식방풍의 성분분리 및 생리활성

김도훈,한지수,김기은,김진효,김성건,김호경,오오진,황완균,Kim, Do-Hoon,Han, Chi-Su,Kim, Gi-Eun,Kim, Jin-Hyo,Kim, Sung-Gun,Kim, Ho-Kyoung,Oh, O-Jin,Whang, Wan-Kyunn 대한약학회 2009 약학회지 Vol.53 No.3

In this study, isolation of antioxidative compounds was performed for development of anti-oxidizing agent. $CHCl_3$, $H_2O$, 30%, 60% MeOH, MeOH fractions were examined antioxidative activity by DPPH, test of inhibition on NO production. It was revealed that 30%, 60% MeOH and $CHCl_3$ fractions had significant antioxidative activity. In 30% MeOH and 60% MeOH, $CHCl_3$ fraction, six compounds were isolated and elucidated as adenosine(I), guanosine(II), peucedanol 7-O-$\beta$-D-apiofuranosyl(1$\rightarrow$6)-$\beta$-glucopyranoside(III), peucedanol 7-O-$\beta$-D-glucopyranoside(IV), peucedanol(V) and scopoletin(VI) by physicochemical data and spectroscopic methods. (Negative FAB-MS, $^{1}H-NMR$, $^{13}C-NMR$). The results from antioxidative activity screening for the each compound showed that compound IV was relatively superior antioxidant ability. In anti-inflammatory activation assay, compound III, IV, VI had concentration-dependent-activity and compound IV had superior anti-inflammatory ability. These results suggest that Peucedani Radix might be developed as a potent anti-oxidative, anti-inflammatory agents and ingredients for related functional foods.

조현병 환자와 발병하지 않은 일차친족에서 신경인지의 결함

김도훈,김지우,황선영,김병수,원승희,Kim, DoHoon,Kim, Jiwoo,Hwang, Sunyoung,Kim, Byungsoo,Won, Seunghee 대한생물정신의학회 2014 생물정신의학 Vol.21 No.2

Objectives This study aimed to identify the differences and the profiles of cognitive deficits in remitted patients with schizophrenia and first-degree relatives of schizophrenic probands. Methods A total of 26 remitted states of schizophrenia patients were included in the study and the same number of unaffected first-degree relatives of schizophrenic probands and healthy controls were matched for age, sex, years of education. Cognitive function of all participants was measured by using the Digit span test, the Continuous performance test, the Rey auditory & visual learning test, the Complex figure test, the Verbal fluency test, the Wisconsin card sorting test and the Finger tapping test. The effects of subsyndromal symptomatology and general intelligence score were controlled. Results Schizophrenia patients' group showed more significant impairment than other groups in verbal memory (learning, immediate recall, delayed recall), visual memory (copy, immediate recall, delayed recall) and cognitive flexibility domains. The family group and the patient group commonly performed significantly worse than healthy controls in working memory and verbal fluency (category) tests. There were no differences in sustained attention, psychomotor performance. Conclusions Our research shows that the deficit in working memory and verbal fluency could be strong candidates of endophenotypic marker in schizophrenia.

2022 동일건축 대학(원)생 설계 VE 경진대회 참관기

김도훈,김용찬,박규호,이정재,황태웅,박민수,김세영,권단비,Kim, Do-Hun,Kim, Yong-Chan,Park, Gyu-Ho,Lee, Jeong-Jae,Hwang, Tae-Ung,Park, Min-Su,Kim, Se-Yeong,Gwon, Dan-Bi 한국건설관리학회 2022 건설관리 : 한국건설관리학회 학회지 Vol.23 No.5

RAPD를 이용한 들깨 유전자원의 유전적 변이 분석

김도훈,양보경,김현경,김나영,정순재,김익수,남재성,이재헌,정대수,Kim, Doh-Hoon,Yang, Bo-Kyung,Kim, Hyeon-Kyoung,Kim, Na-Young,Jeong, Soon-Jae,Kim, Ik-Soo,Nam, Jae-Sung,Lee, Jai-Heon,Chung, Dae-Soo 한국식물생명공학회 2003 식물생명공학회지 Vol.30 No.3

