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괴상형 간세포암 동시 간동맥 항암-방사선요법으로 부분관해 획득 후 근치적 간절제술을 시행한 간세포암
권지숙 ( Jee Suk Kwon ),박우영 ( Woo Young Park ),이경인 ( Kyung In Lee ),이정은 ( Jeong Eun Lee ),김은수 ( Eun Soo Kim ),장병국 ( Byoung Kuk Jang ),정우진 ( Woo Jin Chung ),박경식 ( Kyung Sik Park ),조광범 ( Kwang Bum Cho ),황재 대한간암학회 2009 대한간암학회지 Vol.9 No.-
Advanced hepatocellular carcinoma (HCC) with portal vein thrombosis is not suitable candidates for surgical treatment at the most of diagnosis because of poor liver function, extensive tumor involvement of the liver, vascular involvement, and/or intra/extrahepatic metastasis. We attempted localized concurrent chemo-radiation therapy (CCRT) in patients having locally advanced HCC with left and main portal vein thrombosis. We report a case of locally advanced HCC patient who became surgically resectable by downstaging after localized CCRT. Localized CCRT was performed with a total radiation dose of 5,040 cGy (180 cGy×28 times) and hepatic arterial infusion of 5-fluorouracil (5-FU, 250 mg/day) and cisplatin (10 mg/day) for 5 days via implantable port system during the second and the fifth weeks of the radiotherapy. Marked contraction of HCC was noted on follow up computerized tomography (CT) after localized CCRT, and subsequently surgical resection with curative aim was performed. He was gave a additional transcatheter arterial chemoembolization (TACE) because follow up CT revealed intrahepatic metastasis at subcapsular portion of right hepatic lobe after 3 months of operation. The patient is in complete remission status without recurrence to date.
고등학교 육상 선수와 수영선수의 체격 및 영양섭취 칼로리 분석
권태동(Tae Dong Kwon),이경석(Kyung Suk Lee) 한국발육발달학회 2004 한국발육발달학회지 Vol.12 No.4
High school runners (n=40) and swimmers (n=40) were participated in this experiment to analyze their physique, skinfolds thickness, circumference, and calorie intake. Caloric intake data were obtained for an week using 24 hour recall method. The span was statistically significant between groups (p<.05). In addition, body weight, % body fat, lean body mass, and total body water were statistically significant between groups (p<.05). Among the items of the skinfolds thickness, chest, biceps, subscapular, and thigh back were statistically significant between groups (p<.05). Moreover, chest and abdominal girth were statistically significant between groups (p<.05). However, caloric intake ratio was not statistically significant between groups. These results suggested that adolescent athletes, especially runner and swimmer, were not given sufficient caloric intake compared with the national team as suggested by other researchers. Therefore, adolescent players given more caloric food, especially protein and carbohydrate, during maturation periods.
권순국,이재형,정재성,전일권,김민환,이경도,Kwon, Soon-Kuk,Lee, Jae-Hyoung,Jung, Jae-Sung,Chon, Il-Kweon,Kim, Min-Hwan,Lee, Kyung-Do 한국농공학회 2004 한국농공학회논문집 Vol.46 No.6
The fundamental study of hydrologic redesign of Donghwa area located in a sccond tributary of Seomjin river was performed. The amounts of hydrologic design were estimated using the available cumulated hydrology data provided by Korea Agricultural and Rural Infrastructure Corporation (KARICO). The management status of The water resources in Donghwa area was also widely surveyed. The probability rainfalls, probable maximum precipitation (PMP) and probability floods were estimated and subsequently their changes analyzed. The amount of 200 year frequency rainfall with l day duration was 351.1 mm, 2.5 % increased from the original design value, and The PMP was 780.2 mm. The concentration time was reestimated as 2.5 hours from existing 2.4 hours. Soil Conservation Service(SCS) method was used to estimate effective rainfall- The runoff curve number was changed from 90 to 78, therefore the maximum potential retention was 71.6 mm, 154 % increased from the original value. The Hood estimates using SCS unit hydrograph showed 8 % increase from original value 623 $m^3$/s to 674 $m^3$/s and The probable maximum Hood was 1,637 $m^3$/s. Although the Row rate at the dam site was increased, the Hood risk at the downstream river was decreased by the Hood control of the Donghwa dam.
