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Herbal extract THI improves metabolic abnormality in mice fed a high-fat diet
Han, So-Ra,Oh, Ki-Sook,Yoon, Yoo-Sik,Park, Jeong-Su,Park, Yun-Sun,Han, Jeong-Hye,Jeong, Ae-Lee,Lee, Sun-Yi,Park, Mi-Young,Choi, Yeon-A,Lim, Jong-Seok,Yang, Young The Korean Nutrition Society 2011 Nutrition Research and Practice Vol. No.
Target herbal ingredient (THI) is an extract made from two herbs, Scutellariae Radix and Platycodi Radix. It has been developed as a treatment for metabolic diseases such as hyperlipidemia, atherosclerosis, and hypertension. One component of these two herbs has been reported to have anti-inflammatory, anti-hyperlipidemic, and anti-obesity activities. However, there have been no reports about the effects of the mixed extract of these two herbs on metabolic diseases. In this study, we investigated the metabolic effects of THI using a diet-induced obesity (DIO) mouse model. High-fat diet (HFD) mice were orally administered daily with 250 mg/kg of THI. After 10 weeks of treatment, the THI-administered HFD mice showed reduction of body weights and epididymal white adipose tissue weights as well as improved glucose tolerance. In addition, the level of total cholesterol in the serum was markedly reduced. To elucidate the molecular mechanism of the metabolic effects of THI in vitro, 3T3-L1 cells were treated with THI, after which the mRNA levels of adipogenic transcription factors, including C/$EBP{\alpha}$ and $PPAR{\gamma}$, were measured. The results show that the expression of these two transcription factors was down regulated by THI in a dose-dependent manner. We also examined the combinatorial effects of THI and swimming exercise on metabolic status. THI administration simultaneously accompanied by swimming exercise had a synergistic effect on serum cholesterol levels. These findings suggest that THI could be developed as a supplement for improving metabolic status.
( Jeong Rae Yoo ),( Bo Ra Shin ),( Sujin Jo ),( Sang Taek Heo ) 대한내과학회 2021 The Korean Journal of Internal Medicine Vol.36 No.3
Background/Aims: We introduced the Early Fluconazole Treatment in Candidemia (EFTC) protocol in August 2015 to improve the outcomes of patients with candidemia. This study evaluated the effectiveness of the EFTC protocol. Methods: We conducted a retrospective before-and-after study among patients in the intensive care units and Hemato-Oncology and General Surgery wards of our hospital between January 2013 and December 2018. The EFTC protocol entailed sending an automatic notification by short message service, feedback to the responsible healthcare worker, and regular standardized education of medical staff. On receiving a notification, physicians prescribed empirical fluconazole immediately. The effectiveness of the EFTC protocol was evaluated by multivariate analysis of risk factors for 30-day mortality. Results: Of 103 patients with candidemia, 50 were admitted before (pre-EFTC group) and 53 were admitted after (post-EFTC group) the introduction of the EFTC protocol. Patients’ mean age ± SD was 67.1 ± 18.6 years, and 55 (53.4%) were male. The mean ± SD time from Candida isolation to antifungal drug administration in the pre-EFTC and post-EFTC groups was 89.1 ± 73.6 and -9.8 ± 63.9 minutes, respectively (p = 0.01). The 30-day mortality in the pre-EFTC and post-EFTC groups was 54.5% (95% confidence interval [CI], 42.3 to 66.7), and 37.6% (95% CI, 26.1 to 49.1), respectively (p = 0.05). In the multivariate analysis, implementation of the EFTC protocol was independently associated with a reduction in 30-day mortality (odds ratio, 0.27; 95% CI, 0.12 to 0.63; p = 0.01). Conclusions: The early f luconazole treatment, monitoring, and education were effective in reducing mortality in patients with candidemia.
