C형 간염바이러스 항체 면역블롯검사에서 불확정판정을 받은 헌혈자의 HCV 양성 확인

조연정,서동희,황병갑,김동집,정남현 大韓輸血學會 2001 大韓輸血學會誌 Vol.12 No.2

조혈모세포이식 환자에서 침습성 진균 감염에 대한 Micafungin의 예방 효과 및 안전성

김시현,이동건,최수미,권재철,박선희,최정현,유진홍,이성은,조병식,김유진,이석,김희제,민창기,조석구,김동욱,이종욱,민우성,박종원 대한감염학회 2010 감염과 화학요법 Vol.42 No.3

Background: Micafungin, a potent inhibitor of 1,3-β-D-glucan synthase, is a novel antifungal agent of the echinocandin class. In vitro study showed that micafungin was effective against Aspergillus species as well as Candida species, but clinical data on the prophylactic efficacy against invasive fungal infections (IFIs) other than candidiasis are still lacking. Materials and Methods: We identified 60 consecutive adult hematopoietic stem cell transplantation (HSCT) recipients who received at least 3 doses of micafungin during neutropenic period. Micafungin was started as an alternative in patients who were intolerant or had adverse events (AEs) to primary prophylactic antifungal agents. We retrospectively reviewed the medical records and analyzed the efficacy and safety of micafungin for prophylaxis against IFIs. Results: The patients either had autologous (n=9) or allogeneic (n=51: 1 syngeneic, 24 sibling, 26 unrelated donor) HSCT. Itraconazole oral solution (n=58) was the most frequently used first line antifungal agent for prophylaxis and was administered for median 11 days. The most frequent cause of switch to micafungin was vomiting (n=42). The duration of neutropenia and micafungin administration was median 13 and 12 days, respectively. A successful outcome was achieved in 45 (75%) patients. Empirical antifungal therapy was initiated in 13 (22%) patients. There were 2 cases (3.3%) of breakthrough fungal infections which comprised a probable invasive pulmonary aspergillosis and a possible invasive fungal sinusitis. There was no case of invasive candidiasis. A total of 53 (88%) patients experienced at least one AE regardless of causality during micafungin administration. The most frequent AEs were hypokalemia, vomiting, diarrhea, and elevated serum aspartate aminotransferase or alanine aminotransferase. Among the aforementioned AEs, only 1 case of diarrhea could be classified as a probable relation with micafungin when causality was assessed. There was no AEs that caused discontinuation of micafungin. Conclusions: Micafungin seems to be a safe and effective agent for prophylaxis of IFIs including aspergillosis as well as candidiasis in HSCT recipients. However, further large, prospective, and randomized comparative studies are warranted for aspergillosis.

도시지역 보건사업에서 컴퓨터의 활용방안에 관한 연구

염용태,이명숙,조병희,송동빈 고려대학교 의과대학 1990 고려대 의대 잡지 Vol.27 No.2

Nacessity of new communication media in information society is repidly increasing in many fields of Korea. It includes the field of primary helath care in the courses of collecting informations on demographic feature, social characteristics and health behavior of peoples. In light of above reasons, the authors attempted to utilize personal computers for the primary health services to promote health of unban people as a pilot study in Guro-6- Dong, Seoul. Five nurses working in Guro-6-Dong Health Subcenter completed family health records of 3,930 households among the total of 4,270. A total of 3,904 family health records among 3,930 were computerized and sorted out in categories of population characteristics, population dymanics, characteristics of householders, housing, family planning, maternal and child health(M.C.H), health status of residents and of others. Names of risky category in M.C.H, and family planning were listed and the lists were handed to the nurses concerned in order to practice proper cares in time. Sorted data were compared with ones of City of Seoul, average of other cities, and ones of nationwide. With the results of above practice, in terms of utilization of computer in uban primary health sevices, the following strategy was proposed. In order to provide proper health services the unban people demanded, efficient devices of information collection, processing and interpretation systems on health were urgently needed in every dong unit(health subcenter) of health centers. Recommended was personal computer network as a new communication media. Additional advantages of the devices were continuity and efficiency in services, and utilization in evaluation of health services and analysis of cost -effectiveness.