간외 전이로 처음 발견된 간세포암종 늑골 전이로 발현된 간세포암종
이경인 ( Kyung In Lee ),권영란 ( Young Lan Kwon ),김윤정 ( Yoon Jung Kim ),서혜진 ( Hye Jin Seo ),김용진 ( Yong Jin Kim ),박창욱 ( Chang Wook Park ),김은수 ( Eun Soo Kim ),장병국 ( Byoung Kuk Jang ),정우진 ( Woo Jin Chung ),박경식 대한간암학회 2010 대한간암학회지 Vol.10 No.-
Bone metastasis is not uncommon and shows poor survival in patients with hepatocellular carcinoma (HCC). We describe a case of HCC presenting with rib metastasis in a 54-year-old man. In spite of radiotherapy for rib metastasis, pain was sustained and size of lesions were increased. So we performd CT-guided percutaneous ethanol injection therapy (PEIT). Whenever new metastatic bone lesions were detected, we have done PEIT. However, abdominal CT scan at 25th month after diagnosis shows residual viable tumors in pelvic bone and multiple metastatic nodules in both lung. He is alive by taking conservative management for 27 months after diagnosis.
한방화장품이 건강한 성인 여성의 삶의 질에 미치는 영향에 관한 예비 연구
조가영,박효민,권이경,조성아,강병영,김윤범,Cho, Ga-Young,Park, Hyo-Min,Kwon, Lee-Kyung,Cho, Sung-A,Kang, Byung-Young,Kim, Yoon-Bum 대한한방안이비인후피부과학회 2015 한방안이비인후피부과학회지 Vol.28 No.4
Objective : The aim of this study is to assess the effect of Korean Herbal Cosmetic on quality of life (QoL) of Korean Herbal Cosmetics Using Dermatology Life Quality Index (DLQI) stratified by blind versus non-blinded option.Methods : Forty five healthy females aged 30's to 40's were recruited for this study. Volunteers were divided into two groups : Group A (n=22) was provided an anti-aging cream with ginseng extract in the original packaging including the brand name and logo. Group B (n=23) were provided same cream in a plain white normal jar without any package decoration or logo.Results : All females except two volunteers in group A completed a DLQI questionnaire, baseline, after 4 weeks and 8 weeks of treatment. The baseline of DLQI scores of all groups was 3.23±2.72. There was a significant difference in DLQI scores between before, 4 weeks and 8 weeks after in both groups ; The scores changed from 4.25±3.45 to 0.95±1.15 at 4 weeks, 1.00±1.72 at 8 weeks in group A, The scores of group B changed from 2.35±1.47 to 0.83±1.23 at 4 weeks, 0.65±0.98 at 8 weeks. But both had no interaction effect between follow up times and groups. Subscale DLQI scores improved after 4weeks were 'Symptoms and feelings', only in group BConclusions : Both groups showed significant improvements in QoL quality scores evaluated by DLQI. However, interaction was not observed for whether the participants knew the brand and content of the cream.
