Comparison of Stent-Assisted Coil Embolization Versus Coil Embolization Alone for Ruptured Cerebral Aneurysms with Mild Symptoms: A Single-Clinic Experience

Gayeong Lim,Shang Hun Shin,Tae Young Lee,Woon-Jung Kwon,Byeong-Su Park,Soon Chan Kwon 대한영상의학회 2022 대한영상의학회지 Vol.83 No.4

Purpose To evaluate the safety and efficacy of stent-assisted coil embolization (SAC) in acutely ruptured cerebral aneurysms without severe symptoms, and thus, the usefulness of the stent itself in patients with subarachnoid hemorrhages. Materials and Methods From January 2017 to June 2019, 118 patients were treated with coil embolization for acutely ruptured cerebral aneurysms without severe symptoms (Hunt & Hess grade ≤ 3). The periprocedural complications, six-month modified Rankin scores (mRS), and six-month radiologic outcomes were compared between 56 patients with SAC and 62 patients without SAC (non-SAC). Results The rate of good clinical outcomes (mRS ≤ 2), as well as the rate of hemorrhagic and ischemic complications, showed no significant difference between the SAC and non-SAC groups. Moreover, compared to the non-SAC group, the SAC group showed a lower recanalization rate on the six-month follow-up angiogram (20% vs. 39.3%, p = 0.001). Conclusion Although stent use was not significantly associated with clinical outcomes in coil embolization of ruptured cerebral aneurysms with non-severe symptoms (Hunt & Hess grade ≤ 3), it significantly decreased the rate of recanalization on follow-up cerebral angiograms.

Characterization of Specific IgA Response to Antigenic Determinants of Helicobacter pylori Urease Encoded by ureA and ureB in Children

Min-Kyoung Shin,Jin-Su Jun,Soon-Wook Kwon,Dong-Hae Lee,Jong-Hun Ha,Jin-Sik Park,Dae Hyun Song,Myung Hwan Jung,Hyung-Lyun Kang,Seung-Chul Baik,Ji Sook Park,Hee-Shang Youn,Myung Je Cho,Ji-Hyun Seo,Woo-K 대한미생물학회 2018 Journal of Bacteriology and Virology Vol.48 No.1

전통장류 유래 GB-07균주에 의해 생산된 Compound K 함유 발효인삼의 항산화 및 항염증 활성 연구

신동규(Dong-Gue Shin),서정훈(Jeong-Hun Seo),조상민(Shang-Min Cho),최학주(Hak-Joo Choi) 한국산학기술학회 2017 한국산학기술학회논문지 Vol.18 No.9

인삼은 약용으로 수 천년 동안 소중하게 사용되어 왔으며 근대에 들어와 단일 성분의 분리와 각 성분에 대한 효능의 과학적인 연구가 활발히 이어져 오고 있다. 최근에는 인삼 성분 중에 Rg3, compound K 등이 주목 받고 있으며 기능성을 갖는 다양한 소재들이 연구 개발되어 제품화 되고 있다. 본 연구에서는 전통 장류에서 유래한 효모균 (Saccharomyces servazzii, GB-07)을 이용하여 인삼 추출물을 발효하여 compound K를 생산하고 기능성을 확인하여 상업적 이용 가능성을 확인하였다. Compound K 함유 (20 ㎍/g 함유) 인삼 발효 추출물을 이용하여 항산화 및 항염증 활성을 측정하였다. 발효 인삼추출물은 자유 라디칼 DPPH (di(phenyl) -(2,4,6-trinitrophenyl)를 농도 의존적으로 소거하였으며. macrophage(RAW 264.7 cell)에서 ROS의 생성을 농도 의존적으로 억제하였다. 또한 LPS에 의해 유도된 염증 사이토카인 IL-1β와 IL-6 그리고 TNF-α의 생성을 억제하는 것으로 나타났다. 본 연구 결과는 향후 공정개발과 다양한 효능 시험을 통해 compound K를 함유한 제품의 개발을 통한 산업화의 가능성 시사하고 있다. Ginseng, whichhas long been used for its medicinal properties, has recently been investigated by scientific research to identify its components and evaluate its efficacy. Recently, two components of ginseng, Rg3 and compound K, have been attracting attention and various functional materials containing these materials have been developed and investigated. In this study, compound K wasproduced using yeast (Saccharomyces servazzii, GB-07) and To be used for industrialization. The antioxidant and anti-inflammatory activity of compound K (containing 20 g/g) ginseng fermented extract was investigated. In the fermented ginseng extract, the free radical DPPH was scavenged in a concentration-dependent manner and the production of ROS was inhibited in macrophages(RAW 264.7 cell). Moreover, the LPS-induced inflammatory cytokines IL-1β, IL-6 and TNF-α were suppressed. These results suggest the possibility of industrialization viathe development of products containing compound K through future process development and various efficacy tests.

