항균성 펩타이드인 Mastoparan B의 살조효과

서정길,김찬희,배윤정,문호성,김근용,박희연,윤호동,김창훈,변대석,홍용기,박남규 한국어병학회 2003 한국어병학회지 Vol.16 No.3

Mastoparan B (MPB)는 벌독으로부터 정제된 양친매성α-helical 구조를 취하면서 14개의 아미노산 잔기로 구성된 염기성 항균성 펩타이드로서 여러 가지 생물막과 작용한다. 본 연구에서는 우리 나라 연안의 적조 (HABs, harmful algal blooms)를 일으키는 4종의 적조생물 (Alexandrium tamarense, Chattonella catenatum)에 대한 MPB의 살조효과를 조사하였다. MPB의 4종의 적조생물에 대한 살조효과는 31.3㎍/㎖에서 세포의 lysis또는 ecdysis와 같은 형태로 현미경으로 관찰할 수 있었다. 또한 MPB는 C. marina 및 C. polykridorides에 대해서 A. tamarense와 G. catenatum보다 더욱 강한 살조효과를 나타내었다. 이러한 MPB의 HABs에 대한 살조효과연구는 새로운 살조물질을 개발하기 위한 자료가 될 것으로 생각된다. Mastoparan B (MPB), an antimicrobial cationic peptide isolated from the venom of the hornet Vespa basalis, is a basic amphipathic a-helical peptide composed of fourteen amino acid residues. In this study, we have investigated the algicidal effect of MPB against hatmful algae blooms (HABs) casative Alexandrium tamarense, Chattonella marina, Cochlodinium polykrikoides and Gymnodinium catenatum. The algicidal effect of MPB showed in the concentration of 31.3 ㎍/㎖ to 500 ㎍/㎖ against 4 HAB species and observed cell lysis or cell ecdysis by microscopy. MPB reacted more sensitive to C. marina and C.polykrikoides than A. tamarense and G. catenatum. The algicidal study of MPB against HABs will provides much insight into development of new algicidal substances.

탄소 나노튜브의 길이변화에 따른 물리적 특성에 관한 이론적 연구

문원하,변기량,황호정 중앙대학교 기술과학연구소 2001 기술과학연구소 논문집 Vol.31 No.-

본 연구에서는 나노 단위의 소자개발을 위하여 (6, 6) 탄소 나노튜브의 유한길이에 따른 물리적 특성에 관해 알아보았다. 먼저 브레너 전위식을 이용하여 모자가 씌워진 탄소 나노튜브의 최적화된 구조를 얻어내었다. 그후 탄소 나노튜브의 최적화된 구조를 가지고 TBMD 시뮬레이션을 수행하였다. TBMD 결과, 에너지 밴드갭은 길이에 따라 반비례하는 것을 알 수 있으며 특히 길이가 20 이하인 경우 탄소와 탄소간의 나타나는 π 결합의 영향으로 인하여 길이에 따라 에너지 밴드갭이 민감한 변화를 보이며 진동함을 알 수 있다. 여기서 (6, 6) 탄소 나노튜브의 에너지 배드갭은 0.3∼2.5 eV 정도임을 알 수 있다. The electronic properties of Carbon Nanotube(CNT) are currently the focus of considerable interest. In this paper, the electronic properties of finite length effect in CNT for carbon nano-scale device is presented. To Calculate the electronic properties of CNT, Empirical potential method (the extended Brenner potential for C-Si-H) for carbon and Tight Binding molecular dynamic (TBMD) simulation are used. As a result of study, we have known that the value of the band gap decreases with increasing the length of the tube. The energy band gap of (6,6) armchair CNT have the ranges between 0.3 eV and 2.5 eV. Also, our result are in agreements with the result of the other computational techniques.

