http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Stable Generation of Neural Precursor Cells from Human Embryonic Stem Cells
( Song Ee Lee ),( Mira Park ),( Na Yeon Lee ),( Byoung Gi Chun ),( Seong Jun Choi ),( Ji Hwan Song ) 한국조직공학과 재생의학회 2008 조직공학과 재생의학 Vol.5 No.2
Human embryonic stem cells(hESCs) have the capacity to selfrenew and to differentiate into all cell types in the body. For this reason, they have been regarded as the ideal sources for cell replacement therapy. In this study, we explored the optimal conditions for neuronal differentiation of hESCs, by coculturing with PA6 stromal cells. We found that neural precursor cells(hESCNPs) can be stably generated by coculturing with PA6, which were confirmed by morphology and immunocytochemical methods. We also established an optimal culture condition for hESCNPs, which allows a longterm proliferation and a largescale expansion of hESCNPs. Considering the developmental potential of hESCNPs, we speculate that they can serve as useful cell sources for treating various neurological diseases, such as stroke.
S-445 : Primary B-lymphoblastic lymphoma of gallbladder diagnoseed by laparosscopic cholecystectomy
( Song Ee Park ),( Jae Hyun Tae ),( Min Suk Kwon ),( Hee Jun Kim ),( Eun Kyung Park ),( Ing Yu Hwang ),( Jung Sun Jang ) 대한내과학회 2013 대한내과학회 추계학술대회 Vol.2013 No.1
The patient was a 72-year-old man who presented for evaluation of painless hematuria which he stated had been present for at least 1month. At the time of presentation, the patient did not report any systemic symptoms and had no fever, weight loss or dysuria. Computed tomography (CT) also showed several enhancing, sessile polyps in the gall bladder (1.5 cm and smaller). No associated stone or biliary dilation. Since no other abnormality was evident, we performed laparoscopic cholecystectomy. He was diagnosed as having B-cell lymphoblastic lymphoma (B-LBL) after surgical resection of his gall bladder (GB). A gall bladder, measuring 7.5×4.0 cm. The serosal surface is smooth and glistening. The mucosa shows four sessile polypoid lesions, measuring 1.8×1.5 cm, 1.1×0.9 cm, 0.7×0.7 cm, and 0.8×0.7 cm. The surface of the lesions is whitish and firm. No surface ulceration or hemorrhage is noted. The tumor was B-LBL LCA (+), CD20 (focal+), CD79a (+), CD3 (+), CD45RO (+), Bcl-2 (+), Ki-67 (30%). After the surgery, metastaric work-up including CT scan of the chest, positron emission tomography (PET) and bone marrow biopsy was performed. The PET revealed an increased fluorodeoxyglucose-uptake in the left maxilla, left mandible, right humerus, T12 and lt mandible mass. The clinical course suggested GB tumor was growth of the B-LBL. The definitive pathological diagnosis was B-LBL, stage IV. Systemic chemotherapy was started and subsequent response in size of the lt mandible mass. Since lymphomas of GB are exceedingly rare, the differential diagnosis would be difficult.