사무직 공무원의 스트레스 수준 및 관련요인

조광희,이동배,조영채 대한산업의학회 2007 대한직업환경의학회지 Vol.19 No.1

목적: 사무직 공무원들의 사회심리적 스트레스 수준을 파악하며, 이에 관여하는 제 특성을 알아보고자 시도하였다. 방법: 대전광역시에 소재하고 있는 정부 공공기관의 사무직 공무원 1,005명을 대상으로 구조화된 무기명 자기 기입식 설문지(self-administered questionnaire)를 이용한 설문조사를 실시하였다. 조사는 2005년 12월 5일 부터 2006년 1월 31일까지의 기간 동안에 실시하였으며, 연구에 사용한 설문지의 구성은 조사대상자의 인구사회학적 및 직업관련 특성, 건강관련행위, 업무요구도, 업무자율성, 직장의 사회적지지, A형 행동유형, 통제신념, 자기존중감, 사회 심리적 스트레스수준 등으로 구성하였다. 분석은 사회심리적 스트레스 수준을 종속변수로, 기타 제 변수를 독립변수로 하여 단변량분석 및 다중선형회귀분석을 실시하였다. 결과: 전체 연구대상자의 사회심리적 스트레스 수준은 건강군이 10.3%, 위험수준은 아니지만 스트레스로부터 위협을 받을 수 있는 잠재적 스트레스군이 64.9%, 심각한 수준의 스트레스를 받고 있는 고위험스트레스군이 24.8%로 나타났다. 또한 스트레스는 인구사회학적 특성이나 직급, 근무경력 등의 직업관련 특성뿐만 아니라 건강관련행위의 실천 여부, 직무요구도, 직무자율성, 직장 내에서의 사회적 지지와 같은 직무내용 및 인성(A형 행동유형, 통제신념)이나 자기 존중감 등에 의해서도 많은 영향을 받고 있었다. 결론: 따라서 공무원들의 스트레스를 감소시키기기 위해서는 직무내용의 개선 및 인성관리를 위한 프로그램의 개발 및 시행이 필요할 것으로 생각된다. Objectives: This study was performed to determine the levels of psychosocial distress among clerical public officers to reveal the various related factors. Methods: A self-administered questionnaires was administered between Dec. 5th, 2005 and Jan. 31st, 2006, to 1,005 individuals in the service of general administration located in Daejeon City. The survey items included the subjects' socio-demographic and job-related characteristics, health-related behavior, degree of job demand, job autonomy, social support in work, type A behavior pattern, locus of control, sense of self-esteem, and psychosocial distress. Results: The results showed that 24.8% of subjects were categorized as high risk stress, 64.9% as latent stress, and 10.3% as normal. The level of psychosocial distress was influenced by various sociodemographic characteristics, such as personality traits (type A behavior pattern, locus of control, self-esteem) and whether performing health-related behavior or not, as well as according to job-related characteristics such as rank in work, job career, job specifications, job demand, job autonomy, social support in work. Conclusions: The effective strategy for stress reduction among governmental employees requires additional programs focusing on innovated job specifications and managed personality traits.

