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기능성 식품 복합처방을 이용한 항산화 및 항염증제 개발
조형권,김진표,전인주,함인혜,황완균 중앙대학교 약학연구소 2003 약학 논총 Vol.17 No.-
To investigate the antioxidant activitys of Biofuntional Foods Prescriptions(BFP), we were measured radical scavenging activity with DPPH method and anti-lipid peroxidative efficacy on human LDL with TBARS assay. The DPPH was revealed that Two BFP have siginificantly antioxidant activity. But, TBARS assay showed that Rx B which was signifacantly antioxidant activity had lower anti-lipid peroxidative efficacy when compared to that of contrast drug, ascorbic acid. The anti-inflammatory potential of ethanol exracts of Rx B was evaulated against model of inflammation such as carragenin induced paw edema in rats. 100㎎/㎏, 200㎎/㎏, and 400㎎/㎏ fractions of Rx B showed 20.95%, 12.56%. 18.95% when compared to that of control animals at one hour after oral administration. The effect was comparable with that of the standard drug indomethacin, a standard non-steroidal anti-inflammatory drug. Inhibition rates of each fraction showed a few lower than that of standard drug, indomethacin. At two, three, four hour after oral administration, 100㎎/㎏ fraction showed 26.9.3%, 33.73%, 21.4%, 200㎎/㎏ fraction showed 20.4%, 22.99%, 15.24%, and 400㎎/㎏ fraction showed 21.43%, 21.30%, 10.85%. Inhibition rates of each fractions were significantly reduced when compared to that of the standard drug indomethacin that showed 27.79%, 35.81%, 22.40% at two, three, four hour after oral administration
해동피를 포함한 생약복합제제 HP-04의 퇴행성 골관절염에 대한 항염효과
조형권,김대성,김정영,박영미,신동엽,이학용,김훈,이동성,조성완 한국생약학회 2020 생약학회지 Vol.51 No.2
To investigate the anti-inflammatory effect on Degenerative Osteoarthritis, Male sprague-Dawley rats were randomized and classified into three different concentration groups. We measured weekly weight change, dietary intake, drinking water intake, blood analysis like TNF-a (tumor necrosis factor-a), IL-6 (interleukin 6), TIMP-1 (tissue inhibitor of metalloprotease-1), MMP-2 (matrix metalloprotease-2), MMP-9 (matrix metalloprotease-9) and micro CT analysis. The results suggest that the treatment with herbal complex HP-04 improved the Monosodium iodoacetate (MIA) induced degenerative osteoarthritis and it could be applicable for the improvement of arthritic symptoms as a new therapeutic agent.
建築設備工事의 施工性 向上에 관한 硏究(Ⅱ) : Focued on the Changes and Prior Coodinate 설계변경 또는 공사변경 및 이에 따른 사전협의를 중심으로
具滋斗,趙炯權 호남대학교 산업기술연구소 1999 산업기술연구논문집 Vol.7 No.-
건축물의 규모가 대형화, 고층화, 복잡화됨에 따라 건축설비공사의 중요성은 점차 증대되고 있다. 이에 본 연구에서는 건축설비공사와 관련된 설계변경 또는 공사변경 및 이에 대한 사전협의에 관한 설문조사를 실시하여 주력사업별과 자격 및 경력별로의 분석을 통해 건축설비공사의 시공성 향상을 증진하는 기초자료를 제공하고자 한다. Recently construction has become large in scale, high, complex, diverse, and professional, design and construction in building services must improve in precision. However, quite often people who carry out building services works do not prepare design documents, and poor construction with defects occur in construction site many times. To address this matter, I have conducted a questionnaire survey for this study. After the collected guestionaire data divided according to the kinds of major business and qualification educational background work experiences, the changes and prior coodinate in the design and construction of building services works are analyzed. Base on the above results, to suggest basic methodology of constructability improvement of building services work.
조형권(Hyoung Kwon Cho),함인혜(In Hye Ham),황완균(Wan Kyunn Whang) 대한약학회 1999 약학회지 Vol.43 No.3
From the water fraction of the MeOH extract, three compounds, 1,3,4,5-terrahydroxycyclohexanecarboxylic acid 3-(3,4-dihydroxycinnamate) (chlorogenic acid), quercetin 3-O-beta-D-galactopyranoside (hyperoside), and 1(R)-hydroxy-3,4-seco-lup-4(23),20(30)-dien-3,11alpha-olactone-1apha-L-rhamnopyranosyl(1->4)-beta-D-glucopyranosyl(1->6)-beta-L-glucopyranosyl ester (chiisanoside) were isolated and their strutures determinated by 1H-NMR, 13C-NMR, IR, and FAB-Nass. Chlorogenic acid and Chiisanoside had been quantitated by HPLC from eight Acanthopanax species per 10g A. koreanum 19.82, 4.17mg, A. nambunensis 65.00, 1.86mg, A chiisanense 67.19, 4.72mg, A. albeofructus 69.58, 4.96mg, A. chungbunensis 31.96, 6.73mg, A. pedunclus 13.95, 1.52mg, A. senticosus 27.19, 8.17mg, A. sessiliflorum 7.49, 5.88mg.
장보윤,조형권,전기용,허종문,박현,김성연 한국생약학회 2010 생약학회지 Vol.41 No.3
Acute toxicity on the polysaccharide fraction of Pueraria lobata was examined using male and female Sprague-Dawley rats. The polysaccharide fraction of Pueraria lobata was orally administered at a dose of 5 mg/kg, 50 mg/kg, 500 mg/kg, 2,000 mg/kg and 5,000 mg/kg and observed for two weeks. No mortality and abnormal clinical signs were observed at the doses used. There were not any significant differences in parameters of blood biochemical values and urinalysis by the treatment of test material. All rats were appeared to be healthy and normal throughout the observation period. Also there was no difference in net body weight gain and gross pathological findings among the groups rats treated with different doses of the polysaccharide fraction with Pueraria lobata.