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알레르기성 비염 환자에서 절지동물성 특이항원의 양성율 및 항원간 일치율
황규윤,남해선,박준수,권준택,백병준,김장묵,오천환,조성란 순천향의학연구소 2000 Journal of Soonchunhyang Medical Science Vol.6 No.2
The current study was designed to evaluate the positive rates of arthropod allergens by Korean inhalant panel of MAST-CLA in patients with allergic rhinitis. One hundred sixty patients, diagnosed to allergic rhinitis in an Out Patient Center of Soonchunhyang University Chunan Hopsital during Aug 1998 to July 2000, were studied. 1. The overall positive rate among 35 specific allergens was 59.4% (95 patients). 2. The arthropod related allergen accounted for 82.1% (78 patients) of the positive rate. 3. Each positive rate of Dermatophagoides farinae (Df), Dermatophagoides pteronyssinus (Dp), house dust (Hd), and cockroach mix (Cm) was 45.0% (72 patients), 43.1% (69 patients), 28.1% (45 patients), and 8.8% (14 patients), respectively. 4.Significant agreement between arthropod allergens was observer (P < 0.05). 5. The obseved agreement between Df and Dp was 95.6%, showing most significant Kappa index (Kappa = 0.911, P < 0.001). There results suggested that although MAST-CLA is a useful measure of identifying specific allergens, the specificity of two mite allergen relatively low, implying because of common allergen between mites in Korean panel of MAST-CLA. Our data also supported that arthropod is the major cause of allergen in patients with allergic rhinitis, however, the MAST-CLA should be modified in order to exclude common allergen of mite and to include more specific mite allergen.
소아에서 굴곡성 기관지 내시경술을 이용한 무기폐 치료의 유용성
전윤홍 ( Yoon Hong Chun ),강성실 ( Sung Shil Kang ),방경원 ( Kyung Won Bang ),김환수 ( Hwan Soo Kim ),이의경 ( Eu Kyoung Lee ),윤종서 ( Jong Seo Yoon ),김현희 ( Hyun Hee Kim ),김진택 ( Jin Tack Kim ),이준성 ( Joon Sung Lee ) 대한소아알레르기호흡기학회 1991 소아알레르기 및 호흡기학회지 Vol.1 No.3
Purpose: This study was to evaluate the effect of flexible bronchoscopy for the treatment of secondary atelectasis of children following respiratory infection. Methods: The medical records for a total of 19 cases of flexible bronchoscopy were reviewed retrospectively, which were performed for the treatment of secondary atelectasis at the Department of Pediatrics of the Catholic University of Korea Seoul St. Mary’s Hospital from April 2007 to January 2013. Results: A total of 18 patients (11 males and 7 females) were involved in the study. The range of age was 4 months to 15 years old. The causative underlying diseases were 17 cases of pneumonia, 1 case of bronchiolitis and 1 case of bronchial asthma. The most common location of atelectasis was right middle lobe and right middle lobe with left lower lobe was next. Bronchoscopy revealed inflammatory changes in 12 cases (63.2%) such as mucus plug (n=4), profuse secretion (n=4), mucosal edema (n=3), and bronchial narrowing (n=1), although 7 cases (36.8%) showed normal airway. Other additional findings were bronchomalacia, tracheomalacia, and bronchial tree abnormality. Seven out of 19 cases who received therapeutic intervention had complete or partial reexpansion of their atelectasis. Cases who occurred atelectasis within 6 weeks showed significantly higher improvement than cases occurred after 6 weeks (70% vs. 11.1%, P=0.019). Complications including seizure, fever, hypoxia, mucous bleeding, and hypotension were observed in 6 cases. Conclusion: Flexible bronchoscopy revealed to be effective and safe treatment modality in treatment of secondary atelectasis of children. Timely therapeutic intervention in pediatric patients should be considered. (Allergy Asthma Respir Dis 2013;1:274-279)
Sodium sulfite enhances rhinovirus-induced chemokine production in airway epithelial cells.
