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폐경기전후 한국 여성의 비타민 - D 수용체 유전자의 Restriction Fragment Length Polymorphisms 과 골밀도 및 골표지자와의 관계에 대한 고찰
김극배,한인권,서교일,변동원,김상우,유명희,문인걸 대한내분비학회 1995 Endocrinology and metabolism Vol.10 No.3
Osteoporosis is now a major health problem because of the increasing elderly population and related osteoporosis fractures. Recently, it has been suggested that lower bone mass with/and high bone turnover rate is considered to be important in the developing of osteoporosis, and so there has been many efforts to identify the risk factors which is considered to cause lower bone mass and high bone turnover. Osteocalcin, the most abundant noncollagenous protein in bone, is a marker of bone turnover and its synthesis is induced by calcitriol(the active form of vitamine-D) through the vitamine-D receptor(VDR) and a specific vitamine D-responsive element in the osteocalcin gene promoter. Serum concentrations of osteocalcin are under the strong genetic influences and may reflect allelic variation in VDR gene. Therefore, the present study were designed to find the relationships among the polymorphisms of Vitamine-D receptor gene, bone mineral density and bone markers. We analysed the restriction fragment length polymorphisms of VDR gene with Bsm I endonuclease enzyme in relation to bone mineral density by using DEXA(dual energy X-ray absorptiometry, QDR-2000) and bone markers, especially serum osteocalcin concentrations in 356 pre- and postmenopausal Korean women. The frequence of RFLPs of VDR gene is 3.3% in BB type, 10.1% in Bb type, 86.6% in bb type. The concentrations of osteocalcin, alkaline phosphatase, procollagen-C and urinary deoxypyridinoline/creatinine were found to be higher in postmenopausal than premenopausal women and the levels of BMD were lower in postmenopausal than premenopausal women. The BB type, which is known to have a strong genetic determinant, is less frequently encountered in Korean women and does not correlate with levels of bone markers and bone mineral density. Even though the number of women with BB type is small, we noted the mean serum level of each bone marker was greater in postmenopausal women with BB type than in premenopausal women with the same genotype. In conclusion, this may suggest a partial agreement of our data with that of Australlian group and that we have to try to find out another genotype specifically related with lower bone density in Korean women(J Kor Soc Endocrinol 10: 249-261, 1995)
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간경변증 및 뇌질환 환자의 혈장 APV의 측정과 수분대사에 대한 연구
김극배 순천향대학교 1984 논문집 Vol.7 No.1
In order to studying the water balance in brain disease and liver cirrhosis. 15normal control subjects, 10 patients of liver cirrhosis and 20 patients of brain disease were subjected to determine plasma AVP levels by sensitive radioimmuno assay and simultaneous determined plasma and urine osmolality, Results were. 1. Plasma AVP concentration in raodomly hydrated normal adult control was average 2.0 pg/ml with range of 0.4~5.6 pg/ml. Results was fairly correlated the serum osmolality and osmotic threshold was 280.4 mOsm/kg. 2. Plasma AVP level in 10 patient of liver cirrhosis was average 2.8pg/ml. with range of 0.2~9.0 and plasma and urine osmolality ratio was marked decrease in compare with normal subjects and poorly corrlated with plasma AVP and plasma osmolality. 3. Plasma AVP level in 20 patients of brain disease was average of 0.4~9.0pg/ml. There are no difference of plasma level in average concentration with normal control but marked fluctuation between patients. And also poorly correlated with plasma AVP and plasma osmolality. 4. There are negligible AVP concentration and marked decreased U/P ratio in two cases of polyuric patients. 5. Studies suggested there are more complex osmotic, nonosmotic stimuli and inhlbitory stimuli affected in liver cirrhosis and brain disease.
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갑상선질환에서 thyroid stimulating immunoglobulin의 측정
한동철,유명희,김극배 순천향대학교 1985 논문집 Vol.8 No.1
To investigate the role of thyroid stimulating immunoglobulin(TSI) in various thyroid diseases, we measured TSI activity by TSH receptor Ab in 17 patients with Grave's diseases(GD), 4 patients with thyroiditis and 4 patients with thyroid nodules and also measured serum T₃, T₄, TSH, T₃RU by radioimmunoassay. 1) In patients with 14 hyperthyroid GD, the levels of serum T3,T4, were significantly increased than normal control. The levels of serum T3 in patients with thyroiditis and the levels of serum T4 in patients with thyroid nodule was significantly increased than normal control. 2) the levels of TSI in hyperthyroid GD(33.4±27.7%) and euthyroid GD (22.9±18.3%) were significantly increased than normal control. There was no correlation between the levels of TSI and thyroid function tests in patients with GD. 3) Decreased levels of TSI was observed after antithyroid drug theraphy in patients with 4 GD.
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당뇨병 환자에서 임상증상 및 자율신경장애와 감각신경장애와의 상관관계
김진오,유용규,문승혁,김효석,봉형근,변동원,서교일,조용욱,유명희,김극배 순천향대학교 1994 논문집 Vol.17 No.2
In a group of 47 diabetic patients and 60 controls, we measured vibration perception threshold with biothesiometer, and autonomic nerve function by means of the five classical cardiovascular tests (Valsalva ratio, R-R interval variations during deep breathing, sustained handgrip, lying to standing, and postural hypotension). Results of cardiovascular reflex results were compared with symptoms of autonomic dysfunction and vibration perception threshold. The object of this study was to assess the physiological and clinical correlation of autonomic and sensory neuropathy in diabetic patients and results of this study could be applying patients for therapeutic approach and follow up diabetic neuropathy. Vibration perception threshold correlated with Valsalva ratio(p<0.01) and deep breathing(p<0.01). Patients score was significantly lower than controls in vibration perception threshold and all of the autonomic function tests. According to the results of cardiovascular tests, patients were divided into two different groups : presence(DAN+: ≥3) or abscence(DAN-: <3) of autonomic neuropathy. DAN () group(n=25, 53.2%) showed no significant differences from the DAN(+) group(n=22, 46.8%) in age, fasting and 2 hours postprandial blood sugar, body mass index, and cholesterol but associated with duration of diabetes. Vibration perception threshold measured at the first toe tip and at external malleolus in DAN(+) patients were significantly higher than DAN () patients and controls. We diagnosed sensory impairment when vibration perception threshold value is above 95th percentile of controls and we observed a significant correlation between autonomic and sensory neuropathy. These findings suggested that there is a correlation between autonomic and sensory neuropathy in diabetic patients, even in the absence of symptoms.
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