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( Yoon Suh Do ),( Seung-jae Myung ),( Sun-young Kwak ),( Soo Han Cho ),( Enoch Lee ),( Min Jeong Song ),( Chang Sik Yu ),( Yong Sik Yoon ),( Hye Kyung Lee ) 대한소화기기능성질환·운동학회 2015 Journal of Neurogastroenterology and Motility (JNM Vol.21 No.4
Background/Aims Chronic intestinal pseudo-obstruction (CIPO) is a disorder characterized by recurrent symptoms suggestive of obstruction such as abdominal pain, proximal distension with extremely suppressed motility in the absence of lumen-occluding lesion, whose etiology/ pathophysiology is poorly understood. In this study we investigated a functionally obstructive lesion that could underlie symptoms of CIPO. Methods We studied colons surgically removed from 13 patients exhibiting clinical/pathological features of pseudo-obstruction but were unresponsive to standard medical treatments. The colons were characterized morphologically, functionally and molecularly, which were compared between regions and to 28 region-matched controls obtained from colon cancer patients. Results The colons with pseudo-obstruction exhibited persistent luminal distension proximally, where the smooth muscle was hypertrophied with changes in the cell phenotypes. Distinct luminal narrowing was observed near the distal end of the dilated region, close to the splenic flexure, previously referred to as the “transition zone (TZ)” between the dilated and non-dilated loops. Circular muscles from the TZ responded less to depolarization and cholinergic stimulation, which was associated with downregulation of L-type calcium channel expression. Smooth muscle contractile protein was also downregulated. Myenteric ganglia and neuronal nitric oxide synthase (nNOS) positive cells were deficient, more severely in the TZ region. Interstitial cells of Cajal was relatively less affected. Conclusions The TZ may be the principal site of functional obstruction, leading to proximal distension and smooth muscle hypertrophy, in which partial nNOS depletion could play a key role. The neuromuscular abnormalities probably synergistically contributed to the extremely suppressed motility observed in the colonic pseudo-obstruction. (J Neurogastroenterol Motil 2015;21:560-570)
압전방식을 이용한 담낭결석의 체외충격파 쇄석술에 관한 실험적 연구
서경석,도영수,한준구,최병인,박용현,한만청,윤용범,최대섭,김주완,신용문,한기석 대한소화기학회 1992 대한소화기학회지 Vol.24 No.1
Extracorporeal, Shock Wave Lithotripsy (ESWL) was performed in 87 gallstones from 47 patients with the piezoelectric lithotriptor to evaluate the fragmentation rate and average number of shock waves according to the characteristics of gallstones. Sixty seven gallstones were classified as cholesterol stones (pure: 7, mixed: 42, and combination: 18), 15 stones as pigment stones (calcium bilirubinate: 7, and black pigment: 8), and five stones as rare stones on the basis of external morphology and internal structure of cut surface of stones. Size of gallstones was ranged from 5 to 30 ㎜ (mean: 13.0±4.6 ㎜). Sonography arid plain radiography of each gallstone was performed to evaluate the characteristics of stones. Sonographic findings of gallstones were classified into two types; type Ⅰ: surface echo with variable internal echo of gallstones and clean posterior acoustic shadow, type Ⅱ: echo of whole gallstones with posterior acoustic shadow. Sixty-six (95.7%) of 69 stones with sonographic type Ⅰ were cholesterol stones and 15 (83.3%) of 18 stones with sonographic type Ⅱ were pigment stones (p$lt;0.01). On plain radiographs, 35 stones were radiolucent and 52 stones had calcifications with variable laatterns. All 87 gallstones were fragmented by the piezoelectric lithotriptor. Average number of shock waves for complete fragmentation of stones less than 2 ㎝ and stones mare than 2 ㎝ wad 1052.5 and 7454. 2, respectively(p$lt;0.01). Average number of shock waves for fragmentation of sonographic type Ⅰ and Ⅱ was 1845.3 and 147.4 respectively (p$lt;0.01). Average number of shock waves for fragmentation of noncalcifed stones and calcified stones were 1901.8 and 1219.5, respectively (p:0.260). However, fragmentation of stones with diffuse calcification was easier than those of other types of calcification (p$lt; 0.05). On the basis of our results, the most important variables determining the degree of fragmentation of gallstones using piezoelectric lithotriptor were not their chemical composition (p:0.093) or sonographic type (p:0.098) but their size (p$lt;0.001) and calcification pattern (p:0.023).