Chun, Yoon Hong,Kim, Hyun Sook,Lee, Huisu,Won, Sulmui,Yoon, Jong-seo,Kim, Hyun Hee,Kim, Jin Tack,Lee, Joon Sung Springer Verlag 2012 Bulletin of environmental contamination and toxico Vol.89 No.4
<P>We investigated the effects of sodium sulfite (Na(2)SO(3)) on rhinovirus (RV)-induced chemokine production in A549 airway epithelial cells. Our results demonstrated that the treatment of A549 cells with 2,500 관M Na(2)SO(3) enhanced the mRNA expression of RV-induced interleukin (IL)-8 1.8 fold (p = 0.025); and regulated on activation, normal T cell expressed and secreted (RANTES), 2.9 fold (p = 0.025). Moreover, the secretion of IL-8, RANTES, and interferon-관-inducible protein (IP)-10 was increased in a statistically significant manner without affecting cell viability and RV replication. Our results suggest that Na(2)SO(3) may potentiate RV infection by enhancing chemokine production.</P>
소아에서 굴곡성 기관지 내시경술을 이용한 무기폐 치료의 유용성
전윤홍 ( Yoon Hong Chun ),강성실 ( Sung Shil Kang ),방경원 ( Kyung Won Bang ),김환수 ( Hwan Soo Kim ),이의경 ( Eu Kyoung Lee ),윤종서 ( Jong Seo Yoon ),김현희 ( Hyun Hee Kim ),김진택 ( Jin Tack Kim ),이준성 ( Joon Sung Lee ) 대한소아알레르기호흡기학회 2013 Allergy Asthma & Respiratory Disease Vol.1 No.3
Purpose: This study was to evaluate the effect of flexible bronchoscopy for the treatment of secondary atelectasis of children following respiratory infection. Methods: The medical records for a total of 19 cases of flexible bronchoscopy were reviewed retrospectively, which were performed for the treatment of secondary atelectasis at the Department of Pediatrics of the Catholic University of Korea Seoul St. Mary’s Hospital from April 2007 to January 2013. Results: A total of 18 patients (11 males and 7 females) were involved in the study. The range of age was 4 months to 15 years old. The causative underlying diseases were 17 cases of pneumonia, 1 case of bronchiolitis and 1 case of bronchial asthma. The most common location of atelectasis was right middle lobe and right middle lobe with left lower lobe was next. Bronchoscopy revealed inflammatory changes in 12 cases (63.2%) such as mucus plug (n=4), profuse secretion (n=4), mucosal edema (n=3), and bronchial narrowing (n=1), although 7 cases (36.8%) showed normal airway. Other additional findings were bronchomalacia, tracheomalacia, and bronchial tree abnormality. Seven out of 19 cases who received therapeutic intervention had complete or partial reexpansion of their atelectasis. Cases who occurred atelectasis within 6 weeks showed significantly higher improvement than cases occurred after 6 weeks (70% vs. 11.1%, P=0.019). Complications including seizure, fever, hypoxia, mucous bleeding, and hypotension were observed in 6 cases. Conclusion: Flexible bronchoscopy revealed to be effective and safe treatment modality in treatment of secondary atelectasis of children. Timely therapeutic intervention in pediatric patients should be considered. (Allergy Asthma Respir Dis 2013;1:274-279)
천명이 있는 소아에서 인터페론-감마 유도 단백질 10 kDa의 임상적 특성
김범준 ( Beom Joon Kim ),배길성 ( Kil Seong Bae ),김환수 ( Hwan Soo Kim ),전윤홍 ( Yoon Hong Chun ),윤종서 ( Jong-seo Yoon ),김현희 ( Hyun Hee Kim ),김진택 ( Jin Tack Kim ) 대한천식알레르기학회(구 대한알레르기학회) 2016 Allergy Asthma & Respiratory Disease Vol.4 No.3
Purpose: Recent studies have shown that interferon-gamma-inducible protein of 10 kDa (IP-10/CXCL10) levels is increased in acute bronchiolitis and asthma. The aim of this study was to examine the levels of IP-10 in children with wheezing and whether it correlates with other clinical variables. Methods: A total of 62 subjects children were hospitalized for lower respiratory tract infection with wheezing and visited the Emergency Department due to an acute exacerbation of asthma. IP-10 levels were measured using enzyme-linked immunosorbent assay in the serum collected at admission. Serum IP-10 levels were evaluated for the relationships with age, sex, blood eosinophils counts, acute phase reactant, allergic sensitization, history of wheezing, and chest X-ray findings. Results: Age showed a significant negative correlation with serum IP-10 levels (P=0.002). The serum levels of IP-10 were also significantly increased in patients with pneumonic infiltration on X-rays compared to those with normal or hyperinflation (P<0.009). There was no significant difference in the serum IP-10 level according to the other factors, including allergic sensitization. Conclusion: Serum IP-10 is significantly associated with inflammation of the lung and age, but not with allergic inflammation. (Allergy Asthma Respir Dis 2016;4:174-180)
