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Thang Phan,Ha Phan Ai Nguyen,Cao Khoa Dang,Minh Tri Phan,Vu Thanh Nguyen,Van Tuan Le,Binh Thang Tran,Chinh Van Dang,Tinh Huu Ho,Minh Tu Nguyen,Thang Van Dinh,Van Trong Phan,Binh Thai Dang,Huynh Ho Ngo The Korean Society for Preventive Medicine 2023 예방의학회지 Vol.56 No.4
Objectives: The coronavirus disease 2019 (COVID-19) pandemic has increased the workload of healthcare workers (HCWs), impacting their health. This study aimed to assess sleep quality using the Pittsburgh Sleep Quality Index (PSQI) and identify factors associated with poor sleep among HCWs in Vietnam during the COVID-19 pandemic. Methods: In this cross-sectional study, 1000 frontline HCWs were recruited from various healthcare facilities in Vietnam between October 2021 and November 2021. Data were collected using a 3-part self-administered questionnaire, which covered demographics, sleep quality, and factors related to poor sleep. Poor sleep quality was defined as a total PSQI score of 5 or higher. Results: Participants' mean age was 33.20±6.81 years (range, 20.0-61.0), and 63.0% were women. The median work experience was 8.54±6.30 years. Approximately 6.3% had chronic comorbidities, such as hypertension and diabetes mellitus. About 59.5% were directly responsible for patient care and treatment, while 7.1% worked in tracing and sampling. A total of 73.8% reported poor sleep quality. Multivariate logistic regression revealed significant associations between poor sleep quality and the presence of chronic comorbidities (odds ratio [OR], 2.34; 95% confidence interval [CI], 1.17 to 5.24), being a frontline HCW directly involved in patient care and treatment (OR, 1.59; 95% CI, 1.16 to 2.16), increased working hours (OR, 1.84; 95% CI,1.37 to 2.48), and a higher frequency of encountering critically ill and dying patients (OR, 1.42; 95% CI, 1.03 to 1.95). Conclusions: The high prevalence of poor sleep among HCWs in Vietnam during the COVID-19 pandemic was similar to that in other countries. Working conditions should be adjusted to improve sleep quality among this population.
Chemical Constituents of the Morinda tomentosa Leaves and their α-Glucosidase Inhibitory Activity
Vu, Huong Giang,Ninh, Khac Ban,Nguyen, Xuan Nhiem,Phan, Van Kiem,Chau Van, Minh,Hoang, Le Tuan Anh,Pham, Hai Yen,Bui, Huu Tai,Nguyen, Xuan Cuong,Nguyen, Hoai Nam,Kim, Seung Hyun,Kwon, Young-In,Kim, Yo Korean Chemical Society 2013 Bulletin of the Korean Chemical Society Vol.34 No.5
Discovery of cycloartane-<i>type</i> triterpene saponins from <i>Mussaenda glabra</i>
Thu, Vu Kim,Bach, Nguyen Xuan,Anh, Luu The,Trang, Do Thi,Nhiem, Nguyen Xuan,Tai, Bui Huu,Van Kiem, Phan,Van Minh, Chau,Park, SeonJu,Seo, Yohan,Namkung, Wan,Kim, Seung Hyun Elsevier 2019 PHYTOCHEMISTRY LETTERS Vol.33 No.-
<P><B>Abstract</B></P> <P>Five new cycloartane saponins, mussaglaosides A–E (<B>1</B>–<B>5</B>) together with five known saponins, mussaendoside O, mussaendoside, G mussaendoside U, mussaendoside P, and mussaendoside Q (<B>6</B>–<B>10</B>) were isolated from the leaves of <I>Mussaenda glabra.</I> Their structures were determined on the basis of extensive spectroscopic methods, including 1D-, 2D-NMR, and MS data. All compounds were evaluated for ANO1 inhibitory activity using calcium-activated chloride channel and YFP expressing HT29 cells. Among the tested compounds, compound <B>6</B> strongly inhibited chloride channel activity with IC<SUB>50</SUB> value of 22.0 ± 1.7 μM without any cytotoxicity.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Five new cycloartane saponins, mussaglaosides A–E (<B>1</B>–<B>5</B>) were isolated from <I>Mussaenda glabra</I>. </LI> <LI> The structures were successfully determined by spectroscopic evidence. </LI> <LI> Compound <B>6</B> strongly inhibited chloride channel activity (IC<SUB>50</SUB> value of 22.0 ± 1.7 μM). </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Inhibitory Effects of Vietnamese Medicinal Plants on Monoamine Oxidase Activity
Hung, Vu Manh,Minh, Chau Van,Kiem, Phan Van,Dang Thi Lan Huong,Nguyen Tien Dat,Kim, Young Ho 충남대학교 약학대학 의약품개발연구소 2002 藥學論文集 Vol.17 No.-
In vitro in screening test aiming to find monoamine oxidase (MAO) inhibitors from Vietnamese medicinal plants, the MeOH extracts of seventeen medicinal plants were tested for the inhibitory effects on monoamine oxidase activity. MAO was purified from mouse brain and its activity was determined by fluorospectrophotometer using kynuramine as a substrate. Five MeOH extracts of medicinal plants including Cnidium monnineri showed quite strong inhibitory effects at the concentration of 250 ㎍/㎖. Six MeOH extracts of herbs including Astragalus membranaceus showed moderate inhibitory effects on this enzyme. Seven medicinal plants which showed good inhibitory effects on MAO were fractionated with CH_2Cl_2, EtOAc, BuOH and H_2O, successively. They were investigated for the inhibitory effects on MAO.
Triterpenoids from aerial parts of Glochidion eriocarpum.
Thu, Vu Kim,Kiem, Phan Van,Yen, Pham Hai,Nhiem, Nguyen Xuan,Tung, Nguyen Huu,Cuong, Nguyen Xuan,Minh, Chau Van,Huong, Hoang Thanh,Lau, Trinh Van,Thuan, Ngo Thi,Kim, Young Ho Natural Product Communications 2010 Natural product communications Vol.5 No.3
<P>From the aerial parts of Glochidion eriocarpum, a new triterpene, glochieriol (1), three new triterpenoid saponins, glochieriosides C - E (2 - 4), together with four known triterpenes (glochidonol, glochidiol, lupeol, and 3-epi-lupeol) were isolated by using combined chromatographic separations. The structures of the new compounds were elucidated on the basis of spectroscopic data, including FTICR-MS, 1D and 2D NMR.</P>
New Dibenzocyclooctadiene Lignan from Kadsura induta and Their Cytotoxic Activities
Pham, Thi Hong Minh,Do, Tien Lam,Nguyen, Quyet Tien,Nguyen, Ngoc Tuan,Vu, Phuong Nhung,Nong, Van Hai,Phan, Van Kiem,Nguyen, Xuan Nhiem,Chau, Van Minh,Park, SeonJu,Kim, Seung Hyun Korean Chemical Society 2014 Bulletin of the Korean Chemical Society Vol.35 No.6