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Cyclic Dipeptides from Lactic Acid Bacteria Inhibit Proliferation of the Influenza A Virus
곽민규,Rui Liu,Jun-Oh Kwon,김민규,Andrew HyoungJin Kim,강사욱 한국미생물학회 2013 The journal of microbiology Vol.51 No.6
We isolated Lactobacillus plantarum LBP-K10 from the traditional Korean fermented food kimchi. When organic acids were removed, the culture filtrate of this isolate showed high antiviral activity (measured using a plaque-forming assay) against the influenza A (H3N2) virus. Two fractions that were active against influenza A virus were purified from the culture filtrate using a C18 column with high-performance liquid chromatography. These active fractions were crystallized and identified to be the cyclic dipeptides cis-cyclo (L-Leu-L-Pro) and cis-cyclo(L-Phe-L-Pro) using gas chromatography-mass spectrometry; this identification was confirmed by X-ray crystallography. These cyclic dipeptides were identified in the culture filtrate of other lactic acid bacteria,including Lactobacillus spp., Leuconostoc spp., Weissella spp.,and Lactococcus lactis.
Cyclic Dipeptides from Lactic Acid Bacteria Inhibit the Proliferation of Pathogenic Fungi
곽민규,Rui Liu,김민규,문도현,김형진,Sung-Hyun Song,강사욱 한국미생물학회 2014 The journal of microbiology Vol.52 No.1
Lactobacillus plantarum LBP-K10 was identified to be the most potent antifungal strain from Korean traditional fermented vegetables. The culture filtrate of this strain showed remarkable antifungal activity against Ganoderma boninense. Five fractions from the culture filtrate were observed to have an inhibitory effect against G. boninense. Also, the electron ionization and chemical ionization indicated that these compounds might be cyclic dipeptides. Of the five active fractions,two fractions showed the most significant anti-Ganoderma activity, and one of these fractions inhibited the growth of Candida albicans. These compounds were identified to be cis-cyclo(L-Val-L-Pro) and cis-cyclo(L-Phe-L-Pro), as confirmed by X-ray crystallography.
성문암에서 레이저 성대절제술 후의 음성 및 삶의 질 평가
곽민규,지용배,윤보람,송창면,김경래,태경 대한이비인후과학회 2014 대한이비인후과학회지 두경부외과학 Vol.57 No.6
Background and Objectives Laser cordectomy is considered one of the best techniques for the treatment of early stage glottic cancer. But voice outcome and quality of life (QOL) after laser cordectomy is controversial. The aim of this study is to evaluate the voice outcome after laser cordectomy in glottic cancer and its association to QOL. Subjects and Method 43 patients who underwent laser cordectomy from January 2002 to December 2008 were enrolled in this study. We evaluated the objective and subjective voice outcomes using acoustic analysis, aerodynamic study and voice handicap index (VHI). We also assessed QOL using EORTC QLQ-C30/H&N35 questionnaire. We compared the voice outcome according to the type of laser cordectomy and analyzed correlation between voice outcome and QOL. Results Harmonic to noise ratio, maximum phonation time and VHI of patients treated with Types I, II cordectomy was significantly improved after operation. Functional VHI after Types I, II cordectomy was significantly lower than Types III-VI cordectomy. The postoperative QOL score of glottic cancer patients were not statistically different between Type I, II and Type III-VI cordectomy. QOL score had a positive correlation with postoperative VHI. Conclusion Objective and subjective voice outcomes after laser cordectomy showed favorable results, especially in patients who were treated with Types I, II laser cordectomy. QOL scores were correlated with VHI scores, but not with acoustic parameters. Korean J Otorhinolaryngol-Head Neck Surg 2014;57(6):390-5
A Case of Otogenic Brain Abscess Causing Loss of Consciousness
곽민규,정재호,이승환,박철원 대한청각학회 2014 Journal of Audiology & Otology Vol.18 No.2
Acute or chronic otitis media can cause intracranial complications, one of the most serious being brain abscess. Empirical antibiotic treatment and proper surgical management should be considered to avoid fatal consequences. However, proper extent and optimal timing of surgical intervention are still matters of debate. We present a case of a 31-year-old man who presented with acutely altered mental status, caused by otogenic brain abscess who we treated successfully with antibiotics and otologic surgery and no neurosurgical treatment.
곽민규,정재호,박철원,김경래,김선욱,이승환 대한이비인후과학회 2015 대한이비인후과학회지 두경부외과학 Vol.58 No.6
Background and Objectives Cochlear microphonic (CM) is an electrical potential generated by outer hair cells in response to acoustic stimulation. The aim of this study is to evaluate the significance of CM in neonatal hearing loss. Subjects and Method From April 2013 to April 2014, 64 neonates hospitalized in neonatal intensive care unit were enrolled. Subjects underwent transient evoked otoacoustic emission (TEOAE), auditory brain stem response (ABR) and CM. We analyzed the results of hearing tests and the correlation between CM and the other test modalities. Results Ninety two ears showed normal ABR waves whereas the other 36 ears had abnormal ABR. There were two neonates who were suspected of auditory neuropathy because of the presence of TEOAE and CM. Among 14 ears who showed abnormal OAE results, 12 ears (86%) were identified as having CM. The amplitudes of CMs were correlated with the reproducibility of TEOAE (p<0.005). Between the ears with positive TEOAE and others with negative TEOAE, the amplitudes of CMs were significantly different (p<0.005). Conclusion Many ears were identified with the presence of CM without TEOAE response because of the the vulnerability of OAE from middle ear status and environment. We suppose that CM might provide information on outer hair cell function to complement the OAE in neonatal hearing test.
곽민규,정연주,이지원,이남경,최정현,이지원 대한영상의학회 2016 대한영상의학회지 Vol.75 No.1
Coronary artery variations are associated anomalies in 45% of congenitally corrected transposition of the great arteries (ccTGA) cases, and it is important to detect any coronary artery anomalies before cardiac surgery. We report a case of a 51-year-old woman with ccTGA and an unreported type of coronary artery anomaly.
Gut-Brain Connection: Microbiome, Gut Barrier, and Environmental Sensors
곽민규,장선영 대한면역학회 2021 Immune Network Vol.21 No.3
The gut is an important organ with digestive and immune regulatory function which consistently harbors microbiome ecosystem. The gut microbiome cooperates with the host to regulate the development and function of the immune, metabolic, and nervous systems. It can influence disease processes in the gut as well as extra-intestinal organs, including the brain. The gut closely connects with the central nervous system through dynamic bidirectional communication along the gut-brain axis. The connection between gut environment and brain may affect host mood and behaviors. Disruptions in microbial communities have been implicated in several neurological disorders. A link between the gut microbiota and the brain has long been described, but recent studies have started to reveal the underlying mechanism of the impact of the gut microbiota and gut barrier integrity on the brain and behavior. Here, we summarized the gut barrier environment and the 4 main gut-brain axis pathways. We focused on the important function of gut barrier on neurological diseases such as stress responses and ischemic stroke. Finally, we described the impact of representative environmental sensors generated by gut bacteria on acute neurological disease via the gut-brain axis.