강릉 연안에서 어획한 오징어의 간장 중 일반성분 및 지질 조성의 계절변화

조순영,전미정,주동식,전중균,이미희,정인학 강릉대학교동해안지역연구소 1999 東海岸硏究 Vol.10 No.2

연간 어획량으로 볼 때 오징어는 다른 어종 못지않게 중요한 종류이다. 오징어는 몸통뿐 아니라 내장과 간장 또한 이용가치가 매우 뛰어남에도 불구하고 그동안에는 사료용으로만 약간 사용되고 나머지는 대부분 폐기하였다. 본 연구에서는 이들 간장의 이용도를 넓힐수 있는 기초자료를 확보하고자 간장 중 일반성분과 지질 클래스의 변화를 월별로 조사하였다. 우선, 주문진항에서 4월에서 10월까지의 매월 한차례씩 살아있는 오징어를 구입하여 이들의 체중과 체장, 그리고 내장과 간장의 무게를 재고, 간장은 일반성분과 지질분석을 하였는데, 월별 체중 및 체장은 7월을 기점으로 여름철에 증가하며 체중도 같은 경향을 나타내었다. 그리고 간장의 무게도 체중의 증가와 비례하여 증가하였다. 비만도는 체장의 증가율에 비해 체중의 증가율이 높은 5월이 비만도가 가장 높았다. 같은 기간 중 일반성분의 변화를 보면, 수분은 대체로 감소하는 경향이고 단백질은 7월에서 9월 사이에 증가하는 경향을 보였다. 지질은 단백질과는 반대로 7월에서 9월 사이에 감소하는 경향을 보였으며, 회분은 매월 일정한 값을 나타내었다. 이러한 결과로 어체의 성장이 활발한 여름철에 단백질의 양이 증가하고 반면에 지질의 함량은 감소하는 것으로 나타났다. 한편, 지질 클래스에서 단순지질의 경우 NL은 봄철에서 가을로 가면서 점차 증가하는 경향을 보였고, 반면 S, PL은 감소하는 경향을 보였다. PL에서는 대부분 PC만이 검출되었으며, 계절적으로는 봄에서 가을로 갈수록 감소하는 경향을 보였다. Squid is one of the most popular species over the East coast of Korea and sold as raw or processed one at the market. However, the liver and intestine occupied more than 20% of whole body are discarded wastefully at present. At this point of view, we analyzed lipid classes and fatty acid composition of liver, and tried to develop the utilities on the useful components of liver and intestine of squid. Alive squids were collected at the port of Jumunjin, Kangwon-Do, Korea, from April to Oct., 1988, and measured the body length, body weight and liver weight. Chemical composition of liver was analyzed by general method. Moreover, lipid class of total lipid was analysed using Iatroscan. As a results of this study, body weight, body length and liver weight increased after July, and hepatosomatic index(HSI) increased after May. Moreover, condition factor was maintained at moderate level after May. Among chemical components, water content had negative correlation with lipid and concentrations of protein and ash were not changed remarkly. In analysis of lipid class, it was proved that neutral lipid(NL) fraction of total lipid(TL) contained triacylglyceride(TG), sterol ester(SE) and free fatty acid(FFA) while polar lipid (PL) fraction of TL contained phosphatidylcholine(PC) dominantly.

한국 주요정신장애의 유병률 및 관련요인 : 2006 전국정신질환역학조사

조맹제,장성만,함봉진,정인원,배안,이영문,안준호,원승희,손정우,홍진표,배재남,이동우,조성진,박종익,이준영,김진영,전홍진,이해우 大韓神經精神醫學會 2009 신경정신의학 Vol.48 No.3

Objectives The aims of this study are to estimate the prevalence of the DSM-IV psychiatric disorders in the Korean population using the Korean version of Composite International Diagnostic Interview (K-CIDI), and to compare those with previous studies. Methods The Korean Epidemiologic Catchment Area study Replication (KECA-R) was Conducted between August 2006 and April 2007. The sampling of the subjects was carried out across 12 catchment areas. A multistage, cluster sampling design was adopted. The target Population included all eligible residents aged 181o 64 years. Face-to-face interviews were conducted with the Korean version of Composite International Diagnostic Interview (K-CIDI) based on the DSM-IV (N=6,510, response rate=81.7%). Results A total of 6,510 participants completed the interview. The lifetime and 12-month prevalence rates for all types of DSM-IV disorders were 30.0% and 17.3%, respectively. Those of Specific disorders were as follows : 1) alcohol use disorder, 16.2% and 5.6% ; 2) nicotine use disorder, 9.0% and 6.0% ; 3) specific phobia, 3.8% and 3.4% ; 4) major depressive disorder, 5.6% and 2.5% ; and 5) generalized anxiety disorder, 1.6% and 0.8%. Data relating to nicotine and alcohol use disorder revealed a very high male/female ratio. Mood disorder and anxiety disorder were more prevalent among females than males. Conclusion The prevalence of psychiatric disorders was high. In comparison with other studies, remarkable differences in the distribution of psychiatric disorders across the country and times were observed.

