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( Solam Lee ),( Hanil Lee ),( Chung Hyeok Lee ),( Won-soo Lee ) 대한피부과학회 2018 대한피부과학회 학술발표대회집 Vol.70 No.2
Background: Treatment of androgenetic alopecia (AGA) and alopecia areata (AA) are not so favorable in many cases. Some institutions offer a detailed counseling and assessment including photographic evaluation to provide psychological satisfaction to patients for improving patients’ compliance to treatment. Objectives: To investigate the quantitative effect of photographic assessment on maintaining patients’ adherence to recommended follow-up. Methods: Medical records of patients with AGA or AA who visited our clinic from May 2003 to April 2017 were reviewed. Patients were considered to have undergone photographic assessment when they had photographing session during follow-up including the initial visit. A survival and Cox-regression analysis was performed for follow-up rate. Results: A total of 2999 patients were analyzed. The 1-year follow-up rate was 35.8% (95% CI, 31.6-40.6%) in AGA patients who underwent photographic assessment and 13.5% (95% CI, 11.7-15.6%) in those who did not. Likewise, in AA patients, the 1-year follow-up rate was 50.0% (95% CI, 44.2-56.5%) and 16.3% (95% CI, 14.0-18.9%), respectively. Patients who underwent photographic assessment had independently less risk of being lost to follow-up (adjusted hazard ratio of 0.51 in AGA, 0.41 in AA). Conclusion: To improve overall therapeutic outcome, it might be beneficial to provide photographic assessment to patients with AGA or AA.
( Solam Lee ),( Hye-young Wang ),( Eunjung Kim ),( Hyun Jee Hwang ),( Eunhee Choi ),( Noo Ri Lee ),( Hyeyoung Lee ),( Eung Ho Choi ) 대한피부과학회 2017 대한피부과학회 학술발표대회집 Vol.69 No.2
Background: In patients with atopic dermatitis (AD), the penetration of contact allergens is potentially increased through disrupted barrier, and hence the risk of sensitization is also increased. Objectives: We performed this study to predict allergic contact dermatitis (ACD) accompanied in AD patients. Methods: The clinical and genetic characteristics of 207 AD patients with and without ACD were compared. Results: “AD with ACD” was more common in female (p<0.001). Patients’ age and disease onset age were older in “AD with ACD” (p<0.001). “AD with ACD” patients had more personal and family histories about ACD (p<0.001). Nummular eczema was more common in “AD with ACD” (p=0.019). In multivariate logistic regression analysis, family history of ACD, female, older age had higher odds of ACD (9.82[3.38-30.26], 5.41[2.43-12.97], 1.07[1.05-1.10]). Receiver operating characteristics (ROC) curve analysis of age showed that optimal cutoff value was 7 years and the area under the ROC curve was 0.748 with the sensitivity of 95.3% and specificity of 43.9% (p<0.001). In multivariate logistic regression analysis with propensity score matching for age and gender, the heterozygous mutation in FLG 3321delA had higher odds of ACD (6.81 [1.09-131.79]). Conclusion: The patients with AD who fall into one of the following cases, female over 7 years of aged, show nummular eczema, have heterozygous mutation in FLG 3321delA, should be suspected for accompanied ACD and patch test should be done.
( Solam Lee ),( Hee Chul Chung ),( Hana Bak ),( Jin Wook Lee ),( Sang Hoon Lee ),( Sung Ku Ahn ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.1
Xanthelasma are cholesterol-filled, soft, yellow plaques that usually appear on the medial aspects of the lids bilaterally. A 54-year-old male presented with ten year history of soft, yellowish plaques surrounding each eye mimicking eyeglasses. Biopsy revealed that upper and middle dermis showed infiltration of multiple foamy cells including lipids so that we confirmed xanthelasma. Most lesions were removed after four sessions of carbon dioxide laser. Several unusual forms of xanthelasma have been reported, including bilateral and extensive xanthelasma and unilateral or bilateral tumor-like invasive xanthelasma. However, to the best of our knowledge, no report has described extensive bilateral, spectacles-like xanthelasma. We herein report eyeglasses-shaped, extensive bilateral xanthelasma on both eyelids.
