Serum Galectin-3 Levels in Children with Attention-Deficit/Hyperactivity Disorder

Ümit Is¸ ık,Faruk Kılıç,Arif Demirdas¸,Evrim Aktepe,Pınar Aydog˘ an Avs¸ ar 대한신경정신의학회 2020 PSYCHIATRY INVESTIGATION Vol.17 No.3

Objective Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder with underlying pathogenesis and etiological factors not fully understood. We assumed that galectin-3, which is also linked with inflammatory responses, may play an important role in the ethiopathogenesis of ADHD. In this study, we aimed to investigate whether serum galectin-3 levels are related to ADHD in childhood. Methods The current study consisted of 35 treatment-naive children with ADHD and 35 control subjects. The severities of ADHD and conduct disorder symptoms were assessed via parent- and teacher-rated questionnaires. The severity of anxiety and depression symptoms of the children were determined by the self-report scale. Venous blood samples were collected and serum galectin-3 levels were measured. Results The ADHD group had significantly higher serum Galectin-3 levels than the control group. To control confounding factors, including age, sex, and BMI percentile, one-way analysis of covariance (ANCOVA) test was also performed. Analyses revealed a significantly higher serum log- Galectin-3 levels in children with ADHD compared to controls. No association was found between the mean serum galectin-3 levels and sociodemographic characteristics and clinical test scores, except the oppositional defiant behavior scores. Conclusion Our research supports the hypothesis that serum levels of galectin-3 might be related to ADHD.

The effects of the cooperative learning method supported by multiple intelligence theory on Turkish elementary students' mathematics achievement

Dilek Is¸ık 서울대학교 교육연구소 2009 Asia Pacific Education Review Vol.10 No.4

In the present experimental study, the effects of the cooperative learning method supported by multiple intelligence theory (CLMI) on elementary school fourth grade students' academic achievement and retention towards the mathematics course were investigated. The participants of the study were 150 students who were divided into two experimental (used CLMI) and two control groups (used traditional method). "Mathematics Achievement Test," "Teele Inventory for Multiple Intelligences" and "Personal Information Form" were used as the measurement instruments of the study. The findings of this research have indicated that CLMI has a more significant effect on academic achievement than the traditional method. Yet, regarding the retention scores, CLMI has not significant effect on retention.

Evaluation of the alignment efficiency of nickeltitanium and copper-nickel-titanium archwires in patients undergoing orthodontic treatment over a 12-week period: A single-center, randomized controlled clinical trial

Burcu Aydın,Neslihan Ebru Ş,enış,ık,Ö,zgü,r Koş,kan 대한치과교정학회 2018 대한치과교정학회지 Vol.46 No.3

Objective: The aim of this trial was to compare the alignment efficiency and intermaxillary arch dimension changes of nickel-titanium (NiTi) or copper-nickeltitanium (CuNiTi) round archwires with increasing diameters applied sequentially to the mandibular arch. Methods: The initial alignment phase of fixed orthodontic treatment with NiTi or CuNiTi round archwires was studied in a randomly allocated sample of 66 patients. The NiTi group comprised 26 women, 10 men, and the CuNiTi(27℃) group comprised 20 women, 10 men. The eligibility criteria were as follows: anterior mandibular crowding of minimum 6 mm according to Little’s Irregularity Index (LII), treatment requiring no extraction of premolars, 12 to 18 years of age, permanent dentition, skeletal and dental Class I malocclusion. The main outcome measure was the alignment of the mandibular anterior dentition; the secondary outcome measure was the change in mandibular dental arch dimensions during 12 weeks. Simple randomization (allocation ratio 1:1) was used in this single-blind study. LII and mandibular arch dimensions were measured on three-dimensional digital dental models at 2-week intervals. Results: No statistically significant difference was observed between NiTi and CuNiTi according to LII (p > 0.05). Intercanine and intermolar arch perimeters increased in the CuNiTi group (p < 0.001). Inter-first premolar width showed a statistically significant interaction in week × diameter ×application (p < 0.05). Conclusions: The effects of NiTi and CuNiTi round archwires were similar in terms of their alignment efficiency. However, the intercanine and intermolar arch perimeters, and the inter-first premolar width changes differed between groups.