Genetic variation of Perilla germplasms was investigated using RAPD markers. Forty-two Perilla frutescens lines and cultivars collected form locals were subjected to RAPD analysis using 220 primers. Among them only 13 primers showed polymorphic bands and these 13 primers provided a total of 144 bands, consist of 115 polymorphic and 29 monomorphic ones. The polymorphic bands were subjected to phylogenetic analysis using UPGMA and maximum parsimony (MP) methods. In the UPGMA method, similarity coefficiency of 42 Perilla frutescens lines and cultivars ranged from 0 to 0.7842. The dendrogram of 42 lines and cultivars obtained through UPGMA method resulted in two major groups, and the similar clustering pattern was found by MP method, suggesting Perilla germplasms utilized in this study truly can be divided into two major groups. Although the two major groups were consistent roughly with their phenotypes (under of node, weight of 1,000 grains, and oil content), in detail, much inconsistency also was present.

c-$\phi$ 지반에서의 아칭현상을 고려한 원형수직터널 토압 : II. 실내 모형실험

김도훈,차민혁,이대수,김경렬,이인모,Kim, Do-Hoon,Cha, Min-Hyuck,Lee, Dea-Su,Kim, Kyung-Ryeol,Lee, In-Mo 한국터널지하공간학회 2010 한국터널지하공간학회논문집 Vol.12 No.2

원형수직터널에 작용하는 토압은 아칭효과로 인해 2차원 일반 흙막이벽에 작용하는 토압보다 작으므로 원형수직터널 설계 시 벽체에 작용하는 실질적인 토압의 예측이 필요하다. 본 논문은 두 개의 연속된 논문(Companion papers)의 두번째로서 원형수직터널 설계 시 건조한 사질토뿐만 아니라 c-$\phi$ 지반과 다층지반에서 적용 가능하도록 새롭게 제안된 토압식(김도훈 등, 2009)을 증명하기 위해 대형 모형실험을 수행하였다. 고안된 모형실험 장비는 단계별 굴착이 가능하도록 제작 벽체의 반경을 변화시켜가며 실험을 수행하였다. 또한 강사 방법으로 지반을 조성하기 전 건조한 시료에 물을 첨가하고 불포화사질토를 형성시켜 겉보기 점착력을 발현시킴으로써 c-$\phi$ 지반과 다층지반에서 실험을 진행하였다. 실험 결과로서, 단계별 굴착을 모사하였을 때, 아칭효과에 의해 굴착된 지반에서 굴착되지 않은 지반으로 하중이 전이가 일어나는 확인할 수 있었다. 또한, 동시에 굴착했을 때의 토압은 예측한 값에 비해 상당히 작게 나타났지만, 단계별로 굴착했을 때의 최종 토압은 동시 굴착 시의 토압에 비해 크게 나타나며 새롭게 제안된 토압식과 잘 일치하였고 c-$\phi$ 지반과 다층지반에서 수행한 실험의 결과도 겉보기 점착력의 효과로 인해 토압의 감소를 보이며 이론적인 값과 잘 일치하는 것으로 나타났다. The earth pressure acting on the vertical shaft is less than that acting on the retaining wall due to three dimensional arching effect. Thus, it might be essential to estimate the earth pressure actually acting on the shaft when designing the vertical shaft. In this paper, large-sized model tests were conducted as Part II of companion papers to verify the newly suggested earth pressure equation proposed by Kim et al. (2009: Part I of companion papers) that can be used when designing the vertical shaft in cohesionless soils as well as in c-$\phi$ soils and multi-layered soils. The newly developed model test apparatus was designed to be able to simulate staged shaft excavation. Model tests were performed by varying the radius of vertical shaft in dry soil. Moreover, tests on c-$\phi$ soils and on multi-layered soils were also performed; in order to induce apparent cohesion to the cohesionless soil, we add some water to the dry soil to make the soil partially-saturated before depositing by raining method. Experimental results showed a load transfer from excavated ground to non-excavated zone below dredging level due to arching effect when simulating staged excavation. It was also found that measured earth pressure was far smaller than estimated if excavation is done at once; the final earth pressure measured after performing staged excavation was larger and matched with that estimated from the newly proposed equation. Measured results in c-$\phi$ soils and in multi-layered soils showed reduction in earth pressures due to apparent cohesion effect and showed good matches with analytical results.

