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Woo, Je Moon,Shin, Da-Yong,Lee, Sung Ju,Joe, Yeonsoo,Zheng, Min,Yim, Jin Ho,Callaway, Zak,Chung, Hun Taeg Molecular Vision 2012 Molecular vision Vol.18 No.-
<P><B>Purpose</B></P><P>To determine whether curcumin induces expression of the defensive enzyme heme oxygenase-1 (HO-1) and protects cells against oxidative stress in cultured human retinal pigment epithelial cells.</P><P><B>Methods</B></P><P>Effective concentrations and toxicities of curcumin were determined after 3 h of curcumin treatment with the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. Confluent human retinal pigment epithelium cell lines (ARPE-19) were preincubated with curcumin and oxidatively challenged with H<SUB>2</SUB>O<SUB>2</SUB>. HO-1 expression was determined with western blot analysis. To confirm the protective role of HO-1 in oxidative stress, small interfering RNA (siRNA) against HO-1 or inhibitor of HO-1 was treated with curcumin in retinal pigment epithelium cells. Intracellular levels of reactive oxygen species (ROS) were measured with flow cytometry and confocal microscopy. Apoptosis was evaluated with Annexin V-fluoroscein isothiocyanate staining.</P><P><B>Results</B></P><P>Curcumin had little cytotoxicity at concentrations less than 30 μM, and HO-1 expression was the highest at the 15 μM concentration. At this concentration, curcumin also increased the cytoprotective effect against the oxidative stress of H<SUB>2</SUB>O<SUB>2</SUB> through the reduction of ROS levels in human retinal pigment epithelial cells. Curcumin’s effect on the reduction of ROS was mediated by the increase in HO-1 expression.</P><P><B>Conclusions</B></P><P>Curcumin upregulated the oxidative stress defense enzyme HO-1 and may protect human retinal pigment epithelial cells against oxidative stress by reducing ROS levels.</P>
착화제와 유기산이 Wistar rat체내의 Sr 분포에 미치는 영향
이기호,이제호,박상윤,이승훈,유용운,윤택구 대한방사선 방어학회 1990 방사선방어학회지 Vol.15 No.2
Wistar rat에 85SrCl2를 꼬리 정맥에 주사하여 체내 기관과 혈액 내 분포, 잔존율을 조사하였고 착화제와 유기산을 투여하여 혈장 단백질에 결합하는 Sr양의 변화를 측정하였다. 혈액내에서 Sr은 혈장에 60%, 세포에 40%부착되어 이동하였다. 혈장에 존재하는 Sr중 약 50%정도는 혈장 단백질과 결합한 상태였고, 세표에는 세포 표면에 가볍게 부착되어 있었다. Erythrocyte나 granulocyte보다 lymphocyte에 많은 양의 Sr이 부착되어 있었다. 투여후 초기 1시간 이내에 혈액 내에서 급격히 감소하여 뼈에 침착되었다. 이때 각 기관에서도 Sr의 잔존율은 24시간 이내에 크게 감소하였고, 뼈로 침착된 Sr은 24시간 이후에 서서히 감소하였다. 착화제 EDTA, EGTA 및 DTPA를 투여한 경우, 혈장 단백질에 결합하는 Sr의 양은 대조군의 57%에서 27-33%로 감소하였으며 citrate 및 oxalate의 투여시는 이값이 19%와 40%로 각각 감소하였다. 85SrCl2 was injected to the tail vein of Wistar rats and investigated its distribution and clearance in the tissues and blood. We also measured the changes in Sr binding to the blood plasma protein by administrating chelating agents and organic acids. For the blood, 60% of the Sr occurred in the plasma and 40% on the cell membrane. Fifty percent of Sr in the blood plasma was bound to plasma protein. Sr on the cell membrane seemed to be bound loosely. The binding in the lymphocyte was higher than in the erythrocyte and granulocyte. Within one hour Sr was quickly disappeared from the blood stream, to be accumulated in the bone. Twenty four hours after the injection, Sr decreased rapidly in the organs of soft tissue, but slowly in the bone. The binding of Sr to plasma protien decreased from 57% of the control to 27-33% in the group treated with chelating agents. EDTA. EGTA and DTPA and to 19% and 40% in the groups treated with organic acids, citrate and oxalate, respectively.
高X線 吸收유리에 있어서 BaO, SrO의 含量變化가 液相溫度에 미치는 影響
李卿喜,梁在翊,金德文,姜元浩 明知大學校 産業技術硏究所 1987 産業技術硏究所論文集 Vol.6 No.2
The liquidus temperature was observed according to the change of content BaO 6 W/O ~ 12W/O and SrO 1 W/O~4W/O in R₂O-PbO-Al₂O₃- (BaO+SrO+SiO₂) glass system. The liquidus temperature varied between 810°C ~ 950°C in these glasses. The effect of BaO & SrO content to the liquidus temperature of the glasses are as follows. 1. The variation of the liquidus temperature were remarkable by the content of SrO in the range of BaO contents from 6 W/O to 8 W/O. 2. The minimum liquidus temperature is located at the composition of BaO 8 W/O SrO 4 W/O SiO₂ 68 W/O.
