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( Beom Jun Kim ),( Solam Lee ),( Hye-young Wang ),( Hyeyoung Lee ),( So Yeon Lee ),( Soo-jong Hong ),( Eung Ho Choi ) 대한피부과학회 2017 대한피부과학회 학술발표대회집 Vol.69 No.2
Background: Hereditary factors are important in the development of atopic dermatitis (AD). Objectives: To characterize the clinical features and genetic variation of early onset (≤3 years of age) AD patients. Methods: From AD patients and non-AD controls who visited a university hospital and a birth cohort, AD-related gene variations were compared between patients with and without early onset AD by reverse blot hybridization assay (REBA). Results: In the birth cohort, there were no differences between AD and non-AD groups in the AD-associated gene variations. Comparing AD groups of the university hospital and the birth cohort with non-AD group of the birth cohort, homozygous mutants of KLK7, SPINK5-1188, SPINK5-2475 and DEFB1 were significantly prevalent in AD groups. Between AD group of the birth cohort and non-AD controls of the university hospital, homozygous mutants of SPINK5-1156 and SPINK5-2475, and heterozygous mutants of IL5RA and IL12RB1 were significantly prevalent in AD group. Comparing AD groups of the university hospital and the birth cohort with non-AD controls of the university hospital, homozygous mutant of KLK7 was less prevalent and homozygous mutant of SPINK5-1156 was more prevalent in AD group. Heterozygous mutants of IL5RA and IL12RB1 were significantly prevalent in AD group. Conclusion: In Korea, newborn babies who have family atopic history and gene variations of SPINK5, IL5RA and IL12RB1 might be predicted to develop early onset AD before 3 years of age.
Effect of Black Ginseng on Memory Improvement in the Amnesic Mice Induced by Scopolamine
Lee, Mi-Ra,Yun, Beom-Sik,Liu, Lei,Zhang, Dong-Liang,Wang, Zhen,Wang, Chun-Ling,Gu, Li-Juan,Wang, Chun-Yan,Mo, Eun-Kyung,Sung, Chang-Keun The Korean Society of Ginseng 2010 Journal of Ginseng Research Vol.34 No.1
This study compared the effects of black, white, and red ginseng extracts (WGE, RGE, BGE, 200 mg/kg, p.o.) on learning and memory deficits associated with scopolamine treatment (SCOP, 2 mg/kg, i.p.). Tacrine (THA, 10 mg/kg, p.o.) was used as a positive control. Ginseng significantly reversed SCOP-induced memory impairment in the passiveavoidance test and also reduced escape latency in training trials of the Morris water maze test. The increased acetylcholinesterase (AChE) activity produced by SCOP was significantly inhibited by WGE and RGE (p<0.001). SCOP administration had no effect on choline acetyltransferase (ChAT) activity, but RGE and BGE significantly increased ChAT activity (p<0.05). SCOP administration increased oxidative damage in the brain. Treatment of amnesic mice with ginseng extracts decreased malondialdehyde (MDA) levels and restored superoxide dismutase (SOD) and catalase (CAT) activity to control levels. These results suggest that black ginseng enhances cognitive activity by regulation of cholinergic enzymes and antioxidant systems.
Lee Wang Sik,강태준,Kwak Kyung Jin,박경숙,이소연,Lee Ui Jin,Shin Yong Beom,Jeong Jinyoung 나노기술연구협의회 2020 Nano Convergence Vol.7 No.13
This work reports on a rapid diagnostic platform for the detection of Plasmodium falciparum lactate dehydrogenase (PfLDH), a representative malaria biomarker, using a microfluidic microplate-based immunoassay. In this study, the microfluidic microplate made it possible to diagnose PfLDH with a small volume of sample (only 5 μL) and short time (< 90 min) compared to conventional immunoassays such as enzyme-linked immunosorbent assay (ELISA). Moreover, the diagnostic performance of PfLDH showed high sensitivity, specificity, and selectivity (i.e., 0.025 pg/μL in phosphate-buffered saline and 1 pg/μL in human serum). The microfluidic-based microplate sensing platform has the potential to adapt simple, rapid, and accurate diagnoses to the practical detection of malaria.
Mi-Ra Lee,Beom-Sik Yun,Dong-Liang Zhang,Lei Liu,Zhen Wang,Chun-Ling Wang,Li-Juan Gu,Chun-Yan Wang,Eun-Kyung Mo,이선영,성창근 한국식품과학회 2010 Food Science and Biotechnology Vol.19 No.3
This study was performed to estimate ameliorating effect of aqueous antler extract (AAE) on memory impairments induced by scopolamine (SCOP, 2 mg/kg,i.p.). Tacrine (THA, 10 mg/kg, p.o.) was used as a positive control. The passive avoidance test and Y-maze test results showed that a single AAE (200 mg/kg, p.o.) administration significantly restored memory impairment. Moreover,AAE or THA treatment significantly reduced the escape latency prolonged by SCOP during trial sessions in the Morris water maze test. In vivo study, AAE significantly inhibited acetylcholinesterase (AChE) activity (p<0.001),whereas choline acetyltransferase (ChAT) activity (p<0.05)was enhanced. In addition, SCOP elevated oxidative damage in the brain. However, treatment with AAE to the amnesic mice induced by SCOP considerably decreased malondialdehyde (MDA) level (p<0.01) and restored the activities of superoxide dismutase (SOD) (p<0.01) and glutathione peroxidase (GSH-Px) (p<0.001) approaching the control values. These results suggest that AAE showed the potential cognitive-enhancing activity by regulating cholinergic marker enzyme activities and promoting the antioxidant system.
