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5- Methyl -4- Imidazolecarboxylic Acid Ester 연속합성 반응의 특성 및 공정개발 연구
조욱상,박상진,김성태 ( Wook Sang Cho,Sang Jin Park,Sung Tae Kim ) 한국공업화학회 1995 공업화학 Vol.6 No.2
Ethylacetoacetate 로부터 중간 생성물인 α-acetyl-α-hydroxy iminoacetic acid, α, β-dioxobutylic acid를 거쳐 생성되는 5-methyl-4-imidazolecarboxylic acid ester의 연속반응공정 개발을 위하여 세 경우의 연속 반응기 schemes : 1) Annular Flow Reactor 2) Continuous Flow Stirred Tank Reactor (CFSTR) 3) Heat Exchange Loop/plug Flow Reactor에 따른 반응수율특성, 공정변수 영향 등을 연구하였다. 율속 단계인 α, β-dioxobutylic acid 생성 반응의 수율을 최대로 높일 수 있는 반응기 scheme은 연속적으로 배열된 2중 열교환 루프를 거쳐 냉각조에 잠겨있는 플러그흐름 반응기를 통과시키는 배열이었으며 이때의 수율은 HCl의 농도에 따라 (6.6∼8.3M) 70∼75%이었다. 또한 반응 체류시간은 1∼1.5hr이었으며 발열반응으로 인한 α, β-dioxobutylic acid의 decomposition이 일어나는 온도범위는 12∼15℃ 이었다. 2중 열교환 루프에서의 총괄 전열 계수는 25Btu/hr-ft²-℉이었고 막(film) 전열계수는 약 40Btu/hr-ft²-℉로 추정되었다. 이러한 연속 반응기 scheme은 반응수율의 감소없이 2중 열교환 루프에 허용될 수 있는 최적의 공정변수 (온도, HCl 주입속도, 반응체류시간 등)만 결정되면 상업화 공정 Scale-up이 충분히 가능할 것으로 판단된다. Three continuous reactor schemes : 1) Annular Flow Reactor, 2) Continuous Flow Stirred Tank Reactor (CFSTR), 3) Heat Exchange Loop/Plug Flow Reactor, were tested under the formation of α, β-dioxobutylic acid, which is the rate-controlled step. The reactor scheme which performed best in terms of α, β-dioxobutylic acid yield consists of a heat exchange loop containing two double-pipe exchangers in series, followed by a plug flow reactor immersed in a coolant bath. The rate of formation of α, β-dioxobutylic acid was found to be a function of α-acetyl-α-hydroxy iminoacetic acid and HCl concentration. The decomposition of α, β-dioxobutylic acid was found to occur in the range of process temperature, 12∼15℃. Overall heat transfer coefficient based on inside area and the film coefficient was 25 and 40 Btu/hr-ft²-℉, respectively. The reactor scheme which was developed in this study is scalable to the commercial size, with the optimal determination of process variables.
대퇴신경지각이상증 환자에 대한 침치료 및 근막이완요법 병용 치험 1례
이은지 ( Eun Ji Lee ),김신애 ( Shin Ae Kim ),권민구 ( Min Gu Kwon ),김성태 ( Sung Tae Kim ),신현권 ( Hyun Gwon Shin ),조현정 ( Hyun Jung Cho ),양태준 ( Tae Jun Yang ),김선욱 ( Seon Wook Kim ),정주용 ( Joo Yong Jeong ),강수우 ( Suo 대한경락경혈학회 2016 Korean Journal of Acupuncture Vol.33 No.2
Objectives : The purpose of this case is to report the improvement after treatment about a patient with meralgia paresthetica. Methods : We treated the patient with acupucture therapy, cupping therapy, electroacupuncture therapy, percutaneous radiofrequency thermoablation and myofascial release technique by Turbo SASO from 26th June 2015 to 3rd July 2015 by evaluating femoral function with VAS score. Results : After 5 times of treatment, this patient achieved excellent outcome following the technique, showing that clinical symptom as able to walked and pain was disappeared, VAS changed from 10 to 3 and the result of patrick test came out negative. Conclusions : The various symptoms appear in the Meralgia paresthetica such as numbness, paresthesia, and pain in the anterolateral thigh, which may result from either an entrapment neuropathy or a neuroma of the lateral femoral cutaneous nerve(LFCN). Oriental medical treatment for meralgia paresthetica resulted in satisfactory results by diminishing the symptoms progressively during the five days of treatment. Differential diagnosis was based on careful physical examination. More research of meralgia paresthetica is needed.
요소호기 검사로 평가한 치료 기간에 따른 Helicobacter pylori 제균율의 분석 : OAC 7, 10, 14 일간 병합요법의 비교
이상우,박동규,김성태,이성준,박재홍,이홍식,김창덕,진윤태,최재현,엄순호,류호상,현진해,박철희,조영직,전훈재,고동욱 대한소화기내시경학회 2001 Clinical Endoscopy Vol.23 No.4
Background/Aims: Efficacy of triple therapy with omeprazole, amoxicillin, and clarithromycin (OAC) for Helicobacter pylori (H. pylori) varies among different geographic regions and patient populations. And, there is no full consensus on how long this treatment should be maintained. We assessed the efficacy of the OAC regimen according to the treatment duration (7, 10 or 14 days) using (13)^C-urea breath test ((13)^C-UBT). Methods: Two hundred fifty five H. pylori positive patients with peptic ulcer were randomly assigned to a OAC (omeprazole 20㎎ b.d., amoxicilln 1.0 g b.d. and clarithromycin 500㎎ b.d.) 7, 10 or 14 days regimen. Eradication of H. pylori was assessed by (13)^C-UBT 4 weeks after the completion of the completion of therapy. Results: 140 male and 115 female (mean age, 51.3) patients were enrolled. The overall eradication rate of H. pylori in each group was significantly higher in OAC 14 days regimen than OAC 7 and 10 days regimen (91.9% in OAC 14 days, 74.4% in OAC 7 days, and 80.2% in OAC 10 days, respectively, p$lt;0.05). Conclusions: The overall eradication rate of H. pylori was highest in OAC 14 days regimen in our study. We have found significant differences in eradication rates with previous reports, using CLO and histology, in Korea. Thus, further studies focusing on the treatment period may be warranted.