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( Sang Muk Oh ),( Chang Gyo Park ),( Joo Hee Kang ),( Eun Jung Kim ),( Hee Youn Chee ),( Bong Ho Lee ),( Kyung Bok Lee ) 한국응용생명화학회 2011 Applied Biological Chemistry (Appl Biol Chem) Vol.54 No.3
Dieckol, a polyphenol compound extracted from Brown algae, Ecklonia cava, is known to have anti-inflammatory and anti-tumorigenic activities. However, the underlying molecular mechanism by which dieckol regulates cancer cell growth and proliferation remains elusive. Here we report that dieckol extracted from Ecklonia cava inhibited 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced human hepatocellular carcinoma SK-Hep1 cell motility, and that dieckol decreased extracellular signal-regulated kinases 1/2 and c-Jun N-terminal kinases (JNKs) activities, but not p38 Mitogen-Activated Protein Kinase (MAPK), in dose-dependent manner. Dieckol reduced TPA-induced activator protein-1 transcriptional activity. TPA-induced matrix metalloproteinase-9 (MMP-9) activity was greatly reduced in SK-Hep1 cells by treatment of dieckol. These findings suggest that dieckol functions as a potent inhibitor for tumor promoter-mediated MAPK signaling pathways leading to AP-1 and MMP-9 activation thereby regulates cancer cell motility.
Cutaneous Mycobacterium massiliense Infection associated with bee venom acupuncture
( Kyung Muk Jeong ),( Seung Hwi Kwon ),( Yoo Sang Baek ),( Jiehyun Jeon ),( Chil Hwan Oh ),( Hae Jun Song ) 대한피부과학회 2018 대한피부과학회 학술발표대회집 Vol.70 No.1
Bee venom acupuncture is a variant of acupuncture technic of folk medicine using bee sting. Despite controversies surrounding its effectiveness, various adverse events including nontuberculous mycobacterium (NTM) skin and soft tissue infection has been reported. Mycobacterium massiliense is a rapid growing nontuberculous mycobacterium (NTM) that is closely related to the M. abscessus/chelonae group. It is usually ubiquitous in soil and water, but increasing reports of its isolation in human infection arouse attention for it. A 37-year-old woman presented with tender erythematous indurated patches on lateral side of right knee, which was developed following a bee venom acupuncture procedure. Biopsy revealed chronic granulomatous inflammation with abscess and subsequent pus culture revealed Mycobacterium massiliense growth. The patient treated with 6 months of oral clarithromycin and 14 days of intramuscular amikacin and did not show recurrence afterward. Herein, we report a case of Mycobacterium massiliense granulomatous infection following a bee venom acupuncture procedure.
A case of Intradermal nevus clinically mimicking a tick engorged with blood
( Kyung Muk Jeong ),( Ji Yun Seo ),( Yoo Sang Baek ),( Jiehyun Jeon ),( Chil Hwan Oh ),( Hae Jun Song ) 대한피부과학회 2018 대한피부과학회 학술발표대회집 Vol.70 No.1
Intradermal nevus is a common benign skin tumor presents as a flesh-colored soft papule usually because nevus cells located in the dermis often lose their capacity to produce melanin. However, intradermal nevus may show diverse clinical manifestations to such an extent as to confuse it clinically from other diseases when the nevus presents in a non-typical area with an unusual shape. Ticks are small arthropod living by sucking mammalian blood. Ticks occasionally stick to human during outdoor activities and become engorged after sucking blood. Axilla or inner thigh area is frequently involved site of tick bite. When fully engorged, the tick looks like a pedunculated pigmented nodule, which can be mistaken as strangulated lesion of pyogenic granuloma, soft fibroma, or intradermal nevus with stalk. Herein, we report an interesting case of intradermal nevus mimicking shape and color of an engorged tick. A 55-year-old man presented with a dusky dark brown to black colored smooth surfaced, pedunculated nodule on perianal area. Clinically, it was not typical for intradermal nevus and resembled a tick which is fully engorged after sucking blood. Biopsy revealed a well differentiated intradermal nevus with pigmented nevus cell in upper dermis.
