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( Ye Eun Byeon ),( Hak Hyun Ryu ),( Sung Su Park ),( Yoshihisa Koyama ),( Masanori Kikuchi ),( Min Soo Seo ),( Wan Hee Kim ),( Kyung Sun Kang ),( Oh Kyeong Kweon ) 한국조직공학·재생의학회 2009 조직공학과 재생의학 Vol.6 No.4
The objective of this study is to evaluate the effect of mixtures of β-tricalcium phosphate(β-Ca3(PO4)2, β-TCP) granules with canine allogenic umbilical cord blood derived mesenchymal stem cells(UCB-MSC) and their lysates on bone formation. The mixtures were implanted into cylindrical bone defects(7 mm diameter, 10 mm length) made bilaterally by using the trephine in the medial aspect of the distal femur and proximal tibia. Fluorochromes for bone labeling were administered for measuring the rate of mineral apposition at 4, 6 and 8 weeks after implantation. A radiographic evaluation of the radiopacity of the implant in the bone defect was made at 2 weeks intervals. At 10 weeks, postoperatively, bone regeneration and resorption of β-TCP were assessed by micro-computed tomography(CT) in the tibia and by fluorescence microscopy and histomorphological examination in the femur and tibia. In micro CT, cortical bony bridging in the UCB-MSC, cell lysate and control groups was observed in 2, 1 and 0 out of each of the 3 samples, respectively. Bone mineral densities within trabecular bone defects were significantly different among the different groups(UCB-MSC < cell lysate < control) but the mineral apposition rate per day from 4 weeks after implantation was not different. In histomorphology the rates of new bone formation and resorption of the β-TCP in the UCB-MSC group were significantly higher than in the control group of both femur and tibia than in the cell lysate group in the tibia(p<0.05). The rate of new bone formation in the cell lysate group was not different compared to that of the control group in both the femur and the tibia. However, the absorption rate of the β-TCP in the tibia was significantly higher than that of the control group. The UCB-MSC improved the absorption of β-TCP and bone formation without site-dependence; however their lysates showed site-dependent effects. These results suggested that the canine allogenic UCB-MSC mixed with β-TCP had a higher bone healing activity for bone defects than their lysates.
Enterocutaneous Fistula as a Result of Chronic Bite Wound Repair in a Dog
BYEON, Ye-Eun,PARK, Sung-Su,CHOI, Min-Cheol,KWEON, Oh-Kyeong,KIM, Wan Hee Japanese Society of Veterinary Science 2008 The Journal of veterinary medical science Vol.70 No.11
<P>A 6-year-old castrated male Maltese weighing 4.8 kg was presented with a non-healing wound exhibiting purulent discharge after surgery on scar tissue of a chronic twelve-month-old bite wound on the left caudal abdominal region. The dog had previously undergone four surgeries and had been on continuous antibiotic therapy for eight months. Following radiographic and ultrasonographic examinations, the problem was diagnosed as an enterocutaneous fistula of a herniated bowel loop under the skin. Surgical resection of the fistula involving the bowel loop resolved all symptoms.</P>
Colonic Pseudo-obstruction With Transition Zone: A Peculiar Eastern Severe Dysmotility
Eun Mi Song,Jong Wook Kim,Sun-Ho Lee,Kiju Chang,Sung Wook Hwang,Sang Hyoung Park,Dong-Hoon Yang,Kee Wook Jung,Byong Duk Ye,Jeong-Sik Byeon,Suk-Kyun Yang,Hyo Jeong Lee,Chang Sik Yu,Chan Wook Kim,Seong 대한소화기 기능성질환∙운동학회 2019 Journal of Neurogastroenterology and Motility (JNM Vol.25 No.1