Chun Yan Wang(왕춘연),Chung Ha Lee(이청하),Mi Ra Lee(이미라),Beom Sik Yun(윤범식),Lei Liu(유뢰),Zhen Wang(왕젠),Zhe Ming Fang(방철명),Dong Liang Zhang(장동량),Zheng Li(이정),Chang Keun Sung(성창근) 한국생명과학회 2010 생명과학회지 Vol.20 No.5
본 논문은 선충 포식성 곰팡이에 대한 선충의 영향을 조사한 연구로, 소나무 기생곰팡이인 E. vermicola에 미치는 소나무 선충의 영향을 체계적으로 분석하였다. 선충 대사물과 선충 균질액 모두 E. vermicola의 성장을 빠르게 촉진하였으나, 선충 대사물이 선충 균질액보다 약간 높은 효과를 보였다. 또한 소나무 선충이 생성하는 휘발성 물질이 E. vermicola 성장에 미치는 영향을 분석하는 새로운 실험방법을 개발하였다. 본 연구결과에 따르면, 선충의 휘발성 물질은 E. vermicola에 아무런 영향을 끼치지 않는다는 재현성 있는 결과를 도출하였다. 본 연구는 소나무 선충의 생물학적인 조절인자로서 E. vermicola을 적용할 수 있는 정보를 제공할 수 있을 것이다. The influence of nematodes on nematophagous fungi has seldom been investigated. In the present study, the influence of pinewood nematode on its endoparasitic fungus, Esteya vermicola, was investigated systemically. Although both nematodal metabolite and nematodal homogenate could stimulate and speed up the growth of E. vermicola, the impact of nematodal metabolite was slightly higher than that of nematodal homogenate. In addition, a method was developed to investigate the influence of volatiles, discharged by pinewood nematodes in their metabolic process, on the growth of E. vermicola. Reproductive results were given and confirmed that nematodal volatiles have no influence on the cell growth of E. vermicola. This study may provide information for the application of E. vermicola as biological control agent of pinewood nematode.
Effect of Black Ginseng on Memory Improvement in the Amnesic Mice Induced by Scopolamine
Mi-Ra Lee,Beom-Sik Yun,Lei Liu,Dong-Liang Zhang,Zhen Wang,Chun-Ling Wang,Li-Juan Gu,Chun-Yan Wang,Eun-Kyung Mo,Chang-keun Sung 고려인삼학회 2010 Journal of Ginseng Research Vol.34 No.1
This study compared the effects of black, white, and red ginseng extracts (WGE, RGE, BGE, 200 ㎎/㎏, p.o.) on learning and memory deficits associated with scopolamine treatment (SCOP, 2 ㎎/㎏, i.p.). Tacrine (THA, 10 ㎎/㎏, p.o.) was used as a positive control. Ginseng significantly reversed SCOP-induced memory impairment in the passiveavoidance test and also reduced escape latency in training trials of the Morris water maze test. The increased acetylcholinesterase (AChE) activity produced by SCOP was significantly inhibited by WGE and RGE (p<0.001). SCOP administration had no effect on choline acetyltransferase (ChAT) activity, but RGE and BGE significantly increased ChAT activity (p<0.05). SCOP administration increased oxidative damage in the brain. Treatment of amnesic mice with ginseng extracts decreased malondialdehyde (MDA) levels and restored superoxide dismutase (SOD) and catalase (CAT) activity to control levels. These results suggest that black ginseng enhances cognitive activity by regulation of cholinergic enzymes and antioxidant systems.
이화자 ( Hwa Ja Lee ),유왕진 ( Wang Ja Yoo ),이철규 ( Cheol Gyn Lee ),문종범 ( Jong Beom Moon ),이동명 ( Dong Myung Lee ) 한국경영공학회 2011 한국경영공학회지 Vol.16 No.2
In this paper, previous studies on the promotion factors of work environment, organizational creativity and business performance have been investigated. In addition, a research model was set after studying the specific related items. Then, a questionnaire survey was performed amongst the employees and directors of the Small and Medium Venture Business for empirical analysis. The survey was classified into organizational encouragement, leader`s support, support from the department and individual challenging spirit in terms of the promotion factors of the work environment. Regarding hindrance factors, they were classified into organizational obstacles and heavy workload. To analyze the relationship between technical, customer and financial achievements, a causal relationship was induced using a structural equation with product development capability and production capacity as parameters. The results of the empirical analysis can be summarized as follows: First, it was confirmed that the promotion factors of the work environment have a significant impact on organizational creativity, not on business performance. Second, work environment hindrance factors had no significant impact on either organizational creativity or business performance. When organizational creativity was taken as a parameter through the analysis of covariance, however, a positive relationship was observed between promotion factors and business performance. Third, organizational creativity had a significant impact on business performance.