The Evaluation of Thiol/Disulfide Homeostasis and Oxidative DNA Damage in Patients with Obsessive Compulsive Disorder

Faruk Kurhan,Hamit Hakan Alp,Mesut Iş,ık,Yavuz Selim Atan 대한정신약물학회 2022 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.20 No.2

Objective: In this study, we aimed to examine thiol/disulfide homeostasis and oxidative DNA damage in patients with OCD and compare them with healthy controls. Methods: Thirty-five patients previously diagnosed with OCD in Van Yuzuncu Yil University Department of Psychiatry and thirty-three healthy volunteers were included in the study. The severity of the symptoms was measured using the Yale-Brown Obsessive-Compulsive Scale. Five ml of blood samples were taken from the patient and control groups. The samples were stored at appropriate conditions until use. Leukocyte DNA was isolated and the levels of 8-hydroxy- 2-deoxyguanosine (8-OHdG) and deoxyguanosine were detected to assess the oxidative DNA damage. The level of oxidative DNA damage was expressed as 8-OHdG/106dG. Total thiol/native thiol levels were measured for thiol/disulfide homeostasis. The level of disulfide was determined by subtracting the native thiol value from the total thiol value and the result was divided by two. Results were given as percentages. Results: The total and native thiol levels in patients with OCD were significantly lower, and the disulfide levels were significantly higher in patients with OCD than healthy control subjects. In addition, 8-OHdG, an indicator of DNA damage, was significantly lower in the control group compared to the patient group. Conclusion: Increased levels of disulfide/native thiol and disulfide/total thiol in patients with OCD show that levels of oxidative stress were elevated and therefore, higher 8-OHdG levels in patients with OCD is a marker of oxidative DNA damage.

Evaluation of the alignment efficiency of nickeltitanium and copper-nickel-titanium archwires in patients undergoing orthodontic treatment over a 12-week period

Burcu Aydın,Neslihan Ebru ?enı?ık,Ozgur Ko?kanb 대한치과교정학회 2018 대한치과교정학회지 Vol.48 No.3

Objective: The aim of this trial was to compare the alignment efficiency and intermaxillary arch dimension changes of nickel-titanium (NiTi) or copper-nickeltitanium (CuNiTi) round archwires with increasing diameters applied sequentially to the mandibular arch. Methods: The initial alignment phase of fixed orthodontic treatment with NiTi or CuNiTi round archwires was studied in a randomly allocated sample of 66 patients. The NiTi group comprised 26 women, 10 men, and the CuNiTi (27℃) group comprised 20 women, 10 men. The eligibility criteria were as follows: anterior mandibular crowding of minimum 6 mm according to Little’s Irregularity Index (LII), treatment requiring no extraction of premolars, 12 to 18 years of age, permanent dentition, skeletal and dental Class I malocclusion. The main outcome measure was the alignment of the mandibular anterior dentition; the secondary outcome measure was the change in mandibular dental arch dimensions during 12 weeks. Simple randomization (allocation ratio 1:1) was used in this single-blind study. LII and mandibular arch dimensions were measured on three-dimensional digital dental models at 2-week intervals. Results: No statistically significant difference was observed between NiTi and CuNiTi according to LII (p > 0.05). Intercanine and intermolar arch perimeters increased in the CuNiTi group (p < 0.001). Inter-first premolar width showed a statistically significant interaction in week × diameter × application (p < 0.05). Conclusions: The effects of NiTi and CuNiTi round archwires were similar in terms of their alignment efficiency. However, the intercanine and intermolar arch perimeters, and the inter-first premolar width changes differed between groups.