임플란트 CT에서 방향 표시자의 방향과 잔존골을 고려한 임플란트 식립 방향의 관계에 관한 연구

김도훈,허민석,이삼선,오성욱,최항문,전인성,최순철,Kim Do-Hoon,Heo Min-Suk,Lee Sam-Sun,Oh Sung-Ook,Choi Hang-Moon,Jeon In-Seong,Choi Soon-Chul 대한영상치의학회 2003 Imaging Science in Dentistry Vol.33 No.2

Purpose : To assess the relationship between the direction of the indicating rod of the radiographic stent for ideal prosthetic design and the actual possible path of implant fixture placement when residual ridge resorption is considered. Materials and Methods: The study materials consisted of 326 implant sites (male 214 cases and female 112 cases) from a total of 106 patients (male 65 patients and female 41 patients) who desired implant prostheses. Computed tomography of patients were taken and reformatted using ToothPix/sup (R)/ software. Bony defects, bony sclerosis, the change of the direction of indicating rod, and root proximity of the adjacent teeth were examined on the CT-derived images. Results: The rate of the irregular crestal cortex was relatively high on premolar and molar area of maxilla. Mandibular molar area showed relatively high rate of focal sclerosis on the area of implant fixture insertion. The position of the indicating rods were relatively acceptable on the molar areas of both jaws. However, the position of the indicating rods should be shifted to buccal side with lingual rotation of the apical end on maxillary anterior teeth and premolar area. Conclusion: Clinically determined rod direction and position of the indicating rod for implant placement was not always acceptable for insertion according to the reformatted CT images. The pre-operative treatment plan for implant should be determined carefully, considering the state of the alveolar bone using the reformatted CT images.

