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황토의 식이 내 첨가에 의한 돼지의 생리적 특성과 등급판정에 미치는 영향
오홍근,최용식,오영열,박상훈,이학용,문대인,한주희,신은혜,이봉근,박영미,강양규,김옥진,박광현,채수완 한국유기농업학회 2014 韓國有機農業學會誌 Vol.22 No.2
본 연구의 목적은 황토의 식이 첨가에 의한 돼지의 성장 특성과 혈중 조성물의 변화를 규명하는 것이다. 총 153마리의 돼지(1주령 자돈 60마리 및 성돈 93마리)를 공시하였다. 자돈군은 일반사료 식이군, 0.5% 황토 + 일반사료 식이군, 1% 황토 + 일반사료 식이군으로 무작위로 3군으로 재배치하였다. 각 군간 증체량을 비교하였을 때 1% 황토가 포함된 사료를 식이한 군에서 일반사료와 0.5% 황토 + 일반사료 투여군에 비해 체중 증가가 관찰되었으나 통계적으로 유의하지는 않았다. 혈액학적 분석을 실시한 결과, 총 백혈구 수, 총 적혈구 수, 헤모글로빈 수, 혈액 중 혈구용적율, 평균 세포용적율, 평균 세포 내 헤모글로빈량, 평균 세포 내 헤모글로빈 농도, 평균 적혈구 폭, 혈소판 수치 등에서 각 군간의 유의한 차이가 없음을 확인하였다. 성돈군은 일반사료 식이군과 1% 황토 + 일반사료 식이군으로 구분하였으며, 혈청학적 분석에서 혈청 알부민의 농도는 1% 황토 + 일반사료 투여군에서 다른 군에 비하여 유의하게 증가하여 있는 것을 확인하였으나(p<0.01), 다른 지표들에서는 유의한 차이를 발견할 수 없었다. 황토가 포함된 사료를 투여한 군에서 획득한 분변의 조지방 함량은 다른 군에 비하여 유의하게 감소하는 것을 확인하였으며(p<0.001), 조단백 함량 및 조회분 함량은 유의한 차이를 보이지 않았다. 도체의 무게와 등지방 두께의 측정 결과 각 군간의 유의한 차이는 발견할 수 없었으나, 도체의 등급 판정 결과 황토를 투여한 군의 도체 등급은 비투여군에 비해 유의하게 등급이 향상된 것을 확인하였다. 이러한 결과는 황토의 식이 첨가는 돼지의 영양소 흡수를 개선시킴으로서 도체의 등급을 향상시키는 것을 확인하였다. This study was conducted to examined the effect of dietary supplementation of yellow loess on the growth performance and blood component profiles in pigs. A total of one hundred fifty three pigs (60 one weeks old piglets and 93 adult pigs). Piglets were randomly divided into 3 groups which were control, control + 0.5% yellow loess, control + 1% yellow loess. We measured body weight and weight gain among treatment group. Indeed, we obtained hematological data with WBC, RBC, Hb , Hct, MCV, MCH, MCHC, RDW, and PLT in all loess supplemented group compared to the control. Adults were divided into 2 group (control and control + 1% yellow loess) and serum albumin levels in 1% yellow loess supplemented group was significantly higher than the control group (p<0.01). Amount of crude fat in feces was significantly reduced in yellow loess supplemented group (p<0.001), but no differences were observed at crude protein and crude ash in both groups. In carcass weight and back fat thickness, no significant differences were observed between control and yellow loess supplemented groups. The carcass grade was improved by the dietary supplementation of yellow loess compared to the pig fed control. As a results, dietary yellow loess improves nutrient absorption and carcass grade.
