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( Hye Jung Chang ),( Jae Hoon Lee ),( Young Rok Do ),( Sung Hwa Bae ),( Jung Lim Lee ),( Seung Hyun Nam ),( Sung Soo Yoon ),( Soo Mee Bang1 ) 대한내과학회 2011 The Korean Journal of Internal Medicine Vol.26 No.4
Background/Aims: The clinical efficacy and safety of a three-drug combination of melphalan, prednisone, and thalidomide were assessed in patients with multiple myeloma who were not candidates for high-dose therapy as a firstline treatment. Because the side effects of thalidomide at a dose of ≥ 100 mg daily can be a barrier to effective treatment for these patients, we evaluated the efficacy and safety of a reduced dose of thalidomide, 50 mg, for non-transplant candidates. Methods: Twenty-one patients were treated in 4-week cycles, receiving 4 mg/m2 melphalan and 40 mg/m2 prednisone on days 1-7 and 50 mg thalidomide daily. The primary efficacy outcome was the overall response rate. Aspirin (100 mg daily) was also provided as prophylactic treatment for thromboembolism. Results: The overall response rate was 57.1%; a complete response was seen in 23.8% of patients, a partial response in 33.3%, and stable disease in 9.5%. After a median follow-up time of 16.1 months, the median time to progression was 11.4 months (95% confidence interval, 2.1 to 20.6); the median overall survival was not reached. Grades 3 and 4 adverse events included infection (10%), peripheral neuropathy (5%), diarrhea (5%), thrombosis (10%), and loss of consciousness (10%). Two patients discontinued treatment due to loss of consciousness and neuropathy. Conclusions: Low-dose thalidomide (50 mg) plus melphalan and prednisone is an effective combination drug therapy option for newly diagnosed myeloma patients who are ineligible for high-dose chemotherapy.
Sung-Min Jeong,In-Won Lee,Yu-Jin Jo,Jeong-Kyu Bang,Suk Namgoong,Nam-Hyung Kim 한국동물생명공학회(구 한국동물번식학회) 2017 Reproductive & Developmental Biology(Supplement) Vol.41 No.2
Polo-like kinase 1 (Plk1) plays crucial roles in various stages of oocyte maturation. Recently, we demonstrated that synthesized peptidomimetics AB103-8, targeting the polo- box domain (PBD) of Plk1 disrupted oocyte meiotic maturation and meiosis resumption. However, as a peptidic character of AB103-8 appeared to be defective due to poor membrane permeability and protease stability. To overcome the drawbacks, we designed and synthesized a series of pyrrole-based small-molecule inhibitors and screened against porcine oocyte maturation rates. Among the synthesized compounds, the macrocyclic inhibitor compound 4 displayed the highest inhibition potential against the oocyte meiotic maturation and embryos blastocyst formation. Furthermore, the addition of this compound to culture medium efficiently blocked the maturation of porcine and mouse oocytes, indicating that the lead compound could penetrate zona pellucida and cell membrane. We also investigated the Plk1 inhibiting ability of this compound. Treated mouse oocytes confirmed the Plk1 inhibition by showing abnormal spindle formation. Collectively, these results suggest that the novel Pyrrole-based compounds could be used for the basis of developing contraceptive agents.
Nam Chul Jo,Ki Choon Choi,Sang Pil Na,Chang Yoon,Wan Bang Yook 한국초지조사료학회 2009 한국초지조사료학회 학술대회논문집 Vol.2009 No.08
This study was carried out to investigate the productivity and nutritive values of SSH under Double-cropping SSH followed by whole crop barley (SSFWB) or by Hairy vetch (SSFHV) in paddy land. A field study was conducted at Baeksan-myeon, Kimje, Jeonbuk province in Korea on clay loam soil for 3 years. All plots were arranged in completely randomized design with three replicates. The yield of SSH in SSFWB treatment was higher t㏊n t㏊t of SSFHV (P<0.05). All nutrients values of SSH were not influenced by the cropping system. However, all nutrients of SSH in SSFWB treatment were just a little increase, compared with those of SSFHV.
Nam Chul Jo,Ki Choon Choi,Sang Pil Na,Chang Yoon,Yang Seung Hak,Wan Bang Yook 한국초지조사료학회 2009 한국초지조사료학회 학술대회논문집 Vol.2009 No.08
This study was carried out to investigate the properties of soil and water under Double-cropping SSH followed by whole crop barley (SSFWB) or by Hairy vetch (SSFHV) in paddy land. A field study was conducted at Baeksan-myeon, Kimje, Jeonbuk province in Korea on clay loam soil for 3 years. All plots were arranged in completely randomized design with three replicates. The pH and the contents of T-N and organic matter (OM) in soil samples collected at the end of the experiment were remarkably higher t㏊n those at the beginning of the experiment in both SSFWB and SSFHV treatment (P<0.05). The contents of an exchangeable cations at the end of the experiment were remarkably higher t㏊n those at the beginning of the experiment in both SSFWB and SSFHV (P<0.05). And then, the concentration of NO₃-N, NH₃-N and PO₄-P in discharge and leaching water were not influenced by the cropping system