당뇨병 치료를 위한 SGLT2 억제제의 심혈관계 안전성 관련 최근 임상시험 결과고찰

김혜럼, 한나영, 유미선, 권광일, 윤휘열 충남대학교 약학대학 의약품개발연구소 2017 藥學論文集 Vol.32 No.-

Patients with type 2 diabetes have a two-to three-times greater risk of developing car-diovascular disease than people without diabetes, and the mortality rate from cardiovascular disease is also reported to increase. The reason why cardiovascular disease is more common in type 2 diabetic patients is not only that cardiovascular risk factors are more common than non-diabetic patients, but also that diabetes itself is an independent risk factor for cardiovascular disease. Since rosiglitazone. which was introduced as a treatment for type 2 diabetes in 2000, has been argued to increase cardiovascular disease sluch as myocardial infarction. there were clinical trials of cardiovascular safety of it such as DREAM. ADOPT and RECORD. As a result. rosiglitazone has been banned due to the risk of cardiovascular disease. The US FDA and other regulatory agencies have required clinical trials for type 2 diabetes treatments afterward. 1n this study. it is reviewed that recently developed SGL T2 inhibitors has cardiovascular benefits as a novel mechanism of type 2 diabetes treatment. SGL T2 inhibitors inhibit the renal sodium glucose co-transporter(SGLT2), thereby reducing glucose reabsorption and increasing excretion of it. and consequently lowering blood glucose levels. Recent papers on ongoing cardiovascular-related clinical trials of SGL T2 in-hibitors such as CANVAS. CANVAS-R. CREDENCE of canagliflozin, DECLARE-TIMI 58 of dapagliflozin. and EMPA -REG outcomes of empagliflozin were examined thoroughly as well.

Direct Chemical Synthesis of Plasmonic Black Colloidal Gold Superparticles with Broadband Absorption Properties

Kwon, Nayoung,Oh, Hwisu,Kim, Reehyang,Sinha, Arjyabaran,Kim, Jaeyun,Shin, Jonghwa,Chon, James W. M.,Lim, Byungkwon American Chemical Society 2018 NANO LETTERS Vol.18 No.9

<P>Self-assembly of plasmonic metal nanoparticles can provide an opportunity of creating colloidal superparticles with fascinating optical properties arising from interparticle plasmonic coupling, but typically requires multiple steps involving solvent and/or ligand exchange. We developed a direct, one-step chemical synthesis of plasmonic black colloidal Au superparticles with broadband absorption in visible and near-infrared regions. During the synthesis, the Au superparticles were formed through self-assembly of in-situ-formed Au nanoparticles driven by solvophobic interactions between nanoparticles and solvent. These superparticles could be solution-processed to fabricate a thin film, which exhibited near-perfect absorption over a broad range from 400 nm to 2.5 μm as well as the excellent antireflective property. Thanks to their broadband absorption property, the Au superparticles showed good performances for near-infrared surface-enhanced Raman spectroscopy and light-to-heat conversion.</P> [FIG OMISSION]</BR>

Psycholinguistics expanding eastward

( Nayoung Kwon ) 서울대학교 인지과학연구소 2018 Journal of Cognitive Science Vol.19 No.3

Predicting semantic features in Chinese: Evidence from ERPs

Kwon, Nayoung,Sturt, Patrick,Liu, Pan Elsevier 2017 Cognition Vol.166 No.-

<P><B>Abstract</B></P> <P>This article reports two ERP studies that exploited the classifier system of Mandarin Chinese to investigate semantic prediction. In Mandarin, in certain contexts, a noun has to be preceded by a classifier, which has to match the noun in semantically-defined features. In both experiments, an N400 effect was elicited in response to a classifier that mismatched an up-coming predictable noun, relative to a matching classifier. Among the mismatching classifiers, the N400 effect was graded, being smaller for classifiers that were semantically related to the predicted word, relative to classifiers that were semantically unrelated to the predicted word. Given that the classifier occurred before the predicted word, this result shows that fine-grained semantic features of nouns can be pre-activated in advance of bottom-up input. The studies thus extend previous findings based on a more restricted range of highly grammaticalized features such as gender or animacy in Indo-European languages (Szewczyk & Schriefers, 2013; Van Berkum, Brown, Zwitserlood, Kooijman, & Hagoort, 2005; Wicha, Bates, Moreno, & Kutas, 2003).</P> <P><B>Highlights</B></P> <P> <UL> <LI> Using the classifier system of Mandarin, this study investigated semantic prediction. </LI> <LI> N400s were elicited at the classifier position before the predicted noun. </LI> <LI> In addition, the effect was modulated by semantic relatedness to the predicted noun. </LI> <LI> The results suggest semantic features are pre-activated before the bottom-up input. </LI> <LI> They also suggest that prediction of semantic features could be fine-grained. </LI> </UL> </P>

Processing Asymmetries of Subject and Object pro in Korean

Nayoung Kwon 서울대학교 언어교육원 2015 語學硏究 Vol.51 No.2

Previous studies have shown that object relative clauses incur a heavier processing load than subject relative clauses. The processing advantage of subject relative clauses has been taken to support various processing accounts based on memory resources (Gibson, 1998; Lewis & Vasishth 2005) or linguistic analyses (O’Grady, 1997; Keenan & Comrie, 1977). In this paper, we aim to test these accounts using the construction that has not been previously examined, namely the noun complement construction with subject and object pro (~the fact that __pro threatened the editor vs. ~the fact the editor threatened __pro). Self-paced reading results showed that the processing advantage of subject gap was also found for the noun complement construction with pro. The results are taken to support processing accounts based on linguistic analyses

Collaboration, Coproduction, and Code-Switching: Colonial Cinema and Postcolonial Archaeology