原料乳의 貯藏中 滴定酸度 및 總生菌數의 變化에 關한 硏究 : Ⅰ. 貯藏時間 및 溫度差에 의한 變化 Ⅰ. Studies on the Time of Storage and Difference Temperature

趙永來,尹東根,李乙熙 진주산업대학교 1980 論文集 Vol.18 No.-

機械搾乳한 原料乳를 5℃,15℃ 및 30℃에서 保存하여 5時間 간격을 두고 經視的으로 酸度測定, 總生菌數檢査 및 大腸菌群檢査를 한 結果는 다음과 같다. 1. 搾乳卽時의 滴定酸度는 0.1455%였다. 2. 搾乳卽時의 總生菌數는 4.5×10exp(4)/㎖이었다. 3. 滴定酸度는 5℃에서는 25時間이상 20℃에서는 5∼10時間 사이에 30℃에서는 5時間에서 기준치 이하였다. 4. 총생균수는 5℃에서는 20시간 이상 20℃에서는 10시간 30℃에서는 5시간 保存까지 基準(2×10exp(6)/㎖)이하로 나타났다. 5. 搾乳卽時 大腸菌群은 4.0×10exp(2)/㎖이었으나 15時間까지는 增加하였고 그 率은 점차 감소되었다. This study was conducted to fine out the titratable acidity and microbiological change during storage raw maik. It were taken from the mixed milk by Holstein cows in Jinju Agriculture & Forestry Junier Technical College under temperature of 30℃, 20℃ and 5℃ each for 25 hours in the laboratory. The results obtained were as follows; 1. The titratable acidity was 0.1455% in right after the milking. 2. The total bacterial counts of right after the milking was 4.5×10exp(4)/㎖. 3. The titratable acidity did not increase up to the inedible level of goverment standard until more than 25, between 5 and 10. and before 5 hours at 5, 20 and 30℃ conditions, respectively. 4. The total bacterial counts of raw milk did not increase up to inedible level of goverment standard until more than 20, 10 and 5 hours at 5, 20, and 30℃ conditions, respectively. 5. The colforms count of raw milk of right after the milking was 4.0×10exp(2)㎖ and there after it were incressed a space of 15 hours. But as the time passed it were decreased every temperature conditions.

의료복지용 센서 및 시스템의 개발(Ⅱ)

조진호,강희동 경북대학교 센서기술연구소 1997 연차보고서 Vol.1997 No.-

본 연구에서는 향후 중요한 의료 복지시스템으로 국내외에서 널리 쓰이게 될 MSGC형 온라인 X선 촬영 사진 촬영 장치를 개발하고자 하였다. MSGC형 은라인 X선 촬영장치는 기존의 X선 필름에 비해 조사선량을 크게 낮출 수 있으며 계조도(gray level)및 범위가 디지털 x-ray 시스템에 비해 훨씬 넓다. 그리고 MSGC형 센서는 비슷한 메카니즘으로 작동되는 MWPC형 위치검출센서 보다 높은 해상도를 얻을 수 있으며 센서제작에 대량화와 간편성을 동시에 제공할 수 있는 잇점이 있다. 본 연구는 MSGC센서를 제작하여 이로부터 X선 조사선량에 관계되는 기체 증폭펄스를 얻기 위한 연구 분야와, 이 센서를 이용하여 영상이 얻어질 수 있도록 시스템을 제어하고 영상을 재구성 및 처리하는 두 가지 연구 분야로 나누어 진행된다. MSGC형 센서개발에서는 해상도가 높고 기체증폭이 안정적으로 일어날수 있는 센서를 설계 제작하였고 다양한 실험자료를 수집하였다. MSGC형 센서 개발에서 핵심부분은 기판의 재질과 마이크로스트립형 전극 그리고 챔버 및 기체 증폭이 일어났을 때의 펄스를 샤프하게 분리시켜 계수할 수 있는 기술이다. 디지털 X선 장치 제어 및 영상처리 연구에서는 1차 년도에 제작된 제어 컴퓨터와 X-ray 인터페이스 회로가 가진 수동 조작의 불편함, 타이밍 제어시 오차 발생 및 X-선 Expose속도의 한계 등의 문제점을 개선시킨 인터페이스 보드를 개발하였다. We have developed the MSGC type on-line digital radiography system that will used widely in medical welfare system in future. The MSGC type can reduce the X-ray exposure to the object significantly as compared with X-ray film and its the dynamic range of gray level is more wide than the conventional digital X-ray system. And the MSGC type sensor can obtain much higher resolution than the position detecting sensor of MWPC type which has a similar mechanism to MSGC type and also it can provide an advantage of mass-production and a simplicity to produce the sensors. We divided into two research fields. One is the field of implementing the MSGC sensor and measuring pulses produced by gas multiplication related with the X-ray. The other field is developing the method of controlling digital image acquisition part, image reconstructing, and processing. In the development of MSGC type sensor, we designed and implemented the sensor with a high resolution and a stable gas multiplication. And we collected various experimental data. In the development of MSGC type sensor, the core parts are the materials of substrate, microstrip type electrode and chamber, and technique to split the pulses of gas multiplication sharply and count them. In the field of system controlling and image processing, we developed the new-interface board which has been improved some problems in the first research step, i.e. inconvenient operations of control computer and X-ray interface circuit, error occurrence in timing control, and the limitation of X-ray expose velocity.

