http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
십이지장 궤양에서 Helicobacter pylori 독성인자 유전자 아형과 IS605의 역할
금동주 ( Dong Joo Keum ),한상영 ( Sang Young Han ),김광진 ( Kwang Jin Kim ),지삼룡 ( Sam Ryong Jee ),이종훈 ( Jong Hun Lee ),최석렬 ( Seok Ryeol Choi ),신우원 ( Woo Won Shin ),김정만 ( Jeong Man Kim ),홍숙희 ( Sook Hee Hong ),김 대한소화기학회 2003 대한소화기학회지 Vol.41 No.2
Background/Aims: The Helicobacter pylori (H. pylori) cagA, vacA, and ieeA are considered to be important virulence factors that have been implicated in the development of duodenal ulcers. It was reported that the presence of IS605 elements might be respon
금동주 ( Dong Joo Keum ),양두경 ( Doo Kyoung Yang ),김광진 ( Kwang Jin Kim ),지삼룡 ( Sam Ryong Jee ),윤진혁 ( Chin Hyuk Yun ),이성원 ( Sung Won Lee ),정원태 ( Won Tae Chung ) 대한류마티스학회 2000 대한류마티스학회지 Vol.7 No.3
Behcet`s disease is a recurring illness characterized by the triple symptom complex of aphthous stomatitis, genital ulceration, and uveitis. The disease is multisystemic disorder with involvement of skin, gastrointestinal tract, blood vessels, central nervous system, joints, and epididymis. Vascular involvement of Behcet`s disease affects both arteries and veins and blood vessels of all sizes. Periosteal new bone formation is one feature of hypertrophic osteoarthropathy. Other features are clubbing and arthritis. Periosteal new bone formation on the bones of the lower extremities without other features of hypertrophic osteoarthropathy has been reported in patients with varicose veins, vitamin A intoxication, infantile cortical hyperostosis, tuberous sclerosis, congenital syphilis and chronic renal failure with hyperparathyroidism, and chronic venous insufficiency. However, periosteal new bone formation has not, to our knowledge, been described in patients with Behcet`s disease yet although similar findings are occasionally noted in polyarteritis nodosa. We report a case of Behcet`s disease complicated by leg swelling with periosteal new bone formation of right lower leg.
위선암에서 Helicobacter pylori 독성인자와 유전자 아형의 관련성
신종민,한상영,금동주,김광진,지삼룡,홍기봉,이종훈,최석렬,신우원,Shin Jong Min,Han Sang Young,Keum Dong Joo,Kim Kwang Jin,Jee Sam Ryong,Hong Gi Bong,Lee Jong Hun,Choi Seok Ryeol,Shin Woo Won 대한위암학회 2002 대한위암학회지 Vol.2 No.1
Purpose: The H. pylori cagA gene, vacA gene and iceA gene are considered to be important virurence factors that have been implicated in the development of gastric adenocarcinoma. It was reported that the presence of IS605 elements may be responsible for rearrangements and lead to partial or total deletions of the cag pathogenicity island (PAI) and the virulence of cag PAI may be changed. However, different results regarding the association between these virulence factors and clinical disease have been reported from different geographic regions. This study evaluated the relationship between H. pylori virulence factors such as cagA, vacA, iceA, IS605 and gastric adenocarcinoma. Materials and Methods: H. pylori isolates were obtained from 54 infected patients (24 cases of gastric adenocarcinoma, 30 cases of control). H. pylori isolates were identified by PCR with ureC gene and 16S rRNA. PCR was performed to examine cagA, vacA, iceA and IS605 genotypes. Results: Significant difference was found in the negative rates of cagA between gastric adenocarcinoma group and control ($62.5\%\;vs.\;33.3\%$ P=0.033). No significant difference was found in the prevalence of iceA, vacA between gastric adenocar cinoma and control. The genotype of cagA+ vacA s1-m1 iceA1 was predominant in H. pylori isolates irrespective of the clinical outcome. IS605 in PAI was not found in gastric adenocarcinoma gruop and control. The positive rates of IS605 in genome were $33.3\%$ in gastric adenocarcinoma group and $36.7\%$ in control (P>0.05). In gastric carcinoma, the positive rate of $cagA^{+}/IS605$ was lower than in control ($12.5\%\;vs\;40.0\%$, P=0.025) and the positive rate of cagA-/IS605 was higher than in control ($54.2\%\;vs\;23.3\%$, P=0.02). Conclusion: H. pylori virulence factors had not related significantly with gastric adenocarcinoma. Further study is needed to examine the specificity of H. pylori strains.
