Clinical Significance of Classification of Graves` Disease According to the Characteristics of TSH receptor Antibodies

(Won Bae Kim),(Hyun Kyung Chung),(Young Joo Park),(Do Joon Park),(Hong Kyu Lee),(Bo Youn Cho) 대한내과학회 2001 The Korean Journal of Internal Medicine Vol.16 No.3

N/A Background:It has been widely accepted that the epitope (s) and/or functional characteristics of thyrotropin receptor antibodies (TSHRAb) from Graves` patients are heterogenous among patients. However, the clinical significance of such heterogeneity has not been systematically evaluatedyet. We were to elucidate and find the clinical significance of heterogeneity for TSH receptor antibodies in Graves` disease. Methods:We measured stimulating TSHRAb (TSAb) activities using CHO-hTSHR cells, FRTL-5 cells and chimeric receptor expressing cells (Mc1+2 and Mc2), specific blocking TSHRAb (TSBAb) activities using Mc2 cells and TBII activities using porcine thyroid membrane in 136 patients with untreated hyperthyroid Graves` disease. Results: Based on various TSHRAb activities from each patient, the patients could be categorized into 7 subgroups by cluster analysis; 1) Group 1 (n=41) was characterized by moderate TSAb activities bothin CHO-hTSHR cells and in FRTL-5 cells, typical TSAb epitope, rare blocking antibodies and high TBII activities. 2) Group 2 (n=16) was characterized by the presence of blocking TSHRAb in most patients, albeit the other characteristics were the same as those in Group 1. 3) Group 3 (n=19) patients had low TSAb activities bothin CHO-hTSHR cells and in FRTL-5 cells, seldom had blocking TSHRAb, but they had high TBII activities. 4) Group 4 (n=30) could be categorized as `mild disease` group, as they had low activities in all kinds of TSHRAb assay and had low antim icrosomal antibody activities. 5) Group 5 (n=14) was characterized by moderate TSAb activities with atypical epitope (s), rare blocking TSHRAb and moderate TBII activities. 6) Group 6 (n=10) patients had veryhigh TSAb activities with typical epitopes, seldom blocking TSHRAb and low TBII activities. 7) Group 7 (n=6) was characterized by very high TSAb activities with atypical epitopes and high TBII activities. Pretreatment serum thyroid hormone level was low only in group 4 patients compared to the other 6 groups (p<0.05). The size of goiter was significantly larger in those in group 1 and group 3 (p<0.05) compared to the other 5 groups. The prevalence of clinically significant ophthalmopathy was higher in group 2 patients than the other 6 groups (50%vs.27.5%,p=0.06). Among 6 kinds of TSHRAb activities, only the blocking TSHRAb activity was significantly associated with the presence of ophthalmopathy in multivariate analysis. Conclusion:These results suggest that the differences inepitopes for TSAb or the presence of blocking TSHRAb is not a major factor in determining the degree of thyrotoxicosis in Graves` disease. Although the pathogenic mechanism is not clearyet, we suggest that patients with ophthalmopathy have different TSHRAb repertoire from those without ophthalmopathy in Graves` disease.

두개강내 정맥기형들과 동반된 안와내 해면상 혈관종 1례

조도상,송준혁,김명현,박향권,김성학,신규만,박동빈 대한신경외과학회 1998 Journal of Korean neurosurgical society Vol.27 No.6

Cu-Al-Ni 合金에 있어서 마르텐사이트 變態에 따른 內部摩擦

趙顯麒,禹基道,金圭鎭 慶北大學校 1984 論文集 Vol.37 No.-

The internal friction measurement was carried out by the torsion pendulum method with automatic recording of the virbration patterns. The critical range of the martensitic transformation was checked by measuring the electrical resistance and by morphological observation. The extent of internal friction in the region of the peak depends on the previous rate of temperature change and decreases sharply during a few minutes of isothermal holding. The high level of internal friction found in Cu~Al-Ni alloy is likely to due to the reversible movement of interfacial and twin boundaries on exposure to alternating stresses.

少菌性 癩患者(Paucibacillary leprosy)에서 實施한 레프로민 檢査 結果

曺圭鍾,崔道永,全義湜 大韓癩學會 1986 癩學 會誌 Vol.19 No.1

U-통계량을 이용한 어떤 비모수적인 두표본 위치검정의 점근 상대효율성에 관하여

조규민,조건호,하일도 대구대학교 (한사대학) 산업기술연구소 1993 産業技術硏究 Vol.12 No.-

This paper set up the nonparametric test statistic U₂, which expanded U₁-statistic with degree(3,3) into the form of a two-sample U-statistic with degree(5,5), say U₂for the purpose of developing the statistic that may be more efficient than the U₁-statistic suggested by Shetty & Govindarajulu(1988), in a two-sample location test. We compared the U₂test with the previous test, in the sense of ARE, under some special population distributions. To obtain the ARE of teh U₂test w.r.t. the previous test, the asymtotic null distribution and the efficacy of U₂were derived. Conclusively, we discovered that the U₂test expanded to degree(5,5) was more efficient than the previous test in heavy-tailed distributions like the double exponential and Cauchy.

