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알레르기성 비염 환자에서 절지동물성 특이항원의 양성율 및 항원간 일치율
황규윤,남해선,박준수,권준택,백병준,김장묵,오천환,조성란 순천향의학연구소 2000 Journal of Soonchunhyang Medical Science Vol.6 No.2
The current study was designed to evaluate the positive rates of arthropod allergens by Korean inhalant panel of MAST-CLA in patients with allergic rhinitis. One hundred sixty patients, diagnosed to allergic rhinitis in an Out Patient Center of Soonchunhyang University Chunan Hopsital during Aug 1998 to July 2000, were studied. 1. The overall positive rate among 35 specific allergens was 59.4% (95 patients). 2. The arthropod related allergen accounted for 82.1% (78 patients) of the positive rate. 3. Each positive rate of Dermatophagoides farinae (Df), Dermatophagoides pteronyssinus (Dp), house dust (Hd), and cockroach mix (Cm) was 45.0% (72 patients), 43.1% (69 patients), 28.1% (45 patients), and 8.8% (14 patients), respectively. 4.Significant agreement between arthropod allergens was observer (P < 0.05). 5. The obseved agreement between Df and Dp was 95.6%, showing most significant Kappa index (Kappa = 0.911, P < 0.001). There results suggested that although MAST-CLA is a useful measure of identifying specific allergens, the specificity of two mite allergen relatively low, implying because of common allergen between mites in Korean panel of MAST-CLA. Our data also supported that arthropod is the major cause of allergen in patients with allergic rhinitis, however, the MAST-CLA should be modified in order to exclude common allergen of mite and to include more specific mite allergen.
( Sang Muk Oh ),( Chang Gyo Park ),( Joo Hee Kang ),( Eun Jung Kim ),( Hee Youn Chee ),( Bong Ho Lee ),( Kyung Bok Lee ) 한국응용생명화학회 2011 Applied Biological Chemistry (Appl Biol Chem) Vol.54 No.3
Dieckol, a polyphenol compound extracted from Brown algae, Ecklonia cava, is known to have anti-inflammatory and anti-tumorigenic activities. However, the underlying molecular mechanism by which dieckol regulates cancer cell growth and proliferation remains elusive. Here we report that dieckol extracted from Ecklonia cava inhibited 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced human hepatocellular carcinoma SK-Hep1 cell motility, and that dieckol decreased extracellular signal-regulated kinases 1/2 and c-Jun N-terminal kinases (JNKs) activities, but not p38 Mitogen-Activated Protein Kinase (MAPK), in dose-dependent manner. Dieckol reduced TPA-induced activator protein-1 transcriptional activity. TPA-induced matrix metalloproteinase-9 (MMP-9) activity was greatly reduced in SK-Hep1 cells by treatment of dieckol. These findings suggest that dieckol functions as a potent inhibitor for tumor promoter-mediated MAPK signaling pathways leading to AP-1 and MMP-9 activation thereby regulates cancer cell motility.
건물 옥상녹화에서의 조립식 성형판자재를 이용한 이중바닥 구조의 건식화 및 일체화 시공기술에 대한 연구
장상묵 ( Jang Sang-muk ),문유석 ( Moon You-seok ),송제영 ( Song Je-young ),최성민 ( Choi Sung-min ),오상근 ( Oh Sang-keun ) 한국구조물진단유지관리공학회 2008 한국구조물진단유지관리공학회 학술발표대회 논문집 Vol.12 No.1
Recently, the green roofs market is active, but most constructors use former waterproofing method. So there are a lot of problems in the sub-organization of the green roofs system. I studied to use the plastic panel for the access-floor struct of the green roofs system and I tested about the effectiveness of root barrier, impact resistance, compression load, and dissolution. I have not found any problems about root barrier, impact resistance, compression load, and dissolution in the results. The sub-organization of the green roofs system using the plastic panel is effective for root barrier, impact resistance, compression load, and dissolution. We can apply it to the dried and unified execution technology.
