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김배진,이종원,오세훈,김진남 중앙대학교 생산공학연구소 2000 생산공학연구소 논문집 Vol.9 No.2
종래 기술에 의한 플랫폼 리프트 시스템의 구동장치는, 전체적으로 부피가 큰 관계로 비교적 넓은 설치 공간을 요구할 뿐만 아니라, 모터의 동력을 웜 및 웜 휠의 기어 물림 구조에 의해 구동 풀리로 전달하는 구조로써, 동력 전달을 위한 효율이 낮아 구동시 전력소모가 크게되는 단점이 있는 것이었다. 본 연구의 주목적은 전체적인 형상을 슬림화 하여 설치 공간을 축소시킬 수 있도록 한 리프트 시스템의 구동장치를 제공하려는 것이다. 또한 동력전달과정을 간략화하여 동력전달부재 사이의 마찰 손실을 감소시켜 효율을 보다 향상시킬 수 있도록 한 리프트 시스템의 구동장치를 제공하려는 것이다. The wheelchair lift can widen the walking space of disabled person, Worm gear drive is used for conventional wheelchair lift driving system which is bulky and has very low efficiency. In this thesis, a new driving system of planetary gear is used in order to increase the efficiency and reduce the volume. The driving motor has multiple poles so that the output rpm of motor is very slow but it can give a high output torque. Therefore the ratio of speed reducer is about 4:1 compared to the conventional one 50:1. The efficiency of the conventional one is about 50%, but the new one is nearly 90% up. The most eminent one of the new system is to construct compact one, which consists of pancake motor, a planetary gear reducer, and an input break. This new driving system is expected to be applied for conventional escalator and elevator driving system.
제2형 당뇨질환모델 db/db 마우스에서 부추 추출물 및 유산균 발효물의 항당뇨 효과
김배진,조성경,정유석,정희경 한국식품저장유통학회 2015 한국식품저장유통학회지 Vol.22 No.1
The anti-diabetic effects of Allium tuberosum Rottler extracts (ATE) and ATE fermented with lactic acid bacteria in db/db mice were evaluated. The electron donating activity of ATE fermented with Lactobacillus plantarum, and Lactobacillus casei, respectively, increased compared to that of ATE, but the superoxide radical scavenging activity of the ATE incubated with L. plantarum decreased. The superoxide radical scavenging activity of the ATE fermented with both L. plantarum and L. casei was similar to that of the ATE. Therefore, fermented ATE (FATE) was prepared for in vivo testing by incubating it with both L. plantarum and L. casei. The db/db mice were divided into six groups: normal (non-diabetic mice), diabetic control (DM), and four experimental groups administered 200 or 400 mg/kg/day ATE (ATE200 and ATE400) and 200 or 400 mg/kg/day FATE (FATE200 and FATE400). Weight gain was significantly inhibited in the FATE200 group compared with that in the other db/db mice groups (p<0.05). The areas under the curve of the ATE400 and FATE400 groups were significantly smaller than that of the DM group in the glucose tolerance evaluation. The serum glucagon-like peptide-1 levels in the ATE400 and FATE400 groups increased. These results indicate that administering ATE and FATE may be effective against anti-hyperglycemia by regulating insulin resistance. In particular, FATE may be beneficial for controlling obesity in type 2 diabetes.
김배진,홍주현,정유석,정희경 한국응용생명화학회 2014 Applied Biological Chemistry (Appl Biol Chem) Vol.57 No.6
Probiotics are live microbes that confer health benefitson the host when administered in adequate amounts. To evaluatethe probiotic potential of Bacillus subtilis isolated from Koreanfermented foods, we investigated the resistance to biologicalbarriers and improvement of loperamide-induced constipation. The values of resistance to gastric acidity of B. subtilis CBD2 andKMKW4 strains were 55.34±2.12 and 64.58±2.95%, respectively,whereas the survival rate of B. subtilis KMKW4 (31.17±5.78%)in bile acids was superior to that of CBD2 (8.62±2.09%). Thesestrains also demonstrated adhesiveness to intestinal epithelial HT-29 cells and an inhibitory activity against pathogenic microflora. Furthermore, B. subtilis CBD2 and KMKW4 strains improvedgastrointestinal activity when tested in a loperamide-induced mousemodel of constipation. Pre-treatment with CBD2 and KMKW4strains before the onset of constipation improved fecal output andgastrointestinal transit in loperamide-treated mice. These strainsalso showed inhibitory effects on the activity of β-glucosidase andtryptophanase, harmful enzymes of intestinal microflora. Takentogether, these finding show that B. subtilis CBD2 and KMKW4have high adaptability to gastrointestinal environment, and theability to inhibit pathogenic microflora and prevent constipation,suggesting their activity as potential probiotics.