도심형 메모리얼파크의 사회적 담론 및 인식분석을 통한 4·16 세월호 참사 추모공원 방향성 제안 연구

김도훈,Kim, Do-Hun 한국조경학회 2020 韓國造景學會誌 Vol.48 No.6

The objective of this study is to propose a direction for creating a memorial park for the 250 students victims of the Sewol ferry disaster. To this end, this study first attempted to understand the matters discussed at various levels to create a memorial park and find a way that the park can be built by gathering opinions from the bereaved families and the victims themselves, as well as local residents, and experts. Workshops, competitions, special lectures, and websites, etc, were analyzed. A social discourse analysis methodology was used for systematic analysis, and the analyzed discourse was categorized into 4 types for assessment, and the functions and roles were subdivided into 15 types. To assess the priorities and the adequacy of the discourse, an analytic hierarchy process (AHP) was used among 30 activists, public servants, and experts. Then, a survey was conducted to analyze the perception of the residents (467 participants including the bereaved families) about the memorial park. Based on the results of the analysis, two directions were set for the memorial park. First, is a memorial park to remember the victims in everyday life. It must be a park with various cultural contents instead of a conventional memorial park that is solemn and grave sharing anguish and sorrow. The memorial park for the Sewol ferry disaster must become a space where visitors can naturally encounter and remember the victims. Second, is a park that serves as a catalyst that brings change and innovation to the community. It must be able to bring change to the community with direct and indirect influence. It must serve as an impetus to bring change and innovation to the community in the mid-to-long-term. Having many visitors may also lead to an economic effect. These visitors may not just stay in the park, but even contribute to revitalizing the local businesses. The purpose of this study is to apply the research findings to guide the International Design Competition scheduled for 2020 and serve to establish guidelines for a continuous park management system. 세월호 참사로 희생된 250명의 아이들을 위한 추모공원 조성방향을 제안하는 것이 본 연구의 목적이다. 이를 위해 먼저 지역사회 차원에서 추모공원에 대해 논의했던 사항을 이해하고, 피해당사자인 유가족들과 지역주민, 전문가들의 의견수렴을 통해 추모공원 방안을 모색하고자 했다. 유가족들과 시민들이 함께 국제공모전 시민지침서를 만들고자 진행한 참여형 워크숍, 신진디자인의 아이디어 수렴을 위한 공모전, 인문사회·문화관광·도시재생 전문가들과 함께한 특강, 홈페이지에 게시된 반대청원 등 다양한 활동들이 전개되었다. 이들 과정을 체계적으로 분석하기 위해서 사회적 담론분석 연구방법을 활용하였고, 분석된 담론을 평가하기 위하여 4가지 범주로 유형화하고 기능 및 역할을 15가지로 세분화 했다. 이렇게 도출된 담론들의 우선순위 및 적정성 평가를 위하여 활동가, 공무원, 전문가 30명을 대상으로 계층화 분석방법(AHP)을 수행했고, 설문조사를 시행하여 세월호 유가족 포함 지역주민 467명이 생각하는 추모공원에 대한 인식을 분석했다. 그리고 분석된 연구결과를 바탕으로 세 가지 추모공원 방향을 제안했다. 첫 번째는 일상 속에서 기억하는 추모공원이다. 기존의 추모공원처럼 경건함과 엄숙함으로 아픔과 슬픔을 나누는 공간의 모습에서 탈피하여 문화적 콘텐츠가 다양한 공원이 되어야 한다는 것이다. 그리고 이러한 공원생활 속에서 희생된 아이들을 자연스럽게 만나게 되고, 기억하는 것이 나아가야 하는 방향이다. 두 번째는 지역사회의 변화와 혁신을 유도하는 촉매제와 같은 공원이다. 세월호 추모공원이 존재함에 따라 지역사회에 직·간접적인 영향으로 변화를 줄 수 있는 공간이 되어야 한다. 중장기적인 관점에서 작은 공간 하나 만드는 것을 넘어 지역사회의 변화와 혁신을 만들어가는 계기가 되어야 한다. 세 번째는 사회적 공유과정을 거쳐서 모든 이들이 함께 하는 공원이 되어야 한다는 지점이다. 도심형 메모리얼 파크가 혐오시설이라는 인식 때문에 아직도 반대하는 이들이 일부 있는데, 이들을 포용하여 함께 할 수 있는 방법을 찾는 것이 중요하다. 본 연구를 통해서 도출된 연구내용이 2021년 예정된 국제설계 공모지침서에 반영되고, 중장기적 관점에서 지속적 공원운영 관리 가이드라인 역할을 하도록 하는 것이 목적이다.

전치의 심미치료를 위해 투명교정장치를 사용한 다각적 진료접근법

김도훈,Dohoon KIM 대한심미치과학회 2023 Journal of the Korean Academy of Esthetic Dentistr Vol.32 No.2

