複合 韓藥劑 淸籬滋坎湯의 抗癌效果 및 作用機轉 糾明

Cho, Kyung-Sam,Kim, Si-Young,Park, Jai-Kyung,Choi, Seung-Hoon,Chung, Se-Young,Yoon, Hwi-Joong 경희대학교 동서의학연구소 1999 INTERNATIONAL SYMPOSIUM ON EAST-WEST MEDICINE Vol.1999 No.1

Kyung Sam Cho¹Si Young Kim¹, Jai Kyung Park²,Seung Hoon Choi³,Se Young Chung⁴, Hwi Joong Yoon¹¹College of Medicine, ²East-West Medical Research Institute, ³College of Oriental Medicine, ⁴College of Pharmacology, Kyung Hee University,Seoul, Korea. The Anti-cancer Effect of Oriental Medicine Chung-Ri-Ja-Gam-Tang in the Mouse with Metastatic Lung Cancer. Proceedings of International Symposium on East-West Medicine, Seoul. 231-243, 1999.-The oriental medicine Chung-Ri-Ja-Gam-Tang is an herbal medicine which has been used for pulmonary diseases and known as having immune stimulatory effects. It has been known effective in lung cancer. So we studied the effects and the mechanisms of this herbal medicine it the mouse with metastatic lung cancer. The metastatic lung cancer of the mouse was produced with melnoma cell line(B16BL/6).5×10□/mouse tumor cells were injected intravenously to the CDF1 mouse via tail vein. The mice were divided 4 groups. The first group was treated with 50mg/kg extract of Chung-Ri-Ja-Gam-Tang per oral for 10 days after cancer cell injection, second group treated with saline after cancer cell injection, the third group with medicine without cancer cell, and the last group with saline only. After 10 days treatments some of the mice were scarificed and the lung and spleen was removed. The survival duration, weight change, the number of metastatic cancer nodule of the lung, the NK cell activity, the capacity of cytokines(INF-γ,INF-α,IL-2) production and the proliferation activities of mouse lymphocytes were measured. The surival times of the group 1 mice were longer and the weight loss was less than the group 2 significantly. The number of the metastatic nodule of the lung were decresed in the group 1 than the group 2. The production of INF-γ,was increase in group 2 than group 3 and 4, IL-2 production was increased in group 1 than group 2,3,4 significantly. There was no difference in TNF- α production and proliferation activity of lymphocyte in each group. The NK cell activity was significantly increased in group 1 than group 2,3,4. We conclude that the Chung-Ri-Ja-Gam-Tang has the effect of increasing the NK cell activity of the CDF1 mouse with metastatic lung cancer(B16BL/6). And it is suggested that the increased production of the IL-2 is the mechanisms of enhanced NK cell activity.

배달 미니 게임 개발:"최고의 웨이터를 꿈꾸며"

김정훈,정한교,김영옥,김중곤,박정윤,윤진성,김경식 호서대학교 반도체제조장비국산화연구센터 2001 반도체장비학술심포지움 Vol.2001 No.-

본 미니 게임은 웨이터라는 직업을 모티브로 하여서 남녀노소 누구나 재미를 느낌과 동시에 기억력 향상시켜 주는 게임제작이라는 목적아래 제작되었다.본 논문에서는 이 게임의 제작과정을 기술하고자 한다.이 게임은 제3회 AGC(한국 아마추어 게임제작 공모전)에서 우수 작으로 선정되었다.

서울의 PPNG 발생 빈도(1991-1992)

김재홍,윤기범,박평원,김영진,전경민,김영태,김중환,곽호,구상완,송민석,유옥,지혜구,김동원,문상은,박영립,정승호,성범진,성순제,엄주용,황정열,이기홍,이주협,전태진 대한화학요법학회 1994 대한화학요법학회지 Vol.12 No.1

The prevalence of PPNG among pretreated gonorrhea cases isolated at the STD clinic of Choong-Ku Public Health Center in Seoul has been studied and reported annually since 1981. In 1991, 123 strains of N.gonorrhoeae were isolated, among which 58(47.1%) were PPNG. In 1992, 98 starains of N.gonorrhoeae were isolated, among which 51(52.0%) were PPNG. In all, 109(49.3%) strains were found to be PPNG among 221 strains isolated between 1991-1992. The prevalence of PPNG in Seoul showed increased tendency till 1989, thereafter, it has been stationary or slightly decreasing.

강판의 자동 형상제어 장치의 특성에 관한 연구

전언찬,김중완,김문경,김순경 동아대학교 공과대학부설 생산기술연구소 1996 生産技術硏究所硏究論文集 Vol.1 No.2

In this paper, the performance and functions of automatic flatness control system installed on the 4 hi-reversing mill and has been investigated under actual conditions. A new automatic flatness control system incorporates a measuring roll for measurement and correction calculations, hydraulic roll benders, selective roll cooling, and a programmable controller forinterface and data logging. The test results are as following. The more the exit steel strip thickness is thick, the smaller the I value, and the more it is thin, the larger the I value. And, a complex distribution of strip tension was controlled, for example, not only a quarter buckle but also a simple center wave and edge wave. Because the tension deviation is larger at acceleration speed and deceleration speed than steady speed. so automatic flatness control system of contact type is better to adopt over 450 m/min, automatic flatness control system reduces rapidly large flatness deviation. The maximum I value of strip has been decreased to 13 I, and defects caused by poor flatness have been drastcally decreased. And coolant temperature for work roll cooling system on the automatic flatness control system is better to adopt about 50-55℃.