위상피이형성과 위암종에서 FasL의 발현 및 Apoptosis에 관한 연구
박건욱,한상영,이종훈,금동주,노명환,최석렬,김종성,노미숙,Park Gun Uk,Han Sang Young,Lee Jong Hun,Keum Dong Joo,Roh Myung Hwan,Choi Seok Ryeol,Kim Jong Seong,Roh Mee Sook 대한위암학회 2001 대한위암학회지 Vol.1 No.2
Purpose: This study was to observe whether the apoptotic function of tumor-infiltrating lymphocytes (TIL) is induced in human gastric epithelial dysplasia and gastric adenocarcinoma according to the role of FasL expression. Materials and Methods: A total of 56 gastric epithelial dysplasia and gastric adenocarcinoma patients were enrolled in this study: 9 cases of gastric epithelial dysplasia, 18 cases of early gastric carcinomas (EGC) and 29 cases of advanced gastric carcinomas (AGC). Immunohistochemical staining was performed for FasL and CD45, and the terminal deoxynucleotidyl transferase mediated dUTP nick end labelling (TUNEL) method was used to detect cell death in tumor-infiltrating lymphocytes. Results: 1) Positive reactions of FasL to neoplastic cells were $88.9\%$ (8/9) in gastric epithelial dysplasia, $83.3\%$ (15/18) in EGC, and $75.9\%$ (22/29) in AGC. 2) Expression of TIL was decreased in the FasL positive region and was increased in the FasL negative region, and significant expression of TIL was observed in the AGC group (P=0.001). 3) Expression of apoptotic TIL was very similar to the FasL expression, and $100\%$ expression was observed in gastric epithelial dysplasia group. 4) Expression of apoptotic TIL was increased in the FasL positive region and decreased in the FasL negative region, and significant apoptotic expression was observed in the gastric epithelial dysplasia and EGC groups (P=0.0420, P=0.0263, respectively). Conclusion: These results suggest that FasL is a prevalent mediator of immune privilege in epithelial dysplasia and cancer of the stomach.
식도절제술 환자에서 식도내압 및 위배출시간에 대한 고찰
지삼룡 ( Sam Ryong Jee ),최석렬 ( Seok Reyol Choi ),김광진 ( Kwang Jin Kim ),금동주 ( Dong Joo Keum ),홍기봉 ( Ki Bong Hong ),이종훈 ( Jong Hun Lee ),한상영 ( Sang Young Han ),최필조 ( Pill Jo Choi ) 대한소화기학회 2002 대한소화기학회 춘계학술대회 Vol.2002 No.-
〈목적〉 식도절제술은 식도암에 있어서 장기생존 및 증상의 호전을 위하여 치료원칙이 되며, 증상의 호전을 위한 고식적 수술로도 시행된다. 또한, 식도의 양성 협착 질환이나 식도 천공의 치료법으로도 행해진다. 그러나, 식도절제술후의 식도 운동기능의 양상과 위배출능에 대한 국내문헌은 찾아보기 힘든 실정이다, 이에 저자들은 식도절제술후 호소하는 증상과 식도내압 및 위배출시간과의 연관성을 알아보고자 하였다. 〈방법〉 1994년 10월부터 1998년 11월 사이에
식도절제술 환자에서 식도내압 및 위배출시간에 대한 고찰
이철종(Cheol Jong Lee),최석렬(Seok Reyol Choi),지삼룡(Sam Ryong Jee),김광진(Kwang Jin Kim),금동주(Dong Joo Keum),홍기봉(Ki Bong Hong),이종훈(Jong Hun Lee),한상영(Sang Young Han),최필조(Pill Jo Choi) 대한소화기기능성질환·운동학회 2001 Journal of Neurogastroenterology and Motility (JNM Vol.7 No.2