포진후 통증환자에 대한 신경차단술의 효능 : 예비적 보고

신규만,조도상,조용재,김명현,김상진,김성학 이화여자대학교 의과대학 2005 EMJ (Ewha medical journal) Vol.28 No.1

Objectives : Of all the chronic pain syndromes postherpetic neuralgia ranks the most refractory to treatment. The eight postherpetic neuralgia patients have been treated with nerve blocks or neurolysis and obtained good result. We evaluate the therapeutic effect of nerve blocks for postherpetic neuralgia and reviewed the pathology, clinical consideration, treatments and prevention. Materials and Methods : Eight patients with established postherpetic neuralgia enrolled in pain clinic of Mokdong Hospital of Ewha Womans University from March,2004 to December. Average age at 58 and about 63% of patients were over 68 years. Affected area of forehead was two patients. They have been treated with stellate ganglion block (SCB), two times supraorbital and supratrochlear nerves blocks and neurolysis with absolute alcohol. Face affected patient has was one and has been treated with 5 times SGB, 2 times supraorbital and supratrochlear nerves blocks, infraorbital and mental nerves blocks, and then 2times maxillary and mandibular nerves blocks. Chest affected two patients were treated with intercostal nerve blocks. Thoracic wall affected one patient received 2 times thoracic epidural blocks and thoracic nerve block. Scapalur and thoracic wall affected patient has been treated with SGB and 2 times thoracic epidural block. The chest and thoracic wall affected patient received 10 times intercostal blocks,2 times thoracic epidural blocks,3 times thoracic root block and neurolysis of intercostal nerves with absolute alcohol. The injected agents were 1% mepibacaine or 0.25% mercain heavy and methylprednisolone succinated, and at weekly intervals the agents were injected. Results : All patient having been treated with nerve blocks were free of pain at 3-9 months. Conclusion : Although no controlled trial has been done of nerve blocks to treat postherpetic neuralgia, this technique is safe in experienced hands and, if effected, may be repeated. It suggested that local anesthetics and steroid are the effective components in nerve blocks. Data on the relief of acute pain with nerve blocks, however cannot be extrapolated to predict the prevention of postherpetic neuralgia. The best way to prevent herpes zoster becasuse of post herpetic neuralgia is so difficult to treat.

슬관절 골관절염 증상이 환자에게 미치는 우울 효과

박영규,이윤영,이계우,김정아,윤도경,박승회,조경환,홍명호,박용규 대한노인병학회 2001 대한노인병학회지 Vol.5 No.4

유압 모터 시스템에 대한 극점 배치 제어

황규동,이창훈,조영돈,김도석 충주대학교 2006 한국교통대학교 논문집 Vol.41 No.-

Pole Placement Control has been well establish in its theory. However, its practice value is yet to be appreciated in most industries. This paper presents an account in which the control strategy is run on the hydraulic motor. Using the input and output data from actual system, estimation of the model parameters are obtained by a function ARMAX(Autoregressive Moving Average with am exogenous signal) in Matlab and controller synthesis is achieved by a Pole placement control. Estimation system from a ARMAX is defined by third order and application of Pole placement control technique will be provide not only stability but also good performance for motion of hydraulic motor in any operation condition.

전기도금계에서 유발되는 자연대류에 의한 물질전달 특성

윤도영,조규택,송항옥 光云大學校 1995 論文集 Vol.24 No.-

In the present study, onset conditions and transfer characteristics have been investigated experimentally through electrochemical technique. Cupric sulfate-sulfuric acid solution confined between two horizontal copper electrodes was used. The magnitude of current estimating transfer rate was measured at an adopted constant electrical potential. Due to the change of the polarity of electrodes, the diffusion and natural convection have been induced respectively. The dimensionless onset time and correlation equations were as follows. r=70.57Ra-? Sh=0.04731Fa? Above results have differences comparing with existing data which ignore the electrical migration effects. It is considered that the difference between ours and others comes from the effects of migration which we have applyed quantatively. Also, it is ween that the electrical migration not only retards the onset of natural convection, but reduces the transfer rates.

슬관절 골관절염 환자에서 근육내 자극요법의 치료 효과

박영규,우종웅,안승렬,김정아,윤도경,박승회,조경환,홍명호 대한노인병학회 2001 대한노인병학회지 Vol.5 No.4