Lactobacillus bifermentans로 발효한 율피의 항아토피 효과
김배진(Bae Jin Kim),손우림(Woo Rim Son),최미옥(Mi Ok Choi),조성경(Seung Kyeung Jo),정희경(Hee Kyoung Jung),이진태(Jin Tae Lee),김학윤(Hak Yoon Kim),권대준(Dae Jun Kwoen) 한국식품영양과학회 2013 한국식품영양과학회지 Vol.42 No.9
본 연구에서는 DNCB 도포를 통해 아토피 피부염을 유발시킨 NC/Nga mice에 율피 발효물을 각각 0.1%, 1%, 5%로 도포하고 항아토피 효능을 평가하였다. 율피 발효물의 유효성분은 HPLC 분석 결과, gallic acid와 ellagic acid가 각각 10.18 mg/g, 2.14 mg/g 함량을 나타내었다. 실험군 간의 유의적 체중 변화는 관찰되지 않았으며, 육안 평가를 통해 홍반, 가려움과 피부건조, 부종과 혈종, 짓무름 그리고 태선화와 같은 일반적인 아토피 피부염 증상의 심각도를 측정한 점수 결과에서는 DNCB 도포를 통해 아토피 피부염을 유발한 atopic dermatitis(AD)군(13.17±0.40)과 비교 시, 아토피 피부염 유발 후 5% 율피 발효물을 도포한 fermented Castanea crenata inner shell(FCS) 5군에서 7.50±0.43으로 나타나 아토피 피부염 증상이 빠르게 개선되는 것을 확인하였다(P<0.01). 피부 측정 기기인 MPA5 580을 이용하여 피부멜라닌지수, 피부홍반지수, 피부수분지수를 측정한 결과, AD군은 각각 296.61±8.11, 264.33±10.15, 3.15±0.54를 나타내었으며 FCS 5군은 각각 105.86±2.92, 199.56±4.22, 17.62±1.75로 개선효과가 유의적으로 나타났다(P<0.05). 각 실험군 mice의 면역반응을 확인하기 위해 비장 무게(mg)를 체중(g)으로 나누어 산출한 비장 수치의 경우, 아토피 피부염 유발로 인해 AD군에서 증가된 비장 수치(5.55±0.31)가 FCS 0.1군, FCS 1군, FCS 5군에서는 각각 4.53±0.24, 3.80±0.40, 3.32±0.24로 나타나 율피 발효물의 도포 농도에 의존적으로 감소되는 경향을 나타냈으며 특히 FCS 5군에서는 유의적으로 낮게 나타났다(P<0.05). 이는 율피 발효물이 아토피 피부염 상태에서 증가된 비장 내 T-림프구를 효과적으로 억제할 수 있음을 나타낸다. Quantitative real-time PCR을 통해 피부조직에서 IL-1β, TNF-α와 같은 염증 유전자의 발현 변화를 분석한 결과, 두 유전자 모두 정상군의 relative quantification값이 1일 때 AD군은 각각 1.30, 1.26으로 증가되었으며 FCS 5군에서는 1.11, 0.93으로 나타나 율피 발효물 도포에 의한 유의적인 감소(P<0.05)를 확인할 수 있었다. 아토피 피부염의 면역학적 지표인 혈청 내 IgE 함량을 분석한 결과에서는 각 실험군 간의 유의적 차이는 보이지 않았으나 AD군(1,628.71±202.59 ng/mL)과 비교 시, 율피 발효물을 도포한 FCS 0.1군, FCS 1군, FCS 5군에서 각각 1,530.15±198.70 ng/mL, 1,462.15±83.79 ng/mL, 1,187.47±140.09 ng/mL로 나타나 율피 발효물 도포에 의해 감소되는 경향을 확인할 수 있었다. 따라서 율피 발효물은 아토피 피부염 증상 개선을 위한 기능성 천연물의 소재로 활용될 수 있을 것이라 생각된다. Atopic dermatitis (AD) is a common skin disease characterized by chronic and relapsing inflammatory dermatitis with immunological disturbances. In spite of the continuous increase in the incidence of AD, it is regrettable that till date there is no effective treatment to treat the same. Therefore, the present study was designed to examine the possible anti-atopic effects of Castanea crenata inner shell extracts fermented by Lactobacillus bifermentans (FCS) in 2,4-dinitrochlorobenzene (DNCB) induced AD in NC/Nga mice. Based on the results of HPLC analysis, we found that FCS contains anti-inflammatory factors such as gallic acid (10.18 mg/g) and ellagic acid (2.14 mg/g). The groups that we have used in this study included 0.1%, 1%, 5% fermented Castanea crenata inner shell extracts (FCS 0.1, FCS 1, FCS 5), 1,3-butylene glycol treated control (AD), and normal mice. After topical FCS treatment, we observed that the clinical severity score for AD was lower in both the FCS 1 and FCS 5 groups than the AD group. We also proved beyond doubt that there was improvement of melanin, erythema and skin moisture indices in the FCS 5 group. Spleen index and gene expression levels of pro-inflammatory cytokines such as IL-1β and TNF-α were significantly decreased in the FCS 5 group compared to the AD group (P<0.05). Further, we also found that the level of serum immunoglobulin E (IgE) in the FCS-treated group was decreased in a concentration-dependent manner. The results of our study suggest that FCS can be effectively used as a cosmeceutical ingredient for both the prevention and improvement of AD.