( Jeong-min Ha ),( So-ra Choi ),( Chan-keol Park ),( Su-jin Yoo ),( In-seol Yoo ),( Jin-hyun Kim ),( Seung-cheol Shim ),( Seong-wook Kang ),( Young Lee ),( Young-joon Seo ),( Chang-deok Kim ),( Jeung- 대한피부과학회 2017 대한피부과학회 학술발표대회집 Vol.69 No.2
Background: Psoriatic arthritis (PsA), associated with psoriasis (PsO), is a chronic inflammatory disease of the joints. The prevalence of PsA among the PsO patients is significantly different between previous studies, and there is little research on the prevalence in Korea. Objectives: To measure the prevalence of PsA among PsO patients and validate the PsA screening questionnaires. Methods: A cross-sectional observational study was conducted on 220 patients with PsO by using Psoriatic Arthritis Screening and Evaluation tool (PASE) and Psoriasis Epidemiology Screening Tool (PEST). To confirm the diagnosis of PsA, patients with possibility of PsA were finally referred to the rheumatologist. Results: Among 220 patients, 48 patients in PEST and 24 patients in PASE showed high scores in the screening questionnaires, and only 9 of these 52 patients were diagnosed with PsA by radiological and serological tests. In this study, the prevalence of PsA in PsO patients was 4% and the sensitivity was higher in PEST compared to PASE. Most PsA patients had polyarthritis, and joints on the fingers and knees are the most common. There was no association between PsA and current Psoriasis Area Severity Index(p=0.715), but 77% (n=7/9) of patients with PsA had nail involvement. Conclusion: Through this study, we have identified the low prevalence of PsA in Korean PsO patients and concluded that the PsA screening questionnaire might be helpful in the screening and treatment of PsA in dermatologists or PsO patient
법정보호종, 흰발농게(Austruca lactea) 서식 개체수 추정에 대한 검토와 대안
유재원(Yoo, Jae-Won),김창수(Kim, Chang-Soo),박미라(Park, Mi-Ra),정수영(Jeong, Su-Young),이채린(Lee, Chae-Lin),김성태(Kim, Sungtae),안동식(Ahn, Dong-Sik),이창근(Lee, Chang-Gun),한동욱(Han, Donguk),백용해(Back, Yonghae),박영철(Park, Yo 한국습지학회 2021 한국습지학회지 Vol.23 No.2
본 연구에서는 우리나라의 갯벌에서 조사대상으로 삼는 멸종위기야생생물이자 해양보호생물, 흰발농게(Austruca lactea)의전체 개체수 추정 방법을 검토하였다. 일반적으로 무한모집단에 대한 전수조사는 불가능하며 이는 갯벌 내 제한된 서식처에서 개체수를 추정하더라도 마찬가지이다. 표본으로부터 추정되는 서식 밀도 역시 다양한 생물학적, 생태학적 요인들로 인해높은 변동성을 보인다. 서식처 경계와 면적은 측정 오차뿐만 아니라 생물의 주기성이나 리듬 활동(주야, 간만 주기 등)에따라서도 달라진다. 따라서 밀도와 서식처 면적으로 산출되는 전체 개체수는 일시적인 것으로 간주되어야 한다. 이 같은 추정은 인천 송도 갯벌에서 3년 간 관찰된 흰발농게(A. lactea)의 평균 밀도와 표준오차 범위 그리고 공간분포의 시공간적 변동성에 근거하면 타당한 것으로 볼 수 있었다. 본 연구에서는 로지스틱 회귀모형의 출현 확률인 50%를 기준으로, 서식처 보존 가치의 중요성을 반영하는 잠재적 서식처 면적을 전체 개체수 추정의 대안으로 제시하였다. 보편성을 갖춘 모형으로부터 예측되는 잠재적 서식처는 대상종의 주요 환경조건이 급격하게 변하지 않는다면 시간에 따라 일정한 모습을 유지할 것이다. 특정종을 대상으로 개발되는 모형은 추후 서식처 복원/조성 사업에서도 원하는 생물의 정착을 유도하는데도 활용이 가능할 것으로 기대된다. We reviewed the methods employed in Korean tidal flat surveys to measure the local abundance of the endangered wildlife and marine protected species, the fiddler crab, Austruca lactea. A complete census for infinite population is impossible even in a limited habitat within a tidal flat, and density estimates from samples strongly vary due to diverse biological and ecological factors. The habitat boundaries and areas shift with periodicities or rhythmic activities of organisms as well as measurement errors. Hence the local abundance calculated from density and habitat areas should be regarded as transient. This conjecture was valid based on the spatio-temporal variations of the density averages, standard error ranges, and spatial distribution of the crab, A. lactea observed for 3 years (2015-2017) in Songdo tidal flat in Incheon. We proposed the potential habitat areas using the occurrence probability of 50% from logistic regression model, reflecting the importance of habitat conservation value as an alternative to local abundance. The spatial shape of potential habitat predicted from a generalized model would remain constant over time unless the species’ critical environmental conditions change rapidly. The species-specific model is expected to be used for the introduction of desired species in future habitat restoration/creation projects.
So Ra Kim,Mi-Kyung Kwak,Hye Ran Kang,Seug Yun Yoon,Seong Soon Kwon,Bo Young Kim,Hoo Nam Choi,Hye Jeong Kim,Jae Wook Kim,So-Young Jin,Hyeong Kyu Park,Dong Won Byun,Kyoil Suh,Myung-Hi Yoo 순천향대학교 순천향의학연구소 2014 Journal of Soonchunhyang Medical Science Vol.20 No.2
Although the prognosis of papillary thyroid cancer (PTC) is extremely good, locoregional recurrences after initial treatment occur. Thyroglobulin (Tg) is a reliable tumor marker to detect recurrence or persistence of PTC. However, occasionally serum Tg may miss the detection of a recurrence. We report a 54-year-old female presented with hoarseness due to cervical recurrence without concomitant elevation of serum Tg and anti-Tg antibody, in contrast to extremely increased needle-washout Tg, who had undergone a total thyroidectomy and radioiodine ablation as initial therapies for PTC. Several factors causing such discrepancy between needlewashout Tg and serum Tg can be suggested including site of recurrence, volume of tumor, interference by some kind of plasma antibodies other than anti-Tg antibody, and any conformational defect of Tg protein. Among them, the most convincing explanation is that any conformational defect of Tg may lead to impaired secretion of Tg to blood. We suggest that more studies are needed to find the cause for potential mechanisms involved in PTC recurrences without increased serum Tg.