종합부동산세법의 헌법합치성에 관한 소고

李東植(Dong Sik Lee),李相信(Shang Shin Lee),朴薰(Hun Park) 한국세법학회 2007 조세법연구 Vol.13 No.2

2005년부터 시행된 종합부동산세법은 여러 쟁점에서 위헌 여부가 다투어지고 있다. 이 글에서는 법리적인 측면에서 적어도 5가지 쟁점에 있어서는 종합부동산세법이 위헌이라 보기 어렵다는 결론에 도달했다. 그 세부적인 사항은 다음과 같다. 첫째, 이중과세로 인한 위헌은 아니다. 종합부동산세법은 종합부동산세액에서 기납부한 재산세액을 전액 공제하여 세액을 계산하도록 규정하고 있으므로 종합부동산세와 재산세의 이중과세문제가 발생하지 아니한다. 종합부동산세는 재산보유세이므로 수득세인 양도소득세, 상속ㆍ증여세와는 이중과세문제가 발생하지 않는다. 종합부동산세를 수득세로 보더라도 헌법재판소 2006.3.30 선고, 2003헌가11 결정 사건의 취지를 고려할 때 양도소득세, 상속ㆍ증여세에서 기납부한 종합부동산세를 공제해 주지 않는다고 하여 위헌이 되는 것은 아니다. 둘째, 미실현이득에 대한 과세로 인한 위헌도 아니다. 종합부동산세는 미실현이득 과세라고 단언하기 어렵다. 미실현이득 과세로서의 성격을 인정하는 경우에도 그러한 이유만으로 위헌은 아니다. 미실현이득에 대해 과세하는 경우 그 방법이 적정한지가 논란이 될 수는 있다. 이에 대해서는 공시가격의 자의성과 관련해서 검토해 볼 필요가 있다. 셋째, 원본잠식에 따른 위헌도 아니다. 원본에 대한 과세가 이루어진다고 해서 그것이 바로 재산권을 침해하여 위헌이 되는 것은 아니다. 종합부동산세가 원본침해의 위험이 있더라도 처분의 자유나 사유재산제도의 부인이 되는 것은 아니므로 본질적 침해라고 하기도 어렵다. 넷째, 고시가격의 자의성으로 인한 위헌도 아니다. 현행 종합부동산세 과세표준의 중요한 요소인 공시가격제도는 실제거래가액은 아니지만 부동산가격공시법상의 규정과 실제 공시가격 결정과정을 볼 때 정부가 자의적으로 결정하는 것은 아니다. 공시가격 결정에 있어 이해관계자의 이의신청제도를 둔다는 점에서도 공시가격제도가 위헌이라 할 정도의 자의성이 있다고 보기 어렵다. 다섯째, 소급과세금지원칙 위반도 아니다. 과세기준일 이전에 과거 지가 상승분을 반영하여 공시지가를 시가에 가깝게 한 경우에는 소급과세금지원칙 위반이라고 하기 어렵다. Several issues remain controversial and under discussion concerning the constitutionality of the 2005 Composite Real Estate Tax Law(CRETA). This study has reached the conclusion that, according to the principles of law, CRETA cannot be found to be unconstitutional for at least five issues in controversy. The details are as follows : First, the law cannot be found to be unconstitutional on charges of breach of double taxation. The composite real estate tax law contains a provision stipulating that the amount of property tax already paid by taxpayers be wholly deducted from the taxable amount of the composite real estate tax, thus a valid case cannot be established to support the accusation of double taxation. The composite real estate tax is an ownership tax, so there is no double taxation with for - profit taxes like capital gains tax, inheritance tax, and gift tax. Even if the composite real estate tax is considered as a for - profit tax, we cannot find it unconstitutional just because it does not deduct the amount of capital gains tax, inheritance tax, or gift tax that have been already paid, when considering the Constitutional Court's decision on case 2003CCA(Heon Ga)11 dated March 30, 2006. Second, the law cannot be found to be unconstitutional on charges of taxation on unrealized gains. It is not a valid argument to say that the composite real estate tax impose taxes on unrealized gains. Even if it is interpreted as taxation on unrealized gains, that alone does not make the law unconstitutional. However, the question as to whether or not the tax on unrealized gains is levied in an appropriate way is likely to remain controversial, so it would be necessary to evaluate whether the posted prices for taxable properties have been fairly and reasonably assessed. Third, the law cannot be found to be unconstitutional on charges of erosion of the original value. Taxation on the original value does not violate the Constitution by infringing on property rights. Even if the tax might erode the original value to a certain extent, it does not infringe on the constitutional right for property disposal, nor deny the private property system. Fourth, the law cannot be found to be unconstitutional on charges of arbitrary assessment of the posted prices. The publicly-posted prices serve as a basis for taxation. They are not the actual transaction prices, but it should be noted from the provisions of the Real Estate Price Posting Law and the actual decisionmaking process that the prices are not determined arbitrarily by the government. Additionally, the law cannot be found to be unconstitutional as it allows the taxpayers and related parties to file an administrative appeal if they disagree. Fifth, the law cannot be found to be unconstitutional on charges of non-conformity with the principle of retroactive taxation. It cannot be seen as breach of the principle of retroactive taxation as long as the posted prices reflect the increase of actual market prices before the taxation base date, and get close to them.

