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Kwak Mi Young,Jo Eun Young,Chin Bum Sik,Park Se Eun,Yim Jun,Lee Jung Eun,Jo Kyung Eun,Kim Yeon-Sook,Lee Jeong Eun,Yoon Young Kyung,Seo Yu Bin,Jeong Su Jin,Kang Yu Min,Joo Eun-Jeong,Yoon Jong Hyun,Kim 대한감염학회 2022 Infection and Chemotherapy Vol.54 No.2
Despite the coronavirus disease 2019 (COVID-19) vaccination roll-out, variant-related outbreaks have occurred repeatedly in Korea. Although public hospitals played a major role in COVID-19 patients’ care, difficulty incorporating evolving COVID-19 treatment guidelines called for a clinical pathway (CP). Eighteen public hospitals volunteered, and a professional review board was created. CPs were formulated containing inclusion/exclusion criteria, application flow charts, and standardized order sets. After CP roll-out, key parameters improved, such as increased patient/staff five-point satisfaction scores (0.41/0.57) and decreased hospital stays (1.78 days)/medical expenses (17.5%). The CPs were updated consistently after roll-out as new therapeutics drugs were introduced and quarantine policies changed.
A Mutation in <i>PMP2</i> Causes Dominant Demyelinating Charcot-Marie-Tooth Neuropathy
Hong, Young Bin,Joo, Jaesoon,Hyun, Young Se,Kwak, Geon,Choi, Yu-Ri,Yeo, Ha Kyung,Jwa, Dong Hwan,Kim, Eun Ja,Mo, Won Min,Nam, Soo Hyun,Kim, Sung Min,Yoo, Jeong Hyun,Koo, Heasoo,Park, Hwan Tae,Chung, Ki Public Library of Science 2016 PLoS genetics Vol.12 No.2
<▼1><P>Charcot-Marie-Tooth disease (CMT) is a heterogeneous group of peripheral neuropathies with diverse genetic causes. In this study, we identified p.I43N mutation in <I>PMP2</I> from a family exhibiting autosomal dominant demyelinating CMT neuropathy by whole exome sequencing and characterized the clinical features. The age at onset was the first to second decades and muscle atrophy started in the distal portion of the leg. Predominant fatty replacement in the anterior and lateral compartment was similar to that in CMT1A caused by <I>PMP22</I> duplication. Sural nerve biopsy showed onion bulbs and degenerating fibers with various myelin abnormalities. The relevance of <I>PMP2</I> mutation as a genetic cause of dominant CMT1 was assessed using transgenic mouse models. Transgenic mice expressing wild type or mutant (p.I43N) <I>PMP2</I> exhibited abnormal motor function. Electrophysiological data revealed that both mice had reduced motor nerve conduction velocities (MNCV). Electron microscopy revealed that demyelinating fibers and internodal lengths were shortened in both transgenic mice. These data imply that overexpression of wild type as well as mutant <I>PMP2</I> also causes the CMT1 phenotype, which has been documented in the <I>PMP22</I>. This report might expand the genetic and clinical features of CMT and a further mechanism study will enhance our understanding of <I>PMP2</I>-associated peripheral neuropathy.</P></▼1><▼2><P><B>Author Summary</B></P><P>Isolation of causative mutation is still challenging in genetic diseases with a variety of genetic causes. We discovered a mutation in a novel gene from a family exhibiting a peripheral neuropathy by virtue of next-generation sequencing. Although the family shows characteristic clinical features of hereditary motor and sensory neuropathy, we could not find a mutation from well-known genes. To demonstrate the clinical relevance of the novel gene, we generated transgenic mice, which carry the patients’ mutation within their chromosome. The transgenic mice exhibited the same phenotype as the patients including peripheral neuropathic symptoms and reduced locomotor function. We also observed the affected peripheral nervous system through electron microscopy. It seems that the expression of the mutant protein impairs the myelin of peripheral nervous system. These data might expand the genetic, clinical, and pathophysiological features of the peripheral neuropathy and a further investigation will enhance our understanding of disease in the peripheral nervous system.</P></▼2>
곽효성,한영민,임영수,전수빈,이상용,정경호,김종수,손명희,최기철 의과학연구소 1998 全北醫大論文集 Vol.22 No.1
