다. $H_2O_2$에 의해 유발(誘發)된 지질(脂質)의 과산화(過酸化)는 배기음(排氣飮)과 DPPD에 의해 억제되었다. $H_2O_2$에 의해 유발(誘發)된 DNA의 손상(損傷)은 배기음(排氣飮)에 의해 방지되었으며 용량에 의존하는 양상을 보였다. $H_2O_2$에 의해 유발(誘發)된 DNA의 손상은 catalase와 deferoxamine에 의해 억제되었지만 DPPD는 억제시키지 못했다. 배기음(排氣飮)은 $H_2O_2$에 의해 유발(誘發)된 ATP의 소실을 회복시켰다. 이러한 실험결과 $H_2O_2$에 의해 유발(誘發)된 세포(細胞)의 손상(損傷)은 지질(脂質)의 과산화(過酸化)와는 다른 독립적인 기전에 의해 일어남을 나타낸다. 결론 : 이러한 결과들로 볼 때 Caco-2 세포(細胞)에서 배기음(排氣飮)이 항산화작용(亢酸化作用)보다는 다른 기전을 통하여 Caco-2 세포안에서 산화제(酸化劑)에 의해 유발(誘發)된 세포(細胞)의 사망(死亡)와 DNA의 손상(損傷)을 방지할 수 있다는 것을 가리킨다. 따라서 본 연구(硏究)는 배기음(排氣飮)이 반응성산소기(反應性酸素基)에 의해 매개된 인체(人體) 위장관질환(胃腸管疾患)의 치료(治療)에 사용할 수 있을 가능성(可能性)이 있음을 제시하고 있다.

한의약 건강증진 사업의 현황과 발전방안 연구

차종열,김원일,Cha, Jong-yeol,Kim, Won-ill 대한한방내과학회 2021 大韓韓方內科學會誌 Vol.42 No.3

Objectives: We conducted research on 100 cases of Korean medical health promotion programs to determine how they work. The objective was to report trends in such programs and, by extension, to suggest a development plan for the Korean medical public health program. Methods: To research 100 Korean medical health promotion programs, we analyzed source data published by the Korea Health Promotion Institute in 2014-2018 using 10 criteria. Results & conclusions: Based on effective trends, the development of a Korean medical public health program requires the following options. First, we should complement the systems with related legislation and deal with Korean medical doctors who mainly participate in public health programs. Second, we should improve the infrastructure of the program with internal support from the Korean medical association and clarifying the legal basis of the national budget. Third, we should seek substantiality of public health programs. Korean medical doctors should actively participate in the program, and related agencies should support the public health care center for the development of Korean medical public health programs in which many people can participate.

Effect of Baegi-eum (BGU) on mepirizole-induced gastrointestinal tissue injury in rabbit

김우환,김원일,Kim, Woo-Hwan,Kim, Won-Ill The Society of Internal Korean Medicine 2001 大韓韓方內科學會誌 Vol.22 No.1

목적 : 본 연구는 배기음(排氣飮)이 토끼의 위장관내에서 화학물질에 의해 유발된 장관의 궤양에 유효한 효과를 발휘할 수 있는지를 검증하기 위한 실험이다. 방법 : 토끼 5마리를 한 군으로 하여 정상군과 체중 1kg당 200mg 분량의 mepirizole을 경구 투여한 군과 100mg/kg의 배기음(排氣飮)(경구투여)과 800Units/kg 분량의 catalase(정맥주사)를 mepirizole을 경구투여하기 2시간 전에 각각 전처치한 군으로 나누었다. Mepirizole을 경구 투여한 후 각각 24hr와 48hr에 토끼를 희생시켜 위장, 십이지장부의 궤양성 병변을 관찰하였다. 결과 : Mepirizole을 경구투여하여 위장 및 십이지장 기부의 궤양성 병변이 유발되었다. 배기음(排氣飮)(경구투여)과 catalase(정맥주사)를 전처치하였을 경우 궤양의 크기가 현저하게 줄어들었다. Mepirizole은 십이지장 점막에서 지질의 과산화를 증가시키는데 이는 수산화기와 관련되어 있음을 시사한다. 배기음(排氣飮)과 catalase를 전처치함으로써 mepirizole에 의해 유발된 지질의 과산화가 현저하게 억제되었다. 형태학상의 연구에서도 mepirizole의 처치에 의한 십이지장의 손상과 배기음(排氣飮)에 의한 방지효과가 나타났다. 결론 : 이러한 결과들로 볼 때 반응성산소기는 mepirizole에 의해 유발된 위장관 궤양의 병리변화 형성에 주요한 영향을 미치며 배기음(排氣飮)이 항산화작용을 통해 궤양의 형성을 억제하는 역할을 하고 있음을 나타낸다. 따라서 본 연구는 배기음(排氣飮)이 반응성산소기에 의해 매개된 인체 위장관질환에 치료적 역할을 할 수 있음을 제시하고 있다.