찬물 강제수영이 남성화된 암컷 생쥐의 통각예민도에 미치는 영향
이국희,박제민,김명정,양구범,전명호 대한생물치료정신의학회 2001 생물치료정신의학 Vol.7 No.1
The aim of the study was to test the hypothesis that the mice androgenized in their perinatal period show in their later life heightened basal pain sensitivity and lowered analgesic effect induced by cold water swim. Entered into the experiment were 29 female mice androgenized by intraperitoneal injection of 100㎍ testoste-rone propionate within 24 hours after birth and 30 female mice given with intraperitoneal injection of the same amount of normal saline as the control group. On 160th day after birth, the pain sensitivity was measured in terms of the tail flick latency using 52±1℃ water before and after forced swim in cold water(15±1℃) for six minutes to see the change of the pain sensitivity. The results were as follows 1) The androgenized mice revealed significantly heightened basal pain sensitivity as compared to the control mice. 2) The lowering effect of the pain sensitivity by cold water forced swim was significant in both the androgenized and the control groups, but the effect was significantly less in the androgenized mice than in the control group. From these results, the author suggests that the androgenized female mice exposed to the testosterone in the neonatal period have heightened basal pain sensitivity and lowered cold water swim-induced analgesia than the normal female mice in their later lives.
동종 골수이식을 시행받은 환자에서 폐색성 세기관지염에 의하여 발생한 자발성 기종격동과 피하 기종
이병환,이제중,이연경,안재숙,김여경,황호인,박무림,조상희,정익주,김형준 대한조혈모세포이식학회 2002 대한조혈모세포이식학회지 Vol.7 No.2
저자들은 만성골수성백혈병으로 동종 골수이식과 이식편 부전으로 인하여 추가적인 말초혈액 조혈모세포이식을 시행 받은 환자에서 만성 이식편대숙주질환과 그 폐 합병증인 폐색성 세기관지염에 동반된 자발성 기종격동과 피하 기종이 병발한 1예를 경험하였기에 이를 보고하는 바이다. Obstructive lung disorders following after allogeneic bone marrow transplantation (BMT) in association with graft- versus-host disease (GVHD) contribute significant morbidity and mortality. We report a case of a 28-year-old man who developed spontaneous pneumomediatinum and subcutaneous emphysema complicating bronchiolitis obliterans after allogeneic BMT. He received an allogeneic BMT for chronic phase of chronic myeloid leukemia. Five months after BMT, he was boostered by allogeneic peripheral blood stem cells from the same donor due to graft failure. One month after the boostering, chronic GVHD developed and were treated with cyclosporine and steroid. The patients developed spontaneous pneumomediatinum and subcutaneous emphysema secondary to severe bronchiolitis obliterans 4 months after boostering donor cells. The air-leak syndromes were recovered by conservative management, including high-flow oxygen.
고교 야구 선수들의 견관절 외회전 및 내회전근의 근력 및 그 특성
이제운,윤승호 충남대학교 의과대학 지역사회의학연구소 1993 충남의대잡지 Vol.20 No.2
The imbalance of rotator muscles of shoulder frequently causes shoulder injury in many baseball players. This study was intended to evaluate the strength characteristics of external and internal rotator muscles in high school baseball players. Isokinetic tests of external/internal rotators were performed using Cybex Ⅱ^+ Isokinetic dynamometer in nine pitchers, thirteen nonpitchers and twenty normal control subjects. And the flexibility of external rotator muscles of shoulder was evaluated by the hand-to-shoulder-blade Test. The results were as follows : 1) In pitchers, mean peak torque ratios of external/internal rotators were significantly high in nondominant side at 180 and 300 deg/sec, mean peak torque and mean peak torque body weight ratios of external rotators were significantly high in nondominant side at 180 deg/sec, 180 and 300 deg/sec respectively, mean peak torque of internal rotators were significantly high in dominant side at 300 deg/sec. 2) In nonpitchers, peak torque ratios of external/internal rotators were significantly high in nondo minant side at 180 deg/sec, but peak torque and peak torque body weight ratios of internal rotators were both significantly high in dominant side at 180 and 300 deg/sec. 3) In comparison between pitchers and nonpitchers, peak torque ratios of external/internal rotators in dominant side were significantly high in nonpitchers at 180 and 300 deg/sec, but there were no significant differences in nondominant side. 4) In flexibility tests of external rotators, pitchers showed statistically significant tightness in external rotators than nonpitchers and control group in dominant side, but there were no statistically significant differences in nondominant side. In conclusion, pitchers showed weakness and tightness in shoulder external rotators, which may lead to major shoulder injury. Therefore evaluation of muscle power and flexibility was thought to be one of the very useful screening tests for the prevention of shoulder injury.