1970년 부산에서 유행한 콜레라에 대한 역학적 조사

김돈균,김준연,서영태,Kim, Don-Kyoun,Kim, Joon-Yun,Suh, Young-Tae 대한예방의학회 1970 예방의학회지 Vol.3 No.1

An epidemiological survey on cholera was made toward the 291 cases admitted in Pusan National University Hospital. The results were as follows. 1. The most predominant age groups among all cholera patients were from 30 to 39(21.3%). 2. 74.9% of all cases got under the educational background of primary school and 69.4% of all cases occurred at the low income group. 3. Daily average numbers of patient were 6.2 and maximum numbers wore 15, August 19, 1970. 4. Among the food eaten prior to onset, drinking water was the most predominant with 16.2% and next, food and noodle groups were 14.8% and 10.3% respectively. 5. Regarding incubation period, it was found that 'within 48 hours' was 83.5%. 6. Patients occurred mainly in Suh Ku area with 105(36.1%) of all cases. 7. Carrier rates among family members were 1.78%. 8. Carrier rates among residents of epidemic area were 0.12%.

일부 도시 영세지역 노인들의 영양상태와 관련인자에 관한 연구

조봉수,김돈균,이수일,조병만,김영욱,고광욱,Cho, Bong-Soo,Kim, Don-Kyoun,Lee, Su-Ill,Cho, Byung-Mann,Kim, Young-Ook,Koh, Kwang-Wook 대한예방의학회 1995 예방의학회지 Vol.28 No.1

부산시 해운대구 반송2동 운봉 영구임대 아파트에 거주하는 60세 이상의 노인 135명 (남자 36명, 여자 99명), 기타 지역에 거주하는 일반가정의 60세 이상 노인 136명(남자 45명, 여자 91명)을 대상으로 1994년 3월부터 8월까지 6개월에 걸쳐 영양섭취 상태 및 관련 요인들을 분석한 결과를 요약하면 다음과 같다. 1. 대상자의 일반특징 두 지역에서 성별 분포와 연령의 평균치에는 차이가 없었으며 소득수준의 경우 유의한 차이가 있어서 대상지역이 영세지역을 나타내고 대조지역이 일반가정을 나타낸다는 가정은 충족되었다. 2. 영양섭취에 관련된 요인 지난 한 해 동안의 입원 여부나 위장관계 질환, 음주, 흡연은 유의한 차이가 없었으나 만성질환, 투약, 비타민제 복용, 건강인식상태 등은 유의한 차이를 보여 일부 요인에 있어 대상지역의 건강관련상태가 더 나쁜 것으로 나타났다. 3. 영양소 섭취 상태 일부 항목은 권장량을 초과하는 것도 있으나 대부분의 영양소는 섭취량이 부족하였고, 더욱이 대조지역과 비교할 때 영양상태가 유의하게 낮아 소득수준을 포함한 경제수준의 차이가 영양상태를 나타낸다는 가설을 증명할 수 있었다. 4. 식생활 관련 지식과 행동 식생활관련 지식의 경우 유의하게 대상지역이 낮았으나 행동의 경우 큰 차이가 없었다. 이는 소득 수준이 행동에 영향을 준다고 가정한 가설에 어긋나는 결과로 교육수준 등 다른 교란변수들이 미치는 영향이 더 큰 것으로 볼 수 있었다. 5. 영양소 섭취에 영향을 미치는 인자 영양소 섭취에 영향을 미치는 주된 인자는 교육과 소득, 식생활 관련 지식이었으며, 대상지역의 경우 식생활 관련 지식이 영양섭취에 영향을 미쳐, 영양상태의 개선을 위해 영세지역의 노인들을 대상으로 한 올바른 식지식에 대한 교육이 필요할 것으로 생각된다. This study was carried out to analyze the food intake and associated factors of the urban poor elderly by comparing poor district, Unbong rental apartment in Bansong 2 dong with other areas in Pusan. 135 elderlies(men 36, women 99) in Unbong rental apartment, 136 elderlies(men 45, women 91) in the other areas were investigated during the period of March to August in 1994. The assumption that the study area represented poor district was satisfied because the age and sex distribution was not significantly different, and the income of the study area was significantly lower than that of the control area. The variables of hospitalized in previous 12 month, gastrointestinal problem, alcohol drinking, cigarette smoking did not differ significantly. But the variables of chronic disease, take medicine, perceived health, vitamin supplement differed significantly between two groups. Therefore some factors associated with health state in the study area are worse than those of the control area. At most of all variables, nutrients intake of the study area did not reach the recommended dietary allowances(RDA) for Koreans, and that nutrient intakes of the study area were significantly lower than those of the control area. The hypothesis of this study that nutrient status depends on economical status was proved. As for the score of nutritional knowledge, the study area was significantly lower than the control area. But as for the score of nutritional behavior, two areas were not significantly different. The latter is counter result of our hypothesis, owing to the effect of the confounding factors including education etc. As for the correlation of variables, not only economic status and educational level, but the score of nutritional knowledge effects strongly on nutrient status in the study area, the poor district. Therefore, adequate nutritional education to the elderly in e poor district should be considered.

