Axial Compressive Performance of CFRP Confined Self-stressing High-strength Concrete Cylinders

Qi Cao,Xiaojun Liu,Rongxiong Gao 대한토목학회 2019 KSCE JOURNAL OF CIVIL ENGINEERING Vol.23 No.9

Due to the advantages of FRP (fiber reinforced polymer), such as light weight, high strength and corrosion resistance, FRP-confined concrete columns are gradually applied in civil engineering structures and have drawn wide attention from the engineering community. In order to avoid the stress hysteresis of CFRP (carbon fiber reinforced polymer) and make full use of FRP materials, expansive agent was added to concrete to make self-stressing high-strength concrete. In this study, the axial compression performance of 18 CFRP-confined self-stressing high-strength concrete cylinders was examined. The parameters include the CFRP layers and the level of prestress (with or without prestress). Experimental results show that 3.53 − 5.34 MPa prestress in concrete and 799.3 − 1,584.2 MPa prestress in CFRP are produced in the composite cylinder. The stress-strain curves obtained from the experiment shows that the intercept stress, inflection stress and peak stress of the self-stressing specimens are all higher than those of the non-prestressed specimens. With the application of prestress, the utilization ratio of CFRP increases as well. In the theoretical calculation of intercept and peak stress, by modifying the existing models, the experimental results are in good agreement with the calculated results.

COMPUTATION OF TRANSONIC TURBULENT SEPARATED FLOW AROUND AN AIRFOIL WITH SUCTION AND BLOWING

Qi Peng Cao,De Hong Li 대한기계학회 1992 International Conference on Fluid Machinery Vol.1 No.1

Cost-Effective Replication Schemes for Query Load Balancing in DHT-Based Peer-to-Peer File Searches

( Qi Cao ),( Satoshi Fujita ) 한국정보처리학회 2014 Journal of information processing systems Vol.10 No.4

In past few years, distributed hash table (DHT)-based P2P systems have been proven to be a promising way to manage decentralized index information and provide efficient lookup services. However, the skewness of users`` preferences regarding keywords contained in a multi-keyword query causes a query load imbalance that combines both routing and response load. This imbalance means long file retrieval latency that negatively influences the overall system performance. Although index replication has a great potential for alleviating this problem, existing schemes did not explicitly address it or incurred high cost. To overcome this issue, we propose, in this paper, an integrated solution that consists of three replication schemes to alleviate query load imbalance while minimizing the cost. The first scheme is an active index replication that is used in order to decrease routing load in the system and to distribute response load of an index among peers that store replicas of the index. The second scheme is a proactive pointer replication that places location information of each index to a predetermined number of peers for reducing maintenance cost between the index and its replicas. The third scheme is a passive index replication that guarantees the maximum query load of peers. The result of simulations indicates that the proposed schemes can help alleviate the query load imbalance of peers. Moreover, it was found by comparison that our schemes are more cost-effective on placing replicas than PCache and EAD.

miR-101 Inhibiting Cell Proliferation, Migration and Invasion in Hepatocellular Carcinoma through Downregulating Girdin

Cao, Ke,Li, Jingjing,Zhao, Yong,Wang, Qi,Zeng, Qinghai,He, Siqi,Yu, Li,Zhou, Jianda,Cao, Peiguo Korean Society for Molecular and Cellular Biology 2016 Molecules and cells Vol.39 No.2

miR-101 is considered to play an important role in hepatocellular carcinoma (HCC), but the underlying molecular mechanism remains to be elucidated. Here, we aimed to confirm whether Girdin is a target gene of miR-101 and determine the tumor suppressor of miR-101 through Girdin pathway. In our previous studies, we firstly found Girdin protein was overexpressed in HCC tissues, and it closely correlated to tumor size, T stage, TNM stage and Edmondson-Steiner stage of HCC patients. After specific small interfering RNA of Girdin was transfected into HepG2 and Huh7.5.1 cells, the proliferation and invasion ability of tumor cells were significantly inhibited. In this study, we further explored the detailed molecular mechanism of Girdin in HCC. Interestingly, we found that miR-101 significantly low-expressed in HCC tissues compared with that in matched normal tissues while Girdin had a relative higher expression, and miR-101 was inversely correlated with Girdin expression. In addition, after miR-101 transfection, the proliferation, migration and invasion abilities of HepG2 cells were weakened. Furthermore, we confirmed that Girdin is a direct target gene of miR-101. Finally we confirmed Talen-mediated Girdin knockout markedly suppressed cell proliferation, migration and invasion in HCC while downregulation of miR-101 significantly restored the inhibitory effect. Our findings suggested that miR-101/Girdin axis could be a potential application of HCC treatment.