Lee, Sang-Hoon,Kim, Pyeung-Hyeun,Oh, Sang-Muk,Park, Jung-Hwan,Yoo, Yung-Choon,Lee, Junglim,Park, Seok-Rae The Korean Association of Immunobiologists 2014 Immune Network Vol.14 No.6
TGF-${\beta}$ induces IgA class switching by B cells. We previously reported that Smad3 and Smad4, pivotal TGF-${\beta}$ signal-transducing transcription factors, mediate germline (GL) ${\alpha}$ transcription induced by TGF-${\beta}1$, resulting in IgA switching by mouse B cells. Post-translational sumoylation of Smad3 and Smad4 regulates TGF-${\beta}$-induced transcriptional activation in certain cell types. In the present study, we investigated the effect of sumoylation on TGF-${\beta}1$-induced, Smad3/4-mediated $GL{\alpha}$ transcription and IgA switching by mouse B cell line, CH12F3-2A. Overexpression of small ubiquitin-like modifier (SUMO)-1, SUMO-2 or SUMO-3 did not affect TGF-${\beta}1$-induced, Smad3/4-mediated $GL{\alpha}$ promoter activity, expression of endogenous $GL{\alpha}$ transcripts, surface IgA expression, and IgA production. Next, we tested the effect of the E3 ligase PIASy on TGF-${\beta}1$-induced, Smad3/4-mediated $GL{\alpha}$ promoter activity. We found that PIASy overexpression suppresses the $GL{\alpha}$ promoter activity in cooperation with histone deacetylase 1. Taken together, these results suggest that SUMO itself does not affect regulation of $GL{\alpha}$ transcription and IgA switching induced by TGF-${\beta}1$/Smad3/4, while PIASy acts as a repressor.
A case of accessory tragus on buccal area
( Kyung Muk Jeong ),( Ji Yun Seo ),( Jin Young Song ),( Yoo Sang Baek ),( Hae Jun Song ),( Chil Hwan Oh ),( Jiehyun Jeon ) 대한피부과학회 2018 대한피부과학회 학술발표대회집 Vol.70 No.1
Accessory tragus is a congenital anomaly of the external ear arised from the abnormal development of the auricular tubercles or from the tissues surrounding the second, third and fourth branchial clefts. It presents in males and females equally with a prevalence of approximately 2-6 per 1000 live births. Clinically, this anomaly is usually presented as a small skin-colored tag or nodule near the tragus, but rarely, along an imaginary line drawn back from the tragus to the angle of the mouth, or along the anterior edge of the sternocleidomastoid muscle and the sternoclavicular region. The diagnosis is made by the age of onset, site of localization, and affirmative histopathology. We report a 12-month-old male who congenitally presented with a solitary flesh colored pedunculated nodule on the left buccal area. Shave biopsy was performed on this lesion. Histologically there are numerous follicles, prominent connective tissue framework in the sub cutaneous fat and central core of cartilage. It diagnosed as accessory tragus and the patient is under observation without complications. Herein, we report a case of accessory tragus arising in buccal area as an interesting example.
Kyoung-Muk Lee,Seh-Min Oh,Sung-Man Lee* 대한화학회 2008 Bulletin of the Korean Chemical Society Vol.29 No.6
A carbon composite was synthesized by mechanical mixing of ball-milled graphite and PVC powders, followed by pyrolysis reaction of PVC. Natural graphite ball milled under atmosphere of argon or air leads to a disordered structure. It appears that the electrochemical lithium intercalation reaction is dependent on the atmosphere in which the graphite is ball milled. The carbon composite obtained using air-milled graphite shows a high reversible capacity and high initial coulombic efficiency compared to argon-milled graphite. This is attributed to the enhanced thermal stability of a disordered structure in the air milled sample. For the one with air-milled graphite, the disordered structure is maintained during heat treatment, while argon-milled graphite is partially crystallized.