Electrografting and Surface Properties of Some Substituted Nitrophenols on Glassy Carbon Electrode and Simultaneous Pb²⁺ - Cd²⁺ Analysis via Assist of Graphene Oxide Terminated Surface

Erkal, Aslı,Erdoğ,an, Mehmet Selç,uk,Aş,ık, İ,hsan,Ekş,i, Haslet,Jeon, Seungwon,Solak, Ali Osman,Ü,stü,ndağ,, Zafer The Electrochemical Society 2014 Journal of the Electrochemical Society Vol.161 No.10

<P>A new electrode was prepared by the electrooxidation of orto-, meta-, and para-substituted nitro phenols on glassy carbon electrode. Electrochemical modification of the electrodes was carried out in 0.01 M HCl using cyclic voltammetry (CV). Then nitro groups in the covalently grafted nitro phenol derivatives on GC electrode were reduced to amine groups in 0.01 M HCl. The electrochemical behavior of the modified electrodes was studied in the presence of electroactive redox probes such as ferrocene and ferricyanide by CV and electrochemical impedance spectroscopy (EIS). X-ray photoelectron spectroscopy (XPS) was employed to characterize the surface structure and composition of the modified substrates. Thickness of the films was measured by using an ellipsometer. Surface topography of the nanofilms and bare GC was characterized via AFM. Graphene oxide (GO) was covalently attached on 4-aminophenyl involved surface through EDC. Simple immersing of the GO covered nanoplatform into a sample solution led to the chemical deposition by means of the interaction with Cd<SUP>2+</SUP> and Pb<SUP>2+</SUP> ions, simultaneously. Various analysis parameters that affect the simultaneous analysis of the ions such as deposition time, pH factor and deposition temperature, were optimized. Calibration curve for the GO grafted electrode surface with Square-wave anodic stripping voltammetry (SWASV) were obtained in the concentration range between 1 × 10<SUP>−8</SUP> M and 1 × 10<SUP>−12</SUP> M for Pb<SUP>2+</SUP> and Cd<SUP>2+</SUP>. The detection limits of the modified electrode for Pb<SUP>2+</SUP> and Cd<SUP>2+</SUP> ions were determined to be about 3.2 (± 0.1) × 10<SUP>−13</SUP> M and 2.4 (± 0.2) × 10<SUP>−13</SUP> M, respectively.</P>

Electronic Structure Mapping of Branching States in Poly[methyl(phenyl)silane] Upon Exposure to UV Radiation

Frantiˇsek Schauer,Luk´aˇs Tk´aˇ,Miroslava Oˇzvoldov´,Vojtech Nad´aˇzdy,Katar´ana Gmucov´a,Karol V´egs¨,Miroslava Tk´aˇcov´,Juraj Chlp´ık 한국물리학회 2016 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.68 No.4

The origin of white photoluminescence in polysilanes has long been disputed, and this emission is closely connected with information recording in nanotechnologies. We elucidated UV degradation of an archetypal model polymer poly[methyl(phenyl)silane] by using a new method for electronic structure mapping of organic semiconductors, energy-resolved electrochemical impedance spectroscopy (ER-EIS) and photoluminescence spectroscopy. UV exposure at 345 nm resulted in two defect bands above the highest occupied molecular orbital (HOMO) in the energy region from −5.5 eV to −3.5 eV with respect to the zero vacuum energy level. The respective density of states was 1016 − 1017 cm−3eV−1, and the total integrated concentration was 0 − 1017 cm−3. The photoluminescence in the long-wavelength region gave wide bands with photon energies from 2.2 eV to 3.2 eV (corresponding to wavelengths from 600 nm to 390 nm). The observed bands were interpreted by assuming the formation of energetically distributed Si branching radiative states, whose distribution in the HOMO − lowest unoccupied molecular orbital (LUMO) gap was observed by using ER-EIS. The quantum efficiency of defect state formation increased from (x)345 nm = 0.0045 to (x)290 nm = 0.053. The obtained results may contribute to the production of effective polysilane nanomasks and to information recording.