1. Purpose : To evaluate of the effectiveness of bronchial arterial embolization acdording to the causess of hemoptysis. 2. Materials and methods : This study included 39 patients who had undertaken arterial embolization for the control of hemyptysis. The patinets were classified 1. Purpose: To evaluate of the effectiveness of bronchial arterial embolization according to the causes of hemoptysis. 2. Materials and methods: This study included 39 patients who had undertaken arterial embolization for the control of hemoptysis. The patinets were classified into the three groups: pulmonary tuberculosis (n=22), idiopathic bronchiectasis (n=10), lung cancer (n=7). Gelfoam particle were used as embolized material for all patients. And only for two patients, embolization coil was interpolated. The period of follow-u[ was from 1 to 66 months after arterial embolization. Immediate results were assessed based on careful observation of patients for 1 month after arterial embolization: success, indicating complete cessation of hemoptysis for 1 month: and fail, indicating continued hemoptysis or recurrent hemoptysis within 1 month. Long-term results were evaluated in patients with immediate success who could be followed for at least 1 month. Patients were classified into the three categories: complete remission, indicating complete cessation of bleeding during the observation period : partial remission, indicating complete cessation of hemoptysis with recurrent bloody sputum during the observation period : and recurrence, indicating recurrent hemoptysis. 3. Results : immediate success rate was 76.9%(30/39), and as classified into the causes, idiopathic bronchiectasis 90.0% (9/10), pulmonary tuberculosis 81.8% (18/22), lung cancer 42.9%(3/7). Long-term results in the causes of idiopathic bronchiectasis showed a high remission rate (77.8%), a low recurrence rate (22.2%). In pulmonary tuberculosis, remission rate was 70.8%m recurrence rate was 29.4%. No recurrence was observed in the cases of success of the lung cancer. During and after embolization, the complications were mild chest pain 1 or fever, which relieved spontaneously within a few days. 4. Conclusion : The benign diseases such as pulmonary tuberculosis and idiopathic bronchiectasis showed a high immediate success rate and a high long-term remission rate. The lung cancer showed a low immediate success rate. But during observation period, lung cancer showed no recurrence. (Key Words : Lung, hemorrhage, therapeutic, blockade)
실리콘 마이크로스피어를 이용한 LED 광학 특성 변화에 관한 연구
강영래(Young-Rae Kang),김완호(Wan-Ho Kim),장민석(Min-Suk Jang),오미연(Mi-Yeun Oh),주재영(Jae-Young Joo),송상빈(Sang-Bin Song),곽준섭(Joon Seop Kwak),김재필(Jae-Pil Kim) 한국조명·전기설비학회 2011 한국조명·전기설비학회 학술대회논문집 Vol.2011 No.5월
본 연구에서는 조명용 백색LED의 지향각에 따른 색온도 균일성을 향상하기 위해 LED 용봉지재에 실리콘 마이크로스피어를 첨가하여 LED 광원을 제작하였다. 형광체를 혼합하지 않은 경우, 지향각은 실리콘 마이크로스피어 첨가비율을 0w t%에서 1 wt%까지 증가에 따라 97.5°에서 109°까지 증가하였으며, 형광체와 11㎛ 실리콘 마이크로스피어는 첨가비율에 상관없이 지향각 109°를 유지하였다. 실리콘 마이크로스피어의 첨가비율 1 wt%일 때 Photometry ratio는 2% 감소하였지만, 지향각에 따른색 균일성(Color Uniformity)평가 결과 0w t%일때 Δ색온도 775K에서 1 wt%일때 Δ색온도 615K로 감소함에 따라 26%의 개선효과를 보였다.
Glasswort Powder Diet Activates Lipid Metabolism in Rat
Hyo Bin Seo,Yunyoung Kwak,Ju-Ock Nam,Young Ju Song,Byung-Oh Kim,Sungpil Ryu 한국생명과학회 2012 생명과학회지 Vol.22 No.4
본 연구에서는 함초분 섭취가 지질대사에 미치는 영향을 알아보고자 하였다. 흰쥐를 일반식이 대조군(CON), 고지방식이 대조군(HFC), 고지방식이에 함초분 첨가군(HFG)로 각각 구분하여 4주간 섭취시켰다. 체중은 HFG가 HFC에 비하여 9% 정도 낮았다. 분변칼로리 분석을 한 결과, HFG의 지방량(CON에 비하여 120%, HFC에 비하여 138)과 분변 칼로리(약 110%)가 높은 것으로 나타났다. 혈중 중성지방과 LDL-C는 HFG가 HFC에 비하여 낮았으며(각각 71.8% 및 58%), HDL-C는 HFG가 HFC에 비하여 152% 높았다. 간의 FABP 발현은 HFG가 HFC보다 197% 높았으며, CPT-1 역시 동일한 경향을 보였다. 이러한 결과는 함초분 섭취가 체중의 증가를 억제하였고, 간세포 수준에서의 지방대사를 개선하였다는 점을 시사한다. 이러한 결과를 함초분이 소화관에서의 지방흡수를 억제함으로써 항비만 효과를 가지는 것으로 제안하고자 한다. The purpose of this study was to investigate the effects of glasswort powder intake on lipid metabolism. Rats were divided into three groups: a group fed a normal diet (CON), one fed a high fat diet (HFC), and one fed a high fat diet with glasswort powder (HFG). They were fed their respective diet for four weeks. Body weight was significantly lower (9%) in the HFG group than in the HFC group at the fourth week. According to the feces analysis, the HFG group showed the highest fat level (120% vs. CON; 138% vs. HFC) and fecal calories (110%). The concentration level of TG and LDL-C was 71.8% lower in the HFG group compared to the HFC group, while the concentration level of HDL-C was 152% higher in the HFG group. Expression of FABP in the liver was 197% greater in the HFG compared to the HFC group, with the expression of CPT-1 showing a similar tendency. These results suggest that glasswort powder intake suppresses weight gain and improves fat metabolism at the level of liver cells. From these results, we suggest that glasswort powder is effective against obesity by inhibiting the absorption of fat in the digestive tract.