규폐증환자의 신기능 평가를 위한 요중 N-acetyl-$\beta$-D-glucosaminidase활성치 측정의 의의

이후락,김돈균,이수일,조병만,김화조,Lee, Hoo-Rak,Kim, Don-Kyoun,Lee, Su-Il,Cho, Byung-Mann,Kim, Wha-Jo 대한예방의학회 1993 예방의학회지 Vol.26 No.1

규폐증의 신기능 장애 평가를 위한 기초 자료를 제공하기 위하여, 우리나라 일부 지역의 진폐요양기관에서 규폐증으로 치료중인 환자 58명을 실험군으로 하고 폐결핵으로 6 개월이상 치료중인 환자 40명을 결핵 대조군 그리고 일반사무직 근로자 51명을 건강대조군으로하여, 신기능 장애의 예민한 지표로 알려진 요중 N-ncetyl-$\beta$-D-glucosaminidase (NAG) 활성치를 측정하여 얻은 바를 아래와 같이 요약 한다. 1. 조사대상자 전체의 혈중 요소질소와 혈청 크레아티닌은 대상자 모두에서 참고치내에 있어 임상적으로 신장장애의 소견을 보이지 않았으나, 요중 NAG 활성치는 $7.25{\pm}7.31U/g\;creatinine$으로서 신기능 장애 선별기준 이상의 측정치를 보여 보다 민감한 검사 결과를 나타내었다. 2. 규폐증군의 요중 NAG 활성치는 $11.98{\pm}9.05U/g\;creatinine$으로서 결핵대조군($5.71{\pm}4.33U/g\;creatinine$) 및 건강대조군($3.63{\pm}1.67U/g\;creatinine$)에 비하여 통계학적으로 유의하게 증가되어 있었으나(p<0.05), 결핵대조군과 건강대조군에서는 유의한 차이를 나타내지 않았다(p>0.05). 3. 결핵대조군에서 결핵의 병증에 따라 요중 NAG 활성치가 증가되는 양상을 보였으나 통계학적으로 유의 하지않았고(p>0.05), 치료약제중 신장애 유발 항결핵제를 사용한 대상자에서 요중 NAG 활성치는 유의하게 증가되어 있었다(p<0.05). 4. 규폐증군에서 결절의 크기가 클수록 그리고 신장애 유발 항결핵제를 사용한 자 및 발병기간이 짧았던 자의 경우 요중 NAG 활성치가 증가되는 양상을 보였으나, 통계학적으로 유의한 차이는 아니었다(p>0.05). 5. 신독성 항결핵제 사용자를 제외한 요중 NAG 활성치는 건강대조군과 결핵대조군에서 각각 3.63U/g creatinine, 3.60U/g creatinine으로 차이를 보이지 않았으나, 규폐증군에서는 10.90U/g creatinine 으로 현저히 증가되어 있었다. 이상의 결과로 규폐증에서는 일반적인 건강진단 항목상의 신기능 검사에 이상소견을 보이지 않은 경우라도 신장기능의 변화가 동반될 수 있으며, 요중 NAG 활성치를 분진 폭로 근로자에게 적용하면 산업보건학적 측면에서 근로자의 건강관리를 위하여 매우 유익한 자료가 될 것으로 생각한다. To provide the basic data for assessment of renal dysfunction related to silicosis, urinary N-acetyl-$\beta$-D-giucobarninidase(NAG) activity known as a sensitive markers for early renal damage were measured in 58 silicosis patients, and control subjects of 40 pulmonary tuberculosis Patients and 51 official workers. The results were summarized as fellows. 1. The values of blood urea nitrogen and serum creatinine in all subjects were within reference limits. But the mean value of urinary NAG activity($7.25{\pm}7.31U/g\;creatinine$) was beyond reference value and more sensitive test than others. 2. The mean value of urinary NAG activity in silicosis group was $11.98{\pm}9.05U/g\;creatinine$ and significantly higher than in tuberculosis and healthy group(p<0.01), but the mean values of NAG activity in tuberculosis and healthy group were not different(p>0.05). 3. The value of NAG activity in tuberculosis had a tendency to be increased according to severity of disease, but that was not significant(p>0.05). The value of NAG activity was increased significantly by use of nephrotoxic antituberculosis drugs(p<0.05). 4. The value of NAG activity in silicosis had a tendecy to be increased according to the size of nodule, use of nephrotoxic antituberculosis drugs and shortness of onset duration, but the increase was not significant(p>0.05). 5. After excluding the users of nephrotoxic antituberculosis drugs, the mean values of NAG activity in healthy control and in tuberculosis control were same as 3.63 U/g creatinine and 3.60 U/g creatinine, respectively. But the mean value of NAG activity in silicosis group was remarkably increased as 10.90 U/g creatinine(p<0.01). As above results, even though there are no abnormal finding in screening renal function test, silicosis can be related with renal dysfunction. And it will be very useful to apply urinary NAG activity in health management of workers exposed to dust.