NaI ( T1 ) 섬광결정과 위치민감형 광전자증배관을 이용한 유방암 진단용 소형 감마카메라 개발
김종호,최용,권홍성,김희중,김상은,최연성,이경한,김문회,주관식,김병태 ( Jong Ho Kim,Yong Choi,Hong Seong Kwon,Hee Joung Kim,Sang Eun Kim,Yearn Seong Choe,Kyung Han Lee,Moon Hae Kim,Koan Sik Joo,Byung Tae Kim ) 대한핵의학회 1998 핵의학 분자영상 Vol.32 No.4
Purpose: The conventional gamma camera is not ideal for scintimammography because of its large detector size ( 500 mm in width) causing high cost and low image quality. We are developing a small gamma camera dedicated for breast imaging. Materils and Methods: The small gamma camera system consists of a NaI (Tl) crystal (60 mm X60 mm X6 mm) coupled with a Hamamatsu R3941 Position Sensitive Photomultiplier Tube (PSPMT), a resister chain circuit, preamplifiers, nuclear instrument modules, an analog to digital converter and a personal computer for control and display. The PSPMT was read out using a standard resistive charge division which multiplexes the 34 cross wire anode channels into 4 signals (X, X, Y, Y ). Those signals were individually amplified by four preamplifers and then, shaped and amplified by amplifiers. The signals were discriminated and digitized via triggering signal and used to localize the position of an event by applying the Anger logic. Results: The intrinsic sensitivity of the system was approximately 8,000 counts/.'ec/pCi. High quality flood and hole mask images were obtained. Breast phantom containing 2-7 mm diameter spheres was successfully imaged with a parallel hole collimator. The image displayed accurate size and activity distribution over the imaging field of view. Conclusion: We have succesfully developed a small gamma camera using NaI(T1)-PSPMT and nuclear instrument modules. The small gamma camera developed in this study might imprnve the diagnostic accuracy of scintimammography by optimally imaging the breast. (Korean J Nucl Med 1998;32:365-73)
박일권,송치원,이경열,권효정,김무강,이강이,정영길,이남섭,하권수,Park, Il-kwon,Song, Chi-won,Lee, Kyung-youl,Kwon, Hyo-jung,Kim, Moo-kang,Lee, Kang-iee,Jeong, Young-gil,Lee, Nam-seob,Ha, Kwon-soo 대한수의학회 2000 大韓獸醫學會誌 Vol.40 No.3
The locus coeruleus(LG) is known to be observed a sexual dimorphism in rat CNS. LC is the largest collections of norepinephrine(NE)-containing neurons in the mammalian brain. Especially in rat, all LC neurons contained NE unlike other mammalians, so that specific reactions were found in the tyrosine-hydroxylase(TH) immunoreactive neurons. Sexual dimorphism of rat LC has affected by genes before sex hormone appeared, thereafter affected by sex hormones. In these day, many scientists founded morphological differences between male and female LC morphology, but differences of entire structure was not founded. Thus we investigated sex differences of the LC neuron's morphology in rat by three-dimensional(3-D) reconstruction using Confocal laser scanning microscopy(CLSM). We reported that neuron's shape was relatively-large multipolar neurons and neuron's processes in dorsal LC proceeded to ventral direction in the male and female rat. Male had a longer anterior-posterior length than female had in dorsal LC. In addition to middle-LC, male rat's LC had a more thicker posterior region but had not viewed in a previous study. In reverse, female rat's LC had a thicker anterior region like a previous study. This results using 3-D reconstruction by CLSM showed that the male's LC was more wide-ranging than female's relatively.
김형수(Hyoung-Soo Kim),권이경(Lee-Kyung Kwon) 한국콘텐츠학회 2013 한국콘텐츠학회논문지 Vol.13 No.6
본 연구는 노인자살증가의 원인을 파악하기 위해 거시적인 측면의 관점에서 노인자살률과 사회·경제적요인의 관련성을 분석하였다. 노인자살의 이론적 배경은 사회학적 관점과 경제학적 관점에 기초하여 설명하였다. 노인자살률의 경제적 요인에는 경제성장률과 실업률 그리고 노인의 경제활동참가율과 상대적 빈곤율(소득불평등율)을 포함하며, 사회적 요인의 범주에 속하는 변수로는 사회복지지출비, 이혼율, 그리고 고령화비 증가율과 노인부양비를 포함한다. 주요 연구결과로는 첫째, 노인의 경제활동참가율이 낮을수록 노인자살률이 높아지는 경향이 있었다. 둘째, 사회복지지출비가 낮을수록 노인자살률이 증가하는 것으로 나타났다. 셋째, 상대적 빈곤율, 고령화비 증가율, 그리고 노인부양비는 공히 이들이 증가할수록 노인자살률도 동시에 증가하는 것으로 나타났다. 끝으로 한국노인자살률의 지속적 증가를 예방하기 위해서 거시적 차원의 사회·경제적 정책방안을 제언하였다. This study analyzed the relationship between elderly suicide rates and socio-economic factors from the macroscopic perspectives. As certain theoretical background of elderly suicide, sociological and economic perspectives are applied. The economic factors of elderly suicide rates consisted of economic growth and unemployment rate, economic activity rate of the aged, and relative poverty rate (income inequality rate). The sociological factors included social welfare spending, divorce rate, growth rate of population aging, and elderly dependency ratio. According to research findings, first, the more economic activity of the aged is low, the more elderly suicide rate is high. Second, the more social welfare spending rate goes flat, the more elderly suicide rate is growing. Third, the more relative poverty rate (income inequality), increasing population aging rate, and elderly dependency ratio are high, elderly suicide rate goes high at the same time. Finally, this study proposed several socio-economic policy alternatives for preventing continuous growth of Korean elderly suicide rate.
