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Cytotoxic Constituents of Diadema setosum
Chau Van Minh,Phan Van Kiem,Le Mai Huong,김영호 대한약학회 2004 Archives of Pharmacal Research Vol.27 No.7
5,8-Epidioxycholest-6-en-3-ol (1), cholesterol (2), glycerol 1-palmitate (3) and glycerol 1,3- dioleate-2-stearate (4) were isolated from the methanol extract of the sea urchin Diadema setosum, which was collected from the Halong sea, Vietnam. Chemical structures were established based on extensive 1D, 2D-NMR, FAB-MS, EI-MS spectroscopic data and GC-MS analysis. The NMR spectral data of compound 1 were reassigned by using HMQC and HMBC. Compound 1 was found to have strong cytotoxic effect against various cancer cell lines, such as KB (IC50, 2.0 mg/mL), FL (IC50, 3.93 mg/mL), and Hep-2 (IC50, 2.4 mg/mL) by in vitro assay.
Chemical constituents and antioxidant activity of Ficus callosa.
Van Kiem, Phan,Cuong, Nguyen Xuan,Nhiem, Nguyen Xuan,Hang, Dan Thi Thuy,Nam, Nguyen Hoai,Ban, Ninh Khac,Minh, Chau Van,Bing, Zhou,Jang, Hae Dong,Kim, Young Ho Natural Product Communications 2011 Natural product communications Vol.6 No.2
<P>One new megastigmane glycoside, ficalloside (1), and eleven known compounds, were isolated from methanol extract of Ficus callosa leaves by repeated column chromatography. Their structures were established on the basis of spectral and chemical evidence. The antioxidant activities of these compounds were measured using the oxygen radical absorbance capacity (ORAC) assay. Compound 8 exhibited potent antioxidant activity of 10.6 microM trolox equivalents at the concentration of 2 microM. At this concentration, compounds 4-7 and 9-12 showed significant antioxidant activity with ranging of 2.1-6.1 microM trolox equivalents.</P>
Chemical constituents of Trichosanthes kirilowii and their cytotoxic activities
Chau Van Minh,Nguyen Xuan Nhiem,Hoang Thi Yen,Phan Van Kiem,Bui Huu Tai,Hoang Le Tuan Anh,Truong Thi Thu Hien,박선주,김나영,김승현 대한약학회 2015 Archives of Pharmacal Research Vol.38 No.8
One new lignan, trichobenzolignan (1), and seven known compounds, ligballinol (2), (-)-pinoresinol (3), ehletianol C (4), luteolin 7-O-b-D-glucopyranoside (5), chrysoeriol-7- O-b-D-glucopyranoside (6), 10a-cucurbita5,24-dien-3b-ol (7), and arvenin I (8). Their structures were established on the basis of spectral and chemical evidence, which were in agreement with those reported in literature. The cytotoxic activities of these compounds were evaluated on four cancer cell lines such as A-549 (human lung cancer), HT-29 (human colon adenocarcinoma), OVCAR (human ovarian carcinoma), and MCF-7 (human breast cancer). As the results, compound 7 showed significant activity on HT-29 and OVCAR cancer cell lines with IC50 of 4.1 and 6.5 lM, respectively. Compounds 1, 5, 6, and 8 exhibited moderate activities in all cancer cell lines with IC50 ranging from 11.3 to 42.8 lM.
Van Thanh, Nguyen,Jang, Hyun-Jae,Vinh, Le Ba,Linh, Kieu Thi Phuong,Huong, Phan Thi Thanh,Cuong, Nguyen Xuan,Nam, Nguyen Hoai,Van Minh, Chau,Kim, Young Ho,Yang, Seo Young Elsevier 2019 Bioorganic chemistry Vol.88 No.-
<P><B>Abstract</B></P> <P>In a search for anti-inflammatory activity in resources from Vietnamese mangroves, we found that a methanolic extract from the leaves of <I>Calophyllum inophyllum</I> (CIL) showed significant anti-inflammatory effects <I>in vitro</I>. Using various chromatographic techniques, we subsequently isolated 12 compounds (<B>1</B>–<B>12</B>) from a methanolic extract of CIL, including two novel compounds (<B>1</B>–<B>2</B>). The inhibitory effects of these compounds on lipopolysaccharide-induced nitric oxide (NO) production in RAW264.7 cells were also evaluated. Compound <B>1</B> significantly suppressed NO production (IC<SUB>50</SUB> = 2.44 ± 0.88 µM), the secretion of pro-inflammatory cytokines (including interleukin-1 beta and tumor necrosis factor alpha), and the expression of inducible nitric oxide synthase through downregulation of nuclear factor-kappa-B signaling cascades. These results suggest that <I>C. inophyllum</I> leaves might be a useful resource for the development of drugs for the treatment of inflammation.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Twelve compounds were isolated from Vietnamese mangrove <I>Calophyllum inophyllum</I>. </LI> <LI> Two new compounds <B>1</B> and <B>2</B> were determined by spectroscopic methods. </LI> <LI> Compound <B>1</B> showed significant anti-inflammatory activity. </LI> <LI> These results suggested that <I>C. inophyllum</I> might useful as the anti-inflammation drug. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
New Alkaloids and Anti-inflammatory Constituents from the Leaves of Antidesma ghaesembilla
Van Kiem, Phan,Cuong, Le Canh Viet,Trang, Do Thi,Nhiem, Nguyen Xuan,Le Tuan Anh, Hoang,Tai, Bui Huu,Huong, Le Mai,Van Minh, Chau,Lee, Taek Hwan,Kim, Sun Yeou NATURAL PRODUCT COMMUNICATIONS 2017 Natural product communications Vol.12 No.1
Extended Airtime Fair Scheduling Method for a Zigbee Network
Van-Tu Chau,T.T. Quyen Bui,Anh-Tuan Do,Quang-Vinh Thai 제어로봇시스템학회 2014 제어로봇시스템학회 국제학술대회 논문집 Vol.2014 No.10
In a Zigbee network, when many nodes simultaneously send data packets to a Zigbee coordinator through routes (branches), the Zigbee coordinator cannot deal with all signals. Interference and noises are existed during data transmission. This problem is still one of challenges in the network communication. In this paper, we propose an extended airtime fair algorithm in which throughput of a Zigbee network is maximized and fractions of airtime are taken into account. We adapt a utility function that is proposed by Kelly (1997) in maximizing the network throughput; nevertheless, throughput of each branch is multiplied by a fraction of airtime. Fractions of airtime play a role in creating a balance of throughputs of branches: the throughput and fairness of each branch is guaranteed. Moreover, the usefulness of our proposed algorithm for a Zigbee network is presented; simulation results show that the throughput and fairness are better than those of a case of not using airtime fair.