분진 발생 작업장의 분진 발생 실태 및 영향인자에 관한 연구

김희만,김돈균,Kim, Hee-Man,Kim, Don-Kyoun 한국산업보건학회 1993 한국산업보건학회지 Vol.3 No.2

The author selected 77 dust emissing processes from 71 types of industries which placed in Sasang Industrial Complex in Pusan. The level of total dust was measured as areal concentration and personal exposure concentration by low volume air sampler and personal air sampler, respectively. Collected samples were classified into 5 groups (chemicals and rubber product, metal product, sawmills and wood, foundries and others). Respirable particulate and total dust of areal and personal exposure were analyzed. The results were as follows; 1. All of the respirable dust concentration and total dust of areal and personal concentration were log-normally distributed. 2. Geometric mean of respirable particulate of personal exposure concentration measured $0.55mg/m^3$ in the first group, $0.86mg/m^3$ in the second group, $0.39mg/m^3$ in the third group, $0.81mg/m^3$ in the forth group and $0.52mg/m^3$ in the fifith group. The exceed rates over TLV (thehold limit values) of total dust were 31.3% in the first group, 31.3% in the second group, 70% in the third group, 80% in the forth group and 13.3% in the fifth group. 3. There were singnificant difference between areal and personal exposure concentration and personal exposure concentration was higher than that of area. 4. In the case of high ratio of respirable particulate to total dust, pneumoconiosis incidence was high even though the workshop was opened and emissing dust concentration was low. These findings suggest that it is desirable to measure respirable particulate in environmental assessment of dust emissing workshops.

Chinese Hamster Ovary $K_1$ 세포의 자매염색분체교환에 미치는 카드뮴의 영향에 관한 연구

황인경,김돈균,Hwang, In-Kyung,Kim, Don-Kyoun 대한예방의학회 1990 Journal of Preventive Medicine and Public Health Vol.23 No.2

In order to examine the mutagenicity of cadmium dichloride the author studied the induction of sister chromatid exchanges in chinese hamster ovary $K_1$ cells which treated with cadmium dichloride at various concentrations. The results obtained were as follows : 1. In cells treated with $10^{-4}M$ cadmium dichloride, a small number of cells were viable but no mitosis was bound. 2. The frequencies of sister chromatid exchanges in cells treated with $10^{-5}M\;and\;10^{-6}M$ cadmium dichloride as $10.7{\pm}1.9\;and\;8.3{\pm}2.1$, respectively, were significantly increased for control ($6.0{\pm}2.3$). (P<0.05). 3. There were dose-dependent relationship between the concentration of cadmium dichloride and frequency of sister chromatid exchanges in cells treated with cadmium dichloride at concentration ranging from $10^{-5}\;to\;10^{-7}M$.

부산 일부지역 근로자들의 재해성 요부손상에 대한 사회의학적 조사

박종욱,김돈균,이수일,조병만,조봉수,김영욱,Park, Jong-Ook,Kim, Don-Kyoun,Lee, Su-Ill,Cho, Byung-Mann,Cho, Bong-Soo,Kim, Young-Wook 대한예방의학회 1994 Journal of Preventive Medicine and Public Health Vol.27 No.2