Monte Carlo 시뮬레이션을 이용한 이온 주입시의 점결함 분포의 계산

손명식,이준하,변기량,황호정 중앙대학교 기술과학연구소 1995 기술과학연구소 논문집 Vol.25 No.-

이온 주입시의 점결함 분포를 간접적으로 계산하기 위해 단결정 실리콘에서의 3차원 이온 주입 시뮬레이터인 TRICSI (TRansport Ions in Crystal Slilicon) Monte Carlo 코드를 확장하여 Boron 이온 주입시의 에너지와 dose에 따른 불순물(particle) 및 점결함 분포(point defect)를 계산하였다. 결함 분포는 Modified Kinchin-Pease equation을 단결정 실리콘에 적용하여 displacement damage에 의해 발생한 Frenkel Pair(vacancy-interstitial)분포를 계산하였으며 이온 주입시의 웨이퍼 온도에 의한 Frenkel Pair 소멸 효과는 고려하지 않았다. 계산 결과는 3차원 각면으로의 2차원 투영 불순물 농도로 표현하고 주입된 dose와 에너지에 다른 마스크 주입시의 에너지 및 dose 의존성 도펀트 분포와 이에 따른 damage 분포를 이해하는 데 중요한 정보가 될 것으로 기대된다. We extended our ion implantation simulator, TRICSI (TRansport lons in Crystal Slilicon) Monte Carlo(MC) code, and indirectly calculated particle and its generating point defect distributions depending on energy and dose during boron implantation into <100> single0crystal silicon. The point defect distribution of Frenkel Pair(vacancy-interstitial) was abtained by applying the modified Kinchin-Pease equation, which usually uses in MC simulation in amorphous target, to MC simulation in crystalline silicon. We did not considered the annihilation of Frenkel Pairs due to wafer temperature. The calculated results were projected onto each free-dimensional plane, presented as two-dimensional concentration profile on it. The particle concentration profile was presented with typical open mask structure. We expect that these results help understand the dopant and its generating damage distributions depending on energy and dose during boron implantation.

중부지역 대학생의 남녀평등의식에 관한 실태조사

최덕경,최동숙,강기정,유을용,변미희 한국청소년복지학회 2004 청소년복지연구 Vol.6 No.1

This study investigated gender eqalitarianism of university students. The purpose of this study was to offer basic information and desirable direction for the education program of student's sex-role indentity. The data collection was based on Korean Questionnaire of Gender Equality Perception developed by Korean Women Development Center. Its reliabilitv(Cronbach α) was .84. In this study.982 university students were sampled in Kyunggi, Gangwon and Chungchong provinces. T-test and One-way ANOVA was conducted with the SPSS 10.0 version program. The major findings of this study were as follow: First, university student showed the highest gender eqalitarianism in educational life field. But they have the lowest in social and cultural life field. Second, male university students showed lower gender eqalitarianism than female university students. Third. student who is middle or last in brother order showed higher than one who is first or only son. Forth, student who is grown up in urban showed higher gender eqalitarianism than one in country.

Female with 46, XY karyotype

( Eun Jung Jung ),( Do Hwa Im ),( Yong Hee Park ),( Jung Mi Byun ),( Young Nam Kim ),( Dae Hoon Jeong ),( Moon Su Sung ),( Ki Tae Kim ),( Hyo Jung An ),( Soo Jin Jung ),( Kyung Bok Lee ) 대한산부인과학회 2017 Obstetrics & Gynecology Science Vol.60 No.4

Disorders of sex development (DSD) are congenital conditions characterized by atypical development of chromosomal, gonadal, and phenotypic sex. 46, XY DSD can result from disorders of testicular development or disorders of androgen synthesis/action. Prophylactic gonadectomy should be considered in patients with 46, XY DSD because of the increased risk of gonadal malignancy. We report two rare cases of 46, XY DSD, including XY pure gonadal dysgenesis and complete androgen insensitivity syndrome, who underwent a prophylactic gonadectomy.

Spontaneous Low-Frequency Cerebral Hemodynamics Oscillations in Restless Legs Syndrome with Periodic Limb Movements During Sleep: A Near-Infrared Spectroscopy Study

Byun, Jung-Ick,Jung, Ki-Young,Lee, Gwan-Taek,Kim, Choong-Ki,Kim, Beop-Min 대한신경과학회 2016 Journal of Clinical Neurology Vol.12 No.1