Background/Aims Previous studies from Korea have described chronic intestinal pseudo-obstruction (CIPO) patients with transition zone (TZ) in the colon. In this study, we evaluated the pathological characteristics and their association with long-term outcomes in Korean colonic pseudo-obstruction (CPO) patients with TZ. Methods We enrolled 39 CPO patients who were refractory to medical treatment and underwent colectomy between November 1989 and April 2016 (median age at symptoms onset: 45 [interquartile range, 29–57] years, males 46.2%). The TZ was defined as a colonic segment connecting a proximally dilated and distally non-dilated segment. Detailed pathologic analysis was performed. Results Among the 39 patients, 37 (94.9%) presented with TZ and 2 (5.1%) showed no definitive TZ. Median ganglion cell density in the TZ adjusted for the colonic circumference was significantly decreased compared to that in proximal dilated and distal non-dilated segments in TZ (+) patients (9.2 vs 254.3 and 150.5, P < 0.001). Among the TZ (+) patients, 6 showed additional pathologic findings including eosinophilic ganglionitis (n = 2), ulcers with combined cytomegalovirus infection (n = 2), diffuse ischemic changes (n = 1), and heterotropic myenteric plexus (n = 1). During follow-up (median, 61 months), 32 (82.1%) TZ (+) patients recovered without symptom recurrence after surgery. The presence of pathological features other than hypoganglionosis was an independent predictor of symptom recurrence after surgery (P = 0.046). Conclusions Hypoganglionosis can be identified in the TZ of most Korean CPO patients. Detection of other pathological features in addition to TZ-associated hypoganglionosis was associated with poor post-operative outcomes.
Eun Hye Oh,Jeongseok Kim,Namseok Ham,Sung Wook Hwang,Sang Hyoung Park,Dong-Hoon Yang,Jeong-Sik Byeon,Seung-Jae Myung,Suk-Kyun Yang,Byong Duk Ye 거트앤리버 소화기연관학회협의회 2020 Gut and Liver Vol.14 No.3
Background/Aims: Studies on long-term outcomes of adalimumab therapy in non-Caucasian patients with ulcerative colitis (UC) are lacking. Methods: We analyzed long-term outcomes of Korean UC patients treated with adalimumab at the Asan Medical Center, Seoul, Korea. Results: Between July 2013 and October 2018, adalimumab therapy was started in a total of 100 patients with UC (65 males [65.0%]; median age, 39.5 years [interquartile range, 23.3 to 49.8 years]; and median disease duration, 3.0 years [interquartile range, 1.0 to 7.0 years]). The median duration of adalimumab therapy was 13.5 months (interquartile range, 4.0 to 32.0 months). Eight of 100 patients (8.0%) received induction therapy only, four (4.0%) of whom ultimately underwent colectomy. Of 92 patients who received adalimumab maintenance therapy, 30 (30.0%) stopped adalimumab therapy due to loss of response, and one patient (1.0%) was lost to follow-up. Among the 92 patients who received adalimumab maintenance therapy, the cumulative proportions of patients remaining on adalimumab maintenance therapy were 70.0% at 1 year and 48.9% at 5 years. High partial Mayo score after 8 weeks of adalimumab therapy (hazard ratio [HR], 1.217; 95% confidence interval [CI], 1.040 to 1.425; p=0.014) and a history of exposure to two biologic agents before adalimumab therapy (HR, 4.722; CI, 1.033 to 21.586; p=0.045) were predictors of adalimumab discontinuation. Conclusions: Long-term outcomes of adalimumab therapy in Korean UC patients appear to be comparable to those in previously published Western studies. Furthermore, previous exposure to multiple biologic agents before adalimumab therapy and disease activity after 8 weeks of adalimumab therapy were predictors of adalimumab discontinuation.