고지방식이에 의한 비만 동물모델에서 유산균 마분말의 항비만 효과
박영미,오홍근,강양규,김영필,신홍식,장승환,김희정,이상왕,이학용 한의병리학회 2015 동의생리병리학회지 Vol.29 No.3
The purpose of this study was to examine the antiobesity effects of lactic acid bacteria-fermented Dioscoreae Rhizoma powder (LDR) in Sprague-Dawley rats with high-fat diet (HFD)-induced obesity. Rats were divided into 5 groups: normal diet group, control (high fat diet-vehicle) group, 0.4 g/kg LDR (high fat diet + 0.4 g/kg lactic acid bacteria-fermented Dioscoreae Rhizoma powder) group, 1 g/kg LDR (high fat diet + lactic acid bacteria-fermented Dioscoreae Rhizoma powder) group, 2.5g/kg LDR (high fat diet + lactic acid bacteria-fermented Dioscoreae Rhizoma powder) group. Our results indicate that LDR administration has effects on decreasing of body weight, fat weight, blood parameters and adipocyte size in the obesity animals. In addition, verified that fat degeneration and ballooning degeneration were alleviated in the experimental group fed on a high fat diet combined with LDR groups. These results indicate that lactic acid bacteria-fermented Dioscoreae Rhizoma powder may reduce elevating body weight and lipid accumulation in rat fed a high fat diet, suggesting its usefulness as a functional food for reducing body fat and obesity.
박영미,이봉건,박상훈,오홍근,강양규,김옥진,권이성,김용필,최민휴,정용섭,오지선,이학용 한국실험동물학회 2015 Laboratory Animal Research Vol.31 No.2
Gastrodia elata (GE) is traditionally used for treatment of various disorders including neurodegenerative diseases such as Alzheimer’s disease. To investigate the neuroprotective effect of GE, amyloid-β peptide (Aβ)-treated PC12 cells were cultured with GE aqueous extract. In vitro assay demonstrated that 50 μM of pre-aggregated Aβ was lethal to about a half portion of PC12 cells and that Aβ aggregate-induced cell death was significantly decreased with GE treatment at ≤10 mg/mL in a dose-dependent manner. To further examine in vivo cognitive-improving effects, an artificial amnesic animal model, scopolamineinjected Sprague-Dawley rats, were orally administered the extract for 6 weeks followed by behavioral tests (the passive avoidance test and Morris water maze test). The results showed that an acute treatment with scopolamine (1 mg/kg of body weight) effectively induced memory impairment in normal rats and that the learning and memory capability of scopolamine-treated rats improved after prolonged administration of GE extract (50, 250 and 500 mg/kg of body weight for 6 weeks). These findings suggest that a GE regimen may potentially ameliorate learning and memory deficits and/or cognitive impairments caused by neuronal cell death.
Improving Effects of Brassica oleracea L. var. italica Sprout Extract on Alcoholic Liver Dysfunction
김민정,양혜정,이학용,박영미,신동엽,이양희,강양규,김태수,이성표,박광현 한국자원식물학회 2020 한국자원식물학회지 Vol.33 No.3
Alcoholic fatty liver disorder has become a frequent health concern worldwide. To investigate the effects ofBrassica oleracea (B. oleracea) sprout extract (BOE), the present study was designed with alcoholic fatty liver in the rat. Initially, the effects of BOE on liver parameters were examined. Male rats were divided into five groups. The normal controlgroup was fed the normal diet, and the BOE group was fed the high fat diet and ethanol with/without BOE for 4 weeks. After4 weeks feeding period, rats were sacrificed and their livers and blood were used for fatty liver-related biomarkers analyses. As a result, BOE ameliorated fatty liver-related enzymes profiles in liver tissues and also reduced blood alcoholconcentration in rat model. We demonstrated that BOE protected the high fat diet and alcohol-induced fatty liver in ratmodel. Furthermore, BOE increased detoxificative abilities against alcohol.
