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안병훈(Byung Hoon Ahn),박선호(Sun Ho Park),김덕준(Deok Jun Kim),송달원(Dal Won Song) 대한두경부종양학회 1997 대한두경부 종양학회지 Vol.13 No.2
저자들은 30여년전 비인강 혈관 섬유종으로 방사선 치료를 받은 남자환자의 하악골에 발생한 방사선 속발골육종 1예를 경험하였기에 문헌 고찰과 함께 보고하는 바이다. Although primary surgical excision is the treatment of choice for the vast majority of patients with nasopharyngeal angiofibroma, radiation therapy is also employed as a primary tool or in the cases of tumor recurrence or massive intracranial extension. But, especially in young patients, postradiation sequelae such as osteomyelitis, atrophic rhinitis, thyroid or bone malignancy are of concern. Postirradiation osteosarcoma is a rare, but well-recognized complication of radiotherapy, which comprise roughly 2 to 5 percent of all osteogenic sarcoma. Recently we experienced a case of postirradiation osteosarcoma of the mandible who had treated by radiation therapy for the nasopharyngeal angiofibroma 30 years ago, presently he is ongoing chemotherapy and relatively being well.
NM23/NDP Kinase 유전자가 도입된 세포주에서 NM23/NDP Kinase 유전자와 c-myc 유전자 발현과의 관계
이근양(Kun Yang Lee),송달원(Dal Wan Song),김덕준(Deok Jun Kim),김동선(Dong Sun Kim),장성익(Sung Ik Chang),이인환(In Hwan Lee) 대한체질인류학회 1998 해부·생물인류학 (Anat Biol Anthropol) Vol.11 No.1
NM23/NDP kinase 유전자는 1988년 Steeg 등에 의해 항 전이유전자로 알려진 이래 여러 다양한 기능이 보고되었다. 1993년 Postel 등은 NM23/NDP kinase 유전자가 c-myc의 necllease hypersensitive element (NHE)와 반응하는 전사인자 PuF가 NM23/NDP kinase에 그 서열이 있다고 보고하였다. 두경부의 편평상피암에 있어서 c-myc 암유전자의 증폭은 잘 알려져 있으며 전이와도 깊은 관계를 가진다. (Schantz 1993) 이 c-myc 암유전자가 NM23/NDP kinase 유전자에 의한 조정을 규명하기 위해 두 유전자의 발현을 여러 세포주에서 비교하였으나 직접적 관계는 찾을 수 없었다. 전사인자로서 역할을 규명하기 위하여 c-myc 유전자의 분절이 CAT (chloramphenicol acety ltransferase) 유전자 상부에 위치하는 plasmid DNA 를 조성하여 CAT assay를 하였다. 쥐의 흑색종 세포에서 쥐에서 유래된 NM23- M2 와 c-myc CAT를 세포내 도엽 (gene transfer) 하여 CAT 효소의 활성이 증가됨을 보았다. 사람의 NM23- H2 와 c-myc CAT 로 조합하여 쥐의 흑색종 세포에 유전자 세포내 도업을 하였을 경우 앞에서와 같은 CAT 효소의 활성을 볼수 없었다. 쥐세포에서는 쥐에서 유래된 NM23-M2 만 이 c-myc 전사인자로서 역할을 하는 것으로 보아 NM23/NDP kinase 가 전사인자로서 역할을 하기 위해서는 다른 세포성 인자가 필요하다고 여겨진다. 한연 증식이 유도된 사람 간암세포에서도 NM23-H2와 c-myc의 발현 변화가 유사하여 사랑세포에서도 NM23 H2의 c-myc에 대한 전사효과가 유추된다.
김중강,신무진,류태선,오춘석,김덕준 啓明大學校 醫科大學 1994 계명의대학술지 Vol.13 No.4
Choanal polyps can be defined as paranasal sinus polyps that pass through sinus ostia and protrude into the boundary between the nasal cavity and nasopharynx-the choana. The most common choanal polyp is the antrochoanal polyp, but sphenochoanal and ethmoidochoanal polyps are rarer. We experienced a case of choanal polyp originating from the nasal mucosa of the sphenoethmoid recess, not from the paranasal sinuses. It was removed with intranasal endoscopy, and 6 months follow-up has not shown any recurrence. So we report this very rare case with review of literatures.