Colonic Chicken Skin Mucosa is an Independent Endoscopic Predictor of Advanced Colorectal Adenoma
( Eun Ju Chung ),( Ji Young Lee ),( Jaewon Choe ),( Hye Sook Chang ),( Jongcheol Kim ),( Dong Hoon Yang ),( Byong Duk Ye ),( Jeong Sik Byeon ),( Kyung Jo Kim ),( Suk Kyun Yang ),( Jin Ho Kim ),( Seung 대한장연구학회 2015 Intestinal Research Vol.13 No.4
Background/Aims: Chicken skin mucosa (CSM), surrounding colorectal adenoma, is an endoscopic finding with pale yellowspeckled mucosa; however, its clinical significance is unknown. This study aimed to evaluate the prevalence and clinical characteristics of CSM, and the association between colorectal carcinogenesis and CSM. Methods: This cross-sectional study was performed in 733 consecutive patients who underwent endoscopic polypectomy for colorectal adenoma after the screening of colonoscopy at the Asan Health Promotion Center between June 2009 and December 2011. The colonoscopic and pathological findings of colorectal adenoma including number, size, location, dysplasia, morphology, and clinical parameters were reviewed. Results: The prevalence of CSM was 30.7% (225 of 733 patients), and most CSM-related adenomas were located in the distal colon (93.3%). Histological analysis revealed lipid-laden macrophages in the lamina propria of the mucosa. Multivariate analyses showed that CSM was significantly associated with advanced pathology, including villous adenoma and high-grade dysplasia (odds ratio [OR], 2.078; 95% confidence interval [CI], 1.191-3.627; P=0.010), multiple adenomas (i.e., ≥2 adenomas; OR, 1.692; 95% CI, 1.143-2.507; P=0.009), and a protruding morphology (OR, 1.493; 95% CI, 1.027-2.170; P=0.036). There were no significant differences in polyp size or clinical parameters between patients with and without CSM. Conclusions: CSMrelated adenoma was mainly found in the distal colon, and was associated with advanced pathology and multiple adenomas. CSM could be a potential predictive marker of the carcinogenetic progression of distally located colorectal adenomas. (Intest Res 2015;13:318-325)
NGS 기반 밀양23호/기호벼 재조합자식 유전집단(MGRIL)을 이용한 CAPS 마커 개발 및 줄기 굵기 형질 관련 QTL 분석
이예지(Ye-Ji Lee),변은주(Eun-Ju Byeon),배선화(Seon-Hwa Bae),지현소(Hyeonso Ji),이강섭(Gang-Seob Lee),윤웅한(Ung-Han Yoon),김태호(Tae-Ho Kim) 한국육종학회 2016 한국육종학회지 Vol.48 No.3
The rice recombinant inbred lines derived from Milyang23 and Gihobyeo cross were used in genetic mapping and QTL analysis studies. In this study, we developed a new 101 CAPS markers based on the SNPs in the whole genome region between these varieties. As a result, the total genetic distance and average distances were 1,696.97 cM and 3.64 cM, respectively. In comparison to the distance of the previous genetic map constructed based on 365 DNA markers, the new genetic map was found to have a decreased distance. The map was applied for the detection of QTLs on all seven traits relevant to diameter of stem internode, length of culms, length of panicles and the number of panicles including the correlation analysis between each trait. The QTLs results were similar to the report in previous studies, whereas the distance between the markers was narrowed and accuracy increased with the addition of 101 CAPS markers. A total of 9 new QTLs were detected for stem internode traits. Among them, qI1D-6 had higher LOD of 5.1 and phenotype variation of 50.92%. In this experiment, a molecular map was constructed with CAPS markers using next generation sequencing showing high accuracy for markers and QTLs. In the future, developing more accurate QTL information on stem internode diameters with various agriculturally important traits will be possible for further rice breeding.