The Efficacy of Simultaneous Bilateral Internal Carotid Angiography during Coil Embolization for Anterior Communicating Artery Aneurysms

Kwon, Soon-Chan,Park, Jun-Bum,Shin, Shang-Hun,Sim, Hong-Bo,Lyo, In-Uk,Kim, Young The Korean Neurosurgical Society 2011 Journal of Korean neurosurgical society Vol.49 No.5

Objective : Successful coil embolization of anterior communicating (A-com) artery aneurysms requires good visualization and understanding of the entire H complex. Bilateral carotid angiography may optimize anatomical understanding and visualization of the H complex. We therefore assessed the efficacy of simultaneous bilateral internal carotid angiography during coil embolization for A-com artery aneurysms. Methods : Of the 153 patients with intracranial saccular aneurysms who underwent embolization between July 2008 and December 2009, 12 had A-com artery aneurysms and were embolized under bilateral carotid angiography. Patients were evaluated angiographically, immediately and 6 months (n=11) after embolization, using a 3-point scale (complete, residual neck, residual aneurysm). The safety, performance and efficacy of this approach were retrospectively evaluated. Results: In all patients, bilateral internal carotid artery angiography provided more detailed anatomical information and understanding around the A-com artery, and, in complex situations, it allowed for more effective coil embolization through bilateral routes to the A-com artery. Angiography immediately after embolization showed occlusion of 11 of the 12 (92%) aneurysms, with none of these 11 showing evidence of recanalization at 6 months. Conclusion : These findings indicate that simultaneous bilateral carotid angiography during coil embolization of selected complex A-com artery aneurysms provided improved anatomical understanding, and resulted in more effective and safer procedures than typical unilateral angiography.

방사선 조사가 단순포진 바이러스의 증식에 미치는 영향

이유철,조유진,신상훈 대한감염학회 1999 감염 Vol.31 No.2

Purification and Characterization of Bile Salt Hydrolase from Lactobacillus plantarum CK 102

( Chul Gyu Ha ),( Jin Kook Cho ),( Young Gyu Chai ),( Young Ae Ha ),( Shang Hun Shin ) 한국미생물생명공학회 2006 Journal of microbiology and biotechnology Vol.16 No.7

Hepatitis B-related Polyarteritis Nodosa with Aortic Dissection Presenting as Diffuse Alveolar Hemorrhage

( Chan Sung Park ),( Bon Seung Ku ),( Seon Ho Lee ),( Shang Hun Shin ),( Yang Jin Jegal ),( Jong Joon Ahn ),( Seung Won Choi ),( Kwang Won Seo ) 대한결핵 및 호흡기학회 2006 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.103 No.-

Altered microRNA expression profiles are involved in resistance to low-dose ionizing radiation in the absence of BMI1 in human dermal fibroblasts.

Bae, Seunghee,Kim, Karam,Cha, Hwa Jun,Choi, Yeongmin,Shin, Shang Hun,An, In-Sook,Lee, Jae Ho,Song, Jie-Young,Yang, Kwang Hee,Nam, Seon Young,An, Sungkwan Lychnia 2014 International journal of oncology Vol.45 No.4

<P>The polycomb group RING finger protein, B-cell?specific moloney murine leukemia virus integration site?1 (BMI1), has emerged as a key regulator of cell proliferation, cell cycle, cell immortalization, chemoresistance and radioresistance. Although the radioresistant effect of BMI1 has been thoroughly investigated, the effectiveness of this factor on low-dose radiation (LDR) resistance has not been explored. Here, we demonstrate that BMI1 is not critical for altering cell viability or cell growth in response to LDR, but BMI1 changes cellular gene expression profiles in response to LDR. Normal human dermal fibroblasts (NHDFs) stably expressing BMI1 short hairpin RNA (shRNA) did not exhibit changes in cell viability or cell cycle distribution assays following exposure to 0.1?Gy of γ-radiation. However, microRNA (miRNA) microarrays revealed that a lack of BMI1 leads to changes in miRNA expression in response to LDR. Bioinformatics analyses demonstrated that predicted target genes of the altered miRNAs are functionally involved in both negative and positive regulation of cell growth, cell proliferation, cell cycle and apoptosis. Therefore, these results indicate that low radiosensitivity even in the absence of the radioresistant factor BMI1 is related with the altered miRNA expression profiles in NHDF.</P>

Cholesterol Lowering Effect of Lactobacillus plantarum Isolated from Human Feces

( Chul Gyu Ha ),( Jin Kook Cho ),( Chi Ho Lee ),( Young Gyu Chai ),( Young Ae Ha ),( Shang Hun Shin ) 한국미생물생명공학회 2006 Journal of microbiology and biotechnology Vol.16 No.8