그레이브스병 환자에서 혈청 Soluble ICAM-1 과 갑상선 호르몬, 갑상선 자극호르몬 수용체 항체 및 말초혈액 단핵구의 Interleukin-6 치의 상관관계에 관한 연구
김덕준,박근용 대한내분비학회 1995 Endocrinology and metabolism Vol.10 No.4
Lymphocytic infiltration of the thyroid gland is a hallmark of the human thyroid autoimmune disease. Enhanced expression of immunoglobulin and adhesion molecules are consistently found in patients with autoimmune thyroid diseases. And cytokines are implicated in enhancing the expression of adhesion molecules. It has been suggested that adhesion-molecule expression within thyroid glands mediates lymphocyte homing events to the target of the autoimmune process. The expression of ICAM-1 was shown to be up-regulated on thyroidal perifollicular endothelial cells and thyrocytes in autoimmune thyroid diseases both in vitro and in vivo. Therfore, we investigated the correlation between thyroid hormone, TSH receptor antibodies, Interleukin-6 and soluble ICAM-1 in patients with Graves' disease before and 2 months after treatment with prophylthiouracil(PTU). Serum concentrations of soluble intercellular adhesion molecule-1(sICAM-1), T_3, T_4, TSH-receptor antibodies(TSH-R-Ab) and Interleukin-6(IL-6) of peripheral blood monocytes were measured in patients with Graves' disease. Serum levels of sICAM-1 were elevated in patients with Graves' disease before treatment with PTU, but serum levels of sICAM-1 did not correlate with the serum concentration of thyroid hormone and TSH-R-Ab before and after treatment. In addition, no correlation between serum levels of sICAM-1 and IL-6 of peripheral blood monocyte. We conclude that although the elevated serum levels of sICAM-1 may contribute to the autoimmune process in Graves' disease, we need more future studies for the role of sICAM-1 and correlation between adhesion molecule and thyroid hormone or cytokines in patients with Graves' disease(J Kor Soc Endocrinol 10: 405-410, 1995).
김중강,김종훈,안주선,방성혁,김덕준 啓明大學校 醫科大學 1992 계명의대학술지 Vol.11 No.2
Authors had clinical analysis on 100 patients (101 ears) of traumatic tympanic membrane perforation who were treated between January, 1986 to December, 1986. We analized them by age, sex, cause, symptom, location, size, and shape of the traumatic tympanic membrane perforation. The majority of patients (62%) visited to our department within 5 days after trauma. The results were as follows: Young age groups(20's, 30's, 10's in the declining order) and female were involved more frequently. Left side was more frequently involved(73%). The most common cause is hand slap, especially in the young age group. The main subjective symptoms were hard of hearing(35%), tinnitus(28%), earfullness(21%), otalgia(10%) in the declining order. The most common location of the tympanic membrane perforation was anteroinferior quadrant(32.7%), and posteroinferior quadrant occupies the next order. The size of the tympanic membrane perforation showed 82 cases(gradeⅠ), 13 cases(grade Ⅱ), 3 cases(grade Ⅲ), 3 cases(grade IIII) in the declining order. The most common shape of the tympanic membrane perforation was round to oval(73 cases), and triangular to slit(20 cases), rectangular or irregular(8 cases) in the declining order.
송달원,김덕준,이태휘 啓明大學校 醫科大學 1993 계명의대학술지 Vol.12 No.4
Tracheostomy is an ancient surgical procedure which has endured with few changes for over 2000 years. It remains today the focal operation of the upper respiratory tract and is increasingly indicated with advancing medical and surgical technology. 79 cases of tracheostomy were analyzed at the Department of Otolaryngology, Keimyung University Hospital from Jan. 1984 through Dec. 1990. The result were as follows. Although the most common predisposing condition was upper respiratoy tract obstruction, the conditions of secretional ventilatory insufficiency and mechanically disabled respiration has increased gradually. The ratio of make to female was 4 : 1, and the number of tracheostomy was highest in 7th decade. Most of the tracheotomies(68 cases, 86.1%) were undertaken within 2 days after the onset of respiratory symptoms. Decannulation was performed mostly(21 cases) over 1 month after tracheostomy and most of this late decanunulation occurred in laryngeal cancer patients. The postoperative complications occurred in 12 cases after emergency tracheostomy and 2 cases after ordinary tracheostomy. The most common complication was laryngotracheal stenosis(7 cases). Laryngotracheoplasty with Montgomery stent or T-tube insertion were done for laryngotracheal stenosis and 5 out of cases were able to decannulated.