Nayoung Aimee Kwon 고려대학교 민족문화연구원 2012 Cross-Currents Vol.- No.5

This article reassesses the issue of colonial collaboration in the Japanese empire by examining the rise of cinematic coproductions between Japanese and Korean filmmakers. By the late 1930s, colonial Korea’s filmmaking industry had been fully subsumed into the Japanese film industry, and regulations were established that required all films to assimilate imperial policies. The colonial government’s active promotion of colonial “collaboration” and “coproduction” between the colonizers and the colonized ideologically worked to obfuscate these increasing restrictions in colonial film productions while producing complex and contentious desires across the colonial divide. The very concepts of “collaboration” and “coproduction” need to be redefined in light of increasingly complex imperial hierarchies and entanglements. Taking the concept of “code-switching” beyond its linguistic origins, this article argues that we must reassess texts of colonial collaboration and coproduction produced at a time when Korean film had to “code-switch” into Japanese—to linguistically, culturally, and politically align itself with the wartime empire. The article argues that recently excavated films from colonial and Cold War archives, such as Spring in the Korean Peninsula, offer a rare glimpse into repressed and contested histories and raise the broader conundrum of accessing and assessing uneasily commingled colonial pasts of Asian-Pacific nations in the ruins of postcolonial aftermath.

Race for Empire : Koreans as Japanese and Japanese as Americans During World warⅡ

Nayoung Aimee Kwon(서평자) The Academy of Korean Studies 2014 THE REVIEW OF KOREAN STUDIES Vol.17 No.1

BLE 기반 자전거 보행자 간 안전 응용을 위한 브로드캐스트 채널들의 링크 품질을 고려한 비콘 전송 기법

권나영(Kwon NaYoung),강가현(Kang GaHyeon),고지현(Ko JiHyun),권용준(Kwon YongJun),배영준(Yeongjoon Bae),박형철(Hyeongcheol Park),이성원(Sungwon Lee),김동균(Dongkyun Kim) 한국통신학회 2017 한국통신학회 학술대회논문집 Vol.2017 No.11

사용자 맞춤형 운동시설 매칭 시스템 개발

권나영(Nayoung Kwon),김지영(Jiyoung Kim),윤은주(Eunju Yoon),최서연(Seoyeon Choi),윤용운(Yongun Yoon) 한국정보과학회 2018 한국정보과학회 학술발표논문집 Vol.2018 No.6

다수준 관점을 활용한 위험감수성향과 창의성과의 관계: 팀 수준 갈등의 매개역할

권나영(Nayoung Kwon),오인수(Insoo Oh),김민수(Minsoo Kim) 한국인사조직학회 2019 인사조직연구 Vol.27 No.1

빠르게 변화하는 환경으로 인해 조직은 끊임없이 혁신을 추구하고 있다. 이러한 기업의 혁신에 중요한 요소 중 하나가 창의성이다. 따라서 조직행동 분야에서는 창의성의 선행요인을 밝히기 위한 연구들이 진행되고 있다. 또한 최근 들어 많은 조직들이 팀을 중심으로 성과를 관리하고 있기에 개인 창의성만큼이나 팀 창의성에 대한 연구 관심도 높아지고 있다. 이에 본 연구에서는 다수준 관점에 따라 개인 창의성과 팀 창의성의 발현과정이 서로 다르게 나타날 것을 예상하고 이를 검증하였다. 먼저, 개인 수준에서는 위험감수성향이 높을수록 창의성도 높아질 것으로 보았다. 반면, 팀 수준의 위험감수 성향은 팀 갈등을 초래하고, 팀 갈등은 팀 창의성에는 부정적 영향을 미칠 것으로 보았다. 가설을 검증하기 위해 국내 여러 기업의 구성원들에게 설문조사를 실시하였으며, 최종적으로 95개 팀 411명의 데이터를 분석에 이용하였다. 또한 본 연구의 데이터 구조가 다수준인 것을 감안하여 다수준구조방정식(Multilevel Structural Equation Modeling)을 활용하여 가설을 검증하였다. 가설 검증 결과 개인 수준에서는 위험감수성향이 높을수록 창의성이 높아지는 것으로 나타났다. 팀 수준에서는 팀 위험감수성향이 높을수록 팀 갈등이 높아지며, 팀 갈등은 팀 창의성을 약화 시키는 것으로 나타났다. 본 연구를 바탕으로 개인의 위험감수성향은 창의성에 긍정적 영향을 미칠 수 있지만, 팀 수준에서는 갈등으로 이어지지 않게 관리해야 할 필요성이 있음을 확인할 수 있었다. 이러한 결과는 창의성연구 확장이라는 의의를 지닐 것으로 기대된다. As employee creativity is an important source of organizational innovation and competitive advantage, organizations are increasingly seeking to foster individual creativity. In addition, with teamwork common in many organizations, individual creativity is often enacted in this context. Consistent with these trends, researchers have shown increasing interest in individual and team creativity. The purpose of this study was to examine the effect of risk-taking orientation on individual and team creativity. We proposed that team risk-taking orientation associated with team creativity through team conflict. This study conducted multi-level analysis considering individual and team level simultaneously when team characteristics are composed of individual characteristics. To test our hypotheses, we collected survey-based data from diverse industries 411 employees and 95 teams in South Korea and utilized multilevel structural equation modeling. Also we used Monte Carlo Method for assessing mediation effect. The results revealed that risk-taking orientation was positively associated with individual creativity, but team risk-taking orientation was positively related to team conflict and that team conflict negatively related to team creativity. Moreover, the indirect effect of team risk-taking orientation through team conflict on team creativity. Based on these results, we discuss the theoretical and managerial implications of the study and suggest directions for future research on creativity.