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김종세,김정상,윤중식,최영복,조광필,김재성,정수만,Kim, Jong-Se,Kim, Jeong-Sang,Yoon, Jung-Sik,Choi, Young-Bok,Cho, Kwang-Phil,Kim, Jae-Sung,Chung, Su-Man 한국현미경학회 1999 Applied microscopy Vol.29 No.2
본 실험은 화상을 입은 생쥐에서 SQ의 치유 효과를 알아보기 위함에 있다. 실험군은 7개군으로 구분하였다; 대조군, 화상군, 그리고 화상을 입헌 후 SQ를 처치한 군. 대조군을 제외한 모든 군은 등 부위에 2도 화상을 입혔다. SQ를 처치한 모든 군은 하루에 한 번씩 10초 간격으로 순수한 SQ 3방울을 도포하였다. 화상 후 10일 동안 조직학적 및 미세구조적 변화를 광학 현미경과 전자현미경으로 관찰하였다. 광학현미경으로 관찰한 결과, 화상군의 표피층의 모든 부분은 SQ를 처치한 군보다 더 심한 상처를 입었다. SQ를 처치한 6째와 10일째 군에서, 기저층은 분화가 활발하였고, 가시층의 각화세포는 수적으로 매우 증가하였다. 전자현미경으로 관찰한 결과, SQ를 처치한 모든 군의 기저층에서 세포분열이 화상군에서보다 더 활발하게 나타났다. 특히, SQ를 처치한 10일군에서는 이상적인 결과를 얻을 수 있었다; 대조군보다 더 두꺼운 가시층과 많은 각화세포, 뚜렷한 세포간교, 그리고 멜라닌세포를 포함하는 튼튼한 기저층. 이와 같은 결과로 보아 SQ은 표피성장인자(EGF)를 활성화시키고, 유해산소의 제거 역할을 하며, 막계에 에너지원을 제공할 가능성이 있다. 이 실험의 결과는 SQ가 화상 치료에 특수한 효과가 있다고 사료된다. The purpose of this experiment was to know the healing effects of saualene on the burned mouses. The experimental groups were divided into seven groups: the control group, the burned groups, and 50 treated groups after burned. All groups except the control group burned with second degree on a dorsoanterior part. All groups that treated with 50 adapted three drops of pure squalene at 10 seconds interval; one time a day. The histological and ultrastructural changes during 10 days after burned were observed by light and electron microscope. Under the light microscope, all parts of epidermal layer of the burned groups were wounded deeper than the 50 treated groups. At 6 and 10 days groups with 50 treated, especially 10 days, the basal layer was greatly differentiated, and the prickle cells in the spinous layer were greatly increased in number. Under the electron microscope, the cell divisions of basal layer in all groups that treated with 50 were more activated and rapidly regenerated than the all burned groups. Especially, some fantastic results obtained from the 10 days group with SQ treated; much thicker spinous layer than the control group, many prickle cells, fine intercellular bridges, and healthy basal layer contained melanocytes. These results suggest that squalene may active the epidermis growth factor (EGF), acts as scavenger, and provide sources of energy in the membrane system. The results of this experiment consider that squalene has specific effects for burn healing and regeneration.
5-Fluorouracil이 생쥐의 간에 미치는 세포독성에 대한 Squalene의 영향
김정상,김재성,박정석,최완수,최영복,김종세,Kim, Jeong-Sang,Kim, Jae-Sung,Park, Jung-Suk,Choi, Wan-Soo,Choi, Young-Bok,Kim, Jong-Se 한국현미경학회 1997 Applied microscopy Vol.27 No.2
This paper aims to prove the effects of Squalene (SQ) on the cellular toxicity of 5-FU to the mouse which pretreated with SQ and then treated with 5-FU. The results of the group A (treated with only 5-FU) are as follows. The nucleus was destroyed at 24 hours and 48 hours group, however, somewhat repaired at 72 hours group. The dilated inner cavity and the irregular lamellae of the rough surfaced endoplasmic reticulum (RER) were observed continually until 72 hours group. The inner cavity of the smooth surfaced endoplasmic reticulum (SER) were dilated in all groups. However, the destroyed and the normal membrane were observed simultaneously at 72 hours group. The inner membrane of the mitochondria were almost repaired at 96 hours group. The results of the group B (treated with 5-FU and squalene) are as follows. The nucleus was a little influenced by the toxicity of 5-FU at 24 hours and 48 hours, RER were observed to keep the typical lamella structure of cisternae from 24 to 72 hours group, but inner cavity kept on dilating. In SER, inner cavity were also observed to flatten from 24 to 72 hours group. Mitochnodria were always shown normal. All cell organelles were simillar to those of normal groups at 96 hours. Accordingly, it can be said that the treatment of 50 prevents the cytotoxicity of 5-FU on cell organelles of liver cell and that is concerned with the formation of membrane system of cell organelles.
사우디아라비아의 통치기본법에 나타난 종교적 정체성과 세속적 정체성
정상률(Jung, Sang-Ryul),안정국(Ahn, Jung-Kook),박현도(Park, Hyondo),김종도(Kim, Jong-Do) 명지대학교 중동문제연구소 2011 중동문제연구 Vol.10 No.2
Generally speaking, the basic law of government or the constitution manifests political, economic and social and cultural identities of a nation-state and is put on a higher plane than any law in the legal system. Thus, an analysis of it is the first step towards understanding political, economic and social and cultural identities, as well as the aspects of people’s lives, of a nation-state. Religious and secular identities are both in harmony and tension with each other in the basic law of government (or the constitution) of the nation-states in the Middle Eastern Arab-Islamic region. In order to fathom national identities in the basic law of government (or the constitution) in the region, this paper attempts to analyze the Basic Law of Government of the Kingdom of Saudi Arabia. In so doing, it endeavors to understand how Islamic shar‘ī principles are reflected in the Kingdom’s Basic Law of Government, and how they regulate the people of the Kingdom.
뇌좌상(腦挫傷)에 단삼(丹蔘), 홍화(紅花), 석창포(石菖蒲)가 미치는 영향(影響)
김행진,전상윤,김정상,김경수,홍석,Kim Haeng-Jin,Jeon Sang-Yun,Kim Jung-Sang,Kim Kyoung-Soo,Hong Seok 대한한의학방제학회 2003 大韓韓醫學方劑學會誌 Vol.11 No.2
This study was done to investigate effects of SR, CF and AR to angiogenesis of cerebral tissues, protecting damage of cerebral neurons and activating them in cerebral contusion-induced rats. I observed these conclusions as follows ; 1. Observation of VEGF-immunoreactive cells : Groups of administered AR were not meaningful in increasing VEGF-immunoreactive cells for 3 days and 7 days, groups of administered SR meaningfully increased them to control groups in all groups, and groups of administered CF meaningfully increased them to control groups in all groups, too, interestingly, increased double to control group for 7 days. 2. Observation on cerebral neurons by Cresyl violet stain : Dendrites and axons of groups of administered SR, AR for 3 days were clearly observed to control group. Cerebral neurons of groups of administered CF for 3days and 7 days were increased a little, but were not meaningful. In conclusion, AR will be careful of being used in cerebral contusion. CF and SR were effective to activating cerebral hemokinesis by inducing angiogenesis in trauma of tissue, but weakly to protecting trauma of cerebral neurons and activating them. I think more studies will be done in these facts.