Evaluation of Time-dependent Strain Loss in CFRP Eccentrically Reinforced Shrinkage Compensating Concrete (SHCC) Flexural Members

Qi Cao,Jianpu Zhou,Xiaofeng Wang,Jizhong Wang,Zhongguo John Ma 대한토목학회 2018 KSCE JOURNAL OF CIVIL ENGINEERING Vol.22 No.1

Eccentrically CFRP enclosed Shrinkage Compensating Concrete (SHCC) flexural members show benefits of easy prestressing, better durability and self-made camber compared with traditional prestressed concrete. This paper presents the experimental and analytical work to evaluate the expansion strain losses in the proposed flexural members. A proposed analytical model to calculate the time-dependent strain losses is established including variables of shrinkage and creep of SHCC concrete based on GL2000 model. The relationship between maximum expansion strain and axial stiffness of FRP (EA) is also constructed. The same procedure was also conducted for Portland Cement Concrete (PCC) for the CFRP-PCC beam specimens. It is indicated that the proposed analytical model produces an accurate prediction in strain losses over time.

Cost-Effective Replication Schemes for Query Load Balancing in DHT-Based Peer-to-Peer File Searches

Cao, Qi,Fujita, Satoshi Korea Information Processing Society 2014 Journal of information processing systems Vol.10 No.4

In past few years, distributed hash table (DHT)-based P2P systems have been proven to be a promising way to manage decentralized index information and provide efficient lookup services. However, the skewness of users' preferences regarding keywords contained in a multi-keyword query causes a query load imbalance that combines both routing and response load. This imbalance means long file retrieval latency that negatively influences the overall system performance. Although index replication has a great potential for alleviating this problem, existing schemes did not explicitly address it or incurred high cost. To overcome this issue, we propose, in this paper, an integrated solution that consists of three replication schemes to alleviate query load imbalance while minimizing the cost. The first scheme is an active index replication that is used in order to decrease routing load in the system and to distribute response load of an index among peers that store replicas of the index. The second scheme is a proactive pointer replication that places location information of each index to a predetermined number of peers for reducing maintenance cost between the index and its replicas. The third scheme is a passive index replication that guarantees the maximum query load of peers. The result of simulations indicates that the proposed schemes can help alleviate the query load imbalance of peers. Moreover, it was found by comparison that our schemes are more cost-effective on placing replicas than PCache and EAD.

Vasodilation Effect of 2-benzyl-5-hydroxy-6-methoxy-3, 4-dihydroisoquinolin- 1-one

Wei-Qi,Yong-Xiao Cao,Zhi-Zheng Xiong,Ting-Ting Chen,Xiao-Yan Gao,Hang Yu,San-Qi Zhang 대한약학회 2012 Archives of Pharmacal Research Vol.35 No.8

A 2-Benzyl-5-hydroxy-6-methoxy-3, 4-dihydroisoquinolin-1-one (ZC2) is a newly synthesized isoquinolinone compound. Its effect on vasodilation was evaluated in the present study. Isometric tension of rat artery rings was recorded by a sensitive myography system in vitro. The results showed that ZC2 relaxed rat mesenteric arteries pre-contracted by KCl, phenylephrine and 9, 11- dideoxy- 11α, 9α-epoxymethano-prostaglandin F2α (U46619), and abdominal aorta pre-contracted by KCl in a concentration-dependent manner. The ZC2-induced vasodilation was not affected by an endothelium denudation. ZC2 rightwards shifted the concentration-contraction curves, induced by KCl, phenylephrine, and 5-hydroxytryptamine (5-HT) in a non-parallel manner, which suggests that the vasodilation effects are most likely via voltage-dependent calcium channel (VDCC) and receptor-operated calcium channel (ROCC). Moreover, in Ca2+-free medium, ZC2 concentration-dependently depressed the vasoconstrictions induced by phenylephrine and CaCl2, and decreased a contractile response induced by caffeine, which indicates a role of extracellular Ca2+ influx inhibition through VDCC and ROCC, and intracellular Ca2+ release from Ca2+ store via the ryanodine receptors. Glibenclamide did not affect the vasodilation induced by ZC2, suggesting that ATP sensitive potassium channel is not involved in the vasodilation. The results indicate that ZC2 induces vasodilation by inhibiting the VDCC and ROCC, and receptormediated Ca2+ influx and release. The inhibition of intracellular Ca2+ release may be mediated via the ryanodine receptors.