Alternative Patterning Process for Realization of Large-Area, Full-Color, Active Quantum Dot Display
Park, Joon-Suh,Kyhm, Jihoon,Kim, Hong Hee,Jeong, Shinyoung,Kang, JoonHyun,Lee, Song-ee,Lee, Kyu-Tae,Park, Kisun,Barange, Nilesh,Han, JiYeong,Song, Jin Dong,Choi, Won Kook,Han, Il Ki American Chemical Society 2016 Nano letters Vol.16 No.11
<P>Although various colloidal quantum dot (QD) coating and patterning techniques have been developed to meet the demands in optoelectronic applications over the past years, each of the previously demonstrated methods has one or more limitations and trade-offs in forming multicolor, high-resolution, or large-area patterns of QDs. In this study, we present an alternative QD patterning technique using conventional photolithography combined with charge-assisted layer-by-layer (LbL) assembly to solve the trade-offs of the traditional patterning processes. From our demonstrations, we show repeatable QD patterning process that allows multicolor QD patterns in both large-area and microscale. Also, we show that the QD patterns are robust against additional photolithography processes and that the thickness of the QD patterns can be controlled at each position. To validate that this process can be applied to actual device applications as an active material, we have fabricated inverted, differently colored, active QD light-emitting device (QD-LED) on a pixelated substrate, which achieved maximum electroluminescence intensity of 23 770 cd/m(2), and discussed the results. From our findings, we believe that our process provides a solution to achieving both high-resolution and large-scale QD pattern applicable to not only display, but also to practical photonic device research and development.</P>
( Song Ee Park ),( Min Suk Kwon ),( Jae Hyun Tae ),( Hee Jun Kim ),( Ing Yu Hwang ),( Jung Sun Jang ),( Eun Kyung Park ) 대한내과학회 2013 대한내과학회 추계학술대회 Vol.2013 No.1
A 52-year-old female was diagnosed with ITP at our hospital in February 1987. Her Platelet count was 4×109/L at diagnosis. She was initially treated splenectomy in April 1987. Since 1987, she was intermittently administered with oral prednisolone. However, No response in her platelet count was observed. September 2009. Blood test indicated severe thrombocytopenia with a platelet count of 4×109/L, a white blood cell count of 22.39×109/L and a hemoglobin level of 12.9 g/dL. The patient was treated with intravenous immunoglobulin (IVIG, 1g/kg/day for 2 days). IVIG treatment was performed 11 times. Oral prednisone was also restarted at a dose of 1 mg /kg/day. However, No response in her platelet count was observed. Treatment with the thrombopoietin receptor (TP069O-R) agonist, eltrombopag at 50 mg/day. Despite the four months the administration Eltombopag, she fell back into the reaction after only 170,000 platelet count is 100,000 or more. Subsequently. another TPO-R agonist, romiplostim, was administered (at a starting dose of 1 μg/kg/week) in place of eltrombopag. Because of the poor response, weekly increases in the dose of romiplostim were required. An increase in the patient`s platelet count was seen at dose 3.7 μg/kg/week. The platelet continued to rapidly increase during the following weeks, up to a maximum count of 352×109/L. During treatment with romiplostim, the patient experienced no specific side effects.
Park, Cheonil,Seong, Yun-Jeong,Kang, In-Gu,Song, Eun-Ho,Lee, Hyun,Kim, Jinyoung,Jung, Hyun-Do,Kim, Hyoun-Ee,Jang, Tae-Sik American Chemical Society 2019 ACS APPLIED MATERIALS & INTERFACES Vol.11 No.11
<P>Poly(lactic acid) (PLA) is the most utilized biodegradable polymer in orthopedic implant applications because of its ability to replace regenerated bone tissue via continuous degradation over time. However, the poor osteoblast affinity for PLA results in a high risk of early implant failure, and this issue remains one of the most difficult challenges with this technology. In this study, we demonstrate the use of a new technique in which plasma immersion ion implantation (PIII) is combined with a conventional DC magnetron sputtering. This technique, referred to as sputtering-based PIII (S-PIII), makes it possible to produce a tantalum (Ta)-implanted PLA surface within 30 s without any tangible degradation or deformation of the PLA substrate. Compared to a Ta-coated PLA surface, the Ta-implanted PLA showed twice the surface roughness and substantially enhanced adhesion stability in dry and wet conditions. The strong hydrophobic surface properties and biologically relatively inert chemical structure of PLA were ameliorated by Ta S-PIII treatment, which produced a moderate hydrophilic surface and enhanced cell-material interactions. Furthermore, in an in vivo evaluation in a rabbit distal femur implantation model, Ta-implanted PLA demonstrated significantly enhanced osseointegration and osteogenesis compared with bare PLA. These results indicate that the Ta-implanted PLA has great potential for orthopedic implant applications.</P> [FIG OMISSION]</BR>