( Solam Lee ),( Beom Jun Kim ),( Chung Hyeok Lee ),( Won-soo Lee ) 대한피부과학회 2018 대한피부과학회 학술발표대회집 Vol.70 No.2
Background: The prognosis of alopecia areata (AA) is primarily associated with the extent of hair loss. Although there were diverse assessment tools and classification systems for AA, their value on quantification of prognosis was limited. Objectives: To identify topographic phenotypes of AA using cluster analysis and to establish prediction model and grading system for stratifying prognosis. Methods: The topographic phenotypes of AA were identified from cluster analysis, and their clinical characteristics and prognosis were analyzed. The prediction model and grading system was evaluated for performance and interobserver repeatability. Results: In total, 321 patients were clustered into five subgroups: Grade I (n = 200; major regrowth, 93.4%; complete regrowth, 65.2%) described limited hair loss. Although grade IIa (n = 66; 87.8%; 64.2%) and IIb (n = 20; 73.3%; 45.5%) were comparable in the extent of hair loss, the latter predominantly involved the temporal area, whereas the former did not. Grade III (n = 20; 45.5%; 25.5%) and IV (n = 15; 28.2%; 16.7%) described extensive or total hair loss. The prediction model and grading system had a superior performance, accuracy and interobserver repeatability. Conclusion: The grading system proposed in this study can deliver the extent and topographical distribution of hair loss and its prognosis effectively.
( Hanil Lee ),( Solam Lee ),( Jong Won Lee ),( Sang Hoon Lee ),( Won-soo Lee ) 대한피부과학회 2019 대한피부과학회 학술발표대회집 Vol.71 No.2
Background: The morphology of hair regrowth in alopecia areata (AA) patches could be classified into four types, namely diffuse (d), irregular (i), marginal (m), and targetoid (t) patterns, according to the DIMT classification. However, factors affecting hair regrowth patterns have not been investigated. Objectives: Investigate whether the hair regrowth pattern in AA patches according to the DIMT classification is associated with the treatment modality used on the patches and their size. Methods: We retrospectively analyzed 152 AA patches with hair regrowth. The treatment modalities were classified into four types as follows: topical corticosteroid (TSC), diphenylcyclopropenone contact immunotherapy (DPCP), systemic and topical corticosteroid (SCS), and triamcinolone intralesional injection (TA ILI). The AA patches were classified into two groups according to sizes of ≤2 and >2 cm. Results: A total of 152 hair regrown AA patches were analyzed. The associations between the diffuse pattern and patch sizes of>2cm (OR: 0.36, 95% CI: 0.17-0.74), between the irregular pattern and triamcinolone intralesional injection (OR: 274.87, 95% CI: 25.75- 2933.56), between the marginal pattern and systemic corticosteroids (OR: 4.89, 95% CI: 1.31-18.27), and between the targetoid pattern and patch sizes of >2 cm (OR: 2.50, 95% CI: 1.10-5.68) showed statistical significance. Conclusion: Treatment modalities and sizes of AA patches are the factors that affect hair regrowth patterns in AA patches.
