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Kim, Young Ho,Sung, Ki Sa,Lee, Sook-Jeong,Kim, Yong-Ou,Choi, Cheol Yong,Kim, Yongsok Elsevier 2005 FEBS letters Vol.579 No.27
<P><B>Abstract</B></P><P>The modification of homeodomain-interacting protein kinase 2 (HIPK2) by small ubiquitin-like modifier 1 (SUMO-1) plays an important role in its targeting into the promyelocytic leukemia body, as well as in its differential interaction with binding partner, but the desumoylation of HIPK2 by SUMO-specific proteases is largely unknown. In this study, we show that HIPK2 is a desumoylation target for the SUMO-specific protease SENP1 that shuttles between the cytoplasm and the nucleus. Mutation analyses reveal that SENP1 contains the nuclear export sequence (NES) within the extreme carboxyl-terminal region, and SENP1 is exported to the cytoplasm in a NES-dependent manner. Sumoylated HIPK2 are deconjugated by SENP1 both in vitro and in cultured cells, and the desumoylation is enhanced either by the forced translocation of SENP1 into the nucleus or by the SENP1 NES mutant. Concomitantly, desumoylation induces dissociation of HIPK2 from nuclear bodies. These results demonstrate that HIPK2 is a target for SENP1 desumoylation, and suggest that the desumoylation of HIPK2 may be regulated by the cytoplasmic-nuclear shuttling of SENP1.</P>
LEE, Hyeon Yong,HWANG, In Koo,KIM, Dae Ho,KIM, Jung Hwa,KIM, Chang Ho,LIM, Beong Ou,KANG, Tae-Cheon,BANG, Kyung Hwan,SEONG, Nak Sul,LEE, Hak Ju,KIM, Jong Dai,WON, Moo Ho Japanese Association for Laboratory Animal Science 2005 EXPERIMENTAL ANIMALS Vol.54 No.1
<P>Although galanin (GAL) protects hippocampal neurons from ischemic damage, no study has examined ischemia-related changes in endogenous GAL in the hippocampal dentate gyrus. We investigated the chronological changes of GAL, well-known as the potassium channel opener, expression in the dentate gyrus at various times after 5 min of transient forebrain ischemia in gerbils. A few GAL-immunoreactive (IR) neurons were found in the polymorphic layer of the sham-operated group. Three hours after ischemia-reperfusion, the pattern of GAL immunoreactivity was similar to that of the sham-operated group and the number of GAL-IR neurons and immunoreactivity were highest 12 h after ischemic insult. At this time, GAL-IR neurons in the polymorphic layer showed strong GAL immunoreactivity. Thereafter, GAL-IR neurons and immunoreactivity significantly decreased in the dentate hilar region. Four days after ischemic insult, GAL-IR neurons were not detectable. In addition, the results of a Western blot study showed a pattern of GAL expression similar to the immunohistochemical changes. GAL protein content also was highest 12 h after ischemia. In conclusion, the increased expression of endogenous GAL in the dentate gyrus after ischemia is related to response to the ischemic damage.</P>
김경애(Kyung-Ae Kim),이병옥(Byeng Ok Lee),김오목(Ou Mok Kim),허명제(Myung Je Hur),김경태(Kyung Tae Kim),노재일(Jae Il Ro),최춘석(Choon Suck Choe),고종명(Jong Myoung Go),김용희(Yong Hee Kim) 대한환경위생공학회 2007 대한환경위생공학회지 Vol.22 No.3
In order to investigate water pollution of spring, we carried out the experiments on mineral water, rainwater and surrounding soil of several springs collected in Incheon area from February to August in 2007. The results were as follows. 1. Soil : This study investigated the pH and organic matter contents in the soil which effect on microorganisms, The pH value was from 4.5 to 5.3 on average and organic matter contents ranged from 1,09 % to 5,6% and E. coli, K. pneumoniae, S.faecalis and other microorganisms were isolated. 2. Natural mineral water : As the rainfall increased, the concentration of No?-N, consumption of KMnO₄ and the number of microorganisms was increased while the other physicochemical items were not affected. The microorganism isolated in the natural mineral water were as follows: E. coli. K. oxytoca S. faecalis, S. facium, and so on from evacuation; E. agglomerans, E. amnigenus, E. cloacae, E. sakazakii and so on from the environments and evacuation. Detection of these microorganisms shows that the environment around the spring had been exposed to excrements of the warm blood animal. 3. Rain : The coliforms in the rain were the identical one detected from the mineral water and the soil. In conclusion the quality of natural mineral water is influenced by rain, resident bacteria of soil and surrounding environment. This study will be the basic data of characteristics of spring in Incheon area and also this result will give useful aids for the efficient control of spring.
집단지성 모델에 기반한 MMORPG 아이템 가격결정시스템 설계
김성호(Sung Ho Kim),김신웅(Sin Wung Kim),최종렬(Ou Bong Kwun),김용성(Yong Sung Kim) 한국컴퓨터게임학회 2013 한국컴퓨터게임학회논문지 Vol.26 No.1
Recently, since the development of internet and online space, people experience new communication space and games different from traditional ones. People share their experiment of games and item in the online space with internet. This paper proposes the design of the MMORPG item's pricing decision system. First, the on-going "chatting" in the game chatting system is collected by chatting API. This collected chatting is the information including terms of game item. Then, extracted terms of game item are classified on the basis of collective intelligence model and generate a table of weight. At last, this system can recommend suitable MMORPG item to users with the obtained weight table storing as ontology.
증예(症例) : 장기 생존을 보인 골, 폐 및 복강내 전이가 있었던 원발성 간세포암종 1예
황민호 ( Min Ho Hwang ),김용문 ( Yong Mun Kim ),김정화 ( Jung Wha Kim ),송민섭 ( Min Sub Song ),윤찬호 ( Chan Ho Yun ),김은화 ( Eun Wha Kim ),최용우 ( Yong Ou Choi ),이용웅 ( Yong Woong Lee ) 전북대학교 의과학연구소 2001 全北醫大論文集 Vol.25 No.1
원발성 간암세포암종의 원격전이는 예후가 불량하며 전이병소에 대한 고식적인 수술적 절제, 방사선 치료, 항암화학요법 등과 이들의 병행치료로 효과가 있다고 보고하고는 있으나, 본 증례에서와 같이 좌측 골반부, 우측 견갑부의 골 전이와 폐 전이, 복강내 전이 등 다발성 원격전이된 환자에서의 보고는 없는 상황에서 적극적이며 주기적인 방사선 치료로 비교적 장기 생존을 하며 치료 효과가 있었던 1 예를 보고하는 바이며, 향후에도 적극적이며 다양한 치료 방법들에 대한 보고들이 계속되어야 할 것으로 판단된다. Primary hepatocellular carcinoma(HCC) is one of the most prevalent cancers in the world, particularly in Asia and parts of Africa. Extrahepatic metastasis by blood stream dissemination are encountered in lung. bone, adrenal glands, pancreas, kidney and the spleen. The prognosis of extrahepatic metastasis from HCC remains lethal and average survival time after the time of diagnosis is under 6 months but appropriate local surgical resection of the metastatic region and systemic control with chemotheraphy and radiotheraphy can result in improved quality of survival. We report the case who had been alive 11 months after left iliac bone and then lung, right shoulder joint and peritoneum metastasis with only irradiation.