황토의 식이 내 첨가에 의한 돼지의 생리적 특성과 등급판정에 미치는 영향
오홍근,최용식,오영열,박상훈,이학용,문대인,한주희,신은혜,이봉근,박영미,강양규,김옥진,박광현,채수완,Oh, Hong-Geun,Chol, Yong-Sik,Oh, Young-Youl,Park, Sang-Hoon,Lee, Hak-Yong,Moon, Dae-In,Han, Ju-Hee,Shin, Eun-Hye,Lee, Bong-Gun,Park, Young-Mi,Ga 한국유기농업학회 2014 韓國有機農業學會誌 Vol.22 No.2
본 연구의 목적은 황토의 식이 첨가에 의한 돼지의 성장 특성과 혈중 조성물의 변화를 규명하는 것이다. 총 153마리의 돼지(1주령 자돈 60마리 및 성돈 93마리)를 공시하였다. 자돈군은 일반사료 식이군, 0.5% 황토 + 일반사료 식이군, 1% 황토 + 일반사료 식이군으로 무작위로 3군으로 재배치하였다. 각 군간 증체량을 비교하였을 때 1% 황토가 포함된 사료를 식이한 군에서 일반사료와 0.5% 황토 + 일반사료 투여군에 비해 체중 증가가 관찰되었으나 통계적으로 유의하지는 않았다. 혈액학적 분석을 실시한 결과, 총 백혈구 수, 총 적혈구 수, 헤모글로빈 수, 혈액 중 혈구용적율, 평균 세포용적율, 평균 세포 내 헤모글로빈량, 평균 세포 내 헤모글로빈 농도, 평균 적혈구 폭, 혈소판 수치 등에서 각 군간의 유의한 차이가 없음을 확인하였다. 성돈군은 일반사료 식이군과 1% 황토 + 일반사료 식이군으로 구분하였으며, 혈청학적 분석에서 혈청 알부민의 농도는 1% 황토 + 일반사료 투여군에서 다른 군에 비하여 유의하게 증가하여 있는 것을 확인하였으나(p<0.01), 다른 지표들에서는 유의한 차이를 발견할 수 없었다. 황토가 포함된 사료를 투여한 군에서 획득한 분변의 조지방 함량은 다른 군에 비하여 유의하게 감소하는 것을 확인하였으며(p<0.001), 조단백 함량 및 조회분 함량은 유의한 차이를 보이지 않았다. 도체의 무게와 등지방 두께의 측정 결과 각 군간의 유의한 차이는 발견할 수 없었으나, 도체의 등급 판정 결과 황토를 투여한 군의 도체 등급은 비투여군에 비해 유의하게 등급이 향상된 것을 확인하였다. 이러한 결과는 황토의 식이 첨가는 돼지의 영양소 흡수를 개선시킴으로서 도체의 등급을 향상시키는 것을 확인하였다. This study was conducted to examined the effect of dietary supplementation of yellow loess on the growth performance and blood component profiles in pigs. A total of one hundred fifty three pigs (60 one weeks old piglets and 93 adult pigs). Piglets were randomly divided into 3 groups which were control, control + 0.5% yellow loess, control + 1% yellow loess. We measured body weight and weight gain among treatment group. Indeed, we obtained hematological data with WBC, RBC, Hb, Hct, MCV, MCH, MCHC, RDW, and PLT in all loess supplemented group compared to the control. Adults were divided into 2 group (control and control + 1% yellow loess) and serum albumin levels in 1% yellow loess supplemented group was significantly higher than the control group (p<0.01). Amount of crude fat in feces was significantly reduced in yellow loess supplemented group (p<0.001), but no differences were observed at crude protein and crude ash in both groups. In carcass weight and back fat thickness, no significant differences were observed between control and yellow loess supplemented groups. The carcass grade was improved by the dietary supplementation of yellow loess compared to the pig fed control. As a results, dietary yellow loess improves nutrient absorption and carcass grade.
고지방식이에 의한 비만 동물모델에서 유산균 마분말의 항비만 효과
박영미(Young Mi Park),오홍근(Hong Geun Oh),강양규(Yang Gyu Kang),김영필(Young Pill Kim),신홍식(Hong Sig Sin),장승환(Seung Hwan Jang),김희정(Hee Jeong Kim),이상왕(Sang Wang Lee),이학용(Hak Yong Lee) 한의병리학회 2015 동의생리병리학회지 Vol.22 No.2
The purpose of this study was to examine the antiobesity effects of lactic acid bacteria-fermented Dioscoreae Rhizoma powder (LDR) in Sprague-Dawley rats with high-fat diet (HFD)-induced obesity. Rats were divided into 5 groups: normal diet group, control (high fat diet-vehicle) group, 0.4 g/kg LDR (high fat diet + 0.4 g/kg lactic acid bacteria-fermented Dioscoreae Rhizoma powder) group, 1 g/kg LDR (high fat diet + lactic acid bacteria-fermented Dioscoreae Rhizoma powder) group, 2.5g/kg LDR (high fat diet + lactic acid bacteria-fermented Dioscoreae Rhizoma powder) group. Our results indicate that LDR administration has effects on decreasing of body weight, fat weight, blood parameters and adipocyte size in the obesity animals. In addition, verified that fat degeneration and ballooning degeneration were alleviated in the experimental group fed on a high fat diet combined with LDR groups. These results indicate that lactic acid bacteria-fermented Dioscoreae Rhizoma powder may reduce elevating body weight and lipid accumulation in rat fed a high fat diet, suggesting its usefulness as a functional food for reducing body fat and obesity.