( Sung Jay Choe ),( Solam Lee ),( Chung Hyeok Lee ),( Hanil Lee ),( Won-soo Lee ) 대한피부과학회 2017 대한피부과학회 학술발표대회집 Vol.69 No.2
Background: Alopecia areata (AA) could manifest various patterns and degree, some of which are known to be associated with prognosis of disease. There are several classifications in AA, however they reflected the various prognostic factors insufficiently. Objectives: We aimed to establish a classification that reflects the prognostic factors affecting the treatment response. Methods: 94 AA patients were enrolled. We assessed correlation between treatment response and disease-related factors, including pattern and extent of scalp lesion, and presence of lesions on the body hair using multivariate logistic regression. In patients with extrascalp lesion, we assessed the correlation between treatment response and affected site and extent of extrascalp lesions separately. Results: There was a poorer response to scalp involvement with increasing extent. Furthermore, there was a significant difference in treatment response according to the pattern of scalp lesion. Besides, in patients with lesions on the extrascalp hair, there was a tendency to show worse results when involved wider areas and more sites of body hair lesions. Conclusion: We applied these results and developed a new classification based on combination of the pattern and extent of scalp hair lesion and the affected body hair site and extent. It is a new systematic, and evidence-based classification that reflects disease-associated prognostic factors.
( Sung Ha Lim ),( Solam Lee ),( Young Bin Lee ),( Chung Hyeok Lee ),( Jong Won Lee ),( Sang Hoon Lee ),( Ju Yeong Lee ),( Joung Soo Kim ),( Mi Youn Park ),( Sang Baek Koh ),( Eung Ho Choi ) 대한피부과학회 2020 대한피부과학회 학술발표대회집 Vol.72 No.1
Background: Whether having a tattoo increases the risk of transfusion transmitted diseases (TTDs) is controversial. Objectives: To identify prevalence and risk of TTDs in people with tattoos as compared with the general population. Methods: A systematic review of the studies published before September 2019 was performed by using the Medline, Embase, and Web of Science databases. Observational studies on hepatitis C virus (HCV), hepatitis B virus (HBV), human immunodeficiency virus (HIV), and syphilis infections in people with and without tattoos were included. Studies that reported disease status without serological confirmation were excluded. Results: A total of 115 studies were quantitatively analyzed. HCV (odd ratio [OR], 2.94; 95% confidence interval [CI], 2.52-3.44), HBV (OR, 1.53; 95% CI, 1.34-1.76), and HIV infections (OR, 3.42; 95% CI, 2.16-5.41) were more prevalent in the tattooed population. In subgroup analyses, after the adjustment of possible publication bias, the prevalence of HCV infection was significantly elevated in the community-dwelling, hospital patient, intravenous (IV) drug user, and prisoner groups. IV drug users and prisoners showed high prevalence rates of HBV infection. The prevalence of HIV infection was significantly increased in the prisoner group. Conclusion: Having a tattoo is associated with an increased prevalence of TTDs. Our approach clarifies in depth and supports a guideline for TTD screening in the tattooed population.
( Sung Ha Lim ),( Hanil Lee ),( Solam Lee ),( Jong Won Lee ),( Sang-hoon Lee ),( Won-soo Lee ) 대한피부과학회 2022 Annals of Dermatology Vol.34 No.1
Background: The morphology of hair regrowth in alopecia areata (AA) patches could be classified into four types, namely diffuse, irregular, marginal, and targetoid patterns, according to the DIMT classification. However, factors affecting hair regrowth patterns have not been investigated. Objective: We investigated whether the DIMT-classified hair regrowth patterns of AA patches are associated with treatment modality and patch size. Methods: We conducted a retrospective, cross-sectional study of 152 AA patches with hair regrowth. Results: The associations between the diffuse pattern and patch size >2 cm (p=0.006; odds ratio [OR]: 0.36, 95% confidence interval [CI]: 0.17~0.74), between the irregular pattern and triamcinolone acetonide intralesional injection (p< 0.001; OR: 274.87, 95% CI: 25.75~2,933.56), between the marginal pattern and systemic and topical corticosteroid (p=0.018; OR: 4.89, 95% CI: 1.31~18.27), and between the targetoid pattern and patch size >2 cm (p=0.028; OR: 2.50, 95% CI: 1.10~5.68) were statistically significant. Conclusion: Treatment modalities and patch size are the factors affecting hair regrowth patterns in AA patches.