<P><B>Background and Purpose</B></P><P>Periodic limb movements (PLM) during sleep (PLMS) are associated with cortical and cardiovascular activation. Changes in cerebral hemodynamics caused by cortical activity can be measured using near-infrared spectroscopy (NIRS). We investigated oscillatory components of cerebral hemodynamics during PLM and different sleep stages in restless legs syndrome (RLS) patients with PLMS.</P><P><B>Methods</B></P><P>Four female RLS patients with PLMS, and four age- and sex-matched normal controls were included. PLM and sleep stages were scored using polysomnography, while the spontaneous cerebral hemodynamics was measured by NIRS. The phase and amplitude of the cerebral oxyhemoglobin concentration [HbO] and the deoxyhemoglobin concentration [Hb] low-frequency oscillations (LFOs) were evaluated during each sleep stage [waking, light sleep (LS; stages N1 and N2), slow-wave sleep (stage N3), and rapid eye movement (REM) sleep]. In RLS patients with PLMS, the cerebral hemodynamics during LS was divided into LS with and without PLM.</P><P><B>Results</B></P><P>The cerebral hemodynamics activity varied among the different sleep stages. There were changes in phase differences between [HbO] and [Hb] LFOs during the different sleep stages in the normal controls but not in the RLS patients with PLMS. The [HbO] and [Hb] LFO amplitudes were higher in the patient group than in controls during both LS with PLM and REM sleep.</P><P><B>Conclusions</B></P><P>The present study has demonstrated the presence of cerebral hemodynamics disturbances in RLS patients with PLMS, which may contribute to an increased risk of cerebrovascular events.</P>

The Significance of VSIG4 Expression in Ovarian Cancer :

Byun, Jung Mi,Jeong, Dae Hoon,Choi, In Hak,Lee, Dae Sim,Kang, Mi Seon,Jung, Keun Ok,Jeon, You Kyung,Kim, Young Nam,Jung, Eun Jung,Lee, Kyung Bok,Sung, Moon Su,Kim, Ki Tae BMJ 2017 International journal of gynecological cancer Vol.27 No.5

<P>Conclusions: VSIG4 is overexpressed in ovarian cancers compared with that in benign tumors. This finding supports VSIG4 being used as a potential therapeutic target for ovarian cancer. Furthermore, soluble VSIG4 levels are associated with the progression and recurrence of ovarian cancer, indicating that soluble VSIG4 may be used as a potential biomarker for predicting tumor prognosis.</P>

Gh Mediates α1-Adrenoreceptor-Induced Transactivation of Integrin Signaling and Hypertrophy in Cardiac Myocytes

( Ki Hyun Byun ),( Woo Chul Chang ),( So Yeon Lim ),( Sun Ju Lee ),( Byeong Wook Song ),( Hye Jung Kim ),( Min Ji Cha ),( Ki Chul Hwang ),( Nam Sik Chung ) 한국조직공학·재생의학회 2008 조직공학과 재생의학 Vol.5 No.4

In cardiac myocytes, stimulation of the alpha(1)-adrenoreceptor(AR) leads to a hypertrophic phenotype. The Gh protein(transglutaminase II, TGII) is tissue type transglutaminase that transmits the alpha(1B)-AR signal with GTPase activity. Recent evidence suggests that integrin activation, in concert with G protein activation, might be essential for cardiomyocyte growth.In this study, our objectives were to evaluate how Gh and integrin interact to promote cardiomyocyte hypertrophy and to identify Gh molecular determinants and downstream signals involved. First, we observed the selectivity of alpha-adrenoceptors in norepinephrine(NE)-induced cardiac hypertrophy by protein synthesis and estimation of the constitutive genes MLC-2 and ß-MHC. NE-mediated hypertrophic responses activated ERK1,2 and their upstream regulators MEK1,2, which were inhibited by siRNA for Gh.We also identified significant activation of ß1-integrin in NE-induced cardiomyocyte hypertrophy. In addition, FAK and Shc, a regulator of FAK, were directly related with integrin and Gh protein in NE-induced cardiomyocyte hypertrophy. The activation of FAK and Shc were suppressed by siRNA for Gh. In conclusion, the hypertrophic response induced by norepinephrine in cardiomyocytes occurs through ß1-Integrin/Shc/FAK/MEK1,2/ERKs signal pathways via α1-AR/Gh.

A case of immune thrombocytopenia associated with invasive thymoma successfully treated with eltrombopag

Jung-Ki Yoon,Hee Ryeong Jang,Jin Hyun Park,Ki Hwan Kim,Eu Youn Roh,Ja Min Byun 대한혈액학회 2019 Blood Research Vol.54 No.1

A case of immune thrombocytopenia associated with invasive thymoma successfully treated with eltrombopag

Jung-Ki Yoon,Hee Ryeong Jang,Jin Hyun Park,Ki Hwan Kim,Eu Youn Roh,Ja Min Byun 대한혈액학회 2019 Blood Research Vol.54 No.1