Effects and mechanism of sinapic acid (SA) on lipid metabolism and oxidative stress in high fat diet (HFD) hamsters

Wenjing Cao,Gao Luo,Keying Wang,Chanhua Liang,Wen He,Zhen Zeng,Qi Qi Pang,Jia-Le Song 한국식품영양과학회 2021 한국식품영양과학회 학술대회발표집 Vol.2021 No.10

To observe the effect of SA on lipid metabolism induced by HFD in Syrian hamsters. Changes in body weight(BW) were observed. The serum and hepatic levels of TC, TG, LDL-C, HDL-C and NEFA were determined by ELISA kits. The levels of PPAR-γ, CPT-1, CYP7A1, FAS, ACC1, SREBP2, HMGCR were detected by Western Blotting. Compared with control (CON) group, the weight of hamsters in the HFD group increased, while the weight and gain of hamsters in SA group decreased significantly (P<0.05). The weight of fat was significantly decreased after intervention with SA (P<0.05). The levels of TC, TG, LDL-C and NEFA in serum and liver were increased by HFD (P<0.05); while the serum levels of TC, TG, NEFA and LDL-C in SA group were decreased and HDL-C level was increased. Western-blot results showed that the HFD group’s levels of PPAR-γ, CPT-1 and CYP7A1 were decreased, and the levels of FAS, ACC1, SREBP1, SREBP2 and HMGCR increased; and SA can ameliorates changes in protein levels caused by HFD.Our results suggested that SA reduced fat accumulation, improve lipid metabolism disorder in hamsters induced by HFD.

miR-101 Inhibiting Cell Proliferation, Migration and Invasion in Hepatocellular Carcinoma through Downregulating Girdin

Peiguo Cao,Ke Cao,Jingjing Li,Yong Zhao,Qi Wang,Qinghai Zeng,Siqi He,Li Yu,Jianda Zhou 한국분자세포생물학회 2016 Molecules and cells Vol.39 No.2

miR-101 is considered to play an important role in hepatocellular carcinoma (HCC), but the underlying molecular mechanism remains to be elucidated. Here, we aimed to confirm whether Girdin is a target gene of miR-101 and determine the tumor suppressor of miR-101 through Girdin pathway. In our previous studies, we firstly found Girdin protein was overexpressed in HCC tissues, and it closely correlated to tumor size, T stage, TNM stage and Edmondson-Steiner stage of HCC patients. After specific small interfering RNA of Girdin was transfected into HepG2 and Huh7.5.1 cells, the proliferation and invasion ability of tumor cells were significantly inhibited. In this study, we further explored the detailed molecular mechanism of Girdin in HCC. Interestingly, we found that miR-101 significantly low-expressed in HCC tissues compared with that in matched normal tissues while Girdin had a relative higher expression, and miR-101 was inversely correlated with Girdin expression. In addition, after miR-101 transfection, the proliferation, migration and invasion abilities of HepG2 cells were weakened. Furthermore, we confirmed that Girdin is a direct target gene of miR-101. Finally we confirmed Talen-mediated Girdin knockout markedly suppressed cell proliferation, migration and invasion in HCC while down-regulation of miR-101 significantly restored the inhibitory effect. Our findings suggested that miR-101/Girdin axis could be a potential application of HCC treatment.

A Novel Nasal Delivery System of a Chinese Traditional Medicine, Radix Bupleuri, Based on the Concept of Ion- Activated in Situ Gel

Cao, Shi-Lei,Chen, En,Zhang, Qi-Zhi,Jiang, Xin-Guo 대한약학회 2007 Archives of Pharmacal Research Vol.30 No.8

The purpose of this study was to develop a nasal in situ gel system for Radix Bupleuri employing gellan gum as a polymer. Radix Bupleuri in situ gel containing 0.2 mL essential oil extracted from 450 g Radix Bupleuri, proper solubilizing agents and gellan gum (0.5% w/v) was prepared and characterized. The antipyretic effect produced by in situ gel formulation was investigated in fevered rabbits and compared to an intranasal solution. The resulting in situ gel was a clear and light-yellow liquid, with viscosity of 346 $mPa{\cdot}s$ and caproic acid content of $1.31{\pm}$ 0.01 mg/mL. Intranasal administration of this preparation to fevered rabbits decreased body temperature markedly ($1.1^{\circ}C$ at the doses of oil from 1.5 g Bupleuri/body) and the effect could last for 20-30 h. The results suggest that Radix Bupleuri in situ gel can be greater effective than the solution in the treatment of fever.