Systemic therapy로 부분 반응 이상의 치료 반응을 보인 간세포암종 환장 증례 : 간동맥내 항암약물 주입요법으로 부분 반응 이상의 치료 반응을 보인 간세포암종 환자 1예
박창욱 ( Chang Wook Park ),권영란 ( Young Lan Kwon ),김용진 ( Yong Jin Kim ),김윤정 ( Yoon Jung Kim ),서혜진 ( Hye Jin Seo ),이경인 ( Kyung In Lee ),김은수 ( Eun Soo Kim ),장병국 ( Byung Kook Jang ),정우진 ( Woo Jin Jeong ),박경식 대한간암연구회 2010 대한간암학회지 Vol.10 No.-
Hepatocellular carcinoma (HCC) is one of the cancers with poor prognosis. Especially potal vein invasion is a grave prognostic indicator in the setting of HCC. There is currently no effective method for treatment of HCC with portal vein invasion. A 61-year-old female patient was diagnosed a massive HCCs in both hepatic lobe with portal vein thrombosis, based on computed tomography (CT) and increased tumor marker, α-fetoprotein. She was treated with intrahepatic arterial CDDP (10 mg on 1~5 day), 5-FU (250mg on 1~5 day) and leukovorin (12mg on 1~5 day) infusion via percutaneously implantable port system (PIPS) every 3 weeks, totally seven times. The patient was still living 6 months after first hepatic arterial infusion chemotherapy (HAIC) and follow-up CT showed partial response with necrosis of HCCs. We report here a case of advanced HCC with portal vein thrombosis that was effectively treated with HAIC via PIPS.
조직별 및 나이에 따른 마이토콘드리아 DNA 결손 (${\Delta}mtDNA^{4977}$)의 축적
정혜진,정형민,조성원,김현아,이경술,권황,최동희,곽인평,윤태기,이숙환,Jeong, Hye-Jin,Chung, Hyung-Min,Cho, Sung-Won,Kim, Hyun-Ah,Lee, Kyung-Sool,Kwon, Hwang,Choi, Dong-Hee,Kwak, In-Pyung,Yoon, Tae-Ki,Lee, Sook-Hwan 대한생식의학회 2003 Clinical and Experimental Reproductive Medicine Vol.30 No.3
Objectives: Controversial arguments exists on both the case for and against on the accumulation of mitochondrial DNA (mtDNA) deletion in association to tissue and age. The debate continues as to whether this mutation is a major contributor to the phenotypic expression of aging and common degenerative diseases or simply a clinical insignificant epiphenomenon. The objective of this study was to determine whether the accumulation of mtDNA deletion is correlated with age-related and tissue-specific variation. Materials and Methods: One hundred and fifty-seven tissues from blood, ovary, uterine muscle, and abdominal muscle were obtained from patients ranging in age from 31$\sim$60 years. After reviewing the clinical reports, patients with mitochondrial disorder were excluded from this study. The tissues were obtained at gynecological surgeries with the consent of the patient. Total DNA isolated from blood, ovary, uterine muscle, and abdominal muscle was amplified by two rounds of PCR using two pairs of primers corresponding to positions 8225-8247 (sense), 13551-13574 (antisense) for the area around deleted mtDNA and 8421-8440 (sense), 13520-13501 (antisense) for nested PCR product. A statistical analysis was performed by $x^2$-test. Results: About 0% of blood, 94.8% of ovary, 71.4% of uterine muscle, and 86.1% abdominal muscle harbored mtDNA deletion. When we examined the proportion of deleted mtDNA according to age deletion rate was 90% of ovary, 63.6% of uterine muscle, 77.7% of abdominal muscle in thirties and 100% of all tissue in fifties. Conclusion: The findings of this study suggest that the mtDNA deletion is varied in tissue-specific pattern and increases with aging.