This survey was performed to obtain the basic information for the prevention and management of occupational low back injury (LBI). The subjects of this survey were 952 workers (male, 892 ; female, 60) who had taken occupational LBI in some industries of Pusan area from January 1 to December 31, 1991. Observation period was 2.6 years from the beginning to the end of medical treatment. The obtained results were summarized as follows ; 1. The proportion of LBI workers was 15.9% of the workers who had taken any occpational injuries and 0.32% of all workers in this surveyed area. 2. 8.0% of the workers had taken LBI on the 1st day of employment and 55.2% of the workers were within one year, 91.4% of the workers were within 10 years according to cumulative frequency distribution. 3. Handling of heavy objects was the most common cause of LBI (32.0%) and fall down (26.9%) and slip down (16.3%) were the next in order. 4. The most common causes of both lumbar sprain and HNP were handling of heavy objects and that of lumbar fracture was fall down. 5. The mean duration for medical treatment of LBI workers was 143 days. 6. The total direct compensation cost for LBI workers was 6,736 million Won and the proportion of medical, resting, disability compensation costs were 25.0%, 37.0%, 38.0 % respectively. 7. The percentages of retreated workers and disabled workers were 11.9% (113 persons) and 22.9% (218 persons) of total LBI workers respectively.

건강 비임신 여성과 임신부들의 혈청 총코레스테롤 함량에 관한 조사

류철인,김돈균,Rhyu, Cheol-In,Kim, Don-Kyoun 대한예방의학회 1990 Journal of Preventive Medicine and Public Health Vol.23 No.2

모성보건관리대책수립을 위한 기초자료를 제공할 목적으로 부산지역에 거주하는 $20{\sim}30$세 사이의 건강한 비임신 여성 167명과 임신부 209명을 대상으로 혈청총코레스테롤 함량과 이에 영향을 미칠 수 있는 생리적 제 인자간의 관련성을 조사한 결과를 요약하면 다음과 같다. 1. 건강여성군과 임신부간에 체중의 증가에 따른 Broca's index의 상승을 제외할 신장, 수축기 및 이완기혈압치에는 큰 차이가 없었다. 2. 건강여성군의 혈청총코레스테롤함량은 165.9 mg/dl, 임신부는 212.6 mg/dl로서 유의한 차이가 있었으나 연령에 따른 차이는 관찰할 수 없었으며 함량별 분포양상은 양자 모두 정규분포형을 나타내었다. 3. 건강여성군에서는 혈청총코레스테롤함량과 체중 및 Broca's index간에 임신부에서는 체중, Broca's index 및 임신기간간에 통계적으로 유의한 상관성이 있었다. 4. 체중별 혈청총코레스테롤함량은 건강여성군은 $162.9{\sim}189.4mg/dl$, 임신부는 $167.2{\sim}246.2mg/dl$로서 체중이 증가됨에 따라 그치도 증가되는 경향이 있었으며 특히 임신부의 경우에 더욱 현저하였다. 5. 임신기간별 혈청총코레스테롤함량은 12주이하군 168.1 mg/dl, $13{\sim}26$주군 209.6 mg/dl, 27주이상군 235.4 mg/dl로서 임신이 진행됨에 따라 그 치도 높아지는 경향이 있었으며 함량별분포양상은 모두 정규분포형을 나타내었다. The author investigated the values of total serum cholesterol and its coreelation with the physical factors to have potential as a line in the chain of basic investigation to establish maternal health program. The study group was composed of 167 healthy non-pregnant and 209 pregnant women in the age of 20-39 residing in Pusan area. The obtained results were as follows : 1. No significant differences were found in height and systolic and diastolic blood pressure in both groups except for the elevation of Broca's index by gaining the weight in pregnant women. 2. There were significant differences in the total serum cholesterol level of the healthy and pregnant women as 165.9 mg/dl and 212.6 mg/dl, repectively, not showing the differences in the age. Total serum cholesterol values in both group followed approximately normal distribution curve. 3. The significant correlation to the values of total serum cholesterol were found between weight and Broca's index in healthy women and between weight, Broca's index and duration of pregnancy in pregnant women. 4. The values of total serum cholesterol by weight were 162.9-189.4 mg/dl in healthy women and 167.2-246.2 mg/dl in pregnant women, showing the increasing tendency of values by weight, especially in pregnant women. 5. The values of total serum cholesterol in pregnant women showed increasing tendency with the duration of pregnancy as 168.1 mg/dl in 12 weeks and below, 209.6 mg/dl in 13-26 weeks and 235.4 mg/dl in 27 weeks and above group. Total nm cholesterol values by duration of pregnancy followed normal distribution curve.