( Suh Eun Bae ),( Kyung Jo Kim ),( Jun Bum Eum ),( Dong Hoon Yang ),( Byong Duk Ye ),( Jeong Sik Byeon ),( Seung Jae Myung ),( Suk Kyun Yang ),( Jin Ho Kim ) 대한소화기학회 2013 Gut and Liver Vol.7 No.4
Background/Aims: Polyethylene glycol (PEG)-based gut lavage solutions are safe and effective, but require the intake of large volumes of fluid. The use of 2 L PEG plus 45 mL sodium phosphate (PEG2 plus NaP) was compared with 4 L PEG (PEG4) for bowel cleansing before colonoscopy. Methods: Patients were randomized to the PEG2 plus NaP group or PEG4 group between January 1, 2009 and March 31, 2010. One hundred and thirty patients were included in the PEG2 plus NaP group, and 141 patients in the PEG4 group. Results: The qualities of the bowel preparation, based on the Ottawa scale were not significantly different between the groups (4. ±2.25 for the PEG2 plus NaP group vs. 5.11±2.26 for the PEG4). In addition, there were no significant differences in side effects. Laboratory findings after bowel preparation, including electrolyte, phosphorus and creatinine levels, were within the normal ranges in both groups. Conclusions: PEG2 plus NaP provides good cleansing that is similar to PEG4, but with a lower volume. However, because PEG2 plus NaP can cause serious side effects such as calcium deposition in the kidneys (i.e., nephrocalcinosis), this solution might be considered for the outpatients who cannot tolerate PEG4. (Gut Liver 2013; 7:423-429)
Medication Adherence in Korean Patients with Inflammatory Bowel Disease and Its Associated Factors
Kyunghwan Oh,Eun Ja Kwon,Jeong Hye Kim,Kyuwon Kim,Jae Yong Lee,Hee Seung Hong,Seung Wook Hong,Jin Hwa Park,Sung Wook Hwang,Dong-Hoon Yang,Byong Duk Ye,Jeong-Sik Byeon,Seung-Jae Myung,Suk-Kyun Yang,Jeo 이화여자대학교 의과학연구소 2022 EMJ (Ewha medical journal) Vol.45 No.2
Objectives: It is important that inflammatory bowel disease (IBD) patients adhere to their prescribed medication regimens to avoid the repeat exacerbations, complications, or surgeries associated with this disorder. However, there are few studies on medication adherence in patients with IBD, especially in Asian populations. So, we analyzed the factors associated with medication adherence in Korean IBD patients. Methods: Patients who had been diagnosed with Crohn’s disease (CD) or ulcerative colitis (UC) more than 6 months previously and receiving oral medications for IBD were enrolled. Medication adherence was measured using the Medical Adherence Reporting Scale (MARS-5), a self-reported medication adherence measurement tool. Results: Among 207 patients in the final study population, 125 (60.4%) had CD and 134 (64.7%) were men. The mean age was 39.63 years (SD, 13.16 years) and the mean disease duration was 10.09 years (SD, 6.33 years). The mean medication adherence score was 22.46 (SD, 2.86) out of 25, and 181 (87.4%) patients had score of 20 or higher. In multiple linear regression analysis, self-efficacy (β=0.341, P<0.001) and ≥3 dosing per day (β=–0.192 P=0.016) were revealed to be significant factors associated with medication adherence. Additionally, there was a positive correlation between self-efficacy and medication adherence (r=0.312, P<0.001). However, disease related knowledge, depression, and anxiety were not significantly associated with medication adherence. Conclusion: To improve medication adherence among patients with IBD, a reduction in the number of doses per day and an improved self-efficacy will be helpful.
Lee Jin Wook,Song Eun Mi,정성애,Jung Sung Hoon,Kim Kwang Woo,고성준,Lee Hyun Jung,Hong Seung Wook,Park Jin Hwa,Hwang Sung Wook,Yang Dong-Hoon,Ye Byong Duk,Byeon Jeong-Sik,Myung Seung-Jae,Yang Suk-Kyun,Park 대한의학회 2021 Journal of Korean medical science Vol.36 No.48
In 2020, the novel coronavirus disease 2019 (COVID-19) began to spread worldwide and remains an ongoing medical challenge. This case series reports on the clinical features and characteristics of patients with inflammatory bowel disease (IBD) and confirmed COVID-19 infection. From February 2020 to March 2021, nine patients with IBD had confirmed COVID-19 across four hospitals in Korea. The median age at COVID-19 diagnosis was 42 years. Six patients were male, and seven patients had ulcerative colitis (UC). No patients required oxygen therapy, intensive care unit hospitalizations, or died. The most common symptom was fever, and gastrointestinal (GI) symptoms developed as diarrhea in five patients with UC. Oral steroids were used to combat UC aggravation in two patients. In this case series of nine IBD patients diagnosed with COVID-19 in Korea, the clinical presentation was predominately a mild respiratory tract infection. Most patients with UC developed new GI symptoms including diarrhea.