서규표,김병용,박손원,윤성도 啓明大學校 醫科大學 1993 계명의대학술지 Vol.12 No.1
Thanatophoric dwarfism is the term applied to a distinctive, lethal form of bone dysplasia described by Maroteax et al. in 1967. Authors experienced a case of fetal dwarfism on antenatal ultrasound and flat abdominal X-ray examinations. The baby was delivered by induction of labor. Diagnosis was confirmed to thanatophoric dwarfism by clinical features, radiological and autopsy findings.
Yoon, Jai-Woong,Park, Young-Guk,Park, Chun-Joo,Kim, Do-Il,Lee, Jin-Ho,Chung, Nag-Kun,Choe, Bo-Young,Suh, Tae-Suk,Lee, Hyoung-Koo Published for the American Association of Physicis 2007 Medical physics Vol.34 No.11
<P>The stationary grid commonly used with a digital x-ray detector causes a moiré interference pattern due to the inadequate sampling of the grid shadows by the detector pixels. There are limitations with the previous methods used to remove the moiré such as imperfect electromagnetic interference shielding and the loss of image information. A new method is proposed for removing the moiré pattern by integrating a carbon-interspaced high precision x-ray grid with high grid line uniformity with the detector for frequency matching. The grid was aligned to the detector by translating and rotating the x-ray grid with respect to the detector using microcontrolled alignment mechanism. The gap between the grid and the detector surface was adjusted with micrometer precision to precisely match the projected grid line pitch to the detector pixel pitch. Considering the magnification of the grid shadows on the detector plane, the grids were manufactured such that the grid line frequency was slightly higher than the detector sampling frequency. This study examined the factors that affect the moiré pattern, particularly the line frequency and displacement. The frequency of the moiré pattern was found to be sensitive to the angular displacement of the grid with respect to the detector while the horizontal translation alters the phase but not the moiré frequency. The frequency of the moiré pattern also decreased with decreasing difference in frequency between the grid and the detector, and a moiré-free image was produced after complete matching for a given source to detector distance. The image quality factors including the contrast, signal-to-noise ratio and uniformity in the images with and without the moiré pattern were investigated.</P>
최근 전국 의과대학 의학과 유급율 분석(1982-1986)
윤성도,서수지,박우현,송준영 啓明大學校 醫科大學 1989 계명의대학술지 Vol.8 No.1
The authors conducted an analysis of recent failure rates in nationwide medical schools in Korea in order to set up a directing post needed because of the rapidly changing and progressive situation of the medical schools. The authors are presently involved with administrative responsibilities for medical school education in this particular institution but have had comparatively little experience in such particular institution in the past. The trends shown in this analysis are the result of questionaires and other materials developed over the five years from 1982 through 1986, and the results are as follows: The present rate of failure at nationwide medical schools reveals a somewhat increasing trend over the past 5 years, with an average rate of 5.5% overall and with breakdown of 4.8% in National Medical Schools, 5.3% in Private Medical Schools, and 8.1% in our Keimyung University Medical School which is a relatively high rate. In general the trend reveals a higher rate in private medical schools than in national medical schools, with local medical schools being higher than the capital region, and the newly established ones being higher than the older ones. It also reveals a decreasing tendency in the higher academic years. A present 5 year failure rate of Keimyung University Medical School gives an average rate of 8.1%, which shows a gradual decrease compared with the peak rate of 16.8% in the 1982. Of the students who are in medical school of Keimyung University, the ratio of failed students to normal students in general is 57% to 43%, which indicates the rate increases as the students progress to higher academic standing. The percentage of students who failed more than twice was 12% and those who failed more than 3 times was 2%.
Primaquine으로 치료된 생식모세포혈증 열대열 말라리아 1예
서인범,윤도경,임채승 대한감염학회 2001 감염 Vol.33 No.4
We experienced a case of Plasmodium falciparum gametocytemia successfully treated with primaquine in a twenty seven-years old woman. The patient had been admitted due to general malaise after diagosis and treatment of P. falciparum at Tanzania one month ago. On microscopic examination, P. falciparum gametocytemia was seen and treated with mefloquine for one week but gametocytemia was not disappeared. After primaquine treatment for two weeks, she was successful treated.(Korean J Infect Dis 33:302~304, 2001)
Basic : A case of hepatic angiomyolipoma misdiagnosis as hepatocellular carcinoma (초)
( Suh Yoon Yang ),( Hyung Joon Kim ),( Hyun Woong Lee ),( Bong Ki Cha ),( Beom Jin Kim ),( Hyoung Chul Oh ),( Chang Hwan Choi ),( Jeong Wook Kim ),( Jae Hyuk Do ),( Jae Gyu Kim ),( Sae Kyung Chang ) 대한간학회 2011 Clinical and Molecular Hepatology(대한간학회지) Vol.17 No.3(S)