N/A Backgroud/Aims: Resection of the esophagus for malignant disease or a benign stenosis, has a choice not only of palliative surgery, but also of replacement of the esophagus with a transposed stomach, jejunum, or colon. The first-line method is replacement with a tubulized stomach. The purpose of this study was to investigate the association of esophageal motor dysfunction and gastric emptying time with symptoms after esophagectomy. Methods: We performed the esophageal manometry and gastric emptying time after esophagectomy for esophageal cancer in 12 patients and for benign esophageal disease in 2 patients. Results: In manometric studies, a zone of high pressure in the esophago-gastric anastomosis distal to the upper esophageal sphincter was associated with symptoms after esophagectomy. The gastric emptying rate was slowed in 7 out of 14 patients, but not associated with symptoms after esophagectomy. Conclusions: Our data suggest that a high-pressure zone distal to the upper esophageal sphincter was associated with symptoms after esophagectomy in manometric study. The gastric emptying rate was not associated with postoperative symptoms. (Korean Journal of Gastrointestinal Motility 2001;7:197-203)
김광진 ( Kwang Jin Kim ),최석렬 ( Seok Reyol Choi ),손승현 ( Seung Hyun Sohn ),이상 ( Sang Lee ),홍기봉 ( Ki Bong Hong ),금동주 ( Dong Joo Keum ),지삼룡 ( Sam Ryong Jee ),이종훈 ( Jong Hoon Lee ),한상영 ( Sang Young Han ),신우원 대한소화기학회 2002 대한소화기학회지 Vol.40 No.6
Neurofibromatosis type I is an autosomal dominant disorder that occurs once in 3,000 births. It is characterized by neurofibromas and caf?au lait spots of the skin. Neurofibromatosis type I gene is a tumor suppressor gene. Patients with neurofibromatosis type I are at an increased risk of developing neural neoplasms including optic glioma, astrocytoma, acoustic neuroma, neurilemmoma, and meningioma. The patients with neurofibromatosis type I showed high incidence of Wilm`s tumor, rhabdomyosarcoma, leukemia, and pheochromocytoma but rare incidence of colon cancer. We experienced a case of sigmoid colon cancer and multiple adenomatous polyps of the colon in a patient with sporadic neurofibromatosis type I. (Korean J Gastroenterol 2002;40:402-405)
범복막염으로 술후 E.coli에 의해 발생한 괴사성 근막염 1예
김동현,금동주,김명준,최슬기,최정석,이현성,이상민,강미선 인제대학교 백병원 2003 仁濟醫學 Vol.24 No.1
Necrotizing fasciitis is an uncommon severe soft tissue infection characterized by extensive necrosis of superficial fascia with widespread involvement of the surrounding tissues and concurrent systemic toxicity. It is accompanied by local pain, fever and systemic toxicity and is rapidly progressive and destructive infection and is often fetal if not promptly recognized and aggressively treated. It is usually caused by mixed aerobic-anaerobic bacteria. It can affect any part of the body but is most common on the extremities, perineum and abdominal wall, especially the leg. Predisposing factors include diabetes mellitus, alcoholism, intravenous drug abusers, abdominal surgery, perineal infection. Tissue damage and systemic toxicity are believed to result from the release of endogenous cytokines and bacterial toxins. Early recognition, broad-spectrum antibiotics coverage and adequate debridement has been associated with improved survival. We report a case of necrotizing fasciitis caused by E. coli after operation.