廳力保存管理를 위한 5年間의 轉向的 調査

김옥현(Ok-Hyun Kim),이수일(Soo Il Lee),김돈균(Don Kyoun Kim),조병만(Byung Man Cho),양승림(Seung Rim Yaang) 한국항공우주의학협회 1994 항공우주의학회지 Vol.4 No.1

젊은 성인 남자 근로자들에 있어서 음주, 흡연, 비만도와 혈중 지질과의 관련성에 관한 조사 연구

이지호,조병만,이수일,김돈균,Lee, Ji-Ho,Cho, Byung-Mann,Lee, Soo-Ill,Kim, Don-Kyoun 대한예방의학회 1992 예방의학회지 Vol.25 No.4

In order to study the relationship between life-style and serum lipids level in young adults, the author measured the concentration of serum total cholesterol (TC), triglyceride (TG) and high density lipoprotein cholesterol (HDL-C) and investigated age, relative weight, weekly alcohol intake and daily cigarette smoking through questionnaire in 310 male workers aged 20 to 39, in Ulsan area. The results obtained were as follows: 1. In the factors being able to influence serum lipids level there was negative correlation between age and alcohol intake, and the positive correlation between age and relative weight, alcohol intake and relative weight, alcohol intake and smoking with the strongest correlation between alcohol intake and smoking. 2. In univariate analysis, mean total cholesterol concentration were significantly different according to age, smoking and relative weight: mean triglyceride concentration were significantly different according to relative weight only; mean HCL-C concentration were significantly different according to alcohol intake alone. 3. In non-drinkers, HDL-C concentration of smokers were significantly lower than that of non-smokers but triglyceride concentration of smokers were significant higher. And in drinkers, total cholesterol concentration of smokers was significantly higher than that of non-smokers. 4. In multiple regression analysis, significant independent variables were relative weight, age and smoking in the total cholesterol concentration, and relative weight, age and alcohol intake in the triglyceride concentration, and alcohol intake, relative weight and smoking in the HDL-C concentration. By these independent variables, total variation in each dependent variable was explained 7.9%, 17.6% and 7.4% respectively.

일부 농촌지역 노인들의 인지 장애에 관련된 요인에 관한 연구

고광욱,조병만,이수일,김돈균,조봉수,김영욱,김영실,강수용,Koh, Kwang-Wook,Cho, Byung-Mann,Lee, Su-Ill,Kim, Don-Kyoun,Cho, Bong-Su,Kim, Yeung-Wook,Kim, Young-Sil,Kang, Su-Yong 대한예방의학회 1996 예방의학회지 Vol.29 No.3

경상남도 일부 지역에서 60세 이상 노인들의 MMSE에 의한 인지 장애 유병률을 조사하고 인지 장애에 영향을 미치는 요인들을 조사하여 다음과 같은 성적을 얻었다. 1. MMSE에 의한 인지 장애의 유병률은 35.9%로 남자에서 18.4%, 여자에서 45.2%였다. 2. 인지 장애 유병률은 여자에서 유의하게 높았고(p=0.02) 무학력자와 문맹자의 인지 장애 유병률이 통계적으로 유의하게 높았다(p=0.03). 3.성별과 교육 수준에 따른 층화 분석에서 알루미늄의 인지 기능에 대한 독성 효과와 칼슘의 보호 효과에 대한 전체적으로 일정한 경향은 관찰되지 않았다(p>0.05). 4. 최종 분석 대상자 전체에서 음용수 중의 알루미늄과 인지 기능 검사 점수간의 상관 계수는 -0.066으로서 미약한 음의 상관관계에 있었으나 통계학적인 유의성은 보이지 않았고(p=0.434), 칼슘과 MMSE 점수와의 관계에서도 기대했던 바의 양의 상관관계는 관찰할 수 없었다. To investigate the factors which affecting the cognitive impairment of the 60 or more age group, the authors surveyed for the subjects in some area of Kyungnam Province. 201 studied subjects were tested for cognitive function with mini-mental state examination(MMSE). Information on demographic characteristics and life style has been collected through direct interview. The concentration of Ai and Ca of subject's drinking water, which might be related with cognition, was measured by Inductively Coupled Argon Plasma Spectrometer. The main results were summarized as follows. 1. The prevalence rate of cognitive impairment was 18.4% in male and 45.2% in female and this sexual difference was statistically significant(p=0.03). And the uneducated or illiterated showed significantly high prevalence rate of cognitive impairment(p=0.02). 2. In stratified analysis by sex md education year, we can not see significant trend indicating the neurotoxic effects of aluminum and protective effects of calcium to the cognitive function(p>0.05). 3. The correlation between the concentration of aluminum in drinking water and the MMSE score in whole subjects showed weak negative relationship(r=-0.066). But there was no statistical significance(p=0.434).