오홍근(Hong-Geun Oh),문대인(Dae-In Moon),김정훈(Jung-Hoon Kim),강영례(Young-Rye Kang),박정우(Jung-Woo Park),서민영(Min-Young Seo),박상훈(Sang-Hoon Park),강양규(Yang-Gyu Kang),최충현(Chung-Hyeon Choe),박인선(In-Sun Park),김주(Ju Kim) 한국식품영양과학회 2012 한국식품영양과학회지 Vol.41 No.5
이 연구에서는 SD rat과 Mongolian gerbil에서 실험적으로 HCl-ethanol(150 mM HCl+60% ethanol)을 투여하여 급성 위염을 유발하고, H. pylori 감염시켜 만성 위염, 위궤양을 유발한 후, 건해삼을 투여하여 건해삼에 의한 항위염, 항위궤양 효과 및 H. pylori 감염 경향성 및 치료율을 검토하였던바 다음과 같은 결과를 얻었다. 7주령 SD rats와 H. pylori에 감염시킨 7주령 Mogolian gerbils를 정상군(Nor, n=6)과 대조군(Con, 60% HCl-ethanol+증류수(vehicle), n=6)에 비하여 실험군 Ⅰ(DSD Ⅰ, 60% HCl-ethanol+건해삼 30 ㎎/㎏, n=6), 실험군 Ⅱ(DSD Ⅱ, 60% HCl-ethanol+건해삼 100 ㎎/㎏, n=6), 실험군 Ⅲ(DSD Ⅲ, 60% HCl-ethanol+건해삼 300 ㎎/㎏, n=6)에서는 건해삼 투여 용량에 따른 항위염, 항위궤양 및 항헬리코박터 효과를 육안적 소견, CLO test 및 병리조직학적 검사를 통해 확인할 수 있었다. 이상의 결과를 종합해볼 때 건해삼이 새로운 위염 및 위손상 치료제와 기능성식품의 개발에 활용할 수 있음을 확인하였다. Sea cucumber, Stichopus japonicus, is used not only as an outstanding tonic food but also as a traditional medicine for the treatment of asthma, hypertension, rheumatism, anemia, and sinus congestion. The purpose of this study was to examine sea cucumber as an anti-gastritis and anti-gastric ulcer in HCl-ethanol-induced gastric and H. pylori-infected animal models. Thirty 7-week-old SD rats and Mongolian gerbils were divided into normal (Nor, n=6), control (Con, 60% HCl-ethanol+water, n=6), groupⅠ (DSCⅠ, 60% HCl-ethanol+sea cucumber 30 ㎎/㎏, n=6), groupⅡ (DSCⅡ, 60% HCl-ethanol+sea cucumber 100 ㎎/㎏, n=6), and group Ⅲ (DSCⅢ, 60% HCl-ethanol+sea cucumber 300 ㎎/㎏, n=6). Sea cucumber significantly suppressed gastric lesions and ulcers in the 60% HCl-ethanol-induced gastric model. Especially, 100 ㎎/kg of sea cucumber showed significantly inhibitory effects. In histopathological analysis of the H. pylori model, we found that sea cucumber augmented the eradication rates of H. pylori and attenuated gastric ulcer formation. Our results suggest that sea cucumber has inhibitory effects on gastritis and gastric ulcers. In addition, sea cucumber can be applied for the treatment of H. pylori.