http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
곽동호(Dong Ho Kwak),이상한(Sang Han Lee),김정희(Chung Hee Kim) 대한구강악안면외과학회 1997 대한구강악안면외과학회지 Vol.23 No.3
The cell cycle is composed of G1, S, G2 and M phase. The transitions between different phases are regulated at checkpoint such as Start(restriction), S phase and mitotic checkpoint. These checkpoints are regulated by specific cyclins and Cdks(cyclin-dependent kinases). Especially, Start checkpoint in late G1 is though to be very important in control of cell cycle. In this study, it was shown various CDKN2(p16ink4A) alteration, including deletions, mutations, down regulations, and performed differential expression of p53, Cdk4, PCNA and pRb in stomach cancer tissues. 1. The frequency of CDKN2 mutations was not observed in the 19 primary stomach cancer tissues. In contrast to the mutations of CDKN2, mRNA levels was showed by Northern blot analysis that expression of CDKN2 was absent or decreased in 10 of the 19(53%) primary stomach adenocarcinoma. Western blot analysis was performed to determine the differential expression of p53, Cdk4, PCNA related to Start checkpoint. Overexpression of p53 was shown 38%, Cdk4 was expressed in all each specimens, and expression of PCNA was not shown. 2. As the other method to determine the differential expression of p53, Cdk4, PCNA and pRb, immunohistochemical analyses were performed on each 14 formalin-fixed and paraffin embedded tumor tissues of stomach adenocarcinoma. p53 overexpression was showed to clear nuclear staining only in tumor cells not in nonneoplastic cells. In staining for cdk4, the tumor was considered to be cdk4 positive if there was nuclear staining in tumor cells, regardless of cytoplasmic staining. PCNA staining for carcinoma tissues showed more intense nuclear staining in tumor cells than in nonneoplastic cells. pRb overexpression was show in tumor cells. Significant differences were observed in the expression of the proteins among the cancers from different anatomic site. Overexpression of adenocarcinomas had high rate of p53(57.1%) and pRb(71.4%), and low late of cdk4(7.1%) and PCNA(14.3%). As these results, deletion of CDKN2 gene in human stomach cancer was not observed but mRNA expression was down regulated in restriction checkpoint, G1 phase. Inactivation of the CDKN2 gene due to hypermethylation may play an important role in development of cancer. And one of the abnormalities in p53, Cdk4, PCNA or pRb function occurs very common in various cancers, especially oral adenocarcinoma, osteosarcoma and squemous cell carcinoma, suggest that components in restriction checkpoint also play an critical role in the carcinogenesis and progression of cancers.
이지용(Ji-yong Lee),곽동호(Dong-ho Kwak),정병준(Byung-jun Jung),김종명(Jong-myung Kim) 한국자동차공학회 2010 한국자동차공학회 학술대회 및 전시회 Vol.2010 No.11
Commonly aluminum alloy is a cheap price, has beautiful appearance. So aluminum alloy is used a lot in the car parts. But external environmental factors occur white-Rust problems and diminish in value of commodities. This research identify aluminum corrosion factors of white-rust, develop White-Rust reduction technology.
곽동호 慶北大學校 醫科大學 1997 慶北齒大論文集 Vol.14 No.-
the cell cycle is composed of g1, s, g2 and m phase. the transitions between different phases are regulated at checkpoint such as start(restriction), s phase and mitotic checkpoint. these checkpoints are regulated by specific cyclins and cdks(cyclin-dependent kinases). especially, start checkpoint in late g1 is though to be very important in control of cell cycle. in this study, it was shown various cdkn(p16ink4a) alteration, including deletions, mutations, down regulations, and performed differential expression of p53, cdk4, pcna and prb in stomach cancer tissues. 1. the frequency of cdkn2 mutations was not observed in the 19 primary shomach cancer tissues. in contrast to the mutations of cdkn2, mrna levels was showed by northern blot analysis that expression of cdkn2 was absent or decreased in 10 of the 19(53%) primary stomach adenocarcinoma. western blot analysis was performed to determine the differential expression of p53, cdk4, pcna related to start checkpoint. overexpression of p53 was shown 38%, cdk4 was expressed in all each specimens, and expression of pcna was not shown. 2. as the other method to determine the differential expression of p53, cdk4, pcna and prb, immunohistochemical analyses were performed on each 14 formalin-fixed and paraffin embedded tumor tissues of stomach adenocarcinoma. p53 overexpression was showed to clear nuclear staining only in tumor cells not in nonneoplastic cells. in staining for cdk4, the tumor was considered to be cdk4 positive if there was nuclear staining in tumor cells, regardless of cytoplasmic staining. pcna staining for carcinoma tissues showed more intense nuclear staining in tumor cells than in nonneoplastic cells. prb overexpression was show in tumor cells. significant differences were observed in the expression of the proteins among the cancers from different anatomic site. overexpression of adenocarcinomas had high rate of p53(57.1%) and prb(71.4%), and low late of cdk4(7,1%) and pcna(14.3%). as these results, deletion of cdkn2 gene in human stomach cancer was not observed but mrna expression was down regulated in restriction checkpoint, g1 phase. inactivation of the cdkn2 gene due to hypermethylation may play an important role in development of cancer. and one of the abnormalities in p53, cdk4, pcna or prb function occurs very common in various cancers, especially oral adenocarcinoma, osteosarcoma and squemous cell carcinogenesis and progression of cancers.
변종수,곽동호 慶北大學校 齒科大學 1987 慶北齒大論文集 Vol.4 No.1
This is a staticstical analysis of outpatients in our dept. from 1986.1.1. to 1986. 12. 31. We analyzed the patients by the sex,age, disease,causes of fracture of facial bones. Particularly, we obtained the rate of the patient of the medical insurance. The results were as follows; 1. The sex ratio was 5.7:4.3 (M:F) 2. Among the total 3,239 cases of the patients, the smiple extraction was 25.41%, surgical extraction was 14.28%, inflammatory disease was 6.73%. cyst was 2.22%, fracture of the facial lone was 1.20% and tumor was 0.96%. 3. The august showed the highest visit ratio in the years. 4. Medical insurance was 65.99%, general patient 2.00%, and industrial accident insurance was 0.65%. 5. The major etiologic factor of the facial bone fracture was fights (38.5%), industrial accident(3%) in orders.
김대성,허광선,권민수,곽동호,원충상 忠州大學校 2010 한국교통대학교 논문집 Vol.45 No.-
There are various ways to operate traffic light system by varying the operational speed of the system. One of the solutions is to vary the length of the clock cycle of the system. It is difficult to vary the length of the signal in systems by varying the period of the clock cycle and nor it is a generalized technology in the current traffic systems. The traffic signal systems of the past used is simply a repetitive traffic signal system which traffic period is consistent, not considering the conditions of traffics. The system that will be introduced in this thesis could substantially improve efficiency of traffic flows by varying the length of traffic signal period with sensors which detect the presence of vehicles on both directions and allows the signal continuously on the direction where there are more waiting vehicles, and even skips the signal where there is no vehicle waiting. In this thesis, it introduces the methodology of detecting the spots that is detected by the sensors of the system and outputs green light in due order in accordance with the priority given to the system. In the meanwhile, the ratio of yellow light and green light is designed to be 1 to 8 in the way that maximizes the efficiency of traffic flows.