자동 형상제어용 측정롤의 특성에 관한 연구

전언찬,김중완,김순경,김문경 동아대학교 공과대학부설 생산기술연구소 1996 生産技術硏究所硏究論文集 Vol.1 No.2

The continuing demand for quality products requires better understanding and improved control of the production process. And, in recent year requirements for flatness control in strip rolling have become increasingly severe because of the control for flatness of cold rolled strip is essential for further down stream processing. Also a speeds of rolling mills to meet productivity requirements puts a demanding requirement on the control of flatness of rolled strip. The demands on a total flatness control system therefore are a measuring and indication system consisting of a measuring roll that is robust, accurate, reliable and require a minimum of maintenance. The critical part of any control system is the quality of the information being provided by measurement instrument or device. It is therefore of utmost importance to have an accurate, repeatable measuring system.

지속가능성장을 위한 윤리정부 정착화 전략

김경중 경희대학교 기업경영연구소 2006 기업경영연구 Vol.12 No.2

The successive government have put an effort to prevention of corruption, so they have succeeded in mufti portion. However, itemized discussion has not made great result in actual condition. The success of prevention of corruption measures has direct relevance to diverse politic, society, and administration circumstance. Operation these elements make decision to effective achievement of anti corruption measures. For the settlement of successful anti corruption measures in ethical government during the period of measures in organization which causes many conflicts between against group and following group has to build new order through interaction among the members. The side of organization, with the new way and thought differ from its past following new government ethical measures, offers working circumstance to government officials. Although successive government suggested many reform measures, only little bit parts succeeded and some organizations have had good results with the same reform measures but others have not. While early majority of people participate in process of expanding about reform measures at first acceptation step, there is no careful mechanism strategy to expand and fix on. It is difficult to expose corruption only specific ministries and central government efforts. It will be able to success that all parts of national institution such as Legislation, administration of justice, administration, discussion and civil society relate each other. The government and propulsion station could not only request to promote to ministries and offices, but also abstract measures without concreteness accept cynical attitude. So it is difficult to get its effectiveness. All fields such as economy, society, culture and also public position in our country situation have to educate the people who could role ethical order parameter and have to settle its strategy. It will be able to succeed by ethical government. Especially, for success of anti corruption measures, it must need consistence will and practice to president, centralized of power and each agency administration in charge. Firm purpose and sustainable principals of president will be motive to expose corruption and also it will be the most important that each class government agency chief who actually acts anti corruption make effort specific practice and purpose.

X-線 照射에 의한 小腸粘膜의 走査電子顯微鏡像

김용가,손경락,손태중 慶北大學校 醫科大學 1991 慶北醫大誌 Vol.32 No.1

저자들은 전신 방사선 조사후 소장의 점막 변화를 주사전자 현미경으로 관찰하여, 급성 방사선 상해의 일단을 알아보기 위해, 흰토끼에 2,000rad를 1회 전신 조사하여 말단회장의 절편을 채취하여 시료로 사용하였다. 융모의 변화는 방사선 조사후 20분 군에서 가장 심하게 나타났으며, 이후 시간이 경과함에 따라 융모의 변화는 경미해 지면서 1일후는 거의 정상 융모의 모양을 나타내었으며, 미융모의 크기 및 분포는 시간의 경과와 관계없이 대체로 일정하였으나 3시간 군까지는 미융모의 일부에서 수포형성이 관찰되었다. 미융모의 밀도는 대조군보다는 방사선 상해를 받은 군에서 더욱 높게 나타났다. 개개 세포는 1시간 군까지 부분적으로 세포의 탈락이 있을 뿐 시간경과에 따른 유의성있는 변화는 관찰되지 않았다. 이상의 검사성적으로 미루어 다음과 같은 결론을 얻었다. 첫째,전신 방사선 조사시 상해는 20분 군에서 가장 심하게 나타났으며, 둘째, 융모의 모양은 방사선 조사후 1일 군부터 거의 대조군과 가까운 소견을 보인 것으로 미루어 상피세포의 재생이 왕성하다고 생각된다. 셋째, 편평한 융모나 거대세포는 관찰되지 않았다. 넷째, 미융모는 방사선 조사후 3시간 군까지 밀도가 증가하였으며, 상피세포가 재생되면서 대조군과 유사해 질수록 미융모의 밀도는 다소 낮아진다. 다섯째, 점막 세포는 1시간 군까지 경한 세포탈락이 있을 뿐 시간경과에 따른 유의성이 없었다. 여섯째, SEM은 방사선 조사시 소장 점막의 3차원적 구조를 관찰하는데 민감한 도구이다. 일곱째, 미융모는 방사선 상해를 받은 군에서 더 발달되어있다. The authors studied acute radiation injury of small intestine by scanning electron microscope. Rabbit as an experimental model was irradiated 2,000rads/once. After that, a segment of terminal ileum was obtained and examined with time. Changes of villi are most severe on the 20 min experimental group and after that the severity was gradually regressed. With time, change of villi becomes mild and nearly normal on the 4day experimental group. Change of size and distribution of microvilli are relatively constnat with time except mild microvesicular changes to the 3hr group. Density of microvilli is usually higher on the irradiated group than control group. Focally cell loss is present but there is no remarkable changes with time on the individual cells. Following are conclusions of this experiment. First, radiation injury is most severe on the 20 min group. Second, shape of villi is close to normal from 1hr group, which suggests that this radiatio ninjury is reversible one. Third, flat villi or giant cell was not observed. Fourth, density of microvilli is increased to the 3hr group but regressed after that. Fifth, mucosal cells reveal relatively unremarkable change with time except mild cell loss to the 1hr group. Sixth, SEM is relatively sensitive method to see 3 dimensional structure of mucosa after radiation injury. Seventh, change of microvilli are more severe on the irradiated group.

