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최정혜,김태민,김효정,고성애,문영철,강혜진,정윤화,심혁,정소영,SUN DER SHENG,이순일,박병배,권정혜,남승현,이준호,유영진,진종률,한재준,김석현 대한암학회 2018 Cancer Research and Treatment Vol.50 No.2
Purpose The treatment strategy for elderly patients older than 80 years with diffuse large B-cell lymphoma (DLBCL) has not been established because of poor treatment tolerability and lack of data. Materials and Methods This multicenter retrospective study was conducted to investigate clinical characteristics, treatment patterns and outcomes of patients older than 80 years who were diagnosed with DLBCL at 19 institutions in Korea between 2005 and 2016. Results A total of 194 patients were identified (median age, 83.3 years). Of these, 114 patients had an age-adjusted International Prognostic Index (aaIPI) score of 2-3 and 48 had a Charlson index score of 4 or more. R-CHOP was given in 124 cases, R-CVP in 13 cases, other chemotherapy in 17 cases, radiation alone in nine cases, and surgery alone in two cases. Twenty-nine patients did not undergo any treatment. The median number of chemotherapy cycles was three. Only 37 patients completed the planned treatment cycles. The overall response rate from 105 evaluable patients was 90.5% (complete response, 41.9%). Twentynine patients died due to treatment-related toxicities (TRT). Thirteen patients died due to TRT after the first cycle. Median overall survival was 14.0 months. The main causes of death were disease progression (30.8%) and TRT (27.1%). In multivariate analysis, overall survival was affected by aaIPI, hypoalbuminemia, elevated creatinine, and treatment. Conclusion Age itself should not be a contraindication to treatment. However, since elderly patients show higher rates of TRT due to infection, careful monitoring and dose modification of chemotherapeutic agents is needed.
최정혜,나주영,진현숙,임수빈,백지선,이미정,장자영,이데레사,홍성기,최효원,김점순 한국식물병리학회 2019 식물병연구 Vol.25 No.4
A total of 1,159 Fusarium strains were isolated from sorghum grown in Danyang and Youngwol in 2017 and 2018. The isolates were analyzed to reveal genetic, toxigenic and pathogenic characteristics. Phylogenetic analysis using TEF-1α and RPB2 genes showed that the samples were contaminated with at least 17 Fusarium species. Among them, F. graminearum, F. proliferatum, F. thapsinum, F. incarnatum, and F. asiaticum were dominant species. In F. graminearum and F. asiaticum, F. graminearum–15-acetyl deoxynivalenol chemotype and F. asiaticum–nivalenol chemotype were frequent. Six Fusarium species tested produced one or more mycotoxins, except F. thapsinum and FTSC 11. F. proliferatum and F. fujikuroi had FUM1 gene (76.0% and 81.6%, respectively) and some isolates produced high level of fumonisin (over 1,000 μg/g). F. proliferatum and F. thapsinum were more virulent than other species on sorghum. These results indicate that Fusarium species in sorghum might produce multiple mycotoxins.
Non-Bacterial Thrombotic Endocarditis in a Patient with Rheumatoid Arthritis
최정혜,박정은,김장영,강태영 대한심장학회 2016 Korean Circulation Journal Vol.46 No.3
Rheumatoid arthritis (RA) is frequently associated with various extra-joint complications. Although rare, thromboembolic complicationsare associated with high morbidity and mortality. We experienced a very rare case of nonbacterial thrombotic endocarditis (NBTE) andsubsequent embolic stroke in a patient with RA. A 72-year-old male with a 15-year history of RA suddenly developed neurologicsymptoms of vomiting and dizziness. Brain magnetic resonance imaging revealed recently developed multiple cerebellar and cerebrallacunar infarctions. Echocardiography showed a pulsating mitral valve vegetation involving the posterior cusp of the mitral valve leaflet,which was confirmed as NBTE. Immediate anti-coagulation therapy was started. The NBTE lesion disappeared in follow-upechocardiography after 4 weeks of anti-coagulation treatment.
최정혜 한양대학교 의과대학 2014 Hanyang Medical Reviews Vol.34 No.1
In the past decades, substantial developments in the understanding of molecular biology in non-small-cell lung cancer (NSCLC) have improved diagnosis and treatment of NSCLC based on the genotype of each patient’s tumor. For example, gain-of function mutations of epidermal growth factor receptor (EGFR) and anaplastic lymphoma kinase (ALK) rearrangement are sensitive biomarkers in predicting tumor response and survival to EGFR tyrosine kinase inhibitor and ALK inhibitor, respectively. However, since NSCLC is one of the most complex and heterogenous cancers and the leading cause of cancer-related death in the world, there are still many challenges for prevention, diagnosis, and treatment of NSCLC. This review summarizes the molecular biology of NSCLC including activation of oncogenes, suppression of tumor suppressor genes, angiogenesis, epigenetic alteration, microRNA, telomerase, cancer stem cell, and cancer genomics using next generation sequencing methods.
유아기 자녀를 둔 다문화가정 부부의 부모역할 및 부모교육 경험에 관한 연구
최정혜 한국코칭학회 2017 코칭연구 Vol.10 No.1
본 연구는 유아기자녀를 둔 다문화가정 부부의 부모역할 및 부모교육 경험에 관한 질적 연 구이다. 연구대상은 다문화가정의 한국인 남편과 결혼이주여성 아내로서 7쌍의 부부, 총 14명 이고, 심층면접을 통해 수집한 자료를 분석하였으며, 연구결과는 다음과 같다. 첫째, 다문화가정 부부의 ‘부모역할 경험’을 살펴보았을 때, 부부 공통으로 자녀양육에서 가 장 큰 기쁨은 자녀출생으로 나타났다. 자녀양육의 가장 큰 어려움은 부부 공통으로 다문화가 정 자녀의 정체성체 대한 걱정과 양육지식의 부족으로 나타났다. 차이점은 남편은 경제적 어 려움을, 아내는 언어소통의 어려움을 가지고 있었다. 자녀양육 어려움의 해결방법은 남편은 이웃이나 모친의 도움이고, 아내는 남편의 도움이었다. 부모로서의 만족감은 남편은 낮고 아내 는 높게 나타났다. 둘째, 다문화가정 부부의 ‘부모교육 경험’을 살펴보았을 때, 남편은 대부분 부모교육을 모르 거나 교육에 참여한 적이 없었으나, 아내는 유치원을 비롯한 다문화가족 지원센터 등을 통해 서 참여 경험이 있는 것으로 나타났다. 부모교육의 필요성에 있어서는 부부 모두 자녀의 성장 및 이해를 위해 꼭 필요하다는 태도를 보였다. 본 연구의 결과는 다문화가정 부부를 위한 부모 교육 프로그램 개발에 유용한 기초자료로 제공될 수 있을 것이다. The purpose of this study is to analyze the experience of seven multi-cultural couples who take care of their children living in Gyeongnam Province, South Korea. Parents’ role and education for their children were analyzed using six main themes with 21 sub-categories. The results are summarized as follows. First, we can show that the happiest event from their experience was the birth of their children, whereas the most difficult problems were ridicule of their children as multi cultural kids and insufficiency of their nurturing information. The degree of satisfaction as parents was shown to be higher for the wives than the husbands. Second, considering their experience as multi cultural parents, we can conclude that most of husbands did not know how to care for their children, whereas the wives perceived many knowledge able aspects at the center by assisting multi cultural families through the education of their kids. However the couples recognized the importance of parents’ education for sound growth and development of their children. These results can provide much valuable information for the development of an educational program that will be very useful for multi cultural parents.