시분할 방식 고주파 공진 인버터의 특성해석

조규판,원재선,김동희,노채균,배영호 영남대학교 공업기술연구소 2000 工業技術硏究所論文集 Vol.28 No.1

In this paper, we propose the high frequency resonant inverter of the time sharing type which has the effects that the duty cycle of each elements and the thermal loss can be reduce. The analysis of the proposed circuit is described generally by using the normalized parameters. Also, the principle of basic operation and the characteristics of drive were estimated by the switching frequency and the load parameters. And we got the data for designing by the characteristic values obtained at the estimate of characteristic. At the same time, the example of the design's method was proposed and the waveforms of simulation were compared with theoretical waveforms. It is certain that the proposed circuit will be used and expanded in the high frequency power supplies like induction heating systems.

노인의 식습관과 건강상태에 관한 연구 : 부산시 남ㆍ녀 노인을 중심으로 the Elderly Man and Woman in Pusan

조경자,한동희 慶星大學校 1994 論文集 Vol.15 No.2

This study was undertaken to investigate the relationship between the food habits and the health status. For this purpose, data were collected from deep interviews with 124 the elderly women and men, age 65 or greater in Pusan, Korea. For the data analysis, percentages, frequencies and means were calculated in order to describe the data. t-test, ANOVA, χ²-test were used. As a result of the data anylsis, the following results were obtained : 1. The age about the object person of research was the most numerous in 79% at 65-74 years old, in 70.9% with any their children, most elderly women and men were without job, regular excercise, regular health check and regular income. 2. The average man's weight was 61.89±6.33kg, woman's weight was 52.75±4.42kg, the average man's height was 166.47±7.92cm, woman's height was 154.96±6.02cm. 3. Both of the elderly men and women had regular meals at breakfast, lunch and supper. The most delicious meal was supper. The style of food intake was vegetables or mixed with vegetables and meats. Eventhough the participating at eating out with family was low, having meals with family at home usually. The problem of food habits was too much salty. 4. Eventhough both of the elderly men and women had eating some snacks between meals, they didn't have any nutritious reasons. Usually their child supplied it and in case of spouse, only the elderly women had the charge. 5. The elderly men were higher than the elderly women in case of smoking and drinking. 6. The elderly men wee better score than the elderly women with food habits. 7. Most of the elderly men and women had any chronic illness. 8. The elderly men were higher score with most areas except respiratory organs, the elderly women were score than the elderly men in the state of health. 9. The relationship between the elderly men and women showed a meaningful difference, fatigue showed a symptom as physical health, and nervousness showed a symptom as mental health with having poor food habits. The chronic illness also connected with poor food habits.