Lee, Sang-Hoon,Kim, Pyeung-Hyeun,Oh, Sang-Muk,Park, Jung-Hwan,Yoo, Yung-Choon,Lee, Junglim,Park, Seok-Rae The Korean Association of Immunobiologists 2014 Immune Network Vol.14 No.6
TGF-${\beta}$ induces IgA class switching by B cells. We previously reported that Smad3 and Smad4, pivotal TGF-${\beta}$ signal-transducing transcription factors, mediate germline (GL) ${\alpha}$ transcription induced by TGF-${\beta}1$, resulting in IgA switching by mouse B cells. Post-translational sumoylation of Smad3 and Smad4 regulates TGF-${\beta}$-induced transcriptional activation in certain cell types. In the present study, we investigated the effect of sumoylation on TGF-${\beta}1$-induced, Smad3/4-mediated $GL{\alpha}$ transcription and IgA switching by mouse B cell line, CH12F3-2A. Overexpression of small ubiquitin-like modifier (SUMO)-1, SUMO-2 or SUMO-3 did not affect TGF-${\beta}1$-induced, Smad3/4-mediated $GL{\alpha}$ promoter activity, expression of endogenous $GL{\alpha}$ transcripts, surface IgA expression, and IgA production. Next, we tested the effect of the E3 ligase PIASy on TGF-${\beta}1$-induced, Smad3/4-mediated $GL{\alpha}$ promoter activity. We found that PIASy overexpression suppresses the $GL{\alpha}$ promoter activity in cooperation with histone deacetylase 1. Taken together, these results suggest that SUMO itself does not affect regulation of $GL{\alpha}$ transcription and IgA switching induced by TGF-${\beta}1$/Smad3/4, while PIASy acts as a repressor.
Kyoung-Muk Lee,Seh-Min Oh,Sung-Man Lee* 대한화학회 2008 Bulletin of the Korean Chemical Society Vol.29 No.6
A carbon composite was synthesized by mechanical mixing of ball-milled graphite and PVC powders, followed by pyrolysis reaction of PVC. Natural graphite ball milled under atmosphere of argon or air leads to a disordered structure. It appears that the electrochemical lithium intercalation reaction is dependent on the atmosphere in which the graphite is ball milled. The carbon composite obtained using air-milled graphite shows a high reversible capacity and high initial coulombic efficiency compared to argon-milled graphite. This is attributed to the enhanced thermal stability of a disordered structure in the air milled sample. For the one with air-milled graphite, the disordered structure is maintained during heat treatment, while argon-milled graphite is partially crystallized.
A case of accessory tragus on buccal area
( Kyung Muk Jeong ),( Ji Yun Seo ),( Jin Young Song ),( Yoo Sang Baek ),( Hae Jun Song ),( Chil Hwan Oh ),( Jiehyun Jeon ) 대한피부과학회 2018 대한피부과학회 학술발표대회집 Vol.70 No.1
Accessory tragus is a congenital anomaly of the external ear arised from the abnormal development of the auricular tubercles or from the tissues surrounding the second, third and fourth branchial clefts. It presents in males and females equally with a prevalence of approximately 2-6 per 1000 live births. Clinically, this anomaly is usually presented as a small skin-colored tag or nodule near the tragus, but rarely, along an imaginary line drawn back from the tragus to the angle of the mouth, or along the anterior edge of the sternocleidomastoid muscle and the sternoclavicular region. The diagnosis is made by the age of onset, site of localization, and affirmative histopathology. We report a 12-month-old male who congenitally presented with a solitary flesh colored pedunculated nodule on the left buccal area. Shave biopsy was performed on this lesion. Histologically there are numerous follicles, prominent connective tissue framework in the sub cutaneous fat and central core of cartilage. It diagnosed as accessory tragus and the patient is under observation without complications. Herein, we report a case of accessory tragus arising in buccal area as an interesting example.