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코카콜라 경구 투여 및 내시경을 통한 코카콜라주입법으로 치료한 활동성 위궤양을 동반한 다발성 거대위석 1예
곽원건,박보라,강지훈,강현우,김재학,임윤정,이준규,고문수,이진호 동국대학교 의학연구소 2009 東國醫學 Vol.16 No.1
위석은 섭취된 이물질이 위내에서 응결된 덩어리로 일반적으로 내시경적 분쇄법 및 화학적 용해법이 치료방법으로 알려져 있다. 최근 코카콜라를 경구 또는 비위관을 통하여 주입하여 치료한 사례들이 보고되고 있으며 경구 투여 및 내시경을 이용하여 위석내 콜라를 주입하는 것이 치료기간 및 위석치료 성공률을 향상시킨다는 보고가 있다. 최근 저자들은 급성 위궤양이 확인된 환자의 거대위석을 코카콜라 경구 및 내시경 직접 주입법을 통하여 치료한 1예를 경험하였기에 보고하는 바이다. Gastric bezoars are concretions of foreign bodies found in the stomach, common method for the treatment was endoscopic fragmentation or chemical dissolution therapy, recently, there were reports on the treatment of bezoars by cola drinking or Coca-Cola gastric lavage, combination therapy with Coca.Cola drinking and endoscopic injection decreases duration of therapeutic time and increases dissolution rate, we report one case of active gastric ulcer with huge gastric Bezoars completely treated by drinking Coca.Cola with endoscopic injection
Han, Sang Won,Koh, Won-Gun American Chemical Society 2016 ANALYTICAL CHEMISTRY - Vol.88 No.12
<P>Matrix metalloproteinases (MMPs) play a pivotal role in regulating the composition of the extracellular matrix and have a critical role in vascular disease, cancer progression, and bone disorders. This paper describes the design and fabrication of a microdevice as a new platform for highly sensitive MMP-9 detection. In this sensing platform, fluorescein isocyanate (FITC)-labeled MMP-9 specific peptides were covalently immobilized on an electrospun nanofiber matrix to utilize an enzymatic cleavage strategy. Prior to peptide immobilization, the nanofiber matrix was incorporated into hydrogel micropatterns for easy size control and handling of the nanofiber matrix. The resultant hydrogel-framed nanofiber matrix immobilizing the peptides was inserted into microfluidic devices consisting of reaction chambers and detection zones. The immobilized peptides were reacted with the MMP-9-containing solution in a reaction chamber, which resulted in the cleavage of the FITC-containing peptide fragments and subsequently generated fluorescent flow at the detection zone. As higher concentrations of the MMP-9 solution were introduced or larger peptide-immobilizing nanofiber areas were used, more peptides were cleaved, and a stronger fluorescence signal was observed. Due to the huge surface area of the nanofiber and small dimensions of the microsystem, a faster response time (30 min) and lower detection limit (10 pM) could be achieved in this study. The hydrogel-framed nanofiber matrix is disposable and can be replaced with new ones immobilizing either the same or different biomolecules for various bioassays, while the microfluidic system can be continuously reused.</P>
이명철,고창순,박형근,양영식,박원창 대한핵의학회 1984 핵의학 분자영상 Vol.18 No.1
Bone scan is a very useful technique for detection of aseptic necrosis and frequently used in the detection of aseptic necrosis of the femoral head. We have used this diagnostic tool in a patient to detect aseptic necrosis of the talus, a common complication resulting from foot injuries.
Lee, Hyun Jong,Koh, Won-Gun American Chemical Society 2014 ACS APPLIED MATERIALS & INTERFACES Vol.6 No.12
<P>In this study, we developed multi-functional biomimetic tissue engineered scaffolds that are capable of controlling the spatial locations of stem cells and releasing multiple growth factors with a controlled dose and rate of delivery. This novel scaffold was fabricated by combining electrospinning and photolithography and consisted of polycaprolactone (PCL)/gelatin fibers and poly(ethylene glycol) (PEG) hydrogel micropatterns. The utility of this system was investigated in the context of the osteogenesis of human mesenchymal stem cells (hMSCs). When hMSCs were seeded onto hydrogel-incorporated fibrous scaffolds, they selectively adhered and grew only in the fiber region due to the non-adhesiveness of the PEG hydrogel, enabling spatial positioning of hMSCs on a micrometer scale. For osteogenic differentiation of hMSCs, basic fibroblast growth factor (bFGF) and bone morphogenetic protein-2 (BMP-2) were loaded on the fibers and within the hydrogel matrix, respectively, to enable sequential delivery of low doses of bFGF during the early stages and sustained release of BMP-2 for long periods. According to in vitro studies, hMSCs cultured on the scaffolds capable of sequential delivery of bFGF and BMP-2 showed stronger osteogenic commitment in culture than those on scaffolds without any growth factors or scaffolds with single administration of either bFGF or BMP-2 under the same conditions. The results demonstrate that hydrogel-incorporated fibrous scaffolds can provide not only biomimetic structures with micropatterned nanostructures but also a suitable biochemical environment with controlled release of multiple growth factors, which may eventually facilitate the control of stem cell fates for various regenerative therapies.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/aamick/2014/aamick.2014.6.issue-12/am501714k/production/images/medium/am-2014-01714k_0010.gif'></P>