Gelman과 Gallistel의 수세기 이론에 기초한 유아수학교육방향 : 사회극놀이를 통한 유아수학교육프로그램 활동제시

김영중,김경희 제주관광대학 2003 論文集 Vol.9 No.-

유아기 수학교육은 생활 속에서의 경험을 재구성하여 수학적 사고와 의사소통이 이루어질 수 있도록 해야 한다. 그런데 유아의 수학적 사고발달과 학습과정, 그리고 다양한 교수방법에 관한 연구결과를 바탕으로 보다 바람직한 유아수학교육의 방향을 제기하는 이론적 동향과는 달리, 많은 유아교육기관에서의 수학교육은 매우 제한되거나 적합하지 않은 방법으로 이루어지고 있다. 이에 본 논문에서는 최근에 보다 타당하고 적합한 것으로 공감을 얻고 있는 Gelman과 Gallistel의 수세기 이론에 기초하여 바람직한 수학교육의 방향을 제시하고 실제로 유아교육현장에서 적용 가능한 활동내용과 방법을 제시하고자 한다.

Regular C -algebra Norm에 대한 고찰

金重熙,嚴璟漣 聖心女子大學校 1994 論文集 Vol.26 No.-

F가 r≥2의 generator를 갖는 discrete free group이고 f∈1¹(F)가 적당한 조건을 만족할 때 C*-algebra norm을 계산하는 공식이 알려져 있다. 그 공식이 F가 infinitely generated free group인 경우에도 유효함을 보이고, r≥2가 반드시 필요한 조건임을 반례를 들어보였다. Let F be a discrete free group on r≥2 generators. Under a condition on f∈1¹(F), we have a formular in [3] for computing the regular C*-algebra norm of f. In this paper, we show the validity of the formula for an infinitely generated free group F and that the condition r≥2 is essential by giving a counterexample.

심초음파로 결정된 응급 심낭천자술의 천자부위

김성환,황성오,이강현,조준휘,강구현,문중범,이승환,윤정한,최경훈,김영식 대한응급의학회 2000 대한응급의학회지 Vol.11 No.3

Background: The aim of this study was to determine whether the conventional subcostal approach is suitable for emergency pericardiocentesis in patients with cardiac tamponade or impending cardiac tamponade. Methods: This study was a prospective, observational study conducted at the emergency department of a tertiary hospital, Patients who had symptomatic pericardial effusion and who needed emergency pericardiocentesis in the emergency department were included in this study. We measured the epicardium-to-pericardium distance at the subcostal, parasternal, and apical area with two-dimensional echocardiography to determine the appropriate puncture site for pericardiocentesis. An epicardium-to-pericardium distance of more than 1.0 cm was considered as the primary safety factor in determining the Puncture site for pericardiocentesis. The skin-to-pericardium distance was considered as secondary safety factor. Results: Ninety-five consecutive patients(55 males and 40 females; total mean age: 53 year old) with cardiac tamponade or impending cardiac tamponade were enrolled in this study. The puncture site for pericardiocentesis, as determined by echocardiography, was the subcostal area in 43 patients(45%), the apical area in 40 patients(42%), the left parasternal area In 11 patients(12%), and the right parastemal area in one patient(1%). Pericardiocentesis failed in 2 patients(2%) with the subcostal approach and in one patient(1%) with the apical approach. The average epicardium-to-pericardium distance was 31 ±21 mm in patients with the subcostal approach and 21±8 mm in patients with other approaches. There were no differences in the amount of pericardial fluid and in the intraperical pressure among patient groups according to puncture site. There were two procedure related complications: a puncture of the right ventricle with the subcostal approach and a ventricular tachycardia with the apical approach.