소아의 굴염에서 생리 식염수 비 세척과 충혈 제거제의 사용에 대한 전향적 무작위 개방 시험
윤종서 ( Jong Seo Yoon ),조연수 ( Yeon Soo Cho ),김민성 ( Min Sung Kim ),전윤홍 ( Yoon Hong Chun ),김현희 ( Yeon Soo Cho ),김진택 ( Jin Tack Kim ),이준성 ( Joon Sung Lee ) 대한소아알레르기호흡기학회(구 대한소아알레르기 및 호흡기학회) 2010 소아알레르기 및 호흡기학회지 Vol.20 No.4
목적: 소아 굴염은 치료방법에 대해 논란이 많다. 일반적으로는 항생제를 사용하는 것이 가장 기본적인 치료로 알려져 있다. 부가적인 치료로서, 식염수로 비강을 세척하는 방법 그리고 충혈 제거제의 사용이 이루어지고 있으나, 이러한 추가적인 치료들의 효과에 대하여는 아직 명확하게 밝혀져 있지 않다. 이에 저자는 굴염의 치료에 있어서, 항생제를 기본적으로 사용하고, 이에 추가로 생리 식염수로 비강을 세척하는 방법 또는 충혈 제거제 복용, 또는 이 두 가지를 함께 추가하는 치료를 시도해서 각 치료 방법의 성과를 비교하고자 하였다. 방법: 소아 호흡기질환 클리닉에 내원한 굴염 환자를 대상으로 분석하였다. 무작위로 다음의 4가지 치료법 중 한 가지의 치료법을 적용하였다. 그룹 1은 고용량 아목시실린만 사용, 그룹 2는 고용량 아목시실린에 추가로 생리 식염수로 비강 세척을 사용, 그룹 3은 고용량 아목시실린에 추가로 충혈 제거제를 사용, 그룹 4는 고용량 아목시실린에 추가로 생리 식염수 비강 세척과 충혈 제거제를 모두 사용한 경우로 하였다. 치료에 대한 반응을 급성 및 아급성 굴염의 경우은 치료 시작 후 최소 4일 후, 만성 굴염의 경우는 치료 시작 후 최소 7일 후에 평가하였다. 결과: 4개의 치료법 간의 치료에 대한 반응을 비교했을 때, 각 그룹간에 차이가 없었다. 환자가 화농성 콧물, 코 막힘, 후비루, 굴 사진에서 특정한 소견, 그리고 아데노이드 비대증을 가지고 있는가에 따라 더 좋은 반응을 보이는 치료 방법은 없었다. 결론: 소아 굴염 환자 치료 시에 고용량 아목시실린에 추가적으로 생리 식염수 비 세척이나 충혈 제거제의 경구 사용은 환자의 증상개선에 있어서 추가적인 이득이 없었다. Purpose: The management of sinusitis in children is controversial. Antibiotic is known as the most essential management. Despite nasal irrigation and nasal decongestant have been used as adjunctive treatments of sinusitis, it is still unclear whether these are effective on sinusitis. Therefore, we used antibiotics with either nasal irrigation and an oral nasal decongestant and tried to estimate the outcome of each case. Methods: This study was conducted with sinusitis patients who visited our pediatric respiratory disease clinic. They were randomized into 4 groups: Group 1 were treated with a high dose of amoxicillin only; Group 2 were treated with nasal irrigation and a high dose of amoxicillin; Group 3 were treated with a nasal decongestant and a high dose of amoxicillin; and Group 4 were treated with nasal irrigation, a oral nasal decongestant, and a high dose of amoxicillin. Responses to treatment were estimated more than 4 days after the beginning of the therapy in acute or subacute sinusitis, and more than 7 days chronic sinusitis. Results: The responses to the treatments the 4 groups were not comparable. A favorable therapy was not found, regardless of whether a patient had suppurative rhinorrhea, nasal stuffness, typical findings of PNS plain radiograph, or adenoid hypertrophy. Conclusion: The use of nasal irrigation or a oral nasal decongestant as an additional therapy to antibiotics for the symptoms of pediatric sinusitis showed no additional effects on sinusitis. [Pediatr Allergy Respir Dis(Korea) 2010;20:232-237]
The Relationship between the Severity of Pulmonary Fibrosis and the Lung Cancer Stage
( Hye Jin Jang ),( Sang Hoon Lee ),( Moo Suk Park ),( Young Sam Kim ),( Joon Chang ),( Jae Ho Lee ),( Choon-tack Lee ),( Ho Il Yoon ) 대한결핵 및 호흡기학회 2020 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.128 No.-
Background Idiopathic pulmonary fibrosis (IPF) is steadily increasing in both incidence and mortality in recent years. The cancer risk is 5 to 7 times higher in IPF patients compared to that of the general population. The purpose of this study is to reveal whether the severity of IPF is related to the time interval between IPF diagnosis and lung cancer diagnosis and the severity of lung cancer at diagnosis. Methods In this retrospective cohort study, we reviewed the medical records of the patients with lung cancer after IPF diagnosis from two tertiary hospitals in South Korea between 2003 to 2018. We identified 61 cases of patients with Lung cancer after minimum 3 months interval of IPF diagnosis. Results Most of patients were male (n=60, 98.4%). Patients had a median age of 71 years and all patients but one were men (98.4%). The interval between IPF diagnosis and lung cancer diagnosis was not related to the GAP stage (p=0.514). However, in cox proportional hazard models, higher GAP stage was significantly correlated with advanced lung cancer stage (OR 11.12, p=0.003). Conclusions The lung cancer stage at diagnosis was higher in patients with higher GAP stage than those with lower GAP stage. Physicians consider the more frequent surveillance such as CT scans in advanced IPF patients.