심미적인 전치부의 모습은 자연스럽고 건강한 미소를 위한 필수요건이며 대인관계의 자신감을 위해서도 중요한 요소이다. 전치부의 총생이=나 전돌이 존재하는 경우 단기간에 해결하기 위해 근관치료 및 과도한 치아삭제가 요구되는 경우가 많다. 하지만 이런 술식은 지속가능한 심미적 결과를 만들기 어렵다. 이런 경우 교정치료가 병행되어야만 수복이 필요한 치아들도 잔존 치질을 최대한 보존할 수 있을 것이다. 중장년층 환자들의 경우 교정 치료의 필요성을 절감하면서도 사회적 시선을 의식하여 브라켓을 이용한 전통적 방식의 교정치료 방법을 주저하는 경우가 많다. 이런 경우 투명교정장치는 좋은 선택지가 될 수 있다. 이에 투명교정만으로 심미적 요구를 해결한 증례와, 투명교정을 동반한 새로운 수복치료를 통해 만족스러운 결과를 얻은 다른 증례를 보고한다. The aesthetic appearance of the incisors is essential for a natural and healthy smile, and it is also an important factor for confidence in interpersonal relationships. If there is crowding or protrusion of the anterior teeth, root canal treatment and excessive tooth removal are often required to resolve it in a short period of time. However, it is difficult to achieve sustainable aesthetic results. In this case, orthodontic treatment will be necessary to preserve the remaining tooth structure as much as possible. Middle-aged and elderly patients are often aware of the need for orthodontic treatment, but they are hesitant to use the traditional orthodontic treatment method using brackets because of the social gaze. In this case, clear aligners can be a good option. So, in this article, a case in which aesthetic needs were resolved with clear aligners alone and another case in which satisfactory results were obtained through restorative treatment following clear aligners application are reported.

c-${\phi}$ 지반에서의 아칭현상을 고려한 원형수직터널 토압: I. 이론

김도훈,이대수,김경렬,이용희,이인모,Kim, Do-Hoon,Lee, Dea-Su,Kim, Kyung-Ryeol,Lee, Yong-Hee,Lee, In-Mo 한국터널지하공간학회 2009 한국터널지하공간학회논문집 Vol.11 No.2

원형수직터널에서 3차원적인 아칭효과를 고려한 토압산정을 위해 여러 연구가 수행되었고 실내시험 및 수치해석을 통해 이를 검증하였으나, 다층지반과 c-${\phi}$지반에서의 적용이 어려웠다. 본연구에서는 c-${\phi}$지반에서의 토압 산정을 위해 c-${\phi}$지반에서 적용 가능한 토압계수 산정식을 구하였으며, 기존 토압식을 수정 제안하였다. 점착력이 토압에 미치는 영향을 파악하기 위해 지반을 가정하여 각 경우별로 토압을 산정하여 비교하였으며, 다층지반에서 파괴면을 가정하는 방법으로 토압을 구하였다. 이 논문은 두 개의 연속된 논문(Companion paper)의 첫 번째로서 모델개발을 위한 이론전개를 다루고 있으며, 대형 모형실험에 의한 실증은 두 번째 논문에서 다룰 것이다. Several researches have been done to estimate the earth pressure on a vertical circular shaft considering three dimensional arching effect and verified them by conducting model tests. However, any equation suggested so far is not applicable in case of multi-layered soils and/or C-${\phi}$ soils. In this study, new equation for estimating the earth pressure acting on the vertical shaft in c-${\phi}$ soils is proposed. A parametric study is performed to investigate the significance of the cohesion when estimating the coefficient of earth pressure in C-${\phi}$ soils and estimating earth pressures in vertical shafts. A method which can estimate the earth pressure on vertical shafts in layered soils is also proposed by assuming a failure surface in layered soils and using the modified equation. This paper is Part I of companion papers focusing on the theoretical aspect of model developments; the experimental verification will be made in Part II.

철강플랜트 제어를 위한 레벨 2 미들웨어

김도훈,황화원,최자영,고재훈,김치하,Kim, DoHun,Hwang, Hwa-Won,Choi, Ja Young,Ko, JaeHoon,Kim, Chee-Ha 대한임베디드공학회 2011 대한임베디드공학회논문지 Vol.6 No.2

In this paper, we proposed a level 2 middleware with common services for controlling steel plants, which is named POSMOS. POSMOS supports eight middleware services currently, but, this paper described in detail two representative services of the common services: file service and external communication service and their respective measured performance. In the experiment section, we described the performance of the two representative services and a case using our middleware which shows better response time than the existing commercial middleware by about 32%.